Stacking Tirz + Reta. Any tips?

[funkytwisternumber9]

Planning on stacking these two but having a bit of trouble finding solid dosing examples. Anybody have some anecdotal advice or research resources?

 

[woundcarping]

Knowing where you are, where you're going, prior GLP exposure experience, and what you're trying to accomplish would be a fantastic baseline level amount of information to start with.

 

[5byfive]

After being on Tirz for awhile, I felt it was hurting my energy levels so I decided to stack. I reduced the Tirz by 1mg and added 1mg of Reta. Seems to be a sweet spot. Solely based on my experience, I would consider them to be about 1:1 on dosage i.e. 1mg of Tirz being equal to 1mg of Reta for dosage. Sample size of 1 so take it with a grain of salt.

 

[funkytwisternumber9]

Knowing where you are, where you're going, prior GLP exposure experience, and what you're trying to accomplish would be a fantastic baseline level amount of information to start with.

Copy, i never want to be that person that asks for help and then just waits for someone to do all the work or planning for them which is why i didn't add more details, i didnt want to come off like that but because you asked i will be very specific about those topics.

I started with Tirz last year around November with a big brand pharmacy and got up to 5 mg a week around month 3 when i decided to go the grey market route instead. I switched to reta and was disappointed with the lack of appetite suppression. Luckily i stayed consistent and noticed i was losing weight even tho i didnt feel many side effects. Thats a little backstory up to where im at now. I was roughly 230 when i started tirz and am currently @ about 192. Tirz got me to 210-205ish and reta has done the rest. I got off of tirz @5 mg and got on reta @4. Body handled it quite well and I am currently @ 8 mg and was planning on staying here until i plateau. The reason why i want to reintroduce tirz is because i really miss the appetite suppression and lack of food noise. It was so heavenly to not think about eating. I do eat and stay hydrated. My goal weight is about 160. I am 5'8 male 24. I will soon introduce cardio and weight training into the equation as well. I am very open minded and take criticism well. Please share your thoughts and feedback.

 

[funkytwisternumber9]

After being on Tirz for awhile, I felt it was hurting my energy levels so I decided to stack. I reduced the Tirz by 1mg and added 1mg of Reta. Seems to be a sweet spot. Solely based on my experience, I would consider them to be about 1:1 on dosage i.e. 1mg of Tirz being equal to 1mg of Reta for dosage. Sample size of 1 so take it with a grain of salt.

thank you for your feedback

 

[woundcarping]

Copy, i never want to be that person that asks for help and then just waits for someone to do all the work or planning for them which is why i didn't add more details, i didnt want to come off like that but because you asked i will be very specific about those topics.

I started with Tirz last year around November with a big brand pharmacy and got up to 5 mg a week around month 3 when i decided to go the grey market route instead. I switched to reta and was disappointed with the lack of appetite suppression. Luckily i stayed consistent and noticed i was losing weight even tho i didnt feel many side effects. Thats a little backstory up to where im at now. I was roughly 230 when i started tirz and am currently @ about 192. Tirz got me to 210-205ish and reta has done the rest. I got off of tirz @5 mg and got on reta @4. Body handled it quite well and I am currently @ 8 mg and was planning on staying here until i plateau. The reason why i want to reintroduce tirz is because i really miss the appetite suppression and lack of food noise. It was so heavenly to not think about eating. I do eat and stay hydrated. My goal weight is about 160. I am 5'8 male 24. I will soon introduce cardio and weight training into the equation as well. I am very open minded and take criticism well. Please share your thoughts and feedback.

A starting BMI of 35 is non negligible and you've dropped that to the same place I'm at currently (BMI 29) and your target is 24 which is practically the same as mine.

If your weight loss has stalled, I'd increase the dose of Reta unless sides are becoming problematic. The sides haven't been an issue for me. I split dose every 3.5 days, originally to abate food noise returning on day ~5 or so when I was on Tirz.

Specifically for adding Tirz, I would maintain Reta and add 1-2mg split from your regular dosing time(s) and evaluate for efficacy.

I'm on an elevated dose of Reta. Food noise, appetite, nor portion control isn't an issue thus far... I like being able to eat and have a general inkling of a "population normal" appetite. If I end up needing assistance, I'm not sure if I'll add Tirz or Cagri. I have plenty of either, although staying with a single peptide is of interest. Another several months and I'll hopefully be at my target and can titrate down to a maintenance dose.

 

[LongevitybroTX]

A starting BMI of 35 is non negligible and you've dropped that to the same place I'm at currently (BMI 29) and your target is 24 which is practically the same as mine.

If your weight loss has stalled, I'd increase the dose of Reta unless sides are becoming problematic. The sides haven't been an issue for me. I split dose every 3.5 days, originally to abate food noise returning on day ~5 or so when I was on Tirz.

