快感缺失……那种无精打采的感觉。

[desinr-gal]

yes i was just reading up on those 3 peptides. What dose did you start on ?

I read 100-300 micg ?

I also read about cortexin.

I started with 300, but later realized I had reconned with a much smaller amount of bac..which kept me up all night.

my latest vial of 10mg I reconned with 3ml. I started at 4 units (around .1) now Im up to 6. which is slightly less than .25. No dramatic effects just steady build in brain energy.

I won 3 games of Mahjong yesterday so it seems to be working. lol

But I am also taking Alpha GPC, and a blend with that plus bacopa, ginko, and lions mane.

 

[Foggy-Hollow]

Only way is to see if it's better.

What medications are we talking about ? Yes it's slows the gut, but I don't know how much compared to the others.

True (one way to see).

My case: Wellbutrin, thyroid, adhd meds. Most anecdotes I see have people increasing dose. Levothyroxine is absorbed just after the stomach and can’t survive the slowed journey through the acid. My other two are extended release so I suspect similar problems: just not designed for it.

 

[desinr-gal]

True (one way to see).

My case: Wellbutrin, thyroid, adhd meds. Most anecdotes I see have people increasing dose. Levothyroxine is absorbed just after the stomach and can’t survive the slowed journey through the acid. My other two are extended release so I suspect similar problems: just not designed for it.

I am on levothyroxine. I am sticking to lower doses of glps so far. I keep hearing about the supposed effects on the thyroid and meds for it. Some saying it exacerbates the T4 others saying the meds wont work. Its very confusing. I havent done any tests recently so I just dont know.

Testing has gotten $$ here for me.

 

[Foggy-Hollow]

I’m just titrating up on levo so don’t really have much of a baseline, had a partial thyroid removal in late August. So far the single bump has been good, started on 50 now I’m on 75 (I think).

I’ve heard the T4 bit too, once - but don’t remember where or how reliable. With Levo itself I’ve heard to allow twice the margin when on GLP-1s - full hour after taking levo before eating or drinking anything, for example. After a certain point it gets a little ridiculous - 4 hour calcium wait becomes 8… I’m going to end up like one lady on Reddit and take it at 2am to be done with the hour counting!

Yes, it’s new territory for sure, everyone is trying to figure out the effects -docs and lab rats alike.

I’m also micro dosing: I don’t need more side effects wrecking my life.

Split dose my Tirz staring with the latest one to see if the smoothing of levels will help my adhedonia. Since it seems to be worst on day 4-5ish, I’m hoping it’s a levels problem and smoothing will be clutch.

Yes labs can get expensive. I’m due, for my HRT provider.

 

[miss-sanne]

I’m just titrating up on levo so don’t really have much of a baseline, had a partial thyroid removal in late August. So far the single bump has been good, started on 50 now I’m on 75 (I think).

I’ve heard the T4 bit too, once - but don’t remember where or how reliable. With Levo itself I’ve heard to allow twice the margin when on GLP-1s - full hour after taking levo before eating or drinking anything, for example. After a certain point it gets a little ridiculous - 4 hour calcium wait becomes 8… I’m going to end up like one lady on Reddit and take it at 2am to be done with the hour counting!

Yes, it’s new territory for sure, everyone is trying to figure out the effects -docs and lab rats alike.

I’m also micro dosing: I don’t need more side effects wrecking my life.

Split dose my Tirz staring with the latest one to see if the smoothing of levels will help my adhedonia. Since it seems to be worst on day 4-5ish, I’m hoping it’s a levels problem and smoothing will be clutch.

Yes labs can get expensive. I’m due, for my HRT provider.

Sounds like a good idea with a full hour.

Or in the night yes, I take iron supplement, and usually when I'm up for peeing.

What about your adhd meds, do they need to be adjusted maybe ?

Great to try split dosing.

What about your HRT.

 

[miss-sanne]

I am on levothyroxine. I am sticking to lower doses of glps so far. I keep hearing about the supposed effects on the thyroid and meds for it. Some saying it exacerbates the T4 others saying the meds wont work. Its very confusing. I havent done any tests recently so I just dont know.

Testing has gotten $$ here for me.

Don't you get tests with your GP ? I test my patients when needed.

but then again, this is Denmark, = free healthcare.

