Using Peptides for reoccurring/chronic infection

[beforetherush 32090]

Has anyone used something like a Thymosin Alpha 1 and KPV protocol for reoccurring/chronic infection. I have a lab rat who has had this going on and appears to get a reoccurring infection every year that requires surgery. Just curious if anyone has tried anything.

 

[RubbaDubba1]

Has anyone used something like a Thymosin Alpha 1 and KPV protocol for reoccurring/chronic infection. I have a lab rat who has had this going on and appears to get a reoccurring infection every year that requires surgery. Just curious if anyone has tried anything.

I'm on my 2nd winter using TA-1 and haven't had a sniffle so far either winter. I bought my 1st full kit a while back and am doing 1mg a day, last couple weeks after my surgery. I have a pretty low White blood cell count and I have another upcoming operation soon. I read that TA1 can potentially raise your WCB and help balance you immune system. This will be the Litmus test for me, if my WBC can be raised up by a fair amount. I'm running a KLOW protocol right now, haven't run KPV by itself. I know this is anecdotal, wish I had something more solid to tell you.

If I'm not being nosy, is the infection where you had a joint replacement or metal being put in your body? I only ask cause I've had a few operations Knees, ankle, weight loss surgery and I take a Antibiotic before my dental appointments, to prevent getting an infection where I have metal in my body.

 

[lessthanhalf]

KPV is an innate antimicrobial peptide, so it has some antibacterial properties. Problem of course is all the research is in cells or mice and zero in humans, and most of the research is not centered on antibacterial effects. Most of the rodent studies used doses a lot higher than are available , so to use human equivalent doses would be super expensive. I looked into it as there is a fair bit about its effectiveness in ulcerative colitis ( which I have ) or at least the mouse experiment version, but the lack of human trials and the fact it would be destroyed before it got to where it was needed in the gut if taken orally and the dose cost issue was a problem. Antibiotics are not rare or difficult to find and there are hundreds of them, all of them having better evidence that they work in real infections in people than any of the peptides.

I cannot really comment on the effects of the other peptides on immune function as I have not read much on that.

 

[Jfrick11]

I'm using Thymalin and Thymosin Alpha-1 together.

 

[Chili777]

I gave myself a sinus infection, either by not filtering my peps or by going 60 days straight of IN with a plethora of nasal sprays. Both equally dumb, in hindsight. I've been on a KPV cycle (500 mcg daily) and I'm in month 2. I also got some TA-1 a few months ago with plans to research that as some point, but I broke it last out Wednesday to research it as a defense. I'm frankly amazed with my response, so far. I'm researching 1.6 mg daily as recommended for an acute infection phase. Other than Astepro for congestion, I haven't been using anything else.

I'm not ready to declare victory yet, but I feel like I'm getting better every day. I will keep TA-1 in my tool kit permanently if it continues like this. Normally, I'd be calling to get an appointment for antibiotics by this point. If I can avoid that, and it's associated microbiome disruption, that's a real win.

 

[beforetherush 32090]

I'm on my 2nd winter using TA-1 and haven't had a sniffle so far either winter. I bought my 1st full kit a while back and am doing 1mg a day, last couple weeks after my surgery. I have a pretty low White blood cell count and I have another upcoming operation soon. I read that TA1 can potentially raise your WCB and help balance you immune system. This will be the Litmus test for me, if my WBC can be raised up by a fair amount. I'm running a KLOW protocol right now, haven't run KPV by itself. I know this is anecdotal, wish I had something more solid to tell you.

If I'm not being nosy, is the infection where you had a joint replacement or metal being put in your body? I only ask cause I've had a few operations Knees, ankle, weight loss surgery and I take a Antibiotic before my dental appointments, to prevent getting an infection where I have metal in my body.

Got a cortisone shot for knee pain. Ever since every year sometimes even 2-3 time a year re-occurring infection. Starts in different areas of the body. Tried surgeries, doses of IV's full of anti-biotics, and other methods. Without fail every year another reoccurring infection.

 

[RubbaDubba1]

Got a cortisone shot for knee pain. Ever since every year sometimes even 2-3 time a year re-occurring infection. Starts in different areas of the body. Tried surgeries, doses of IV's full of anti-biotics, and other methods. Without fail every year another reoccurring infection.

It sounds like you got something deeper going on there. Along with the TA1, looking into LL37 might be beneficial as well. I didn't see much mentioned at all in a search of this sight, but here are a few headlines.

