GreenOlives
GLP-1 Novice 🚫No Source Discussion🚫
I just heard this on a podcast yesterday. Any runners out there using it?
MOTS-c improves Vo2max
- Thread starter GreenOlives
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Turbo-Farmer
GLP-1 Enthusiast
According to my Fitbit, My vo2 max increase from 39- to 42 without any increase in my running since I started using the MOTS-C.
I’m not much of a runner, I just run 2 miles everyday for the last 30 months.
I’m not much of a runner, I just run 2 miles everyday for the last 30 months.
gusterbuster
GLP-1 Apprentice
No idea on my VO2 max as I dont have a power meter on my bike. But on a route I usually average 12.8mph in zone 2 hr. Before the judging, at the end there is a long slow climb thay kills my average speed lol.
Anyways took 5mg MOTSC prior to last ride and averaged 14mph with similar wind, temp, etc. One off example, but next few rides will determine if one off or the norm with MOTSC.
Anyways took 5mg MOTSC prior to last ride and averaged 14mph with similar wind, temp, etc. One off example, but next few rides will determine if one off or the norm with MOTSC.
Airborne Daddy
GLP-1 Specialist
Lol my 63 yo brother in law missed 1 day of running in like 7 years....effin terminator.Turbo-Farmer said:
Turbo-Farmer
GLP-1 Enthusiast
It’s banned by the WADA
Anti-Doping Status
As of the 2025 and 2026 WADA Prohibited Lists, MOTS-c is explicitly classified under Section S4: Hormone and Metabolic Modulators.
• Category: S4.4.1 — Activators of the AMP-activated protein kinase (AMPK).
• Prohibition: It is banned both in-competition and out-of-competition.
• Reasoning: Because MOTS-c acts as a "metabolic shield" and exercise mimetic, it can artificially enhance endurance, glucose metabolism, and fatty acid oxidation, providing an unfair performance advantage similar to other metabolic modulators like GW501516 (Cardarine).
Anti-Doping Status
As of the 2025 and 2026 WADA Prohibited Lists, MOTS-c is explicitly classified under Section S4: Hormone and Metabolic Modulators.
• Category: S4.4.1 — Activators of the AMP-activated protein kinase (AMPK).
• Prohibition: It is banned both in-competition and out-of-competition.
• Reasoning: Because MOTS-c acts as a "metabolic shield" and exercise mimetic, it can artificially enhance endurance, glucose metabolism, and fatty acid oxidation, providing an unfair performance advantage similar to other metabolic modulators like GW501516 (Cardarine).
lessthanhalf
GLP-1 Specialist
From a look on google scholar, there have not ever been human studies of mots-c as a treatment. Lots of studies measuring its levels in various states and conditions, and lots of studies of giving it to rats or mice but none to humans I can find. If you have a reference to where the info came from I would like to see it.GreenOlives said:
Turbo-Farmer
GLP-1 Enthusiast
lessthanhalf
GLP-1 Specialist
Thanks, no results yet unfortunately. There should have been a phase 1 of this but I cannot find it. Not everything gets published.
I'm not a runner at all. I used to run to dinner, but not anymore. One thing I have noticed that supports this theory is what I feel at altitude. When "running" Mots-C I notice that living at 7000' has a much smaller effect on me. I can go up 3 flights of stairs with little effect on my breathing and my recovery is just a few seconds, I don't do that when I'm not using it. I've also noticed that my resistance training is stronger and I can do 10-15 more reps than I can on off days. Something on those days has changed and I think vo2 max explains it.Turbo-Farmer said:
WeezinDaJuice
GLP-1 Enthusiast
I just started a 5mg dose 3x/week (Mon-Wed-Fri) preworkout last week and it can definitely make you a little light-headed as you push harder with it's "boost".
exxige
GLP-1 Novice 🚫No Source Discussion🚫
I started using 2.5 mg 3x a week on my 7+ mile runs and it seems to really help but have only done 4 so far.
sidroponix
Recently Joined 🚫No Source Discussion🚫
I’m a trail runner, I do a 5k track with 1000’ of gain, since I’ve introduced mots-c I’ve been not only pr’ing my runs but I’ve been crushing my CrossFit WODs everyday, I feel like a beast on this stuff! Just checked my stats, looks like it’s pretty consistent with when I started taking mots-c lol
Calm Logic
GLP-1 Specialist
exxige
GLP-1 Novice 🚫No Source Discussion🚫
is that your vo2 max chart? what protocol are you using?sidroponix said:
wildweasel
GLP-1 Apprentice
Is there any actual scientific evidence supporting the claim that MOTS-C increases VO2 max? or are we just discussing what someone heard someone say on some podcast?
is there even a proposed mechanism for this?
According to medical literature it increases glucose uptake, which can plainly account for pr'ing on runs
is there even a proposed mechanism for this?
According to medical literature it increases glucose uptake, which can plainly account for pr'ing on runs
sidroponix
Recently Joined 🚫No Source Discussion🚫
It is my chart…I’m using 2mg mots-c 3x/wk and tirz 12.5mg 1x/week. I run my mountain 4-7days/week plus CrossFit 5x/wkexxige said:
lessthanhalf
GLP-1 Specialist
The short answer is no, there is no direct evidence that mots-c increases vo2 in humans. Claiming this on existing evidence is definite overreach. The only human studies that exist on its development name ( or modified version of it ) of cb4211 was a phase 1 study where it was not toxic and may reduce liver fat. There is a phase 2 study in progress. Given that it is supposed to be an exerkine, or an exercise mimicking hormone of sorts it is possible that it does, it does increase exercise tolerance in rodents, but I do not think they measured vo2 in those studies.wildweasel said:
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