快感缺失……那种无精打采的感觉。

[miss-sanne]

我服用Tirz几个月了，一切都很顺利，体重减轻效果很好，副作用也很小，我真的很喜欢Tirz。但是剂量增加到10-11毫克后，我开始感觉非常沮丧、消沉、抑郁，甚至想着“去你的，我就坐在这儿刷Reddit”，什么都不想做，一点乐趣都没有。虽然我不得不去上班，但回家后就感觉“唉……”。显然

，这是Tirz的副作用，服用Sema时没有这种感觉。

我等了一段时间，但实在无法忍受。目前我正在

逐渐减少Tirz的剂量，同时增加Reta的剂量，还服用了一些Cagri。服用后

感觉好多了，精力也更充沛了。

但服用Reta后，这种情况可能还会再次发生。

请问有人知道或听说过哪些补充剂可以帮助缓解这种快感缺失吗？

谢谢。

 

[Bunny]

你好 我不知道这个建议是否对你有帮助，只是分享一下我的个人经历。我之前服用Tirz大约15个月，期间突然被严重的焦虑症折磨得卧床不起（），而且没有任何明显的原因。现在我减少了Tirz的剂量，并在每周中期服用少量Sema。焦虑症状已经消失了。其实，关键在于尝试不同的药物组合/配方/剂量。每个人的反应都不一样。我相信一定有解决办法。祝你好运

 

[miss-sanne]

你好 我不知道这个建议是否对你有帮助，只是分享一下我的个人经历。我之前服用Tirz大约15个月，期间突然被严重的焦虑症折磨得卧床不起（），而且没有任何明显的原因。现在我减少了Tirz的剂量，并在每周中期服用少量Sema。焦虑症状已经消失了。其实，关键在于尝试不同的药物组合/配方/剂量。每个人的反应都不一样。我相信一定有解决办法。祝你好运

我本来就是这么做的，我只是好奇还有没有其他解决办法。因为焦虑而卧床不起，听起来太可怕了！

 

[DwightTheDelight]

我本来就是这么做的，我只是好奇还有没有其他解决办法。因为焦虑而卧床不起，听起来太可怕了！

Time was the solution in my case. I started at a higher dose of Tirz than most people and felt off for a few months. Those first 3 months felt like I just sat at my office desk or in a recliner and melted.

This went away, but anytime I would bump the dose up, I knew I would feel it for a bit again. It always went away. Eventually, I worked my way up to 15mg every 4/5 days and even at doses that high, I stopped feeling like that.

Hopefully, you'll have a similar outcome. GL

 

[miss-sanne]

Time was the solution in my case. I started at a higher dose of Tirz than most people and felt off for a few months. Those first 3 months felt like I just sat at my office desk or in a recliner and melted.

This went away, but anytime I would bump the dose up, I knew I would feel it for a bit again. It always went away. Eventually, I worked my way up to 15mg every 4/5 days and even at doses that high, I stopped feeling like that.

Hopefully, you'll have a similar outcome. GL

Thank you, but I could't live that way, it was too depressing, - why I went over to reta instead, hoping, it won't do it too.

glad to hear it worked out for you, maybe i'll try again sometime, since i have 3-4 years worth of tirz in the freezer, lol.

 

[DwightTheDelight]

Thank you, but I could't live that way, it was too depressing, - why I went over to reta instead, hoping, it won't do it too.

glad to hear it worked out too, maybe i'll try aain sometime, since i have 3-4 years worth of tirz in the freezer, lol.

I hear ya. Luckily, I'm too dumb to even realize anything was off - as it was happening. I only noticed after I started to return to normal and began wanting to do things again.

GL with reta. Hopefully it is kinder to you than Tirz was.

 

[miss-sanne]

I hear ya. Luckily, I'm too dumb to even realize anything was off - as it was happening. I only noticed after I started to return to normal and began wanting to do things again.

GL with reta. Hopefully it is kinder to you than Tirz was.

True, I didn't think about it at first, because well.... but after some time it got worse and worse, so I looked up side effects.

 

[andreigl]

Jesus, this is the first I heard about this. I thought only BPC-157 had issues like this. I take both tirzepatide and BPC-157.

What I do with BPC-157, is to take NAC too, it was said to help regulate serotonin/dopamine something something..

 

[Foggy-Hollow]

Miss-sanne this is the space I’m in: tirz plus NAD+.

I have tried all 3 of the current GLP-1s (short tries), and had anhedonia on all 3. On sema I got to week three and had to drop it, it was Very Much Not Good. It’s the reason I’ve tried all three, all short term partial doses.

