BPC-157 injection site for achilles injuries?

[lostlakebear]

i take 1mg of bp157 and 1mg of tb500 daily

Late to the party, but I have a relevant comment andquestion.

Question first:

Is there such a thing as "too much" BPC-157, and if "yes", where is that threshold and how would I know if I have approached it? I ask because I have seen these as recommended dosages:

1) 250-500 mcg per day

2) 5000 mcg – 20000 mg per week (recommendation did not say if this should be split into daily)

3) @Phatmax is using 1000 mcg/daily

Comment:

My orthopedic surgeon recommended PRP for an old ankle injury. An old, old ankle injury. I sprained it over 45 years ago. In turns out the sprain was an undiagnosed ligament tear. PRP, combined with (very painful) physical therapy, was close to a miracle for me. My ankle is measurably more stable and less painful than it was.

I am hoping BPC-157/TB-500 well help with the ankle, and more importantly, help with recovery from a cervical fusion (C6/C7) from last summer that hasn't been going well. I have rather suddenly (last two months) lost a great deal of arm strength and stamina since the surgery. Thanks in advance.

 

[yrrdead]

Late to the party, but I have a relevant comment andquestion.

Question first:

Is there such a thing as "too much" BPC-157, and if "yes", where is that threshold and how would I know if I have approached it? I ask because I have seen these as recommended dosages:

1) 250-500 mcg per day

2) 5000 mcg – 20000 mg per week (recommendation did not say if this should be split into daily)

3) @Phatmax is using 1000 mcg/daily

Comment:

My orthopedic surgeon recommended PRP for an old ankle injury. An old, old ankle injury. I sprained it over 45 years ago. In turns out the sprain was an undiagnosed ligament tear. PRP, combined with (very painful) physical therapy, was close to a miracle for me. My ankle is measurably more stable and less painful than it was.

I am hoping BPC-157/TB-500 well help with the ankle, and more importantly, help with recovery from a cervical fusion (C6/C7) from last summer that hasn't been going well. I have rather suddenly (last two months) lost a great deal of arm strength and stamina since the surgery. Thanks in advance.

Who knows, by that I mean there is almost no data/studies. I say this a lot in these threads but its not any less true. Just understand in the case of BPC we really are doing the research.

Though I haven't even seen anecdotal posts about adverse reactions to taking "too much". Not that I would recommend it, just relaying that it appears pretty well tolerated with a good safety profile.

Lastly I would say that compared to PRP these peptides are a significant step down for most people in regards to efficacy. Sure there are going to be some amazing stories but plenty more discussing almost zero effect.

 

[woundcarping]

Late to the party, but I have a relevant comment andquestion.

Question first:

Is there such a thing as "too much" BPC-157, and if "yes", where is that threshold and how would I know if I have approached it? I ask because I have seen these as recommended dosages:

1) 250-500 mcg per day

2) 5000 mcg – 20000 mg per week (recommendation did not say if this should be split into daily)

3) @Phatmax is using 1000 mcg/daily

Comment:

My orthopedic surgeon recommended PRP for an old ankle injury. An old, old ankle injury. I sprained it over 45 years ago. In turns out the sprain was an undiagnosed ligament tear. PRP, combined with (very painful) physical therapy, was close to a miracle for me. My ankle is measurably more stable and less painful than it was.

I am hoping BPC-157/TB-500 well help with the ankle, and more importantly, help with recovery from a cervical fusion (C6/C7) from last summer that hasn't been going well. I have rather suddenly (last two months) lost a great deal of arm strength and stamina since the surgery. Thanks in advance.

I haven’t seen 20mg/week.

I’m taking BPC .5mg 2x daily, for 6-8 weeks. This coming Wednesday makes the 6th week. I’ll probably finish the vial I’m on and stop, although I’ll decide later.

