When Weight-Loss Drugs Don’t Work

[Nabster]

GLP1s never ever helped me lose weight... I lost weight more easily, more quickly and more consistently with Keto... it was so so much eaiser on keto... could always lose 14lbs a month on keto

What GLP1s did thought was absolutely make it more difficult to gain weight... that much is true... overall my journey on GLP1s has been a nightmare tbh... constanty god damned stalls... like I can eat far less or eat far more and I don't gain or lose weight either way... fucking weird... feel trapped tbh cause while the lack of weight gain is nice I desperately want to lose another 25lbs minimum... and it simply will not happen... it seems like the only way I can lose weight, although slowly on GLP1s is cutting out carbs and introducing carbs... and doing this cycle back and forth... only problem is not eating carbs on GLP1s is a hellscape of constant hunger and the worst sleep one can dream of and low blood sugar

 

[Super Trips]

https://share.google/jTyQpIy8C6fxuSXq5

Based on this article it seems 1 of 10 people don't respond the GLP1s at all.

Does anyone know someone that has had zero response?

I do believe this to not only be a physical effect but a mental state of the subject. Some people just are not mentally able to lose weight effectively just yet

 

[tubby]

GLP1s never ever helped me lose weight... I lost weight more easily, more quickly and more consistently with Keto... it was so so much eaiser on keto... could always lose 14lbs a month on keto

What GLP1s did thought was absolutely make it more difficult to gain weight... that much is true... overall my journey on GLP1s has been a nightmare tbh... constanty god damned stalls... like I can eat far less or eat far more and I don't gain or lose weight either way... fucking weird... feel trapped tbh cause while the lack of weight gain is nice I desperately want to lose another 25lbs minimum... and it simply will not happen... it seems like the only way I can lose weight, although slowly on GLP1s is cutting out carbs and introducing carbs... and doing this cycle back and forth... only problem is not eating carbs on GLP1s is a hellscape of constant hunger and the worst sleep one can dream of and low blood sugar

It does seem like results are all over the board on people trying to mix keto and GLPs. Safe to assume you've tried keto again after letting your body acclimate to GLPs for several months (VS bad experience early on making you gun-shy)?

I mean it is claimed that gluconeogenesis is demand-driven (which I personally question, but I digress) so I guess it shouldn't be a total surprise that simulating the "hey there are some carbs coming in" hormone could throw a wrench into the mix there.

 

[UncrossSelector]

I’m currently transitioning from tirzepatide (Eli Lilly’s Mounjaro) to grey retatrutide.

I was running a split dosing protocol—2 × 3.75 mg per week—and I’ve now swapped out my Monday evening dose for 2.5 mg of retatrutide. By Wednesday, I notice the appetite suppression dropping off pretty hard, and my Friday morning Mounjaro shot is just barely on time to get me through the weekend.

Plan is to slowly titrate the retatrutide up and see if I can get stronger, more stable appetite control from it. Once this feels more or less stable across the full week, I’ll fully transitioning over to retatrutide

Upside so far: zero negative side effects from either compound.

Has anyone made a similar transition, and what were your experiences?

I have a single data point.

A friend tritrated up to 10mg Tirz and lost almost nothing. She said she never felt any hunger supression. She stopped about 6 months ago.

She's now on 2mg Reta and is feeling food sizing control - actually eating half a meal and deciding she's full. Fingers crossed it continues to work for her.

 

[Hotlongs]

GLP1s never ever helped me lose weight... I lost weight more easily, more quickly and more consistently with Keto... it was so so much eaiser on keto... could always lose 14lbs a month on keto

What GLP1s did thought was absolutely make it more difficult to gain weight... that much is true... overall my journey on GLP1s has been a nightmare tbh... constanty god damned stalls... like I can eat far less or eat far more and I don't gain or lose weight either way... fucking weird... feel trapped tbh cause while the lack of weight gain is nice I desperately want to lose another 25lbs minimum... and it simply will not happen... it seems like the only way I can lose weight, although slowly on GLP1s is cutting out carbs and introducing carbs... and doing this cycle back and forth... only problem is not eating carbs on GLP1s is a hellscape of constant hunger and the worst sleep one can dream of and low blood sugar

I am really sorry, that is rough. Have you gotten any lab work such as thyroid hormone levels checked? You’d want to rule out metabolic adaptation, hormonal issues, and glucose regulation problems .

 

[HungryBarbie]

https://share.google/jTyQpIy8C6fxuSXq5

Based on this article it seems 1 of 10 people don't respond the GLP1s at all.

Does anyone know someone that has had zero response?

Yes, my husband did't react to semaglutide at all, zero, nada. Reported he felt tired and that's it. Got up to 1 mg dose with zero weight loss.

 

[domin8brix]

https://share.google/jTyQpIy8C6fxuSXq5

Based on this article it seems 1 of 10 people don't respond the GLP1s at all.

Does anyone know someone that has had zero response?

I know one person who did not respond to Semaglutide at all, but Tirz seemed to work for her.