When Weight-Loss Drugs Don’t Work

[sfkid]

https://share.google/jTyQpIy8C6fxuSXq5

Based on this article it seems 1 of 10 people don't respond the GLP1s at all.

Does anyone know someone that has had zero response?

 

[DjJoshua]

https://www.nytimes.com/2026/03/12/well/weight-loss-drugs-response-wegovy-zepbound.html

Based on this article it seems 1 of 10 people don't respond the GLP1s at all.

Does anyone know someone that has had zero response?

Maybe it's just me but that link wants me to create a account to read the article. Is there a different link?

 

[sfkid]

Maybe it's just me but that link wants me to create a account to read the article. Is there a different link?

It worked for me and I don't subscribe.

Try this one

https://share.google/jTyQpIy8C6fxuSXq5

 

[DjJoshua]

It worked for me and I don't subscribe.

Try this one

https://share.google/jTyQpIy8C6fxuSXq5

Same thing on that second try.

I am sure you don't get all your news from the NY times (wink wink)

 

[CNCCurrency]

Same thing on that second try.

I am sure you don't get all your news from the NY times (wink wink)

Worked for me, do you use an ad blocker or vpn? Mine blocks certain sites at times.

 

[FortySeven]

More accurately, one in ten people who were accepted for a clinical trial were deemed "non-responders" -- which didn't even mean zero response, just less response. This is not the same thing as what the catchy subhead claims: 'But one in 10 people are what scientists call “non-responders.”' That suggests that 1 in 10 people in the population of the world are what they would call "non-responders".

This kind of lazy science reporting perpetuates false claims, but I guess it sells papers.

If you think about it, people who were accepted for the clinical trial are not necessarily "average" folks. They had to meet a bunch of qualifications, assumedly. And those qualifications mean that the clinical trial population probably had a higher percentage than the general population of people who were a) obese and b) had tried to lose weight in other ways/maybe with other meds and had failed. (I do not mean to use the word 'failed' as a judgment, btw.)

Anyhow, it's an interesting article, and it links to some other interesting articles (like the one about retatrutide clinical study participants dropping out because the were losing "too much" weight). I just get really annoyed by science reporting that makes to easy-breezy statements without much apparent critical thinking.

 

[randompersonrandom]

Link didn't work for me. I think it's unlikely to say much I don't already know though; there is a certain number of people who don't feel much or eat through it. Which I'm betting we'll find out years later is because people overeat for different reasons, and 90% of them overeat for reasons that are treated with the two receptors tirz treats, but 10% of them overeat for reasons that hitting some other receptor will turn out to work on.

 

[DjJoshua]

Worked for me, do you use an ad blocker or vpn? Mine blocks certain sites at times.

I have it all. VPN ad blocker you name it's on! lol... Even my e-mail is a ghost e-mail.

 

[tubby]

For perspective, here are some waterfall plots from the reta phase 2 trial data supplement.

At 1mg you can see there was a decent percentage of folks that were still pretty close to that 0% line 48 weeks out.



But I'd dare say the 12mg group didn't have anyone who hadn't lost significant weight 48 weeks out.

I'd imagine data from other GLPs show similar results at low vs high dosing.

As usual, I wouldn't take a NY Times article (or really any "news" article) that attempts to cover a scientific topic very seriously, unless your goal is to gain a superficial (and generally incorrect) understanding of the topic.

 

[tubby]

Hmm.... 12mg chart plot doesn't appear to have posted. Let me try again.

 

[Rolltide61]

https://share.google/jTyQpIy8C6fxuSXq5

Based on this article it seems 1 of 10 people don't respond the GLP1s at all.

Does anyone know someone that has had zero response?

Reta does not work for me. Went as high as 10mg. Nothing on Tirz. Used Cagri w/ Reta and still zero hunger suppression.

Now check this out. Went on Melanotan ll. Zero hunger.

Ain't that something.

 

[sfkid]

I have it all. VPN ad blocker you name it's on! lol... Even my e-mail is a ghost e-mail.

NY Times just wants your money and only your money

 

[lessthanhalf]

For perspective, here are some waterfall plots from the reta phase 2 trial data supplement.

At 1mg you can see there was a decent percentage of folks that were still pretty close to that 0% line 48 weeks out.

