Weight regain after stopping GLP's

Status
Not open for further replies.
Calm Logic said:
"Opposite ends of the spectrum" is pretty clear. In any case, I was not going on just the "tool" word. I may be an idiot, but I know my gym bros.

He is assuming a lot about people here (or "some people," as they say) so I feel at liberty to do the same about him:

Weight regain after stopping GLP's

I thought this study was interesting Trajectory of weight regain after cessation of GLP-1 receptor agonists: a systematic review and nonlinear meta-regression https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(26)00043-X/fulltext It shows that people who lost weight on GLP's might...

glp1forum.com
That's fair. I read it as him trying to advocate for his desired GLP approach forcefully and contrasting it to the typical approach, which kind of requires critiquing the typical approach on some level in order to make his point. In my prior response to him I suggested different people might have different approaches (similar to the point you made, I suppose).

My objection to what you said was that you seemed to be dismissing his (largely valid) paradigm, as comparable to someone expecting to maintain steroid results after quitting steroids. His proposed path is certainly not the path of least resistance, but for some it will actually work.
 
tubby said:
My objection to what you said was that you seemed to be dismissing his (largely valid) paradigm, as comparable to someone expecting to maintain steroid results after quitting steroids. His proposed path is certainly not the path of least resistance, but for some it will actually work.
NOT MUTUALLY EXCLUSIVE

You can have your GLPs and lift at the same time.

This is like the old debates in behavioral health. You can take SSRIs and still do therapy. Geez. With ketamine treatments, the ketamine can drip in during talk therapy. Most ppl are smarter than you give them credit for (ala Carl Rogers).
 
bbbilly said:
it kinda feels like we are all having the same mindset, but on opposite ends of the spectrum. we all agree GLPs are helpful, needed and effective. i feel like we are all kind of discussing different levels of dependance on them rather than the use of them as a tool. i myself find even taking 1.25mg/week of my tirz puts me in a much better state of mind to be able to make the right decisions when its needed and to pull myself back from the cliff of a binge. i dont want to waste the meds or set myself back from my progress i want and that thought is what helps me break the cycle, and even when i was off of it for 6 months i knew that just because i was hungry didnt mean i had to eat, so i just ate the same things everyday regardless of hunger levels.

some people seem to rely solely on the meds to achieve their goals. i mean just look at the number of threads in the fitness/nutrition category vs any other non specialized section here. if you stop the meds of course you will gain the weight back. same thing with if you stopped food tracking and/or exercise, i don't think anyone is arguing otherwise. i just personally feel like an over dependance on them will lead to these statistics to stay true, and anecdotally i would guess the ones that you see saying "im not hungry at all but im not losing weight" would be the reason they stay at 95% weight regain after quitting.

so people like me are viewing it from the angle of diet and exercise first then meds, compared to (admittedly most likely people that would be outliers in the studies mindset based only on the limited comments from forums like these without knowing all the work they put into weight management) meds as the heavy lifter and only thing that works.

again im unaware of any studies on this subject aswell, but ive seen a regular thought process from naturally thin people to be "ya im hungry but i dont have time to eat right now so ill just eat later." its not as much of a matter of hunger ques but more so mental awareness on what hunger ques mean, and would be interested to see what would happen if they had a super effective GLP that did nothing but remove the food noise completely., while leaving the appetite suppression and gastric emptying alone. what those studies would look like.
I’ve been pretty open about my use of GLPs. A few people I know have begun their own journeys. I also tell them you don’t get the real benefits by pinning the meds once a week and sleep though the process.

I’m 74 M. Been stressing myself in a variety of ways for many years. I used to do what I called a spring cleaning by going on a juice fast lasting from 5 to 25 days every spring. When bicycle training, I go ride for 3 to 4 hours, bonk, stop and eat bananas and oranges to refuel and head home. Come to find out a nutrient deficiency is therapeutic after I had been working out in the AMs before eating.

I always considered myself as athletic, but the last few years, struggled with weight, energy, exercise, motivation, etc. Started Tirz in Aug 2025, Super responder, Lost 40lb at low doses in a few months. Plateaued a few times but was able to break through by fasting 24-36 hours.

