Epithalon

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vale113 said:
Do you use the same spray and subcutaneous spray? Or are there different ones sold?
Not 💯 sure what you're asking..... I bought the Snoot sterile nasal spray bottles and used sterile water for injection to reconstitute
 
Chili777 said:
These are the studies I found. I asked Gemini to format them and provide links. Semax is actually used in Russia as a treatment following TBI. I think both of them combined would provide an excellent 1-2 punch to both rebuild damage and to limit it. I've also included screen shots from Anela's (creator of the GLOW stack) cycle to show the results of her use of Epitalon to address her brain injury.

I. Clinical Case Studies: Multi-Peptide Protocols ​

Rodeo, S. A., et al. (2024): "Nothing Heals Without Cells: A Case Study on Cognitive Reset."
Context: Evaluation of a combination of Semax, Epitalon , and Exosomes.

Finding: Documented a 7.9-year reduction in biological age and significant improvements in executive function.

Link: Case Study Overview (Restorative Medicine) (Note: Full text availability may vary by institutional access).

Improving Biological Age, Telomere Length, and Cognition: A Case Report

The first case study to report on reducing biological age, increasing telomere length, and improving cognition using this unique combination of therapies.

restorativemedicine.org

II. Foundational Longevity & Cardiovascular Trials ​

Korkushko, O. V., et al. (2006): "Geroprotective Effect of Epithalamine in Elderly Subjects."
Finding: A 12-year study showing a 28% reduction in mortality and a 2-fold reduction in cardiovascular failure using pineal peptides.

Link: PubMed - PMID: 17426848

III. Neurogenesis & Brain Repair Mechanisms ​

Khavinson, V. K., et al. (2020): "AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis."
Finding: Epitalon upregulated biomarkers for axon growth: Nestin, GAP43, and \beta-Tubulin III .

Link: MDPI Molecules - 25(3), 609

Sibarov, D. A., et al. (2002/2024): "Epitalon Influences Pineal Secretion in Stress-Exposed Rats."
Finding: Demonstrated that Epitalon selectively increases c-Fos expression and protects pineal structure specifically during stress/injury.

Link: PubMed - PMID: 12500171

IV. Acute Neuroprotection & Stroke/TBI (Semax) ​

Gusev, E. I., Skvortsova, V. I., et al. (2018/Earlier): "Investigation of Mechanisms of Neuroprotective Effect of Semax."
Finding: Analyzed the shifting of neuromediatory balance and anti-inflammatory reactions in acute brain ischemia and trauma.

Link: PubMed - PMID: 10358912

Lopatina, O. L., et al. (2014): "The Peptide Semax Affects Expression of Genes Related to the Immune and Vascular Systems."
Finding: Genome-wide analysis showing Semax influences 90+ genes involved in neural survival and vascular stability after brain injury.

Link: PMC - PMC3987924

V. Technical Comparison Reference ​

Khavinson, V. K. (2002): "Peptides and Ageing."
Context: A comprehensive review of the transition from Epithalamin (extract) to Epitalon (synthetic tetrapeptide).

Link: Neuroendocrinology Letters - Volume 23
Wow, this is spectacular. Thank you.

I am >25 years post TBI, so I have to temper my expectations a bit, but this is exciting.
 
V6R3W said:
Wow, this is spectacular. Thank you.

I am >25 years post TBI, so I have to temper my expectations a bit, but this is exciting.
Welcome. I'm 10 years from my last one, but it helped. Epitalon and Semax will always be in the toolbox.
 
I will run one mg per day of Epitalon for twenty days every three months until I am dead or until someone makes me stop.

I let my mom have some of my stash to see if she liked it, and now SHE will run one mg per day of Epitalon for twenty days every three months until SHE is dead or someone makes HER stop.

I am feeling miserly about my hoard of it (I currently have 9 vials of 7.5 mg after I send her enough to keep her good for a second cycle) and 2 kits coming from a GB. Now I have to find HER a source too, so that's a whole thing.
 
I do 1mg/day, 2X10mg vials, good for about 22-24 days, depending on overfill. I do that cycle 3-4 times a year. First few cycles were 0.5mg/day (coupled with TA1). I used it with Tirz and Reta. I always sleep 8-9hrs/day, with or without Epi, so cannot comment as a sleep aid.
 