Specifically for adding Tirz, I would maintain Reta and add 1-2mg split from your regular dosing time(s) and evaluate for efficacy.

I'm on an elevated dose of Reta. Food noise, appetite, nor portion control isn't an issue thus far... I like being able to eat and have a general inkling of a "population normal" appetite. If I end up needing assistance, I'm not sure if I'll add Tirz or Cagri. I have plenty of either, although staying with a single peptide is of interest. Another several months and I'll hopefully be at my target and can titrate down to a maintenance dose.

Agreed, I'd recommend dosing up on the Reta, and keeping a bit of tirz in there for good measure. 2.5-5mg is probably ok; since you said you switched over from a relatively low dose anyway, I don't see much of a reason to titrate down unelss you want to for some other reason or are having sides.

 

[BigDog8084]

Copy, i never want to be that person that asks for help and then just waits for someone to do all the work or planning for them which is why i didn't add more details, i didnt want to come off like that but because you asked i will be very specific about those topics.

I started with Tirz last year around November with a big brand pharmacy and got up to 5 mg a week around month 3 when i decided to go the grey market route instead. I switched to reta and was disappointed with the lack of appetite suppression. Luckily i stayed consistent and noticed i was losing weight even tho i didnt feel many side effects. Thats a little backstory up to where im at now. I was roughly 230 when i started tirz and am currently @ about 192. Tirz got me to 210-205ish and reta has done the rest. I got off of tirz @5 mg and got on reta @4. Body handled it quite well and I am currently @ 8 mg and was planning on staying here until i plateau. The reason why i want to reintroduce tirz is because i really miss the appetite suppression and lack of food noise. It was so heavenly to not think about eating. I do eat and stay hydrated. My goal weight is about 160. I am 5'8 male 24. I will soon introduce cardio and weight training into the equation as well. I am very open minded and take criticism well. Please share your thoughts and feedback.

Just a suggestion, you might want to consider adding Cagrilintide for more appetite suppression. Then you wouldn't need to stack Tirz.

 

[eidos]

Get a CGM because you're at risk for hypoglycemia. I had three episodes last month.

I’m now on 10 mg of each per week. I plan to stay on this dose for a while. My blood sugar is much more stable. My weight loss has accelerated a little. I feel tired, though it’s different from the fatigue associated with diabetes. I started taking 5-amino-methylquinolinium a few days ago, and it cuts this fatigue.

 

[ToeMittens 45374]

Hoping to hijack this thread a bit since I’m also looking for tips in this area.

About me:

47/F

Starting: 235 lbs

Current/maintaining around 145 lbs

Started Tirz December of ‘23 and titrated up to 15 mg a week by June of ‘24.

March of ‘26 I moved up to 20 mg a week.

I stalled out on my weight loss about a year ago, which I was mostly okay with considering where I started, but lately the food noise has been creeping back and I’ve found myself making less healthy decisions. I’d really like to drop another 10-15 lbs if I can. I’ve recently boosted my dose to 20 mg per week and it helped a bit. Last week I started splitting my dose and doing 10 mg twice a week (Tuesday PM and Saturday AM) and that has helped some more. I’m just nervous that I’m nearing the end of the usefulness of this peptide, so I’m looking for alternatives.

A few months ago I discovered this whole Grey market thing and initially got into it just to save some money (when I think about how much money I’ve thrown away at Mochi over the last 30 months… /cry), but all this research has opened my eyes to new possibilities.

One of those is maybe switching to a Reta/Cagri stack. I think I’d want to slowly swap Tirz for Reta and complete the switch before trying to add Cagri, but I’m undecided on how much I should start with. Most of the posts I’ve found are from people who are at 10/mg or less of Tirz per week. Would I even notice a Reta dose of 2 mg/week at my current Tirz dose? Should I try that for a few weeks and keep my Tirz dose the same? Should I lower my Tirz dose when I start Reta?

Has anyone else made the switch from such a high Tirz dose as it’s losing effectiveness? Any thoughts, suggestions, or advice? Am I over- or under-thinking this? Any other peps you’d recommend for someone like me in the early stages of Peri?

If you made it through all that, thanks for reading! I appreciate the community here so much!

 

[lessthanhalf]

Has anyone else made the switch from such a high Tirz dose as it’s losing effectiveness? Any thoughts, suggestions, or advice? Am I over- or under-thinking this? Any other peps you’d recommend for someone like me in the early stages of Peri?

