I'm pretty happy to be on reta for the long term, maybe not "life" but at least years. I'm almost at goal and I'm considering lowering dose a bit for maintenance but definitely something to play with and take week by week, I'm committing to nothing at this point. I guess I'd prefer to not be on drugs, but I have lost and regained weight so many times I am under no illusions of how well I'll do on willpower alone. I'm in the old and chronically obese camp.
For those on Reta, what’s your exit strategy?
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Dogmandu
GLP-1 Apprentice
NA-931 was a scam. It will not exist.petros600 said:
Company hype based on press releases and no published science. They've been exposed.
SoCalGirl
GLP-1 Novice 🚫No Source Discussion🚫
I think I'm here for life. It is the ONLY time ever in my life that I have felt like a "normal" eater. I mean, I actually stop eating - even when there is food left on the plate. WHAT?!? 
Eventually, I will lower the dosage down to less than 1mg weekly, titrating down, 1/4 mg at a time until I hit about .25 or .5 a week, but this will not be this year, I don't think. Unless I miraculously hit my goal weight. I think the stuff is amazing. Yeah, I've drunk the kool-aid! 
Eventually, I will lower the dosage down to less than 1mg weekly, titrating down, 1/4 mg at a time until I hit about .25 or .5 a week, but this will not be this year, I don't think. Unless I miraculously hit my goal weight. I think the stuff is amazing. Yeah, I've drunk the kool-aid! 
TooBigtoFail
GLP-1 Enthusiast
Am on Cagri 1mg with Reta 10mg. Am almost at my goal weight. Plan A: I plan on getting off Cagri first, titrating down slowly. Then reduce Reta slowly, over many months, and monitor. If weight begins to climb, Plan B: switch to Orforglipron for 6 months (I already have my supply), stop and monitor/evaluate. If unable to maintain, then Plan C: use up my 1+ year supply of Tirz, cycle in Cagri and Reta ( like many, I have plenty in the freezer).
A research by 'Epic Research' gave me hope to get off glp1, indicating that for those on glp1 for at least one year and down over 40 lbs, where much less likely to regain, or only regain less than 10% in the next year. This reinforces what I read on fat cells epigenetic memory. These fat cells eventually die off, and the new ones do not have the memory effect to where they want to get fat again. But these cells can live up to 10 years.
Some folks expect to use insulin for the rest of their life. My plan D: no exit, stay on glp1 if I must. As time goes on, new products will hit the market (Orforglipron... ), and new solutions/research are being developed. I am now retired, down 92#, feel (and look) like I am 25. ALL my aches are gone. All my Dexa, CT, blood/urine tests are excellent, like the 25 years old version of me.
If you think short term, you may get the same yoyo results of the other fat reducing diets.
As a note: I eat 50% less food than before. Seems the body needs a lot less calories as you get slimmer.
A research by 'Epic Research' gave me hope to get off glp1, indicating that for those on glp1 for at least one year and down over 40 lbs, where much less likely to regain, or only regain less than 10% in the next year. This reinforces what I read on fat cells epigenetic memory. These fat cells eventually die off, and the new ones do not have the memory effect to where they want to get fat again. But these cells can live up to 10 years.
Some folks expect to use insulin for the rest of their life. My plan D: no exit, stay on glp1 if I must. As time goes on, new products will hit the market (Orforglipron... ), and new solutions/research are being developed. I am now retired, down 92#, feel (and look) like I am 25. ALL my aches are gone. All my Dexa, CT, blood/urine tests are excellent, like the 25 years old version of me.
If you think short term, you may get the same yoyo results of the other fat reducing diets.
As a note: I eat 50% less food than before. Seems the body needs a lot less calories as you get slimmer.
Cannonball72
GLP-1 Apprentice
The oral GLP have significantly more contraindications, it’s worth looking into. Orals need to be processed by the liver before entering the bloodstream, my understanding is that this has significant impact on potential downstream Issues.TooBigtoFail said:
DunningKruger
GLP-1 Enthusiast
Currently on the third week of my exit strategy. The goal is to increase my calories over two months while decreasing my dose in order to retrain my system to take in a normal amount of food again without causing the rebound weight gain that re-feeding can cause.
I was on it for 12 weeks at 1, 2, and 3mg. I dropped from 3mg to 1.5mg for 2 weeks, but that was too much too soon, so I raised it to 2mg this past week to give myself more time for my metabolism to kick back into gear. Food noise is definitely back, but it's normal and manageable. I'm not ravenous, I'm eating 1200-1600 cals (1250 is my RMR) and I'm maintaining. Fitness is still the same, dog walks, rebounding, and free weights. I am still on Tesamorelin for strength training goals.
There is a small hint of displeasure at not seeing the scale go down anymore, it almost feels like failure. But I'm at goal, so just I tell my brain to stfu, it doesn't need that dopamine hit, and now the scale is only a tool to maintain.
