That is a good question. It did take 2 days off before it was peed away so I don't think 1 day off would do much. It was strange. I started thinking the tirz was stalled. I started thinking about stacking cag or surv. I was greatly relieved after peeing out 9 lbs. That brought my weight down to a new record low by 2 pounds like normal. What a relief. The tesa/ip is just temporary till I lose visceral weight and protect muscle mass. So far it seems to be working as intended.ScarFace said:
Anyone with tesamorelin experience?
- Thread starter ScarFace
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Calm Logic
GLP-1 Specialist
Bumping this thread with Google Gemini:
"What HGH does that Tesamorelin doesn't is provide a direct, exogenous source of the hormone. Because of this, HGH can have a broader and potentially more powerful effect on overall growth, tissue repair, and metabolism, which can be both a benefit and a source of more significant side effects. Tesamorelin is more targeted, specifically for its effects on fat reduction, and works by leveraging the body's own systems."
OTOH, from the Seeds book:
[Imported image pending local asset: attachments-screenshot_20250909_163552_kindle-webp.8760]
"What HGH does that Tesamorelin doesn't is provide a direct, exogenous source of the hormone. Because of this, HGH can have a broader and potentially more powerful effect on overall growth, tissue repair, and metabolism, which can be both a benefit and a source of more significant side effects. Tesamorelin is more targeted, specifically for its effects on fat reduction, and works by leveraging the body's own systems."
OTOH, from the Seeds book:
[Imported image pending local asset: attachments-screenshot_20250909_163552_kindle-webp.8760]
Calm Logic
GLP-1 Specialist
From 2017, a signification reduction in cholesterol, in a 12-week study of tesa, given 2 mg daily (vs 1 mg or none) in T2D patients (≥50 years of age):
Safety and metabolic effects of tesamorelin, a growth hormone-releasing factor analogue, in patients with type 2 diabetes: A randomized, placebo-controlled trial
Objective Use of growth hormone is associated with side effects, including insulin resistance. The objective of this study was to determine whether tesamorelin, a stabilized growth hormone-releasing hormone analogue, would alter insulin sensitivity or control of diabetes. Design A 12-week...
journals.plos.org
Safety and metabolic effects of tesamorelin, a growth hormone-releasing factor analogue, in patients with type 2 diabetes: A randomized, placebo-controlled trial
Objective Use of growth hormone is associated with side effects, including insulin resistance. The objective of this study was to determine whether tesamorelin, a stabilized growth hormone-releasing hormone analogue, would alter insulin sensitivity or control of diabetes. Design A 12-week...
journals.plos.org
quoted said:
latviantower
GLP-1 Enthusiast
That’s great to know - thanks for sharing. Getting updated lab work tomorrow to see if new statin dose lowered my LDL - if it’s down I can always credit the tesamorelin!Calm Logic said:
I had a similar experience. Started taking Tesa/Ipa a few weeks ago. At first 1MG/day, 5 days a week. All was good. But last week I increased to 1.5MG/day and could tell I retaining water. I actually added a pound of weight during the week and I started thinking the Tirz had stalled. But then I rested this past Saturday and Sunday and my weight this morning, Tuesday, was 5 lbs lighter than it was on Saturday.swimmer said:
3Ljeffy said:
In week four now, Tesamorelin 2mg + 0.2mg CJC1295noDAC + 0.2mg Ipamorelin, nightly 7days/week. This is on top of the GLP1.
Yep, it set me back 7-8lbs of water weight, and it definitely blunts the food noise supression of the GLP1. Tesamorelin is a finicky bastard to reconstitute, and one batch/kit just won't stop gelling even with low-pH water. But the good batch reconstitutes ok, mixes well w CJIPA, and the results are two more notches on the belt. Changes in body geometry/dimension are surprising even if the scale readings have slowed down ...and the biggest change is being able to go on a 1.5hr hike on Friday without getting winded. Two months ago I woulda started wheezing at 10min. Will continue.
I started with CJC/IPA .25mg/.25mg M-F and did that for 2 weeks, but I was reading so many good things about Tesa that I wanted to switch. Now I've been on Tesa/IPA for two weeks M-F. 1st week I did 1/0.33 mg, and 2nd week I did 1.5/.5 mg. I don't want the water retention so I started week 3 yesterday and went back to 1/.33. I too am noticing good results with body composition. I've always carried a lot of fat in my belly/midsection and that's changing. I'm excited to see what another month on this does.3Ljeffy said:
Can I ask why you are adding a small amount of CJC to your Tesa/IPA blend?
flutist-decades.2w
GLP-1 Apprentice
Anyone in this thread experience consistent ISR with Tesa? I've been trying a few things to address ISR and sort of figuring it out and getting better every few days.
First, pinning a blend from a single vial place that was Tesa/Ipa 6/3 ratio, I did 3ML BAC water and while it was a lot of volume to pin, I did 500mcg of Tesa and it stung and itched but, it went away in ~30 mins
Then I got a kit of 20MG Tesa and a kit of 10 MG Ipa, did both of them with 1 ML of BAC water and mixed 1 MG of Tesa and 100 mcg of Ipa. Same thing, stinging, itchy, but went away in about an hour.
Using the same vials, I actually mixed the Ipa into the Tesa, and was fine for a couple of days until upping to 2 MGs of Tesa and all hell broke loose. The ISR was so bad, and it has lasted over a week. It has since subsided. I threw away the mixed vial.
Lastly, I now do 1 MG of Tesa first thing in the morning, and in a separate vial and syringe, I do 100 mcg of Ipa. I repeat midday. I still get ISRs for both of them, but they are very minimal.
