Before I got on Reta, I had concerns about always taking it to keep the weight loss. Prior to getting on I was carnivore and eating once a day, but still gaining weight. After working with a health coach I came to realize that despite clean eating and being in a steep caloric deficit, I dieted my thyroid into the toilet and my body responded by continuing to lower it baseline metabolism. When I started eating three squares a day with carbs (1800 calories) that changed things. Not a dramatic loss in weight, but I was finally moving the right direction.
Which leads me to this. If you use something like Reta, you still need to address the underlying cause of why you gained weight in the first place. Low thyroid, low testosterone, eating at McDonald's every day, inflammatory foods, etc. That has to be addressed if you do want to get off the GLP1s.
That said, even though I think I am addressing the root cause of the previous weight gain, I am strongly considering taking Reta for life at a maintenance dose after I hit my target weight. The other benefits Reta and other peptides provide, besides weight loss, are too good to ignore.
We live in a modern world that is far from pristine, which causes various health issues because it's hard to avoid pollution in our environment and food supply. Hence, I have evolved my thinking to recognize that measures such as lifelong peptide stacks and TRT may be necessary adjustments to accommodate modern living. Many of the diseases people typically die from are metabolic in nature and stem from things like chronic inflammation. Cancer, heart disease, diabetes, Alzheimer's (type 3 diabetes), etc.
Given the costs of a little TRT and peptides (with a clean diet and exercise) compared to doctor visits, drugs, and hospital stays-- this new "lifestyle" seems a lot cheaper in the long run. I am not out of the woods yet, but I am doing a lot better than I was 6 months ago.