Chili777 said:
Welcome. I'm 10 years from my last one, but it helped. Epitalon and Semax will always be in the toolbox.
Could you talk to me about the benefits of Semax? I'm also a little nervous about squirting something other than Flonase up my nose, LOL. I'm dealing with brain fog, overwhelm, and chronic fatigue (Female, 40s), and am looking for something to help. My job is mentally high-pressure. I'd be stacking with Tirz. Thanks!

ETA: Oh, how'd you find your perfect dose?
 
Chili777 said:
You don't need massive doses of Epitalon for it to be effective. My first cycle was 1 mg via IN and I just finished my second at 1 mg SQ. I ran for 20 days the first time and 10 days the second time, but I prefer the longer cycle, which I'll do every 4 months. I might go to 2 mg the next cycle, but no further.
Besides the length of the run did you notice a difference between IN and Subq?

I finally made my first 2 nasal sprays today(NA Selank and NA Semax) and I'm now considering the others I could try like Epitalon, DSIP, Pinealon and Adamax.
 
NBA_MiddleAgedGirl said:
Could you talk to me about the benefits of Semax? I'm also a little nervous about squirting something other than Flonase up my nose, LOL. I'm dealing with brain fog, overwhelm, and chronic fatigue (Female, 40s), and am looking for something to help. My job is mentally high-pressure. I'd be stacking with Tirz. Thanks!

ETA: Oh, how'd you find your perfect dose?
Of course. The first thing I did was research Semax by reading here: https://pep-pedia.org/peptides/semax

Notice if you do another search on Semax, you'll find it and two other derivatives of it. Compare them and see what the offer. Because of my history I tried 500 mcg per spray first for a 1 mg dosage. It ended up being the correct one. And, as a nasal spray, if it too strong, just add more saline and you're good to go.

Semax helps me focus, cleared my COVID brain fog, and helps me remember names and technical terms that I need in my job.

You sound like me a year ago, so you might consider a cycle of Epitalon first, as I did. I made sprays for both of them. Epitalon to me is like tuning up the engine and Semax is like stepping on the gas. You do one before the other. How I made them, and what I used is in the link below.

Post in thread 'Selank + Semax--nasal? Effects?' [archived internal link]
 
Chili777 said:
Of course. The first thing I did was research Semax by reading here: https://pep-pedia.org/peptides/semax

Notice if you do another search on Semax, you'll find it and two other derivatives of it. Compare them and see what the offer. Because of my history I tried 500 mcg per spray first for a 1 mg dosage. It ended up being the correct one. And, as a nasal spray, if it too strong, just add more saline and you're good to go.

Semax helps me focus, cleared my COVID brain fog, and helps me remember names and technical terms that I need in my job.

You sound like me a year ago, so you might consider a cycle of Epitalon first, as I did. I made sprays for both of them. Epitalon to me is like tuning up the engine and Semax is like stepping on the gas. You do one before the other. How I made them, and what I used is in the link below.

Post in thread 'Selank + Semax--nasal? Effects?' [archived internal link]
OMG, thank you so much for this! I really appreciate it. If a year ago your brain was like mine, I'm so happy you found something that works for you. I'm almost desperate. This has been such a helpful post. I'll do my research, look through your previous post, and start with Epitalon before adding Semax. I appreciate your response so much.
 
PinKushn said:
Besides the length of the run did you notice a difference between IN and Subq?

I finally made my first 2 nasal sprays today(NA Selank and NA Semax) and I'm now considering the others I could try like Epitalon, DSIP, Pinealon and Adamax.

IN is near instant onset compared to SQ and it intensifies rapidly. Both methods last about the same time, 3-4 hours, the NA versions last another hour or so.

Adamax duration is 8-10 hours with just 300 mcg SQ, so I would be careful with Adamax via IN. I would start slow, maybe 100 mcg total, and go from there. With the quick onset via IN, I'd feel like I strapped into a rocketship at 300 mcg. This is especially true if you know your Adamax has the Adamantane chain (1032 Da) vs. the Adamax backbone (984 Da).
 
NBA_MiddleAgedGirl said:
OMG, thank you so much for this! I really appreciate it. If a year ago your brain was like mine, I'm so happy you found something that works for you. I'm almost desperate. This has been such a helpful post. I'll do my research, look through your previous post, and start with Epitalon before adding Semax. I appreciate your response so much.
You're very welcome. One thing I should have added is that I didn't filter my very first spray, but I do now. The sinus mucosa has robust defenses, considering what we're exposed to on a daily basis, but I filter everything now. If you have any concerns about your peptides at all, it's another step we can take in the name of harm reduction.
 
