BPC-157 injection site for achilles injuries?

[Calm Logic]

I’m curious where the limiting factor comes in on single dose. Half life is very short, I also wonder about max single dose vs more than twice a day.

Yeah, right now considering doing 500 mcg three times a day.

Incidentally, some crazy (extremely non-scientific) reverse engineering:

Considering some vials of BPC are 20 mg, which is often/usually taken twice a day, and 20 punctures is my ideal upper limit, that gives 10 days of 1 mg BID.

 

[LabRatts]

First experience with researching was Wolverine (bpc/tb500).

We did .5 mg daily then .75 and finished off 6 10/10 vials at 1.25 daily.

Both of us rats are 60ish, lots of chronic pain and some acute, on injection day one we were anyway.

About 4 weeks in (doing .75 daily) we both noticed acute was regulated, and chronic aches drastically. That 8 week cycle, in the end, has reduced my pain to near nil, like nada, and the wife's (rat) corrected some Achilles issues, but not so severe as the OP indicated theirs is\was.

I'll always keep a kit of Wolverine on hand for the hard knocks we al!encounter during active lifestyles.

Prayers for effective treatment for your ailments, regardless of which form they arrive in.

 

[Matvic81]

I've yet to see any research supporting injection near an injury site having more efficacy than anywhere else.

There are no large scale studies. No real studies at all. A few cool things with rats and wound healing.

If you want something that has quite a bit more proven results maybe take a look at PRP injections. Many actual studies on efficacy. Downsides , not covered by most insurance, hurts like a mfer.

I’ve had PRP injections for my spine…what a ride!

 

[Zol1th]

I haven’t seen 20mg/week.

I’m taking BPC .5mg 2x daily, for 6-8 weeks. This coming Wednesday makes the 6th week. I’ll probably finish the vial I’m on and stop, although I’ll decide later.

My rotator cuffs and ECRB tendon (tennis elbow) were my main complaints… both were acute injuries from July 2024 and August 2025. Two orthos said I had good range of motion in the shoulders, avoid pain, live with it (good advice) as surgery would be recovery intensive. The shoulders I avoided doing much lifting higher than my shoulders, and normally they didn’t bother me very much. The ECRB, a steroid shot to treat the symptoms was a choice, surgery would be another choice for me, but the doctor suggested waiting to see. The wait and see period ended at Christmas, it was better, but still not well.

I started lifting last week, after 4 weeks on BPC. I did 5 sets of 10 reps of shoulder presses with no localized discomfort, just typical overall muscle soreness. My ECRB has improved in terms of pain relief as well as load bearing.

While not a “miracle”, and decidedly not scientific, I appear better off than when I started to a measure that is beyond expected healing during that relatively short time.

Pain relief in the elbow was early, perhaps a week. Research suggested that was inflammation reduction, not actual healing. That’s why I waited a month to start lifting.

Did you ever take TB500?

 

[woundcarping]

Did you ever take TB500?

Nope

 

[CycleSloth]

Regarding the place of injection, I didn't inject BPC, but used it sublingually. The problem BPC resolved for me 95% was prostatitis (very painful prostate region flare-ups). The thing is, the prostate should be a problem for many drugs to penetrate. Or, to make things simpler, the journey from under my tongue to my prostate wasn't a problem for BPC to get there and do it's wanders! So, to my experience, once it's in the bloodstream, the efficacy is more dependent on the right dosage.

What's the process for administering BPC sublingually?

 

[marraqy]

I’m currently running 1mg each of BPC and TB-500 for a disc herniation and a right wrist injury. I’ve noticed some relief with the disc, though I’m not calling it a win just yet to avoid a false positive. My wrist hasn't seen much change yet, though.

Since you’re already seeing systemic benefits for your other injuries, trying a more localized approach near the heel might be worth a shot for the Achilles, given how little blood flow that area gets.

 

[Calm Logic]

Since you’re already seeing systemic benefits for your other injuries, trying a more localized approach near the heel might be worth a shot for the Achilles, given how little blood flow that area gets.

Punny.

For me, sitting a lot makes it worse, I guess due to the attached calf and hamstring muscles getting tight.

I would also consider a new pair of shoes (new pair of rocker sneakers or at least inserts for me every 3 months, such as heel lifts).

One sneaker mentioned before:

I had a triple Ankle fusion many moon ago and the Arthritis, along with some other mentioned (Achilles) is back. I really like the Asics Keyano Gel 31. I walked around in a pair at the local shoe place and was sold pretty quick. I work on concrete all day, I'd tell ya to go give these a try if you're out lookin again.

Cut in half: ASICS Gel Kayano 31 Review

ASICS Gel Kayano 31 review: The Gel Kayano has been around us since 1993 and is more alive than ever. After surviving a risky update last year, we found that ASICS has built on its solid foundations by adding subtle improvements to the upper, stability, weight, and fit. It's still a big and...

runrepeat.com

And isometric/loading exercises and heavy slow resistance (HSR):

The modern "gold standard" for Achilles issues usually follows this progression:

Phase 1: Isometrics. If your heel hurts just walking around or during your first few sets of calf raises, start here. Doing 5 sets of 45-second holds can actually "numb" the tendon for several hours, allowing you to get through the rest of your workout.

Phase 2: HSR. Once the sharp pain subsides into a dull ache, you move to HSR. This involves very slow (3 seconds up, 3 seconds down) weighted calf raises. This "slow-cooks" the tendon, forcing the collagen fibers to realign and get stronger.

It's a very slow healing process no matter what. Lots of Youtube videos on Achilles, including how to massage near the tendon.

Some videos by licensed practitioners (Bob & Brad series):

View: https://www.youtube.com/watch?v=qvfm3Lb3Ojs

View: https://www.youtube.com/watch?v=2ke5BXW-ujo

View: https://www.youtube.com/watch?v=xx9rokOgJVA

 

[RubbaDubba1]

Part of my Kitchen Sink Protocol, is I take Tadalafil 5mg 2X a day to help increase blood flow and help get the peps to where they can do there job. I just had shoulder surgery, I got the jacked ankle and a few other things. I'm not just coming out of left field: watch 2 minutes from here

View: https://youtu.be/RgA4Hyr1Hbk?t=2730

 

[Flexon]

What's the process for administering BPC sublingually?

Reconstitute as you would for injection then squirt it gently, drop by drop into mouth under your tongue. Hold it there for 90-120 seconds, then swallow.

 

[CycleSloth]

Thanks - that’s interesting. What does it taste like?

I was asking as I understand for BPC it is recommended to inject daily and I am not sure whether I want to do that. So I might try sublingually, I will research some more to understand this better or are there good resources already available which I haven’t found yet?