As of today I’m 3 doses of tirz in, with roughly 3/week of NAD. So far it’s “okay” the anhedonia creeps through a tad here and there but the other morning I was cracking dad jokes at 6 am (definitely not my MO at F48, menopause-ish).

I have historically had anhedonia that dipped into depression. Seems likely that places me at greater tendency/ risk.

I am also not consistent with exercise (yet) and it’s a good weapon against this grey fog. 20 minutes of breath-moving activity (which a brisk walk works well for) was helpful for my “run of the mill” variety. Can’t say if it will help with this “induced” type but nothing to lose by trying.

My energy seems a little better than without, not sure it helps where really needed though, read: dopamine. When my energy dips I am definitely crankier than normal.

Jesus, this is the first I heard about this. I thought only BPC-157 had issues like this. I take both tirzepatide and BPC-157.

What I do with BPC-157, is to take NAC too, it was said to help regulate serotonin/dopamine something something..

Wait. NAC… do you mean NAD? Am I on the wrong planet and need to consider something different?

 

[nonyabizznez]

I feel better whenever a see a post from @DwightTheDelight!

Hope all is well!

 

[randompersonrandom]

Time was the solution in my case. I started at a higher dose of Tirz than most people and felt off for a few months. Those first 3 months felt like I just sat at my office desk or in a recliner and melted.

This went away, but anytime I would bump the dose up, I knew I would feel it for a bit again. It always went away. Eventually, I worked my way up to 15mg every 4/5 days and even at doses that high, I stopped feeling like that.

Hopefully, you'll have a similar outcome. GL

from your lips to god's ears. I've been pretending like I don't have this going on, but I'm starting to sort of be open to the possibility that I do. Working out more helps it, and it WAS starting to fade off when I bumped my dose a month ago, so I'm hoping if I just keep on keeping on, I'll be fabulously healthy AND not so flat.

 

[miss-sanne]

Jesus, this is the first I heard about this. I thought only BPC-157 had issues like this. I take both tirzepatide and BPC-157.

What I do with BPC-157, is to take NAC too, it was said to help regulate serotonin/dopamine something something..

uuhh nac, as a tablet /capsule ? how much and how many times per day ? Should be easy to get TODAY lol

 

[miss-sanne]

Miss-sanne this is the space I’m in: tirz plus NAD+.

I have tried all 3 of the current GLP-1s (short tries), and had anhedonia on all 3. On sema I got to week three and had to drop it, it was Very Much Not Good. It’s the reason I’ve tried all three, all short term partial doses.

As of today I’m 3 doses of tirz in, with roughly 3/week of NAD. So far it’s “okay” the anhedonia creeps through a tad here and there but the other morning I was cracking dad jokes at 6 am (definitely not my MO at F48, menopause-ish).

I have historically had anhedonia that dipped into depression. Seems likely that places me at greater tendency/ risk.

I am also not consistent with exercise (yet) and it’s a good weapon against this grey fog. 20 minutes of breath-moving activity (which a brisk walk works well for) was helpful for my “run of the mill” variety. Can’t say if it will help with this “induced” type but nothing to lose by trying.

My energy seems a little better than without, not sure it helps where really needed though, read: dopamine. When my energy dips I am definitely crankier than normal.

Wait. NAC… do you mean NAD? Am I on the wrong planet and need to consider something different?

I think she means NAC, I read it somewhere else, but also NAD: I heard to give energy when anhedone. Do you IM ? because I really can't do it..

I'm 49, and perimenopausal and have history of depression.

I think you are right, it makes a person more susceptible to anhedonia, I also read if you have ADHD, and I do have some degree of ADD, no medicine.

I hope , it's better for you now on tirz, you must go slow. I'm so sorry it happened to you.

I just came to realize, I couldn't do it anymore, I loved tirz so much, but 10-11 mg, and I was just as flat as a pancake.

I do exercise a lot, 6 days a week, and I think, it does give some boost, but couldn't help with that.

Now Reta 5 mg.

 

[andreigl]

Miss-sanne this is the space I’m in: tirz plus NAD+.

I have tried all 3 of the current GLP-1s (short tries), and had anhedonia on all 3. On sema I got to week three and had to drop it, it was Very Much Not Good. It’s the reason I’ve tried all three, all short term partial doses.

As of today I’m 3 doses of tirz in, with roughly 3/week of NAD. So far it’s “okay” the anhedonia creeps through a tad here and there but the other morning I was cracking dad jokes at 6 am (definitely not my MO at F48, menopause-ish).

I have historically had anhedonia that dipped into depression. Seems likely that places me at greater tendency/ risk.