Down now about 55 lbs and just about at my GW.

My point in writing this is for folks to understand it isn’t just a miracle drug that transforms us. It is a commitment to change most of our habits that will transform us. Had I not stressed myself earlier in life, I wonder if I could even understand how to get the most benefits from GLPs. GLPs make getting healthy easier, but they do not create health. I had some good habits along with bad ones. GLPs are great tools to help focus on good health choices.

When people say Keto, Ozempic, Jenny Craig, Weight-Watchers, et al diets don’t work since everybody gains the weight back after they quit have kinda missed the point. Of all the weight-loss regimens I’ve seen, GLPs are the miracle solution. Look through this forum. Most folks on GLPs are also on other peps and protocols to increase their health-spans. Most talk of dietary and workout changes. I haven’t seen this in any of the other diet groups. Keep up the good work and be good examples.
 
Calm Logic said:
You can take SSRIs and still do therapy.
LOL, you someone managed to draw an analogy from the one other "scientific" discipline where the research (might be) on shakier ground than nutrition science. But agreed. 🙂
 
Calm Logic said:
You lost 100 pounds on Zepbound, but it's just a "tool:"

[archived internal link]
i have stated several times that i have a different perspective as most in this forum, i am open about that and try to be as objective to seeing both sides. also to be fair i lost those same 100lbs before, when i was in my early 20s and kept it off for nearly a decade until covid hit and they shut down the gyms and i got laid off 6 times in 3 years from the same job. started trying for a baby and released my bloodwork was all fucked up and started getting back in shape, lost 50lbs in 6ish months naturally then started zepbound because my a1c was in pre diabetic range so i qualified and it HELPED me lose the next 50-60lbs. even when i stopped taking it cos my insurance cut me off i held that weight for a while before i decided "you know what, ill get back on it eventually, i might as well take advantage of this off time to try and bulk up and enjoy the pumpkin spice season" (i absolutely love pumpkin spice ANYTHING) so yes from my perspective it is a "tool" one that can be used to get someone in a better place to learn why they do the things they do with food, how to eat, the importance of a well rounded diet etc. if you use the tool to unburden yourself from the mental aspect of food but dont learn anything from it then you are just going to be coming back to this forum every 6 months and post

"not losing weight on max dose reta, should i switch or stack with tirz" then go on to say "i have no hunger and struggle to eat but im not losing weight"

all im trying to say is, if you stop doing whatever it is you did to lose weight and go back to your baseline "intuitive" style eating level most everyone will regain the weight. if you dont put in serious mental effort to keep the weight off it will come back no matter what. but for people that have struggled with food their whole life this time when on a glp should be a great opportunity to be able to self reflect and maybe find those triggers and habits for them. like lessthanhalf said it takes alot of mental effort to not eat what your body tells you to eat, and he has done an amazing job at setting up that structure to help him. i myself find it easiest to simply eat the same things everyday. ive eaten the same dinner almost everyday for the last 3 years, same thing with a different meal for the 5 years before covid came around. if i deviate from my set meal plan i will over eat. if i stick to it i will be distractingly hungry but as long as i dont go off script my weight will stay the same.

and for the record no, i dont think its cheating.
 
bbbilly said:
"not losing weight on max dose reta, should i switch or stack with tirz" then go on to say "i have no hunger and struggle to eat but im not losing weight"

Most people I know on GLPs never got to the max dose and eventually reached their weight loss goals. And even the few I know who were/are on max doses (or higher) are getting to goal or did already.

That there are people who will never get to goal doesn't mean that less GLP is the answer. One can optimize diet and exercise without ever stopping GLPs, possibly adding GH peptides, TRT/HRT, setmelanotide, Jardiance, or even stimulants.

I do like intermittent fasting, plant-based diets, cardio, resistance training, etc. -- all of which I still do. But I would not say that any of that is the secret to my success (since I did all of that before going on GLPs). I do appreciate that even just 12 hours of intermittent fasting is easier to do consistently on GLPs.