You say that tirzepatide is losing it's effectiveness, yet here you are at 145 lbs or so from a start weight of 235 so 90 lbs down. That is a worthwhile and major achievement, and the drug is working perfectly, not losing it's effectiveness. ( unless you are gaining weight ) But what is cannot do from there is cause more weight loss, just stop you from putting it back on. And as far as I am concerned that is by far the most useful aspect of these drugs, their ability to enable you to maintain weight loss. And in terms of long term health and quality of life keeping the weight off is the hardest part and the most important part.

Normally when you lose weight with or without GLPs energy expenditure drops from loss of metabolising fat and organ and muscle, and your body starts trying to conserve energy dropping it even more, plus it makes you more hungry than normal, so lower calorie requirements to maintain the low weight plus extra hunger almost always results in people putting the weight back on, GLP drugs block the increase in appetite and improve metabolic state and consistently show maintenance of weight loss, on the weight loss dose, for up to 4 years so far. There is no good evidence of tolerance to the weight loss effects of these drugs long term.

Transitioning to maintenance is where nearly all diet and exercise based diets fail, and it is not as difficult with GLP drugs but not necessarily easy either. At this point I see staying on tirz or an alternative to maintain the lost weight as critical, but you are asking it even at the higher dose to do more than it could in the studies where max average weight loss was more like 25% and you are asking it to hold back 38% ( 90/245 ).

Swapping to reta instead is an alternative, but I am not sure it will be enough at normal doses to work much better than 20mg of tirz, which you obviously already tolerate ok. ( My choice at 15mg of tirz and still hungry and trying to maintain about a 50% weight loss was to add in 5mg of reta, and then later 0.5 of cagri ) . Swapping to reta instead does carry higher risks of side effects than staying on tirz, but is a valid option. Otherwise adding in cagri very slowly at 0.25mg and increase slowly is the simplest option, with least disruption, or adding reta as well as tirz at not enormous doses as you are already on 20mg of tirz. Or just increase tirz further to 25mg, but there is a reasonable chance you are getting into diminishing returns territory as doses get higher. In theory reta and cargri should be the most effective combo currently possible, but is likely to have more side effects than tirz.

My opinion is that using these drugs at higher than standard doses or in combinations probably does carry added risks of known or unknown adverse effects, but I think that given the situation where it seems to be needed is severe obesity with extremely high long term health risks, the drugs are probably safer than putting the weight back on.

 

[WannabeLoser]

I started tirz in May 2025. In Sept 2025 I added in Reta. I kept my tirz at 7.5mg and started titrating up the Reta. I am currently on Reta 6mg (since March) and am down 100# since last May, 259-159. I plan to just hold steady on these doses for now.

 

[funkytwisternumber9]

Agreed, I'd recommend dosing up on the Reta, and keeping a bit of tirz in there for good measure. 2.5-5mg is probably ok; since you said you switched over from a relatively low dose anyway, I don't see much of a reason to titrate down unelss you want to for some other reason or are having sides.

thank you for your feedback

 

[funkytwisternumber9]

Just a suggestion, you might want to consider adding Cagrilintide for more appetite suppression. Then you wouldn't need to stack Tirz.

I just ordered some more reta and 2 boxes of tirz lol! mayhaps ill look into selling it and introducing cagri, ill have to do more research. Thank you for your feedback!

 

[funkytwisternumber9]

A starting BMI of 35 is non negligible and you've dropped that to the same place I'm at currently (BMI 29) and your target is 24 which is practically the same as mine.

If your weight loss has stalled, I'd increase the dose of Reta unless sides are becoming problematic. The sides haven't been an issue for me. I split dose every 3.5 days, originally to abate food noise returning on day ~5 or so when I was on Tirz.

Specifically for adding Tirz, I would maintain Reta and add 1-2mg split from your regular dosing time(s) and evaluate for efficacy.

I'm on an elevated dose of Reta. Food noise, appetite, nor portion control isn't an issue thus far... I like being able to eat and have a general inkling of a "population normal" appetite. If I end up needing assistance, I'm not sure if I'll add Tirz or Cagri. I have plenty of either, although staying with a single peptide is of interest. Another several months and I'll hopefully be at my target and can titrate down to a maintenance dose.

Holy snap were you helpful thank you for your contribution and feedback! I will keep all of this in mind. Also i wish you the best of luck in your journey and hope you reach your target weight at the time you want

 

[funkytwisternumber9]

Get a CGM because you're at risk for hypoglycemia. I had three episodes last month.

I’m now on 10 mg of each per week. I plan to stay on this dose for a while. My blood sugar is much more stable. My weight loss has accelerated a little. I feel tired, though it’s different from the fatigue associated with diabetes. I started taking 5-amino-methylquinolinium a few days ago, and it cuts this fatigue.

awsome thanks for the suggestion, will look into it.

 

[funkytwisternumber9]

Hoping to hijack this thread a bit since I’m also looking for tips in this area.

