BPC-157 injection site for achilles injuries?

[Thadeus]

I have an old Achilles tendon injury, going on 5 years now. It doesn't stop me from doing active things but it's inflamed after and causes me significant pain. It's the reason I began taking a BPC-157 and TB-500 combo. I have been on 500mcg/500mcg daily dose (split morning and night) injected in the abdomen for about a month. It has helped me feel better from multiple other small injuries but my achillies is still bugging me and is still inflamed (not quite as bad as when I started but still protrudes from my heal about the size of a large marble). I've also been on a ChatGPT perscribed physical therapy regimen and have recently been resting it more than usual. The inflammation and pain is right where my tendon connects to my heal on the outside (confirmed to be soft tissue inflammation via X-ray) and there is really no fat down there to inject into. My question is would I benefit from upping my dose? Should I try injecting near the injury? I have read a lot of anecdotal evidence that BPC is more effective when dosed near the injury. Looking to get some opinions on what my best course of action would be to get it healed.

 

[yrrdead]

I've yet to see any research supporting injection near an injury site having more efficacy than anywhere else.

There are no large scale studies. No real studies at all. A few cool things with rats and wound healing.

If you want something that has quite a bit more proven results maybe take a look at PRP injections. Many actual studies on efficacy. Downsides , not covered by most insurance, hurts like a mfer.

 

[AndyPanda]

I have an old Achilles tendon injury, going on 5 years now. It doesn't stop me from doing active things but it's inflamed after and causes me significant pain. It's the reason I began taking a BPC-157 and TB-500 combo. I have been on 500mcg/500mcg daily dose (split morning and night) injected in the abdomen for about a month. It has helped me feel better from multiple other small injuries but my achillies is still bugging me and is still inflamed (not quite as bad as when I started but still protrudes from my heal about the size of a large marble). I've also been on a ChatGPT perscribed physical therapy regimen and have recently been resting it more than usual. The inflammation and pain is right where my tendon connects to my heal on the outside (confirmed to be soft tissue inflammation via X-ray) and there is really no fat down there to inject into. My question is would I benefit from upping my dose? Should I try injecting near the injury? I have read a lot of anecdotal evidence that BPC is more effective when dosed near the injury. Looking to get some opinions on what my best course of action would be to get it healed.

I hate writing long posts but I kind of know the struggle…

During a deployment I destroyed my ankle and I suffered a peroneal tendon tear. It was horrible! I had surgery to have it reattached but it still caused me serious pain. I wore that stupid boot, did the physical therapy, took pain meds, wore braces, did all the stretches, etc.

Eventually I had another surgery because the Army surgeon didn’t do the greatest job and I wasn’t a good patient during recovery because I wanted to get back into the field. I was young and really abused my body. Eventually I had a second surgery where they cut out scar tissue from the tendon and reattached it. Then I went through everything again. Nothing seemed like it helped and the pain was rough.

Eventually I had PRP therapy (Platelet-Rich Plasma). They draw blood and put it into a centrifuge to separate the plasma from everything else and then they inject it back into wherever you are injured. I had two sessions and each appointment took about an hour. It wasn’t a miracle cure where I felt immediate relief, but over time a good deal of pain subsided. It kind of took the edge off and made it more tolerable.

Recently I had a stellate ganglion block for something else, but as a happy little side effect it took away a lot of discomfort I had in my ankle and knees.

I recommend looking into PRP and a stellate ganglion block. It would take about three hours of your time but it is well worth it.

 

[Sidney]

I was wondering about this too. I had peroneal tendinitis that was not healing. I was wondering about injecting into behind my calf when not flexed. I watched videos of people injecting right into the foot but did not feel comfortable with that. Luckily for me, the inflamed peroneal tendon actually got a lot better with time, a break from running, and PT stretching. So I never ended up using BPC-157/TB-500.

 

[MsGizmo]

I don't think it really matters. The stuff we inject into ourselves works by getting into the blood stream and that goes to every part of the body that has blood in it. The reason we inject into fatty tissue is for a slightly slower absorption rate and reduced injection site pain. If you were to inject it into your foot its still probably going to go into your bloodstream first. It will still work .. but the injection will hurt more.

 

[catdog]

I've yet to see any research supporting injection near an injury site having more efficacy than anywhere else.

There are no large scale studies. No real studies at all. A few cool things with rats and wound healing.

If you want something that has quite a bit more proven results maybe take a look at PRP injections. Many actual studies on efficacy. Downsides , not covered by most insurance, hurts like a mfer.

I think this is the most accurate statement. We are all working off of "Anec Data." PRP and Stem Cell therapies are the most researched items for treatment of tendinopathy/rupture. However, based on anec data and the way most of these subq peptides work, I would figure it would be fine to just inject where you normally inject any other peptide to take effect (insulin, GLP, etc.)