My rotator cuffs and ECRB tendon (tennis elbow) were my main complaints… both were acute injuries from July 2024 and August 2025. Two orthos said I had good range of motion in the shoulders, avoid pain, live with it (good advice) as surgery would be recovery intensive. The shoulders I avoided doing much lifting higher than my shoulders, and normally they didn’t bother me very much. The ECRB, a steroid shot to treat the symptoms was a choice, surgery would be another choice for me, but the doctor suggested waiting to see. The wait and see period ended at Christmas, it was better, but still not well.

I started lifting last week, after 4 weeks on BPC. I did 5 sets of 10 reps of shoulder presses with no localized discomfort, just typical overall muscle soreness. My ECRB has improved in terms of pain relief as well as load bearing.

While not a “miracle”, and decidedly not scientific, I appear better off than when I started to a measure that is beyond expected healing during that relatively short time.

Pain relief in the elbow was early, perhaps a week. Research suggested that was inflammation reduction, not actual healing. That’s why I waited a month to start lifting.

 

[lostlakebear]

Who knows, by that I mean there is almost no data/studies. I say this a lot in these threads but its not any less true. Just understand in the case of BPC we really are doing the research.

Though I haven't even seen anecdotal posts about adverse reactions to taking "too much". Not that I would recommend it, just relaying that it appears pretty well tolerated with a good safety profile.

Lastly I would say that compared to PRP these peptides are a significant step down for most people in regards to efficacy. Sure there are going to be some amazing stories but plenty more discussing almost zero effect.

Good to know. Thank you.

 

[AxlBundy]

I gotta say, I started BPC at the same time I switched Reta vendors and I was sure the 2 week long explosive bowel was because of the Reta, then I saw an influencer blame bpc and I stopped the bpc that day and everything went back to normal. Go figure. I thought bpc was supposed to help your gut. Was pushing .5-1mg

 

[woundcarping]

The only urgency I’ve had was once when I started magnesium glycinate while still taking 21g of PHGG (fiber). I dialed back the fiber and no urgency since while on BPC, tirz, and/or Reta.

 

[Calm Logic]

The inflammation and pain is right where my tendon connects to my heal on the outside (confirmed to be soft tissue inflammation via X-ray) and there is really no fat down there to inject into.

For my Achilles, I use GH peptides (abdominal subq), as well as oral supplements (like collagen, cissus quadrangularis, curcumin, and taurine, with hyaluronic acid on the way). No miracles so far, but most of the time I feel perfectly fine anyway.

I know BPC is touted the most (at least for mice with tendon issues), along with TB-500 and the other ingredients of KLOW (KPV and GHK). So I will finally recon/inject those soon, in addition to ARA-290 for shits and giggles. But I have been taking my time since I am skeptical.

So far, what helps me the most (in addition to stretching and heel raises) is buying new shoes every three months and never going barefoot. I love the Sketchers walking/running shoes with the rocker bottoms (as with the Hoka brand). Driving makes it worse, so the ergonomics of the pedals and using cruise control helps.

 

[osulawkid]

While YouTube is far from medical research, I believe a content creator, Dr. Jones, stated that he used 2mg a day for a shoulder injury. I have a friend who used the same protocol for plantar fasciitis without issue. That would still be less than 20mg a week though.

 

[Calm Logic]

BTW, conflicting info on TRT and Achillies issues ---

"Significant association between Achilles tendon injury and prescription TRT":

Testosterone replacement therapy is associated with increased odds of Achilles tendon injury and subsequent surgery: a matched retrospective analysis - Journal of Foot and Ankle Research

Background Prescription of testosterone replacement therapy (TRT) has increased in the United States in recent years, and though anabolic steroids have been associated with tendon rupture, there is a paucity of literature evaluating the risk of Achilles tendon injury with TRT. This study aims to...

link.springer.com

"Low hormone levels maybe associated with the risk of Achilles tendon rupture":

https://journals.sagepub.com/doi/abs/10.1177/2325967113S00085

Gemini's take is to aim for a consistent, mid-normal range of total testosterone (500 to 799):

Rapid fluctuations in androgen levels are often more taxing on connective tissue than a steady, moderate dose.