 

[Foggy-Hollow]

Thank you for your thoughtfulness miss-sanne. <3

For HRT I use a telehealth provider that has a location in Florida and has licensed prescribers for most states. They will order tests via third party labs that are located in my city, much like how a pre-employment drug screen is done. They keep an eye on my cholesterol since I am on a low dose of testosterone. I don’t remember what else they monitor offhand. I like that they test and they work with HRT regularly.

I had thyroid/parathyroid surgery late August. When I started the thyroid med, I could tell my estrogen levels dipped. Now that I have a higher dose things are generally better but I am indeed due for a labs and an appointment. My thyroid med was adjusted 4 weeks ago so I should wait but I am low on progesterone so will be meeting sooner.

.

ADHD meds … probably need to be bumped if I’m really going to run with tirz. I’m reluctant but I think it’s probably needed.

 

[miss-sanne]

Thank you for your thoughtfulness miss-sanne.

 

[desinr-gal]

Thank you for your thoughtfulness miss-sanne.

 

[Foggy-Hollow]

If it's been 4 weeks since adjusting, it's time for bloodtest soon. Bloodtest is after 5-6 weeks, or at least thats what I do with my patients.

Who monitors your ADHD treatment ? What do you use ?

Adderall generic, extended, 20mg. My psychiatrist prescribes it.

Endocrinologist said check thyroid levels at 8 weeks after adjusting, I’m feeling improved so far. Maybe I can request Defy (HRT) to take a look now, anyway. Current weight indicates 88 might be better but I’m willing to trial 75. Is there a downside even if my TSH is right around 1?

I am sorry you had to have surgery, that's always a trauma. I have many of the same concerns, I find splitting works well.. I too have adhd but never diagnosed or treated. That and age related brain fog, and memory loss are why I am researching Semax. I hope it all helps you.

I have been on Levo for so many years. It was stable but menopause seemed to mess everything up. Im on 88 now. It is good to take in the early am, 2 hours before anything else..but I havent been, doing that, which is probably why Im up to 88.

I am also doing HRT from Winona, no tests.. just feelz. urgg. I am interested in your experience with TRT.

This new period, on Tirz and Reta has gotten me: off alcohol, motivated to workout, lost almost 30lbs, and I feel so much better. So it all seems to be working, but I should do the tests to be sure.

This surgery was a victory lap! I had been chasing feeling poorly for years, HRT folded in there and helped.

With Levo I was told that consistency is king, that levels are adjustable.

The brain fog of peri is real. And yes, everything goes sideways.

Winona was my first provider, small world! After about 1.5 years I was up to 3mg oral estrogen per day and still getting hot flashes, so I needed something else. It took care of 80-85% of the fog. I also wanted to start test, found Defy and have been happy with them. Test took care of another 10% or so, and I call that a win. My job requires thinking, analysis, project juggling, and I got a couple of “performance plans” over the time frame I struggled.

Defy let me finish my stock of progesterone from Winona. Currently on injections for the other two, but I’m pretty sure they will work with what you like. Defy works with LabCorp and Quest. My provider also had a couple other levels to check to investigate brain fog.

It sounds like reta and tirz have been good to you. It isn’t easy to redefine ourselves but it’s kind of where life throws us: either go with the biological change or put in what it takes to make life better, even if it’s not the same. It can be a slog, but hopefully one that spirals up.

 

[Foggy-Hollow]

I have many of the same concerns, I find splitting works well.

The past two days have been good, I am hopeful.

 

[miss-sanne]

@Foggy-Hollow and @desinr-gal : How are you doing ??

 

[desinr-gal]

@Foggy-Hollow and @desinr-gal : How are you doing ??

Great! Thanks for asking

I just passed 30lbs down, and I spent the am trying on all the pants in my closet I had grown out of. I reclaimed 3, and put others on the side, that are now too big.

NSV are very mood boosting.

Also I am seeing muscle type shapes appearing on my arms

How are you Doing??

 

[Foggy-Hollow]

I’m doing okay to good. I stopped the micro-tirz. Decided it would be smarter to get my feet underneath me before adding another factor.

Feet underneath meaning getting thyroid and HRT hormones balanced first. I think I am very close, I am waiting for LabCorps to get the orders.

I was getting buried at work (desk job), my key adhd problem is starting things. Job performance is a top priority, with menopause hormone dip I’ve been through the wringer. I must avoid that with this job.

I need to solve some injection site reactions, I found a thread with suggestions.

Generally good but not exactly sure how to proceed. Not sure if I’m stupid for trying tirz again or if I need to give reta a try.