LL-37 is a human cathelicidin that belongs to a broader family of antimicrobial peptides (AMPs) . It’s primarily produced by certain white blood cells (including macrophages and neutrophils ) and is discussed for roles in both innate and adaptive immunity, with interest as a potential alternative approach to antibiotics in research contexts.

Deeper Research Notes (Summary):

• LL-37 is described as an antimicrobial protein produced by immune cells that fights bacteria and helps regulate inflammation—partly by interacting with bacterial cell walls and disrupting membranes (forming pores), which can lead to bacterial cell death.

• Although elevated LL-37 levels are often noted in inflammatory diseases, some research discussions frame LL-37 as potentially protective against excessive immune reactions; depending on context, it may help boost or calm immune activity to maintain balance.

• LL-37 is discussed as supporting tissue repair in the lungs and intestines by attracting epithelial cells to wound areas, supporting new blood vessel formation (nutrient delivery), and helping regulate inflammation—often mentioned in relation to asthma and inflammatory bowel disease models.

• LL-37 is also discussed for a potential immune-support role in cancer contexts, particularly within the gastrointestinal tract , by helping immune surveillance recognize and clear abnormal cells.

I might get some myself to keep around for a Viral infection after reading up on it. Easy to spend somebody else's money, but this might be something where a Functional Medicine Dr. might be able to help out. Can be thousands easy, I know. I still do telehealth with a Dr. every few months myself. To get a couple things and pick his brain, but can't afford to much longer.

 

[beforetherush 32090]

It sounds like you got something deeper going on there. Along with the TA1, looking into LL37 might be beneficial as well. I didn't see much mentioned at all in a search of this sight, but here are a few headlines.

LL-37 is a human cathelicidin that belongs to a broader family of antimicrobial peptides (AMPs) . It’s primarily produced by certain white blood cells (including macrophages and neutrophils ) and is discussed for roles in both innate and adaptive immunity, with interest as a potential alternative approach to antibiotics in research contexts.

Deeper Research Notes (Summary):

• LL-37 is described as an antimicrobial protein produced by immune cells that fights bacteria and helps regulate inflammation—partly by interacting with bacterial cell walls and disrupting membranes (forming pores), which can lead to bacterial cell death.

• Although elevated LL-37 levels are often noted in inflammatory diseases, some research discussions frame LL-37 as potentially protective against excessive immune reactions; depending on context, it may help boost or calm immune activity to maintain balance.

• LL-37 is discussed as supporting tissue repair in the lungs and intestines by attracting epithelial cells to wound areas, supporting new blood vessel formation (nutrient delivery), and helping regulate inflammation—often mentioned in relation to asthma and inflammatory bowel disease models.

• LL-37 is also discussed for a potential immune-support role in cancer contexts, particularly within the gastrointestinal tract , by helping immune surveillance recognize and clear abnormal cells.

I might get some myself to keep around for a Viral infection after reading up on it. Easy to spend somebody else's money, but this might be something where a Functional Medicine Dr. might be able to help out. Can be thousands easy, I know. I still do telehealth with a Dr. every few months myself. To get a couple things and pick his brain, but can't afford to much longer.

This is great thanks I will look into this as well as TA1!

 

[Chili777]

Well, my experiment with TA-1 and KPV for my sinus infection failed. After 8 days of no improvement, I had to bite the bullet and got a prescription for Augmentin today. I'll continue to use TA-1 daily to use up what I reconstituted and finish my 60 day KPV cycle as well. I know it's fortifying my immune system, but it was too much to ask for a resolution of a major sinus infection.

 

[Jack brown]

It sounds like you got something deeper going on there. Along with the TA1, looking into LL37 might be beneficial as well. I didn't see much mentioned at all in a search of this sight, but here are a few headlines.

LL-37 is a human cathelicidin that belongs to a broader family of antimicrobial peptides (AMPs) . It’s primarily produced by certain white blood cells (including macrophages and neutrophils ) and is discussed for roles in both innate and adaptive immunity, with interest as a potential alternative approach to antibiotics in research contexts.

Deeper Research Notes (Summary):

• LL-37 is described as an antimicrobial protein produced by immune cells that fights bacteria and helps regulate inflammation—partly by interacting with bacterial cell walls and disrupting membranes (forming pores), which can lead to bacterial cell death.

