Jfrick11
GLP-1爱好者
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Notvale113 said:Do you use the same spray and subcutaneous spray? Or are there different ones sold?

Notvale113 said:Do you use the same spray and subcutaneous spray? Or are there different ones sold?
Wow, this is spectacular. Thank you.Chili777 said:These are the studies I found. I asked Gemini to format them and provide links. Semax is actually used in Russia as a treatment following TBI. I think both of them combined would provide an excellent 1-2 punch to both rebuild damage and to limit it. I've also included screen shots from Anela's (creator of the GLOW stack) cycle to show the results of her use of Epitalon to address her brain injury.
I. Clinical Case Studies: Multi-Peptide Protocols
Rodeo, S. A., et al. (2024): "Nothing Heals Without Cells: A Case Study on Cognitive Reset."
Context: Evaluation of a combination of Semax, Epitalon , and Exosomes.
Finding: Documented a 7.9-year reduction in biological age and significant improvements in executive function.
Link: Case Study Overview (Restorative Medicine) (Note: Full text availability may vary by institutional access).
Improving Biological Age, Telomere Length, and Cognition: A Case Report
The first case study to report on reducing biological age, increasing telomere length, and improving cognition using this unique combination of therapies.
restorativemedicine.org
II. Foundational Longevity & Cardiovascular Trials
Korkushko, O. V., et al. (2006): "Geroprotective Effect of Epithalamine in Elderly Subjects."
Finding: A 12-year study showing a 28% reduction in mortality and a 2-fold reduction in cardiovascular failure using pineal peptides.
Link: PubMed - PMID: 17426848
III. Neurogenesis & Brain Repair Mechanisms
Khavinson, V. K., et al. (2020): "AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis."
Finding: Epitalon upregulated biomarkers for axon growth: Nestin, GAP43, and \beta-Tubulin III .
Link: MDPI Molecules - 25(3), 609
Sibarov, D. A., et al. (2002/2024): "Epitalon Influences Pineal Secretion in Stress-Exposed Rats."
Finding: Demonstrated that Epitalon selectively increases c-Fos expression and protects pineal structure specifically during stress/injury.
Link: PubMed - PMID: 12500171
IV. Acute Neuroprotection & Stroke/TBI (Semax)
Gusev, E. I., Skvortsova, V. I., et al. (2018/Earlier): "Investigation of Mechanisms of Neuroprotective Effect of Semax."
Finding: Analyzed the shifting of neuromediatory balance and anti-inflammatory reactions in acute brain ischemia and trauma.
Link: PubMed - PMID: 10358912
Lopatina, O. L., et al. (2014): "The Peptide Semax Affects Expression of Genes Related to the Immune and Vascular Systems."
Finding: Genome-wide analysis showing Semax influences 90+ genes involved in neural survival and vascular stability after brain injury.
Link: PMC - PMC3987924
V. Technical Comparison Reference
Khavinson, V. K. (2002): "Peptides and Ageing."
Context: A comprehensive review of the transition from Epithalamin (extract) to Epitalon (synthetic tetrapeptide).
Link: Neuroendocrinology Letters - Volume 23
Welcome. I'm 10 years from my last one, but it helped. Epitalon and Semax will always be in the toolbox.V6R3W said:Wow, this is spectacular. Thank you.
I am >25 years post TBI, so I have to temper my expectations a bit, but this is exciting.

Yes it helps with sleep, 1 mg per night is all you needvale113 said:Hi guys, Does anyone use Epithalon with Reta? I'd like to try it for sleep. Does it help? What dosage should I start with? Many say mcg, others mg.