CICO (calories in, calories out) is not the magic. The magic is what makes it all behaviorally possible. If you (and your bloodwork) can do just as well without GLPs (such as finding the right hacks), that's great. I don't think most of us are in that category, arguably due to a true GLP deficiency.
 
Calm Logic said:
Most people I know on GLPs never got to the max dose and eventually reached their weight loss goals. And even the few I know who were/are on max doses (or higher) are getting to goal or did already.

I do like intermittent fasting, plant-based diets, cardio, resistance training, etc. -- all of which I still do. But I would not say that any of that is the secret to my success (since I did all of that before going on GLPs). I do appreciate that even just 12 hours of intermittent fasting is easier to do consistently on GLPs.
that was just an overly dramatic hypothetic type situation. but in my short time i have already seen people discussing their stalls on relatively high doses while claiming they have low or no hunger and greatly diminished food noise, and i stay away from posting on those types of comments as i am not trying to make anyone feel attacked. everyone has their own demons and angles and its not up to me to convince them which is which. i was only making a point that if you stop doing the one thing that give you results. yea you are most likely going to lose those results, whether its a glp or a specific lifestyle.

but maybe you are right "this is a glp1 forum" and its super fucking cheap so just up the dose and stop worrying about it.
 
All good points in this discussion. I think the expectation that people should just deal with feeling hungry and miserable, and if they don’t that is a failure of character, has always been a terrible starting point.

I’ve always enjoyed working out to help with stress. I’ve never been more than a pound or two overweight. I’m lucky in that my personal biology and desire to eat more-or-less falls within normal enough ranges that with minimal effort I can stay at a healthy BMI and still eat pizza, cupcakes, spaghetti, etc etc, even though I’m short.

But I can tell you that if my biology didn’t support my love for yummy unhealthy foods, I would be really angry about it. Especially watching other people enjoy some of that stuff without much harm to their physique. (Yes, I have friends who have always hated me a little bit for my easy food habits.)

As for satiating foods… There is no way to fill my stomach with anything in this world that is going to make me not want a donut when I want a donut. It is quite easy to have a full stomach and still feel miserable if my sugar addiction hasn’t been appeased. (I have weird unidentified blood sugar problems, so eating the donut isn’t a good idea either.) Being miserable and counting every calorie obsessively isn’t necessary for everyone and shouldn’t be necessary for anyone. Until we find a way to correct whatever is biologically going on for a certain segment of the population, GLP meds are what we’ve got.

I love my Reta. It makes me gag if I even look at a donut for too long.
 
bbbilly said:
i have stated several times that i have a different perspective as most in this forum, i am open about that and try to be as objective to seeing both sides. also to be fair i lost those same 100lbs before, when i was in my early 20s and kept it off for nearly a decade until covid hit and they shut down the gyms and i got laid off 6 times in 3 years from the same job. started trying for a baby and released my bloodwork was all fucked up and started getting back in shape, lost 50lbs in 6ish months naturally then started zepbound because my a1c was in pre diabetic range so i qualified and it HELPED me lose the next 50-60lbs. even when i stopped taking it cos my insurance cut me off i held that weight for a while before i decided "you know what, ill get back on it eventually, i might as well take advantage of this off time to try and bulk up and enjoy the pumpkin spice season" (i absolutely love pumpkin spice ANYTHING) so yes from my perspective it is a "tool" one that can be used to get someone in a better place to learn why they do the things they do with food, how to eat, the importance of a well rounded diet etc. if you use the tool to unburden yourself from the mental aspect of food but dont learn anything from it then you are just going to be coming back to this forum every 6 months and post