The "sweet spot" is likely balancing the two:

Avoid the "Dip": Low levels (from an inconsistent protocol) will hinder repair.

Control the "Peak": Avoid supra-physiological spikes that encourage the muscle to outpace the tendon.

Leverage BPC-157: This is where BPC-157 becomes relevant. In the studies you were asking about, BPC-157 specifically targets the tendon-to-bone healing junction and fibroblast growth. It essentially acts as a "bridge" to help the tendon catch up to the increased mechanical load provided by the TRT.

Level Type Total T Range Impact on Achilles Tendon Hypogonadal

 

[woundcarping]

It looks like a .246% vs .378% risk, a ~52% increase.

 

[Calm Logic]

It looks like a .246% vs .378% risk, a ~52% increase.

Definitely another reason to "test the test" more frequently, as well as test E2 level (sensitive or otherwise).

Per Gemini, the risk is still low and estrogen can be protective at high-normal (which also reminds me of HCG):

The jump from 0.246% to 0.378% is indeed a 53.6% relative increase. Even with the increase, 99.6% of men on TRT did not experience an Achilles injury during the study period.

Most of these studies don't account for E2 levels. By keeping yours high-normal, you are actively fighting the "tendon stiffness" that likely caused the increased risk in the study cohorts (many of whom may have been using AI or had "dry" joints).

 

[Thadeus]

BTW, conflicting info on TRT and Achillies issues ---

"Significant association between Achilles tendon injury and prescription TRT":

Testosterone replacement therapy is associated with increased odds of Achilles tendon injury and subsequent surgery: a matched retrospective analysis - Journal of Foot and Ankle Research

Background Prescription of testosterone replacement therapy (TRT) has increased in the United States in recent years, and though anabolic steroids have been associated with tendon rupture, there is a paucity of literature evaluating the risk of Achilles tendon injury with TRT. This study aims to...

link.springer.com

"Low hormone levels maybe associated with the risk of Achilles tendon rupture":

https://journals.sagepub.com/doi/abs/10.1177/2325967113S00085

Gemini's take is to aim for a consistent, mid-normal range of total testosterone (500 to 799):

Interesting, thanks, I've actually been on TRT for about a year and half on a once weekly injection protocol. My tendon issue predates that switch for me but this is good food for thought.

 

[Thadeus]

Also just to update, I've finished up the couple vials of BPC/TB I had and switched to KLOW for the last few weeks. The issue hasn't resolved but I'm definitely seeing some improvements. I'm able to jog again even on concrete without significant flare-ups or pain. I've traditionally always used jogging as a way to regulate my weight and it's working for me. Trying to delicately balance the benefits of some weight loss putting less pressure on my achilles and not over doing it and causing more inflammation. So far so good, down about 25lbs since early December and still trending less and less localized pain.

 

[RubbaDubba1]

For my Achilles, I use GH peptides (abdominal subq), as well as oral supplements (like collagen, cissus quadrangularis , curcumin, and taurine, with hyaluronic acid on the way). No miracles so far, but most of the time I feel perfectly fine anyway.

I know BPC is touted the most (at least for mice with tendon issues), along with TB-500 and the other ingredients of KLOW (KPV and GHK). So I will finally recon/inject those soon, in addition to ARA-290 for shits and giggles. But I have been taking my time since I am skeptical.

So far, what helps me the most (in addition to stretching and heel raises) is buying new shoes every three months and never going barefoot. I love the Sketchers walking/running shoes with the rocker bottoms (as with the Hoka brand). Driving makes it worse, so the ergonomics of the pedals and using cruise control helps.

I had a triple Ankle fusion many moon ago and the Arthritis, along with some other mentioned (Achilles) is back. I really like the Asics Keyano Gel 31. I walked around in a pair at the local shoe place and was sold pretty quick. I work on concrete all day, I'd tell ya to go give these a try if you're out lookin again.