Chili777 said:
You're very welcome. One thing I should have added is that I didn't filter my very first spray, but I do now. The sinus mucosa has robust defenses, considering what we're exposed to on a daily basis, but I filter everything now. If you have any concerns about your peptides at all, it's another step we can take in the name of harm reduction.
Appreciate it. I finished reading the thread you posted and caught that. I planned to filter, just because I'm in my head about everything anyway. It's one, inexpensive step to reduce harm...might as well. Thank you!
 
Romulusguy said:
WOAH, you are right: I copied/pasted the link into a browser I never use and I received the same question. I can access the site just fine through CHROME for some reason. VERY STRANGE> I am adding screenshots of what the site says about Epithalon for you.

View attachment 20728

View attachment 20729

View attachment 20730
10mg a day with a ml of water sounds insane to me. Also really expensive if you aren't sourcing from China.
 
So I have some Epithalon on the way, one of a few efforts to try and help my wife start to sleep again- been total garbage for her for the last 3 months.

Planning on starting her @ .5mg SQ and work up to 1mg (perhaps on a subsequent cycle) for 20(ish) days on, 4x/year. Then alternately cycling DISP+CJC+IPA during the “off” cycles.

Does this sound solid? These peps are a new space for me.
 
DragonOfTheSea said:
So I have some Epithalon on the way, one of a few efforts to try and help my wife start to sleep again- been total garbage for her for the last 3 months.

Planning on starting her @ .5mg SQ and work up to 1mg (perhaps on a subsequent cycle) for 20(ish) days on, 4x/year. Then alternately cycling DISP+CJC+IPA during the “off” cycles.

Does this sound solid? These peps are a new space for me.
By DISP do you mean DSIP? Pep-pedia says they are synergistic, so that should work.

DSIP - Dosing, Side Effects, Stacking & Research | Pep-Pedia

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) discovered in 1974 in rabbit brain. Originally...

pep-pedia.org

I have heard, anecdotally, that some people with chronic insomnia have an inverse reaction to Epitalon taken just before bed and it keeps them up, so you may want to experiment with morning vs. late evening. With DSIP, that may not be an issue. I haven't researched the other two, so I can't comment on the combination.
 
vale113 said:
Hi guys, Does anyone use Epithalon with Reta? I'd like to try it for sleep. Does it help? What dosage should I start with? Many say mcg, others mg.
I do 250-500 mcg of epithalon. Cycling it for a month.
 
Chili777 said:
By DISP do you mean DSIP? Pep-pedia says they are synergistic, so that should work.

DSIP - Dosing, Side Effects, Stacking & Research | Pep-Pedia

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) discovered in 1974 in rabbit brain. Originally...

pep-pedia.org

I have heard, anecdotally, that some people with chronic insomnia have an inverse reaction to Epitalon taken just before bed and it keeps them up, so you may want to experiment with morning vs. late evening. With DSIP, that may not be an issue. I haven't researched the other two, so I can't comment on the combination.
Yeah, DSIP, my bad. And yes I’ve heard of the inverse effect, however the sleep issues aren’t insomnia based, they’re a GLP use side unfortunately.

The “sleep optimization stack” actually includes all of the peps I mentioned- DSIP+CJC1295+IPA+EPI. However due to the short cycle of the EPI, and the longer cycle-ability of the others, alternating them seems logical.
 
DragonOfTheSea said:
Yeah, DSIP, my bad. And yes I’ve heard of the inverse effect, however the sleep issues aren’t insomnia based, they’re a GLP use side unfortunately.

The “sleep optimization stack” actually includes all of the peps I mentioned- DSIP+CJC1295+IPA+EPI. However due to the short cycle of the EPI, and the longer cycle-ability of the others, alternating them seems logical.
OK, in that case I've had the same issue. I do sleep better when running epitalon and I can avoid the dreaded 3 am wakeup call. When I'm not cycling it, I've found that Selank (1 mg SQ) has a calming effect and also allows me to sleep well. I usually pin 2 hours before bed. I have noticed I need to go 3 weeks on/1 week off for it to maintain the same effect.
 
Shutterdrive said:
I do 250-500 mcg of epithalon. Cycling it for a month.
How many days do you use it and how many days don't you? Does it work for sleep?
 
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