"not losing weight on max dose reta, should i switch or stack with tirz" then go on to say "i have no hunger and struggle to eat but im not losing weight"

all im trying to say is, if you stop doing whatever it is you did to lose weight and go back to your baseline "intuitive" style eating level most everyone will regain the weight. if you dont put in serious mental effort to keep the weight off it will come back no matter what. but for people that have struggled with food their whole life this time when on a glp should be a great opportunity to be able to self reflect and maybe find those triggers and habits for them. like lessthanhalf said it takes alot of mental effort to not eat what your body tells you to eat, and he has done an amazing job at setting up that structure to help him. i myself find it easiest to simply eat the same things everyday. ive eaten the same dinner almost everyday for the last 3 years, same thing with a different meal for the 5 years before covid came around. if i deviate from my set meal plan i will over eat. if i stick to it i will be distractingly hungry but as long as i dont go off script my weight will stay the same.

and for the record no, i dont think its cheating.
I am fairly sure from your previous posts that you are taking GLP's intermittently or at low doses, so if that is wrong then this response is a bit pointless.

Given your history of basically pre diabetes, there is a fairly good argument on medical grounds to keep taking GLP's at full doses, even if at normal weight, even if you might be able to stop them. Just solely for their effect in preventing diabetes development. Not everyone who develops diabetes is obese, it can and does develop in people with normal BMI's. Even those eating well and exercising. If you are overweight or obese and lose weight the odds of developing it are reduced, but not to zero. GLp's reduce the odds of developing diabetes by a lot, independently of effects on weight. And if at any point you have had tests showing impaired glucose tolerance the long term odds of diabetes are quite high. If you have been significantly obese long term, I would argue they are worth taking at full doses long term for prevention of heart disease, stroke cancer etc , assuming age and overall risk profile indicates being at higher risk than normal. And without knowing all the other relevant numbers just having impaired glucose tolerance at one point probably puts you in a high risk category. As does the degree of previous obesity. They almost certainly work to reduce long term risks in everyone, it is just not proven yet for younger healthier populations. Not sure this is a viable option in more intermediate risk cases at retail prices, but at grey peptide prices it is.
 
lessthanhalf said:
Given your history of basically pre diabetes, there is a fairly good argument on medical grounds to keep taking GLP's at full doses, even if at normal weight, even if you might be able to stop them.
i was wrongfully terminated from my company last august and insurance cut me off so i was forced to stop taking them. i recently connected all the dots with an old back injury that when i was on zep i didn't throw my back out at all for the year ish i was on it. in that time ya my a1c dropped into normal range. after 6 months without it i noticed i was throwing my back out every otherweek and found out my a1c went back up even though i greatly limit my added sugars, do digestion walks after meals and do all the other gym things i do. so i got back on it mainly for those reasons and im trying just half of the lowest dose to see if that is enough.. have not thrown my back out since i started other than the clockwork 36 hour post injection projectile vomiting i get after the first couple doses. last time i was only on 2.5mg for almost the whole yearish and dropped 50-60lbs, other than the last couple months where i tried 5mg just for shits and giggles.. there was no noticeable difference on the 5mg though. now that ive found my way here im going to just bump to the standard 2.5mg and sit at that in perpetuity.
 
Low doses have a significant protective effect against developing diabetes, but I did find one study that showed higher doses were more effective for this than lower ones, but it is still probably a good idea to check blood glucose or hb1ac periodically long term, even if at normal weights. ( as well as lipids and blood pressure )
 
bbbilly said:
but maybe you are right "this is a glp1 forum" and its super fucking cheap so just up the dose and stop worrying about it.

Exactly, haha. Like 30 cents per mg is the going rate for tirz. So only $1.50 for a weekly injection of 5 mg. Since I haven't transitioned to Robinhood yet, I spend more than that on crypto fees.
 
Calm Logic said:
Exactly, haha. Like 30 cents per mg is the going rate for tirz. So only $1.50 for a weekly injection of 5 mg. Since I haven't transitioned to Robinhood yet, I spend more than that on crypto fees.
no joke i just opened an exodus wallet and re activated my old coinbase account.. it had like $40 in it i forgot about from 2018 when i got out of my btc and just left the raminaing... to bad i didnt just hold.. it says like 2,400% gains lol
 
Status
Not open for further replies.

Trending content

Members online

No members online now.

Forum statistics

Threads
2,620
Messages
55,146
Members
1
Latest member
Admin
Back
Top