The next thing I'm going to do is add in more BAC water to see if it is a dilution issue. I'm not sure.
I honestly love how I feel on this mix, but if this continues, I'm going to have to stop and sell the rest of my kits before I have a systemic reaction to this.
Any advice would be greatly appreciated.
First, pinning a blend from a single vial place that was Tesa/Ipa 6/3 ratio, I did 3ML BAC water and while it was a lot of volume to pin, I did 500mcg of Tesa and it stung and itched but, it went away in ~30 mins
Then I got a kit of 20MG Tesa and a kit of 10 MG Ipa, did both of them with 1 ML of BAC water and mixed 1 MG of Tesa and 100 mcg of Ipa. Same thing, stinging, itchy, but went away in about an hour.
Using the same vials, I actually mixed the Ipa into the Tesa, and was fine for a couple of days until upping to 2 MGs of Tesa and all hell broke loose. The ISR was so bad, and it has lasted over a week. It has since subsided. I threw away the mixed vial.
Lastly, I now do 1 MG of Tesa first thing in the morning, and in a separate vial and syringe, I do 100 mcg of Ipa. I repeat midday. I still get ISRs for both of them, but they are very minimal.
The next thing I'm going to do is add in more BAC water to see if it is a dilution issue. I'm not sure.
I honestly love how I feel on this mix, but if this continues, I'm going to have to stop and sell the rest of my kits before I have a systemic reaction to this.
Any advice would be greatly appreciated.
natehawes said:
At the time I read a few recommendations on a wide range of places, from reddit and various bro-science sites, to clinical reports and well... THIS place. In general it seemed/seems that:
Tesamorelin is a growth hormone-releasing hormone (GHRH) analog that directly mimics the body's own GHRH, and does all the visceral-fat reduction action we love and talk about.
CJC-1295 is a GHRH analog that triggers GH secretion by a slightly different mechanism, so the thinking is that it amplifies the Tesa response without the side effects of simply upping the Tesa dosage. Within reason, without venturing into the total unknown.
Ipamorelin mimics the hormone ghrelin, which stimulates the release of GH from the pituitary without affecting cortisol or prolactin levels i.e. minimize side effects.
TL;DR: Two producers and one stereo amplifier.
So, I was curious about the effect of Tesa+CJC as two different ways to make GHRH available from the pitutary without loading up too much one a single one, and Ipa as an amplifier to the effect of both. (Why yes, I do take one aspirin and one ibuprophen, instead of two of one or the other. Why do you ask?
In any case, the effect seems pretty much as expected: after 2-3 weeks the edema stabilized and there was pretty noticeable fat loss from my torso, more than my weight loss would explain. I've gone from turgid to flabby, so I suppose that's progress....?
Calm Logic
GLP-1 Specialist
According to WebMD, even HGH usually only results in a small amount of fat loss:
The Truth About HGH for Weight Loss
The quest for a weight loss solution has some people taking human growth hormone (HGH) in pills, powders and injections. But does it really work?
www.webmd.com
The Truth About HGH for Weight Loss
The quest for a weight loss solution has some people taking human growth hormone (HGH) in pills, powders and injections. But does it really work?
www.webmd.com
quoted said:
Kang-Thang 18234
GLP-1 Novice 🚫No Source Discussion🚫
hahaha, that counts. vivid and honest recounting, respect.3Ljeffy said:
Calm Logic
GLP-1 Specialist
An extremely positive post about tesa and why it can be better than HGH:
https://thinksteroids.com/community/threads/why-do-some-people-run-growth-hormone-releasing-peptides-instead-of-hgh.134432334/post-3599003
https://thinksteroids.com/community/threads/why-do-some-people-run-growth-hormone-releasing-peptides-instead-of-hgh.134432334/post-3599003
Zydeceltico
GLP-1爱好者
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That is a very good and experience-detailed post.Calm Logic said:
HumanusExMachina
GLP-1 Enthusiast
I'm only 3 days into taking tesa/ipa/cjc. Today, I was poking through some of my health tracking numbers and noticed that beginning with the first dose, my HRV (heart rate variability) more than doubled. I've been pretty much stuck at an HRV around 45 since I first started tracking it about 4 years ago. Now it's running 85 to 116. That's an unexpected positive change.
I've also been sleeping better the last 3 nights.
I've also been sleeping better the last 3 nights.
Ziess21
Recently Joined 🚫No Source Discussion🚫
I've been on it for a month now and sleep quality has most definitely improved by both my personal opinion and my watch tracking my sleep. Routinely getting a 99 sleep score.HumanusExMachina said:
Tbagger
GLP-1 Enthusiast
I'm a week on so far. Starting with 1mg a day before bed for the first 10 days then going to bump it up to 2mg for another 5 days before adding in IPA at 250mcg morning and night. So far I haven't noticed much in the water retention but I'm sure it's coming when I jump to 2mg. I don't really care about the water weight though. After it caps out and I start losing again, dropping it at the end of the cycle will be a little bonus to look forward to. I do get little stinging and some itchiness at the injection site as I go to bed, but it's always gone when I wake up. And my sleep has been improving. I'm really optimistic about this stack and am looking forward to seeing some results.
Calm Logic
GLP-1 Specialist
I would go to 1.5 mg before upping to 2 mg. Haven't tried tesa yet, but a buddy of mine had carpal tunnel quickly after going from 1 mg to 2 mg.
Tbagger
GLP-1 Enthusiast
That was a really good read. I was expecting a lot more peptide criticism in a gear forum.Calm Logic said:
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