Stopping GLP-1 Drugs Triggers Weight Regain 4x Faster Than Ending Exercise

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cygnus said:
This is just physics. Exercise really only burns so many calories; it is woefully deficient when it comes to weight loss when compared to calorie deficits, which is what GLPs are good at creating. Nothing new here, just silly headlines to make people scared.
I "discovered" this when I was losing a lb a day. Just fasting. ZERO exercise. 21 days without food. That was 10/23. I've been on a journey since then of discovering what I've been told about diet and exercise is all bs. Only I can control what I become. No one else is responsible for what goes in or comes out.

YMMV
 
JoonyO said:
I "discovered" this when I was losing a lb a day. Just fasting. ZERO exercise. 21 days without food. That was 10/23. I've been on a journey since then of discovering what I've been told about diet and exercise is all bs. Only I can control what I become. No one else is responsible for what goes in or comes out.

YMMV
Agreed 1000% It is however a big distinction. My spouse and I are both on GLP1s but our approach is different. We've lost the same amount of weight but I'm using a body comp scale daily to monitor fat % loss vs lean/muscle gain %.

At the end of the day I'm working out daily and I'm seeing almost 8% fat mass loss and 7ish% lean/muscle gain. She has lost both evenly.

We both show the same delta on weight but end result is huge in body comp!
 
jw717us said:
Agreed 1000% It is however a big distinction. My spouse and I are both on GLP1s but our approach is different. We've lost the same amount of weight but I'm using a body comp scale daily to monitor fat % loss vs lean/muscle gain %.

At the end of the day I'm working out daily and I'm seeing almost 8% fat mass loss and 7ish% lean/muscle gain. She has lost both evenly.

We both show the same delta on weight but end result is huge in body comp!
I don't think anyone is suggesting you shouldn't work out. There are huge benefits that come from it! Just that there are a lot of people in denial in regards to their diets who think that if they start hitting the gym that will make up for a bad diet. It won't.
 
tubby said:
I don't think anyone is suggesting you shouldn't work out. There are huge benefits that come from it! Just that there are a lot of people in denial in regards to their diets who think that if they start hitting the gym that will make up for a bad diet. It won't.
No doubt. Especially when they grab a 500 calorie smoothie on the way out of the gym!
 
swimmer said:
When my insurance first cut me off ozempic I gained 20 pounds in 2 months.
Did your eating or exercise habits changed? You would obviously gain weight if your caloric intake is more than your maintenance for a period of time.
 
I mean it's no different really than yo-yo dieting. I've seen my mom loose a bunch of weight and regain it all multiple times throughout her lifetime. I think for some people, the temptation of bad food is simply too strong and whether they achieved their weightloss with a diet and pure willpower, or a semi forced diet and the assistance of a GLP-1, either the will power fades after dieting for so long or the safety wheels from a GLP-1 get removed, and it all falls apart.

I'm starting to wonder whether there is a huge genetic component to appetite and satiety. Some people are just genetically advantaged with minimal appetite and rapid onset of satiety. And maybe GLP-1 peptides are just the great equalizer.
 
Adham said:
Did your eating or exercise habits changed? You would obviously gain weight if your caloric intake is more than your maintenance for a period of time.
Yes my eating habits changed. The food off switch was broken again. Exercise habits stayed the same: Swimming more than 6 miles per week and hiking 1000 foot ascent hikes 1 or 2 x per week. Sprinkle in a little cycling and weight training. You are correct the caloric intake drastically increased.
 
dogmom said:
I wonder if it depends on how long you are on it. At this point I've been on glp1s for almost 3 years. I've gone at least 4 weeks without any glp1s and my eating and weight stays the same. However, I think if I would have stopped after 6 months I probably would have gained everythng back and then some.

My goal is to develop better habits overall so when I take breaks from it I won’t go bananas. Your theory of time on the meds may have merit. Maybe you’ve adopted better habits.
 
The people I see who say they've gained weight back and then some, all have the same issue of constant hunger after starving themselves to their goal weight.