View attachment 17432

But I'd dare say the 12mg group didn't have anyone who hadn't lost significant weight 48 weeks out.

I'd imagine data from other GLPs show similar results at low vs high dosing.

As usual, I wouldn't take a NY Times article (or really any "news" article) that attempts to cover a scientific topic very seriously, unless your goal is to gain a superficial (and generally incorrect) understanding of the topic.

Really like those graphs. I had not seen them. The other end is just as interesting with maybe 20% losing 15% or more on 1mg and nearly 10% losing close to 30% on 1mg, there really are some super responders.

At 12mg even the worst responders still lost 5% and that looks like about 5% and another 10% only losing 10%. And about 40% lost high 20% weight. and 48 weeks is probably a bit early for everyone to have stopped losing weight so might be a bit better a few months later.

 

[WLBLD]

I thought the trials started at 2mg?

 

[lessthanhalf]

One of the most interesting bits of data out there is that a year of 1mg of reta is surprisingly effective, as seen in the first graph, with an average weight loss of 9%. The other GLP's are nowhere near that effective at low doses. For someone who is mildly obese or just overweight low dose reta is probably a good option. I would even guess they might end up using this in their marketing once reta is finally approved. The obvious advantage is side effects at 1mg are most often going to be pretty minor. It may even have the best side effect to weight loss ratio of all the GLP's, though I would have to look that up to confirm it.

 

[tubby]

Really like those graphs. I had not seen them. The other end is just as interesting with maybe 20% losing 15% or more on 1mg and nearly 10% losing close to 30% on 1mg, there really are some super responders.

At 12mg even the worst responders still lost 5% and that looks like about 5% and another 10% only losing 10%. And about 40% lost high 20% weight. and 48 weeks is probably a bit early for everyone to have stopped losing weight so might be a bit better a few months later.

Here's another one you might enjoy.

 

[Vash_]

https://share.google/jTyQpIy8C6fxuSXq5

Based on this article it seems 1 of 10 people don't respond the GLP1s at all.

Does anyone know someone that has had zero response?

I started Reta at 2mg. Worked my way upto 7.5 and had to quit because of the negative side effects. Didn’t lose any weight.

So technically not a non-responder but not in the intended way.

I did escalate my dose quicker than in the studies. So maybe I messed it up. I let it clear my system and am back on now at 2mg. Going strictly by the titration schedule described in the studies this time. Three weeks in and I’m up a couple pounds.

Still need to do bloodwork. But will give it a solid 8 weeks of use first.

Haven’t had any sides so far. But I didn’t feel anything the first go until 5mg.

Also on test, growth, BPC, and TB500. Figure even if it doesn’t help me lose weight, it should help with negating sides from the growth.

 

[sfkid]

I started at 2mg. Worked my way upto 7.5 and had to quit because of the negative side effects. Didn’t lose any weight.

So technically not a non-responder but not in the intended way.

I did escalate my dose quicker than in the studies. So maybe I messed it up. I let it clear my system and am back on now at 2mg. Going strictly by the titration schedule described in the studies this time. Three weeks in and I’m up a couple pounds.

Still need to do bloodwork. But will give it a solid 8 weeks of use first.

Haven’t had any sides so far. But I didn’t feel anything the first go until 5mg.

Also on test, growth, BPC, and TB500. Figure even if it doesn’t help me lose weight, it should help with negating sides from the growth.

Are you using tirz or reta ?

 

[Vash_]

Are you using tirz or reta ?

Sorry. Retatrutide.

 

[DjJoshua]

I started Reta at 2mg. Worked my way upto 7.5 and had to quit because of the negative side effects. Didn’t lose any weight.

So technically not a non-responder but not in the intended way.

I did escalate my dose quicker than in the studies. So maybe I messed it up. I let it clear my system and am back on now at 2mg. Going strictly by the titration schedule described in the studies this time. Three weeks in and I’m up a couple pounds.

Still need to do bloodwork. But will give it a solid 8 weeks of use first.

Haven’t had any sides so far. But I didn’t feel anything the first go until 5mg.

Also on test, growth, BPC, and TB500. Figure even if it doesn’t help me lose weight, it should help with negating sides from the growth.

Yes keep us in the loop on how Teas and that HGH goes. I have some Tesa on the way now.