I am also not consistent with exercise (yet) and it’s a good weapon against this grey fog. 20 minutes of breath-moving activity (which a brisk walk works well for) was helpful for my “run of the mill” variety. Can’t say if it will help with this “induced” type but nothing to lose by trying.

My energy seems a little better than without, not sure it helps where really needed though, read: dopamine. When my energy dips I am definitely crankier than normal.

Wait. NAC… do you mean NAD? Am I on the wrong planet and need to consider something different?

N-acetylcysteine (NAC) has shown potential in reducing anhedonia, which is the inability to feel pleasure. Animal studies demonstrate that chronic NAC treatment can reverse anhedonic behaviors in models of depression and other conditions, and this effect is linked to improvements in neurotransmitter levels and brain structure, particularly in areas like the nucleus accumbens, a key part of the brain's reward circuitry. From Gemini AI

uuhh nac, as a tablet /capsule ? how much and how many times per day ? Should be easy to get TODAY lol

I always take the usual 600mg daily dose.

 

[Grannuaile]

I think there is a bit of pink cloud effect as the first weight comes off and then we have to contend with the loss of a coping behavior as well as the biological (if I do not eat now and keep eating I shall die) cravings. For me, I tried SSRI and then went to bupropion (61yo, F). You never said how much weight you lost/are losing, Miss-sanne.

 

[YoYoFat]

GLP-1s are believed to work on the same reward centers of the brain triggered by dopamine hits from drugs, alcohol, porn, shopping… all the addictive things, and hence why it’s being studied for SUD treatment. So it would make sense that you’d feel flat when you’re no longer getting a dopamine hit from the things that used to bring you joy, whatever they may be. (For many of us, that used to be food… eating food, thinking about food, planning for food.) I went through something similar a few months in to Tirz, but then it subsided. Been well over a year now and I’m good.

 

[miss-sanne]

N-acetylcysteine (NAC) has shown potential in reducing anhedonia, which is the inability to feel pleasure. Animal studies demonstrate that chronic NAC treatment can reverse anhedonic behaviors in models of depression and other conditions, and this effect is linked to improvements in neurotransmitter levels and brain structure, particularly in areas like the nucleus accumbens, a key part of the brain's reward circuitry. From Gemini AI

I always take the usual 600mg daily dose.

Thank you so much ! i'll do that, it's cheap and easy to get my chubby hands on

 

[miss-sanne]

I think there is a bit of pink cloud effect as the first weight comes off and then we have to contend with the loss of a coping behavior as well as the biological (if I do not eat now and keep eating I shall die) cravings. For me, I tried SSRI and then went to bupropion (61yo, F). You never said how much weight you lost/are losing, Miss-sanne.

Really not a lot, I was 86 kg, 1,69 cm, and now I'm 76,6 kg.

But it was strange to not be able to enjoy the weight going down, it was just 'oh, am I supposed to be happy or ? '

and yes i really was happy, I've always been normal around 65ish. But i became insulin resistant after kid and since covid, when the weight came on (because I became insulin resitstant. )

 

[Big Rossatron]

I had a little bit of this on Tirz but it didn't last, I switched to Reta (mostly for cost and because I kept hearing how much better it was) but since switching my weight is creeping up, my appetite is up a LOT and I'm struggling with inflammation and back pain.

Not convinced my reta is real, I ordered grey market from IndiaMart and I don't have any appetite suppression at all (up to 10mg now)

Hopefully when my new reta and also some cag turns up in a couple of weeks it'll all be okay, otherwise I'll be going back to tirz.

 

[Rejuvenateme000!]

I think she means NAC, I read it somewhere else, but also NAD: I heard to give energy when anhedone. Do you IM ? because I really can't do it..

I'm 49, and perimenopausal and have history of depression.

I think you are right, it makes a person more susceptible to anhedonia, I also read if you have ADHD, and I do have some degree of ADD, no medicine.

I hope , it's better for you now on tirz, you must go slow. I'm so sorry it happened to you.

I just came to realize, I couldn't do it anymore, I loved tirz so much, but 10-11 mg, and I was just as flat as a pancake.

I do exercise a lot, 6 days a week, and I think, it does give some boost, but couldn't help with that.

Now Reta 5 mg.

I had an issue with mood changes. I thought it was perimenopause and stress from an exam I had coming up. I felt when people would talk to me, I didn’t know what to say, words escaped me. I had no emotion and I’m the type to cry at anything! Even when I watched wanda die in dr. strange. I’m sensitive with my patients but I had no emotion. I got on sertaline, but now since I have been feeling better and - weaning off the sertaline (SSRI) the only thing different was a lower dose tirz. Now, I’m thinking if that was the cause.