Me personally, I've been reducing my doses so I have hunger. I don't want to go throughout the day not feeling genuine hunger, or struggle to get my macros in.
 
swimmer said:
Yes my eating habits changed. The food off switch was broken again. Exercise habits stayed the same: Swimming more than 6 miles per week and hiking 1000 foot ascent hikes 1 or 2 x per week. Sprinkle in a little cycling and weight training. You are correct the caloric intake drastically increased.
This would be me if I were to stop taking them. I've come to accept that for me, I can handle being hungry as well as not necessarily feeling "full" during or right after a meal, and I've always been active enough and love the gym. It's completely about the food noise itself. Even now, I will get legit hungry, and know I need to eat, but it's been so absolutely freeing not needing to give into it immediately. I can finish whatever task I'm on, and sometimes even get distracted by another, and then remember I need to eat. The decades of my life of thinking about food taking the top spot in my brain every day are behind me - and I'm kinda pissed that these drugs and grey market purchases weren't available then! - and I will not go back to that misery. I use tirz because it was better than sema for the food noise, but if by the time I'm in maintenance or even just down the road there is an API that just targets food noise, I'll probably take that. But, then again, tirz is tirzing and I've got 4 years of it in my freezer so maybe it'll just be that to the end.
 
swimmer said:
What is so bad about taking something the rest of your life that reduces heart attacks, strokes, risk of dementia etc. People take vitamins and supplements with the hope of a fraction of the benefit of a glp1.
Not to mention the concept of food noise. My spouse has had her eye’s opened to what she describes as “How normal people relate to food”. She always struggled with the background noise and, while successful, it was an ongoing struggle. Add the reduction of THAT mental load to all of the potential benefits? For someone like her I can’t see a reason in the world to not continue at a minimum dose!
 
quoted said:
What’s more, few studies were at low risk of bias.

Click to expand...

This is very important. Bias in = Biased conclusion out.

Also important: HOW did patients discontinue? Every FDA study I've read jerks the dosage from therapeutic to zero. (Remember, therapeutic doesn't mean max dosage.)

If someone took an SSRI and a doc took them from therapeutic dose to zero, the world would see the doc's malpractice.

Maybe, just MAYBE, some people can discontinue, and some cannot, just like SSRIs. It's not a new concept.

Companies have a vested interest in telling the weight gain story. Why would they even attempt to taper off patients?

We need to be cautious of bias in data. At least this one admits to it.

Edit:

For the record, we need to advocate for ourselves, and if that means you need the med, then please take care of yourself!

My beef is the bias data producing headlines.
 
Stuff like this should lead to making it illegal for insurance to cut people off. In addition to the fact that we’d already pre paid for coverage contracts and then they change it mid year
 
Before I got on Reta, I had concerns about always taking it to keep the weight loss. Prior to getting on I was carnivore and eating once a day, but still gaining weight. After working with a health coach I came to realize that despite clean eating and being in a steep caloric deficit, I dieted my thyroid into the toilet and my body responded by continuing to lower it baseline metabolism. When I started eating three squares a day with carbs (1800 calories) that changed things. Not a dramatic loss in weight, but I was finally moving the right direction.

Which leads me to this. If you use something like Reta, you still need to address the underlying cause of why you gained weight in the first place. Low thyroid, low testosterone, eating at McDonald's every day, inflammatory foods, etc. That has to be addressed if you do want to get off the GLP1s.

That said, even though I think I am addressing the root cause of the previous weight gain, I am strongly considering taking Reta for life at a maintenance dose after I hit my target weight. The other benefits Reta and other peptides provide, besides weight loss, are too good to ignore.

We live in a modern world that is far from pristine, which causes various health issues because it's hard to avoid pollution in our environment and food supply. Hence, I have evolved my thinking to recognize that measures such as lifelong peptide stacks and TRT may be necessary adjustments to accommodate modern living. Many of the diseases people typically die from are metabolic in nature and stem from things like chronic inflammation. Cancer, heart disease, diabetes, Alzheimer's (type 3 diabetes), etc.

Given the costs of a little TRT and peptides (with a clean diet and exercise) compared to doctor visits, drugs, and hospital stays-- this new "lifestyle" seems a lot cheaper in the long run. I am not out of the woods yet, but I am doing a lot better than I was 6 months ago.
 
I am absolutely going to be on these in one way or another for the rest of my life, the weight loss has been amazing but the mental changes are even better.

I can see a lot of truth in the claims that people gain the weight back fast after going off the meds, I missed a dose this week due to being away on holiday and even in that short time I found I was able to eat a fair bit more and had the mental drive to do so.
 
Information is power, the best thing is knowing this. You could change up your exercise regime to compensate for the weight gain, hey you could even build more muscle if you plan it right.
 
Chucky said:
The people I see who say they've gained weight back and then some, all have the same issue of constant hunger after starving themselves to their goal weight.

Me personally, I've been reducing my doses so I have hunger. I don't want to go throughout the day not feeling genuine hunger, or struggle to get my macros in.

Yup, exactly what happens to me. I end up weighing more than when I started. I see it as a life long thing that I will be on some form of GLP.
 
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