I was on it for 12 weeks at 1, 2, and 3mg. I dropped from 3mg to 1.5mg for 2 weeks, but that was too much too soon, so I raised it to 2mg this past week to give myself more time for my metabolism to kick back into gear. Food noise is definitely back, but it's normal and manageable. I'm not ravenous, I'm eating 1200-1600 cals (1250 is my RMR) and I'm maintaining. Fitness is still the same, dog walks, rebounding, and free weights. I am still on Tesamorelin for strength training goals.
There is a small hint of displeasure at not seeing the scale go down anymore, it almost feels like failure. But I'm at goal, so just I tell my brain to stfu, it doesn't need that dopamine hit, and now the scale is only a tool to maintain.
woundcarping
GLP-1 Specialist
tubby said:
If test is the measure, I’ve roughly 4x’ed that since January
jjplantgeek
GLP-1 Novice 🚫No Source Discussion🚫
Anybody planning to step to sema for "maintenance"? I started on tirz, am doing hybrid tirz/reta now to help with suppression while getting glucagon benefits (didn't want to invest in cagri). Wondering as I get closer to a goal if it will be worth investing in some sema to maintain, or if I should just go back to tirz. The reudction in inflammation has been amazing with the tirz, not sure if sema gives the same results?
jjplantgeek
GLP-1 Novice 🚫No Source Discussion🚫
Fuuuuck, isn't that the truth. I fired my doc because he was accusing me of supplementing with test when my recent blood test came back at 1150, up from 900 in December and 750 pre-tirz. And all I'm doing is taking tirz/reta and working out.woundcarping said:If test is the measure, I’ve roughly 4x’ed that since January
BNLFL
GLP-1 Specialist
Add me to that list. I've noticed a couple different things too. My cholesterol is great on my last blood test. My doc was semi concerned on the test last year. I and my wife, on it too had some joint stiffness in our fingers. It's basically gone, or 80-90% better. I think my wife will want to stay on it as well.Grogu said:
Peotidethrowaway
GLP-1 Enthusiast
DiDnT yOu lEaRn gOoOd EaTiNg hAB….
Shutterdrive
Recently Joined 🚫No Source Discussion🚫
Hit goal and microdose for anti aging and prevent metabolic disease. Of course with proper lifestyle and eating habitsGortBong said:
riposte
GLP-1 Novice 🚫No Source Discussion🚫
We’re Lewis & Clark out here, no one knows where it leads to. My guess is stay on Reta until there’s a leapfrog drug or tech. Perhaps attempt to wean down once at desired results. The next 5-10 years are going to be wild.
Personally I’ve been on Tirz since Sept 24. Was at 10 mg, but have added 1 mg of Reta a week over the past 6 weeks and am down to 7 mg Tirz. After a plateau at the low-ish Tirz-alone dose, adding that pinch of Reta has lost me another 10 pounds.
Personally I’ve been on Tirz since Sept 24. Was at 10 mg, but have added 1 mg of Reta a week over the past 6 weeks and am down to 7 mg Tirz. After a plateau at the low-ish Tirz-alone dose, adding that pinch of Reta has lost me another 10 pounds.
riposte said:
Yes, the next 5 to 10 years we're going to see a lot of new entrants into the market and probably a lot of folks looking to make these treatments into pill form.
The pipeline is huge, but lots of competition. Many of these will probably never see the light of day. I'm most interested right now on Eloralintide. Cagrilintide without so many side effects.
Four Strategies for Competing in the Crowded Obesity Drug Marketplace - The Dedham Group
Here are four strategies for manufacturers to stand out in the crowded anti-obesity medication market.
dedhamgroup.com
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lessthanhalf
GLP-1 Specialist
What you are saying sounds well thought out and entirely reasonable.MountainsoftheMoon said:I don’t have that answer. I agree that each case is different, and your assessment of the two camps seems to be fairly accurate. I myself fall outside of those two groups, (as a mid-late 30’s non obese, non fitness lifestyle person), but share parallels with each. My issues are primarily phycological/ addiction related, and not metabolic. I am overweight, significantly so when out of shape. However I am not categorized as obese by my doctor, but “at risk for longterm health complications if I don’t start building better habits and get my weight in check”. This has been the same assessment from any doctor for the last 10+ years. Up until my mid 20s, I had no issues with weight gain.
I have struggled with alcohol and drug addiction in my past, and at times, it seemed like there was no way out. But I have been able to shift out of that and maintain sobriety for years. Likewise I was smoker for most of my adult life, and have been tobacco free for 5 years, despite feeling like there was no hope after many attempts at quitting. I hope to build similar pathways in my life around food/ binge eating, which is the last frontier for me.
My intention to eventually be non reliant on peptides is a personal mission. For my own reasons, I want to be in control of my life and my actions. Being able to prove to myself that I can do it without medical intervention is a key goal.