About me:

47/F

Starting: 235 lbs

Current/maintaining around 145 lbs

Started Tirz December of ‘23 and titrated up to 15 mg a week by June of ‘24.

March of ‘26 I moved up to 20 mg a week.

I stalled out on my weight loss about a year ago, which I was mostly okay with considering where I started, but lately the food noise has been creeping back and I’ve found myself making less healthy decisions. I’d really like to drop another 10-15 lbs if I can. I’ve recently boosted my dose to 20 mg per week and it helped a bit. Last week I started splitting my dose and doing 10 mg twice a week (Tuesday PM and Saturday AM) and that has helped some more. I’m just nervous that I’m nearing the end of the usefulness of this peptide, so I’m looking for alternatives.

A few months ago I discovered this whole Grey market thing and initially got into it just to save some money (when I think about how much money I’ve thrown away at Mochi over the last 30 months… /cry), but all this research has opened my eyes to new possibilities.

One of those is maybe switching to a Reta/Cagri stack. I think I’d want to slowly swap Tirz for Reta and complete the switch before trying to add Cagri, but I’m undecided on how much I should start with. Most of the posts I’ve found are from people who are at 10/mg or less of Tirz per week. Would I even notice a Reta dose of 2 mg/week at my current Tirz dose? Should I try that for a few weeks and keep my Tirz dose the same? Should I lower my Tirz dose when I start Reta?

Has anyone else made the switch from such a high Tirz dose as it’s losing effectiveness? Any thoughts, suggestions, or advice? Am I over- or under-thinking this? Any other peps you’d recommend for someone like me in the early stages of Peri?

If you made it through all that, thanks for reading! I appreciate the community here so much!

I had the same feeling about those compounding pharmacies! 350 for 5 mg of tirz is insane! And dont get me started on those reddit resellers. Its just greed on greed on greed on greed. Anyways glad you were able to find a useful thread

 

[funkytwisternumber9]

I started tirz in May 2025. In Sept 2025 I added in Reta. I kept my tirz at 7.5mg and started titrating up the Reta. I am currently on Reta 6mg (since March) and am down 100# since last May, 259-159. I plan to just hold steady on these doses for now.

that's great to hear. glad its going good and thanks for your feedback

 

[ToeMittens 45374]

You say that tirzepatide is losing it's effectiveness, yet here you are at 145 lbs or so from a start weight of 235 so 90 lbs down. That is a worthwhile and major achievement, and the drug is working perfectly, not losing it's effectiveness. ( unless you are gaining weight ) But what is cannot do from there is cause more weight loss, just stop you from putting it back on. And as far as I am concerned that is by far the most useful aspect of these drugs, their ability to enable you to maintain weight loss. And in terms of long term health and quality of life keeping the weight off is the hardest part and the most important part.

Normally when you lose weight with or without GLPs energy expenditure drops from loss of metabolising fat and organ and muscle, and your body starts trying to conserve energy dropping it even more, plus it makes you more hungry than normal, so lower calorie requirements to maintain the low weight plus extra hunger almost always results in people putting the weight back on, GLP drugs block the increase in appetite and improve metabolic state and consistently show maintenance of weight loss, on the weight loss dose, for up to 4 years so far. There is no good evidence of tolerance to the weight loss effects of these drugs long term.

Transitioning to maintenance is where nearly all diet and exercise based diets fail, and it is not as difficult with GLP drugs but not necessarily easy either. At this point I see staying on tirz or an alternative to maintain the lost weight as critical, but you are asking it even at the higher dose to do more than it could in the studies where max average weight loss was more like 25% and you are asking it to hold back 38% ( 90/245)

This is so helpful to read, thank you for putting into perspective like that for me!

When I say losing its effectiveness, I mean have seen the scale tick up (not drastically, but enough to be concerning) and I’ve had to work so much harder to bring it back down. I’m most worried about the weight creeping back on and not having a plan in place to counter it. Added to that is the concern about being at such a high dose with not much wiggle room. If this is the weight I stay at, I can live with that, I just can’t stand the thought of backsliding. I’ve always been fine with the thought of having to be on something like this for the rest of my life, I think I just didn’t come to terms with the fact that one day it wouldn’t be enough to simply maintain my current weight.

Anyway, I’m not done fighting yet. The plan is increased activity and strength training, and I’m hopeful that Reta can help with energy levels for that. We’ll see!

Thanks again for the insight!

 

[woundcarping]

...When I say losing its effectiveness, I mean have seen the scale tick up (not drastically, but enough to be concerning)... I think I just didn’t come to terms with the fact that one day it wouldn’t be enough to simply maintain my current weight....

That's not usually reflected in the trials' data with consistent dosing.

First thoughts revolve around data gathering methodology, CICO variances, and dosing consistency (least likely in my mind).