• Although elevated LL-37 levels are often noted in inflammatory diseases, some research discussions frame LL-37 as potentially protective against excessive immune reactions; depending on context, it may help boost or calm immune activity to maintain balance.

• LL-37 is discussed as supporting tissue repair in the lungs and intestines by attracting epithelial cells to wound areas, supporting new blood vessel formation (nutrient delivery), and helping regulate inflammation—often mentioned in relation to asthma and inflammatory bowel disease models.

• LL-37 is also discussed for a potential immune-support role in cancer contexts, particularly within the gastrointestinal tract , by helping immune surveillance recognize and clear abnormal cells.

I might get some myself to keep around for a Viral infection after reading up on it. Easy to spend somebody else's money, but this might be something where a Functional Medicine Dr. might be able to help out. Can be thousands easy, I know. I still do telehealth with a Dr. every few months myself. To get a couple things and pick his brain, but can't afford to much longer.

I wouldn't use LL37 if I were you: https://pubmed.ncbi.nlm.nih.gov/36138130/

Human antimicrobial peptide LL-37 contributes to Alzheimer's disease progression​[archived internal link]

 

[RubbaDubba1]

I wouldn't use LL37 if I were you: https://pubmed.ncbi.nlm.nih.gov/36138130/

Human antimicrobial peptide LL-37 contributes to Alzheimer's disease progression​

That's good information, haven't run it myself but have some in stock. Definitely something to think about, thank you.

 

[Crumplestiltskin]

Well, my experiment with TA-1 and KPV for my sinus infection failed. After 8 days of no improvement, I had to bite the bullet and got a prescription for Augmentin today. I'll continue to use TA-1 daily to use up what I reconstituted and finish my 60 day KPV cycle as well. I know it's fortifying my immune system, but it was too much to ask for a resolution of a major sinus infection.

Chronic sinus infection is incredibly awful, I'm sorry you are dealing with that. I've had them and a couple of things helped:

Intranasal ozone (can be hard to find, but worth looking); I did twice a day for a few weeks. I saw improvements within a day or two, but continued to make sure it was gone.

Sinus probiotics, specifically L.sakai - this can be bought online; i mix with a few drops of distilled water and apply directly into the nose. Some research showed chronic sinus infection sufferers had too little of that specific probiotic, so It's worth trying.

 

[Chili777]

Thanks. I got the balloon procedure where they open up your sinuses with them about in 2019 and this was my first major infection since then, so that's good. Prior to that, it was 2 or 3 every year which majorly sucked. I did the Nettie bottle with an added ampule of budesinide as instructed, but no joy. I'm sure the TA-1 helped some. I'm on the mend now and almost ready to spray more peps up my nose!

I highly recommend the Balloon Sinuplasty procedure to anyone with chronic sinusitis. It made a huge difference to me and they did it during an office visit. Took 30 min start to finish.

I've also heard recently of a nasal spray of TA-1 and KPV which is said to reduce or eliminate allergy symptoms. I may make my own. This is a place that has one with a 50/50 concentration, but I'm not sure if that's optimal or not, so I will continue researching it. https://ultralifepeptides.com/shop/ta-1-kpv-10-mg-10-mg-n/

 

[Peptidesearch]

Got a cortisone shot for knee pain. Ever since every year sometimes even 2-3 time a year re-occurring infection. Starts in different areas of the body. Tried surgeries, doses of IV's full of anti-biotics, and other methods. Without fail every year another reoccurring infection.

I don't see how a peptide could help, especially with up to 10% failing sterility testing. Have you seen an infectious disease specialist?

 

[beforetherush 32090]

I don't see how a peptide could help, especially with up to 10% failing sterility testing. Have you seen an infectious disease specialist?

Oh yeah, theyve been trying for years to fix the problem. It always comes back.

 

[janedoe]

Well, my experiment with TA-1 and KPV for my sinus infection failed. After 8 days of no improvement, I had to bite the bullet and got a prescription for Augmentin today. I'll continue to use TA-1 daily to use up what I reconstituted and finish my 60 day KPV cycle as well. I know it's fortifying my immune system, but it was too much to ask for a resolution of a major sinus infection.