That being said, here I am after many attempts without, and you could argue that even if I can get off and sustain without peptides longterm, that it was still medical intervention as a catalyst. I am totally fine with that. I think GLPs are a miracle, and a game changer. I do not have any issue with the idea of taking them for life, and I realize for many, that may be non optional. I do not see getting off of them as a higher ground than staying on them. Again this is a highly personal goal.
Ultimately, to your point, being healthy and keeping the weight off is the most important health consideration. With or without the help of peptides. If I am unable to achieve the goal described, I take no issue with staying on them longterm and won’t hesitate to do so. But not until I’ve tried getting off after reaching my targets first!
That’s my story and I’m sticking to it. To each their own
I obviously do not really think there are only 2 types of people on here on GLP's , there is obviously a wide spectrum of different reasons to be on them, it was more that the more severe obesity group often had thought about the long term issues seriously and it seemed more common that younger less obese people were not looking at it from a long term perspective as often. I tend to think that developing good eating and exercise habits on GLP medication, may not be as easily sustained once they are stopped. And wishful thinking is just how peoples brains often work, and is part of the whole weight cycling process, being the belief that despite all previous evidence, this time I will be able to keep the weight off, even after stopping the medication. I am not saying everyone who starts them needs to be on them long term, but I suspect that over the next decade an increasing percentage of those who stop will eventually find they are better off staying on them long term for weight control plus the additional health benefits.
DragonOfTheSea
GLP-1 Enthusiast
Of the peps in the pipeline, I too am most interested in Eloralintide. Sounds like it’s going to be an amazing counterpart to Reta at this point.Grogu said:
As for the thread topic, I’m in the glad to take this forever as long as it’s positively affecting my health, camp. One goal, titrate down to lowest effective dose and cruise… I mean, aside from the number of biological positives that Reta offers, the singular notion that I am in full control of when, what, and how much I eat or drink (especially alcohol) is reason enough to sign me up for life.
JKLIN
GLP-1 Novice 🚫No Source Discussion🚫
I hope the shrinking stomach works for you. I had a sleeve gastrectomy about 15 years ago. My stomach was reduced to about the size of a sharpie pen. That worked for about 7 years, then the small stomach grew and grew until my weight was nearly the same as before surgery. I'm a GLP-1 lifer and that suits me right down to the ground. I need the help and I'm happy to take it for the rest of my life.deleted.user.16 said:
Two additional big picture things to consider in this discussion:
First, it’s interesting that the arguments being presented for stopping the medication focus on thing like developing behaviors that are more likely to sustain the weight loss (which we know very rarely happens), shrinking stomach anatomy (which is bunk), and having the will power to maintain without a medical intervention (which sounds like those who can’t have a character flaw rather than a medical condition). These all sound like blaming oneself for being obese (self loathing fat shaming). Good reasons for stopping would be things like serious side effects and how the medication affects mental health.
Second, there are a BUNCH of people who are on these medications who are not the currently approved intended population. I’m not being judgmental here. I truly don’t care about what people do. If someone is mildly overweight and wants to use glp1s to lose weight, more power to them. This population probably can stop and be successful, since they were never meant to be on the medication in the first place.
For the severely obese, obese, and mildly obese with related health conditions, it’s a totally different situation. But there are various levels of metabolic dysfunction and pathways that create that dysfunction in this population. One binary solution (stop or continue) is too simplistic.
First, it’s interesting that the arguments being presented for stopping the medication focus on thing like developing behaviors that are more likely to sustain the weight loss (which we know very rarely happens), shrinking stomach anatomy (which is bunk), and having the will power to maintain without a medical intervention (which sounds like those who can’t have a character flaw rather than a medical condition). These all sound like blaming oneself for being obese (self loathing fat shaming). Good reasons for stopping would be things like serious side effects and how the medication affects mental health.
Second, there are a BUNCH of people who are on these medications who are not the currently approved intended population. I’m not being judgmental here. I truly don’t care about what people do. If someone is mildly overweight and wants to use glp1s to lose weight, more power to them. This population probably can stop and be successful, since they were never meant to be on the medication in the first place.
For the severely obese, obese, and mildly obese with related health conditions, it’s a totally different situation. But there are various levels of metabolic dysfunction and pathways that create that dysfunction in this population. One binary solution (stop or continue) is too simplistic.
DragonOfTheSea said:
Yes, it's a very exciting medication. On it's own, excess weight loss on eloralintide appears to surpass semaglutide and has comparable results to tirzepatide, but quicker. Reported side effects are less than cargilintide, apparently because eloralintide has a more targeted amlyn receptor agonist than cagri.
I was able to find 3 current clincials on eloralintide and tirzepatide, but none with retatrutide. Probably because reta hasn't been approved on it's own yet, because I'm sure that's the ultimate goal. Exciting stuff.
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