 

[desinr-gal]

I’m doing okay to good. I stopped the micro-tirz. Decided it would be smarter to get my feet underneath me before adding another factor.

Feet underneath meaning getting thyroid and HRT hormones balanced first. I think I am very close, I am waiting for LabCorps to get the orders.

I was getting buried at work (desk job), my key adhd problem is starting things. Job performance is a top priority, with menopause hormone dip I’ve been through the wringer. I must avoid that with this job.

I need to solve some injection site reactions, I found a thread with suggestions.

Generally good but not exactly sure how to proceed. Not sure if I’m stupid for trying tirz again or if I need to give reta a try.

what are you researching right now? Sorry I forgot is you've said it before..

I fully understand the need to be effective at work, and some people experience fatigue on Tirz, so that could be a problem..but I doubt it would happen at a micro dose, though I can see where you might be hesitant.

Reta is like riding on a moving vehicle, and it does raise my heart rate.. The weight is dropping faster, though, which I like. I split these up, every 3 days.

Benadryl cream helps me with ISR, though I haven't had many. When I feel that itch after pinning I rub it in and it goes away. also a cold pack really helped the one time it was bad.

I also have hypo thyroid issues. I thought it was managed but it seems these meds change things.

For the adhd and focus I take alpha GPC, and a blend that has it, and lions mane, bacopa, etc.. It does work. The GPC is essential as it fuels the brain.

I am also researching semax, which I like but it can be too exciting, which can be counter productive. Finding the sweet spot is the goal.

 

[Foggy-Hollow]

I was microdosing Tirz.

I also have hypo thyroid issues. I thought it was managed but it seems these meds change things.

I’m going to become a member of the 1am club, yet.

Are you using the N-Acetyl semax? I don’t know if you could even buy regular but it’s what my vendor of choice has.

The GPC I will have to read up on.

 

[desinr-gal]

I was microdosing Tirz.

I’m going to become a member of the 1am club, yet.

Are you using the N-Acetyl semax? I don’t know if you could even buy regular but it’s what my vendor of choice has.

The GPC I will have to read up on.

No I wanted to try it, but when I was ready to buy a kit, the regular was the only option in stock.

I have read that the other is more potent.

Read on Alpha GPC and Citi choline. They are similar but have different effects.

 

[4StrandKnot]

Adderall generic, extended, 20mg. My psychiatrist prescribes it.

You weren't asking for advice, but I'll just float something your way in case this interests you. Adderall is two amphetamine isomers, levoamphetamine and dextroamphetamine. There has been some research in to pairing dextroamphetamine with Modafinil for treatments of various matters, including cocaine addiction. Modafinil (C-IV) works on a different brain sensor than d-amphetamine, and that sensor is not subject to the same type of burnout.

Modafinil brings other risks, and of course they should be seriously considered. I don't think this is a treatment widely used, but if you curious about an option that didn't involve increasing a C-II dose, that might be a possibility to discuss with the doc. Hope the way forward is a good one, wherever the path may lead.

 

[Foggy-Hollow]

@4StrandKnot 我乐于接受建议，谢谢你的想法。

@miss-sanne 如果可以的话，我想听听你的想法……我刚做了甲状腺检查，我想要求医生把剂量增加到“标准”水平，但又想确认一下我的剂量是否合适？

10月20日，

50微克左甲状腺素钠，血清促甲状腺激素

（TSH）1.34 uIU/mL，参考范围（0.45-4.5），游离甲状腺素

（FT4）1.46 ng/dL，参考范围（0.82-1.77） 。

12月1日（同一实验室，相同的单位/参考值）

，75微克，血清促甲状腺激素（

TSH）1.06，游离甲状腺素（

FT4）1.47。

甲状腺论坛上说促甲状腺激素（TSH）低于1是最佳的，但根据图表，以我的体重和部分甲状腺功能减退的情况，我应该服用88微克左甲状腺素钠。我有点犹豫，要不要要求增加剂量？

问这个问题感觉有点傻。 我挺喜欢我的内分泌科医生，但他之前的一些言论让我很难再信任他，比如他质疑为什么外科医生没有切除我全部的甲状腺。

 

[Foggy-Hollow]

哦！等我甲状腺问题解决了，我想试试 @desinr-gal 的 微剂量组合。我喜欢低剂量、分次服用的理念。听起来你效果不错！

我还会试试 Semax 来提升多巴胺水平。