 

[Calm Logic]

I had a triple Ankle fusion many moon ago and the Arthritis, along with some other mentioned (Achilles) is back. I really like the Asics Keyano Gel 31. I walked around in a pair at the local shoe place and was sold pretty quick. I work on concrete all day, I'd tell ya to go give these a try if you're out lookin again.

Cool:

Cut in half: ASICS Gel Kayano 31 Review

ASICS Gel Kayano 31 review: The Gel Kayano has been around us since 1993 and is more alive than ever. After surviving a risky update last year, we found that ASICS has built on its solid foundations by adding subtle improvements to the upper, stability, weight, and fit. It's still a big and...

runrepeat.com

 

[Flexon]

Regarding the place of injection, I didn't inject BPC, but used it sublingually. The problem BPC resolved for me 95% was prostatitis (very painful prostate region flare-ups). The thing is, the prostate should be a problem for many drugs to penetrate. Or, to make things simpler, the journey from under my tongue to my prostate wasn't a problem for BPC to get there and do it's wanders! So, to my experience, once it's in the bloodstream, the efficacy is more dependent on the right dosage.

 

[Chris Thomas 40923]

I haven’t seen 20mg/week.

I’m taking BPC .5mg 2x daily, for 6-8 weeks. This coming Wednesday makes the 6th week. I’ll probably finish the vial I’m on and stop, although I’ll decide later.

My rotator cuffs and ECRB tendon (tennis elbow) were my main complaints… both were acute injuries from July 2024 and August 2025. Two orthos said I had good range of motion in the shoulders, avoid pain, live with it (good advice) as surgery would be recovery intensive. The shoulders I avoided doing much lifting higher than my shoulders, and normally they didn’t bother me very much. The ECRB, a steroid shot to treat the symptoms was a choice, surgery would be another choice for me, but the doctor suggested waiting to see. The wait and see period ended at Christmas, it was better, but still not well.

I started lifting last week, after 4 weeks on BPC. I did 5 sets of 10 reps of shoulder presses with no localized discomfort, just typical overall muscle soreness. My ECRB has improved in terms of pain relief as well as load bearing.

While not a “miracle”, and decidedly not scientific, I appear better off than when I started to a measure that is beyond expected healing during that relatively short time.

Pain relief in the elbow was early, perhaps a week. Research suggested that was inflammation reduction, not actual healing. That’s why I waited a month to start lifting.

Oh boy, good to hear someone is improving.

I tore something in my shoulder while lifting weights. It was clear I needed to back off and let it heal, but it just never seemed to improve. After several months, I finally went to the doctor. He diagnosed a minor tear with an MRI and recommended a PRP injection.

When I mentioned this to a friend of mine, he suggested adding BPC-157. I was skeptical since I was completely new to peptides, I was also concerned the doctor might hesitate to move forward if he knew I was using a non-approved substance, so I waited until after the injection to start BPC.

It’s been exactly 20-days since the PRP injection, but who is counting. I still feel like I’ve been run over by a truck. I have gotten somewhat better since the ijection, but I still can't even look at weights, I can't imagine benchpressing at 4 weeks. I am currently taking the same dosage as you Mr. Woundcarping.

I am crossing my fingers, there is nothing more that I would like than to be healthy!

Best to all, maybe I will check back in a couple weeks.

 

[Calm Logic]

Anyone who took 1 mg twice a day (2 mg/day)?

 

[woundcarping]

Anyone who took 1 mg twice a day (2 mg/day)?

I may have taken my first 10mg at that rate…

 

[woundcarping]

Anyone who took 1 mg twice a day (2 mg/day)?

Were you going somewhere with that?

I’m curious where the limiting factor comes in on single dose. Half life is very short, I also wonder about max single dose vs more than twice a day.

Best I recall, there isn’t a practical max dose in terms of toxicology.