For the last 5 years or so, I've had crazy sinus infections out of no where... like bleeding, green.... crazy. Headache, eye strain, brain fog, darkening around the eye ( which KPV did help) etc. I had one 2 years ago that cleared after some time with 2 rounds of augmentin, with a break between them. Rx spray doesn't work. I keep a RX of Augmentin in my stash now,

However, since January, I've had one, and KPV has not helped. I was so hoping KPV would, as it works so well for me otherwise. I really wish

LL-37 didn't have the AD correlations, bc other than that concern, it appears to be something that would be helpful.

 

[Chili777]

For the last 5 years or so, I've had crazy sinus infections out of no where... like bleeding, green.... crazy. Headache, eye strain, brain fog, darkening around the eye ( which KPV did help) etc. I had one 2 years ago that cleared after some time with 2 rounds of augmentin, with a break between them. Rx spray doesn't work. I keep a RX of Augmentin in my stash now,

However, since January, I've had one, and KPV has not helped. I was so hoping KPV would, as it works so well for me otherwise. I really wish

LL-37 didn't have the AD correlations, bc other than that concern, it appears to be something that would be helpful.

Have you seen an ENT specialist? I had multiples some years and the ballon sinuplasty is what finally put a stop to them. This was my first one since 2019. I went through 8 or 9 different antibiotics and they were running out of things to try and that's not a good place to be. Three weeks of Augmentin is when I finally asked my doctor to do the sinuplasty. Turned out I should have done it as soon as it was available. Between that, and Astepro to keep my sinuses open, I've been able to fend them off. Hope you and they figure it for your sake.

 

[janedoe]

Have you seen an ENT specialist? I had multiples some years and the ballon sinuplasty is what finally put a stop to them. This was my first one since 2019. I went through 8 or 9 different antibiotics and they were running out of things to try and that's not a good place to be. Three weeks of Augmentin is when I finally asked my doctor to do the sinuplasty. Turned out I should have done it as soon as it was available. Between that, and Astepro to keep my sinuses open, I've been able to fend them off. Hope you and they figure it for your sake.

I did. He was the prescriber of 2 rounds of Augmentin, and rx nasal spray, Ipratropium Bromide. He said I had deviation, based on the scope he pushed into my nasal cavity. He never mentioned surgery. I do recall, intially he wanted to give me Doxy, but told him I wanted the Augmentin. I may inquire on the surgical procedure. It truly has taken a toll on me. I hope to get some relief too. Thanks for the info.

 

[Crumplestiltskin]

For the last 5 years or so, I've had crazy sinus infections out of no where... like bleeding, green.... crazy. Headache, eye strain, brain fog, darkening around the eye ( which KPV did help) etc. I had one 2 years ago that cleared after some time with 2 rounds of augmentin, with a break between them. Rx spray doesn't work. I keep a RX of Augmentin in my stash now,

However, since January, I've had one, and KPV has not helped. I was so hoping KPV would, as it works so well for me otherwise. I really wish

LL-37 didn't have the AD correlations, bc other than that concern, it appears to be something that would be helpful.

Oh, i'm so sorry you are going through that. Among the many things that could help, have you looked into any low-level dental infections? A 3D cone beam can be very helpful to find infections, especially if you've had any past oral surgery like wisdom teeth removal, or even root canals.

 

[janedoe]

Oh, i'm so sorry you are going through that. Among the many things that could help, have you looked into any low-level dental infections? A 3D cone beam can be very helpful to find infections, especially if you've had any past oral surgery like wisdom teeth removal, or even root canals.

My goodness, so true! I know first hand! So 2 years ago, I had one of my crazy sinus infections, went thru 2 rounds of Augmentin w/ my ENT, etc. So, I go to the dentist 2x a year, teeth in great shape. Good dental hygiene. Had 1 cavity in 12 years. Anyhow, doing my x-rays 2 years ago (after my ENT visits), my dentist " saw a shadow", way up above the right side, above my cheek, but no dental issues evidenced. I had no pain, nothing swollen, etc. He knew of my sinus problems and though he's not a fan of root canals, he suggested it bc he said it was right next to the upper sinus cavity, and it may relieve my issues. He was very clear to tell me, he could not say if the issue was the sinus infection or actually issues with the root of my eyetooth that caused infection. (The chicken/ egg issue) , but was clear that either way, both senerios would cause issues both ways.

I went for the root canal and within a few weeks, I was fine. It was amazing. 2 years almost, no issues. I see him 2x a year and all was good. Now since January, it's happening again, it's crazy. I have my 6 month dental appt coming up. I can't wait to go!