This is also why BPC presents as an issue for cancer/tumor growth, because no matter where you inject it seems to provide angiogenesis to other locations as well.

 

[Thadeus]

Thank you everyone for the information, it was very helpful!

 

[hexagonal]

PRP seems to be much more effective for tendon stuff than BPC/TB/etc., but also significantly more expensive.

I've used BPC/TB for more general tendon overuse injuries and they've been effective - but at higher doses than most "protocols" suggest, and I had very little luck with them at the lower doses.

My only long-standing injury is a torn meniscus and BPC/TB did nothing for it. Deca has helped with the pain for day to day/lighter weight stuff, but I still can't back squat/hack squat/safety squat with it (leg press and belt squat are OK due to being able to position my legs differently)

I suspect I'll need surgery to deal with the meniscus issue.

 

[mrfat]

I tried site injection, abdomen subq, and glute IM and didn't notice any difference with any of these injection protocols.

 

[mrcool]

In the belly bro , it’s systemic.

 

[UPresearcher]

I think this is the most accurate statement. We are all working off of "Anec Data." PRP and Stem Cell therapies are the most researched items for treatment of tendinopathy/rupture. However, based on anec data and the way most of these subq peptides work, I would figure it would be fine to just inject where you normally inject any other peptide to take effect (insulin, GLP, etc.)

This is also why BPC presents as an issue for cancer/tumor growth, because no matter where you inject it seems to provide angiogenesis to other locations as well.

What research have you found demonstrating BPC presents an issue for cancer/tumor growth?

 

[Ragnar]

PRP seems to be much more effective for tendon stuff than BPC/TB/etc., but also significantly more expensive.

I've used BPC/TB for more general tendon overuse injuries and they've been effective - but at higher doses than most "protocols" suggest, and I had very little luck with them at the lower doses.

My only long-standing injury is a torn meniscus and BPC/TB did nothing for it. Deca has helped with the pain for day to day/lighter weight stuff, but I still can't back squat/hack squat/safety squat with it (leg press and belt squat are OK due to being able to position my legs differently)

I suspect I'll need surgery to deal with the meniscus issue.

I’m using 500mcg BPC once a day for previous Achilles injury that was surgically repaired 2.5 years ago. So far nothing. Just curious what higher dose you found to be most effective?

 

[woundcarping]

I’m using .5mg 2x daily for 6-8 weeks for my rotator cuffs and tennis elbow. The shoulders were from the summer of 2024, elbow from August 2025.

I’m 3.5 weeks in and have noticed improvement. The most noticeable is with elbow; pain reduction using the tendon with grip strength and wrist extension. Before injections started, I could easily find the painful tendon anchor on bone, now I can’t find a tender spot.

Shoulders used to hurt/were tender when lifting above my shoulders, I’ve been gentle resting that as shoulder repair surgery is something I want to entirely avoid. In a small test last week with light weight, no pain presented.

 

[yrrdead]

What research have you found demonstrating BPC presents an issue for cancer/tumor growth?

There is none, at least that I've found. I found one article by a Dr. suggesting that this may be an issue, then other people and AI have regurgitated that one article.

Nor is there likely to be any research on this, no money in it.

 

[Mr. Blonde]

I’m using 500mcg BPC once a day for previous Achilles injury that was surgically repaired 2.5 years ago. So far nothing. Just curious what higher dose you found to be most effective?

I did 500mcg twice per day (first when waking, second before bed) for a knee injury from bjj. It worked great. First week I actually lost like 3 lbs from pissing out inflammation weight. Month in I was completely healed and rolling again.

Edit: forgot to add that within first week all the other little aches and pains just from life we're all gone. Big fan of bpc. Haven't had a reason to try it yet, but I got some just in case to pair with bpc if needed in future.

 

[Ragnar]

I am only a few days into my protocol but am considering increasing to twice a day based on experiences from @woundcarping and @Mr. Blonde

Appreciate the feedback and am optimistic that my Achilles will improve with time.

I might also add TB500 in future I just get cautious and apprehensive to add too many things at once.

 

[woundcarping]

From my general reading: Inflammation pain is quick to subside, in the first week, but healing takes longer, starting maybe around week 3.

 

[Phatmax]

don't matter where you do it I do in leg or belly and my shoulder is so much better

 

[hexagonal]

I’m using 500mcg BPC once a day for previous Achilles injury that was surgically repaired 2.5 years ago. So far nothing. Just curious what higher dose you found to be most effective?

Double that

 

[Phatmax]

I’m using 500mcg BPC once a day for previous Achilles injury that was surgically repaired 2.5 years ago. So far nothing. Just curious what higher dose you found to be most effective?

i take 1mg of bp157 and 1mg of tb500 daily