New Reta Triumph 1 Results

[Smiter]

For the ones that started getting Reta at 80 weeks, they were in the control group before that. Picture it as consecutive trials with the control groups running concurrently for the placebo and lower dose escalation trials

Right, that's how I saw it, too. IMO, that methodology seems flawed to me because the moment we give the real drug to a group, how can they be called placebo group after that? Also, doesn't that defeat the whole purpose of a placebo group in the first place? IMO, if we want to test the efficacy of a drug over long-slow-titration, quick-dose-escalation, and a real placebo group, shouldn't we keep a third group who never gets the drug? Do you get my assertion?

 

[V6R3W]

I find it interesting that at least one member of the placebo group lost 35% of their body weight with no drug whatsoever. Clearly, there were some lifestyle changes involved.

 

[Bioexplorer]

The real question is why did the participants remain in the trial after it became obvious they were in the placebo group? Apparently the monetary incentive was adequate to keep them ethical.

I told my brother about the Reta trials enrolling and he immediately looked into it. Fortunately, he didn't qualify since he previously was on tirz. He's the kind of participant nobody wants in their trial. He is familiar with GLP-1 effects and told me he would drop out in the first week if he didn't feel any effects.

 

[Airborne Daddy]

The real question is why did the participants remain in the trial after it became obvious they were in the placebo group? Apparently the monetary incentive was adequate to keep them ethical.

I told my brother about the Reta trials enrolling and he immediately looked into it. Fortunately, he didn't qualify since he previously was on tirz. He's the kind of participant nobody wants in their trial. He is familiar with GLP-1 effects and told me he would drop out in the first week if he didn't feel any effects.

Better yet how did placebo group at 104 weeks post numbers not too far off from the 4mg reta group....

 

[Grogu]

Better yet how did placebo group at 104 weeks post numbers not too far off from the 4mg reta group....

Yeah, that's hard to believe because the 4mg was on reta for 80 weeks and the placebo on nothing for those 80 weeks and then both groups titrated up to the maximum tolerated dose. That doesn't speak well for staying on lose doses for long periods of time.

 

[alphaamigo]

The real question is why did the participants remain in the trial after it became obvious they were in the placebo group? Apparently the monetary incentive was adequate to keep them ethical.

I told my brother about the Reta trials enrolling and he immediately looked into it. Fortunately, he didn't qualify since he previously was on tirz. He's the kind of participant nobody wants in their trial. He is familiar with GLP-1 effects and told me he would drop out in the first week if he didn't feel any effects.

You get paid to participate in a medical trial whether you are on the real deal or a placebo. When I did medical trial, it was $1000/wk for the 8 weeks. (Not a weight loss trial)

 

[chewonmysac]

The side effects profile was much more pronounced in higher dosages. If anything, these results just reaffirmed my choice to stick with Tirzepatide, as my personal results have exceeded the Reta trial results without any of the side effects. Down 35.4% total weight in 52 weeks.

 

[BNLFL]

View attachment 24125

Found this one on reddit.

I've had none of these, and I'm on 8mg.

 

[mybodyisasewer]

The side effects profile was much more pronounced in higher dosages. If anything, these results just reaffirmed my choice to stick with Tirzepatide, as my personal results have exceeded the Reta trial results without any of the side effects. Down 35.4% total weight in 52 weeks.

Sometimes I wonder how different my opinion would be if I had tried tirz instead of reta when I first got into this.

But I tried reta. So it's the best one. And your opinion is wrong.

 

[SVT810E]

That's why it seemed sketchy to me, meaning the study methodology. How can you call them a placebo group when they were given the real deal? Second, some indicate they were given the drug later on and then they got huge weight loss...All of that seemed off to me.

It was an extension, not part of the main trial. The main trial ended with the placebo group still injecting sterile water. Only after that did they get switched.

 

[lessthanhalf]

Interesting , the fact that further weight loss occurred after 80 weeks with increased doses is useful to know, it suggests that the plateau in weight loss is determined by dose more so than just time.

And the vomiting rate of 25% for 9 or 12mg is not fantastic.

 

[BNLFL]

Interesting , the fact that further weight loss occurred after 80 weeks with increased doses is useful to know, it suggests that the plateau in weight loss is determined by dose more so than just time.

And the vomiting rate of 25% for 9 or 12mg is not fantastic.

My wife or I never even come close the nausea feeling. We're on 8mg Reta.

 

[TooGood76]

shout out to the 14% of the placebo group who thought themselves into diarrhea and special thanks to the 4% who talked themselves into a UTI

 

[woundcarping]

Interesting , the fact that further weight loss occurred after 80 weeks with increased doses is useful to know, it suggests that the plateau in weight loss is determined by dose more so than just time...

Nice to see actual research supporting the idea that "low and slow" may not be as detrimental as I thought, even if it doesn't make sense to me for people trying to drop substantial amounts of fat.

And the vomiting rate of 25% for 9 or 12mg is not fantastic.

For better or worse, I've had basically no nausea and zero vomiting with Reta beyond trialed levels... I wonder if all it takes to be counted as a symptom in the study is one event in the two years of the study where they vomited or had the tracked symptoms. Placebo should offset that but .

 

[TooGood76]

Nice to see actual research supporting the idea that "low and slow" may not be as detrimental as I thought, even if it doesn't make sense to me for people trying to drop substantial amounts of fat.

For better or worse, I've had basically no nausea and zero vomiting with Reta beyond trialed levels... I wonder if all it takes to be counted as a symptom in the study is one event in the two years of the study where they vomited or had the tracked symptoms. Placebo should offset that but .

There's a psychosomatic aspect as well if the doctor is asking you if you had bowel issues or nausea weekly and you have to fill out a survey etc you can't help but start to think about it. That's why such a big portion of the placebo had nausea.

 

[Ascojoerg]

There's a psychosomatic aspect as well if the doctor is asking you if you had bowel issues or nausea weekly and you have to fill out a survey etc you can't help but start to think about it. That's why such a big portion of the placebo had nausea.

I am sure that plays a role in the placebo results. I personally just think a much simpler answer is at play here. They had real nausea over the trial period but it was unrelated to the medication. This would also help to put the non-placebo nausea numbers into perspective, perhaps those RS would have had nausea from food or whatever else regardless of being part of the trial.

 

[TooGood76]

I am sure that plays a role in the placebo results. I personally just think a much simpler answer is at play here. They had real nausea over the trial period but it was unrelated to the medication. This would also help to put the non-placebo nausea numbers into perspective, perhaps those RS would have had nausea from food or whatever else regardless of being part of the trial.

Right I mean over 2 years having nausea a few times isn't remarkable at all.

 

[Ryanking11]

It really is incredible at what it does

 

[CallieKat]

So now I know why reta 4 made me so skinny compared with tirz 5…

 

[Bushum]

Yeah, that's hard to believe because the 4mg was on reta for 80 weeks and the placebo on nothing for those 80 weeks and then both groups titrated up to the maximum tolerated dose. That doesn't speak well for staying on lose doses for long periods of time.

Can you please explain the bolded part? This is my plan, to stay on a very low dose for years, but I am not clear on your implication. Thank you!