After one year on Tirz, I introduced protein shakes to replace breakfast, as I read that glp1 could eat up some of your muscle mass. I never worried as less weight requires less muscles (IMO). I never exercise (+am retired). After 1 year on tirz, I switched to reta, as tirz stopped working. I am almost at my 2 year mark, 100# down. I eat anything, but in smaller portions (I also use Cagri: it makes me nauseous, so I really do not feel like eating much). I cut carbs by over 75%. Eat mainly proteins, and fruits/vegy(antioxydants). Am 4# from my goal. Adding proteins shakes helped me a lot, especially when I get the munchies at night. Went from BMI 41 to 26. I may keep going to reach BMI 24. In past year, my ketones are always high, confirming my protein intake is at a good level. Data shows is much more effective (Return on effort) to cut calories than to try to burn them.