MakeNoPeaceWithEvil said:
I'm not complaining, I'm normally very hot natured but I been able to sleep without sweating for the first time since I can remember....even before I became overweight. I'm sleeping in long sleeves and pants now, and sleep great...anyone else? I'm at 6mg every 5 days now.
Anyone know the mechanism by which this is happening? I think I heard somewhere maybe fat mobilization increase subq blood flow which in turn rejects heat.
Blood flow is part of it. I'm normally a heat factory, but my hands and feet have been cold for 6 months, since I started. I asked Gemini about this a few months ago. It seems to be as good an explanation as any I've found:
Reasons for Feeling Cold on GLP-1 Medications
Weight Loss and Insulation Loss
Fat Loss: GLP-1 medications, like semaglutide (Ozempic, Wegovy), promote weight loss by reducing appetite and caloric intake. As patients lose body fat, they lose natural insulation, making it easier for body heat to escape.
Thermoregulation: Fat serves as insulation, and its reduction affects the body's ability to retain heat. This can lead to increased sensitivity to cold.
Metabolic Changes
Lower Caloric Intake: Reduced food consumption leads to less energy available for thermogenesis, the process of heat production in the body. This can result in a lower body temperature.
Decreased Metabolic Rate: As weight decreases, the resting metabolic rate may also drop, further reducing heat generation.
Circulatory Adjustments
Blood Flow Changes: Weight loss can alter blood circulation, prioritizing core warmth over extremities. This may cause hands and feet to feel colder.
Hormonal Influences
Thyroid Function: Weight loss can impact thyroid hormone levels, which play a crucial role in regulating body temperature. Fluctuations in these hormones can contribute to feeling cold.
Managing Cold Sensitivity
Dress in Layers: Wearing extra clothing can help retain body heat.
Balanced Diet: Eating regular, balanced meals can support metabolic function and help maintain body temperature.
Stay Active: Regular exercise can generate body heat and help maintain muscle mass, which is important for warmth.
Feeling cold while on GLP-1 medications is generally a normal response to weight loss and metabolic changes, not a direct side effect of the medication itself.