Could you talk to me about the benefits of Semax? I'm also a little nervous about squirting something other than Flonase up my nose, LOL. I'm dealing with brain fog, overwhelm, and chronic fatigue (Female, 40s), and am looking for something to help. My job is mentally high-pressure. I'd be stacking with Tirz. Thanks!Chili777 said:Welcome. I'm 10 years from my last one, but it helped. Epitalon and Semax will always be in the toolbox.
Besides the length of the run did you notice a difference between IN and Subq?Chili777 said:You don't need massive doses of Epitalon for it to be effective. My first cycle was 1 mg via IN and I just finished my second at 1 mg SQ. I ran for 20 days the first time and 10 days the second time, but I prefer the longer cycle, which I'll do every 4 months. I might go to 2 mg the next cycle, but no further.
Of course. The first thing I did was research Semax by reading here: https://pep-pedia.org/peptides/semaxNBA_MiddleAgedGirl said:Could you talk to me about the benefits of Semax? I'm also a little nervous about squirting something other than Flonase up my nose, LOL. I'm dealing with brain fog, overwhelm, and chronic fatigue (Female, 40s), and am looking for something to help. My job is mentally high-pressure. I'd be stacking with Tirz. Thanks!
ETA: Oh, how'd you find your perfect dose?
OMG, thank you so much for this! I really appreciate it. If a year ago your brain was like mine, I'm so happy you found something that works for you. I'm almost desperate. This has been such a helpful post. I'll do my research, look through your previous post, and start with Epitalon before adding Semax. I appreciate your response so much.Chili777 said:Of course. The first thing I did was research Semax by reading here: https://pep-pedia.org/peptides/semax
Notice if you do another search on Semax, you'll find it and two other derivatives of it. Compare them and see what the offer. Because of my history I tried 500 mcg per spray first for a 1 mg dosage. It ended up being the correct one. And, as a nasal spray, if it too strong, just add more saline and you're good to go.
Semax helps me focus, cleared my COVID brain fog, and helps me remember names and technical terms that I need in my job.
You sound like me a year ago, so you might consider a cycle of Epitalon first, as I did. I made sprays for both of them. Epitalon to me is like tuning up the engine and Semax is like stepping on the gas. You do one before the other. How I made them, and what I used is in the link below.
Post in thread 'Selank + Semax--nasal? Effects?' [archived internal link]
PinKushn said:Besides the length of the run did you notice a difference between IN and Subq?
I finally made my first 2 nasal sprays today(NA Selank and NA Semax) and I'm now considering the others I could try like Epitalon, DSIP, Pinealon and Adamax.
You're very welcome. One thing I should have added is that I didn't filter my very first spray, but I do now. The sinus mucosa has robust defenses, considering what we're exposed to on a daily basis, but I filter everything now. If you have any concerns about your peptides at all, it's another step we can take in the name of harm reduction.NBA_MiddleAgedGirl said:OMG, thank you so much for this! I really appreciate it. If a year ago your brain was like mine, I'm so happy you found something that works for you. I'm almost desperate. This has been such a helpful post. I'll do my research, look through your previous post, and start with Epitalon before adding Semax. I appreciate your response so much.
Appreciate it. I finished reading the thread you posted and caught that. I planned to filter, just because I'm in my head about everything anyway. It's one, inexpensive step to reduce harm...might as well. Thank you!Chili777 said:You're very welcome. One thing I should have added is that I didn't filter my very first spray, but I do now. The sinus mucosa has robust defenses, considering what we're exposed to on a daily basis, but I filter everything now. If you have any concerns about your peptides at all, it's another step we can take in the name of harm reduction.

10mg a day with a ml of water sounds insane to me. Also really expensive if you aren't sourcing from China.Romulusguy said:WOAH, you are right: I copied/pasted the link into a browser I never use and I received the same question. I can access the site just fine through CHROME for some reason. VERY STRANGE> I am adding screenshots of what the site says about Epithalon for you.
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By DISP do you mean DSIP? Pep-pedia says they are synergistic, so that should work.DragonOfTheSea said:So I have some Epithalon on the way, one of a few efforts to try and help my wife start to sleep again- been total garbage for her for the last 3 months.
Planning on starting her @ .5mg SQ and work up to 1mg (perhaps on a subsequent cycle) for 20(ish) days on, 4x/year. Then alternately cycling DISP+CJC+IPA during the “off” cycles.
Does this sound solid? These peps are a new space for me.

I do 250-500 mcg of epithalon. Cycling it for a month.vale113 said:Hi guys, Does anyone use Epithalon with Reta? I'd like to try it for sleep. Does it help? What dosage should I start with? Many say mcg, others mg.

Yeah, DSIP, my bad. And yes I’ve heard of the inverse effect, however the sleep issues aren’t insomnia based, they’re a GLP use side unfortunately.Chili777 said:By DISP do you mean DSIP? Pep-pedia says they are synergistic, so that should work.
DSIP - Dosing, Side Effects, Stacking & Research | Pep-Pedia
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) discovered in 1974 in rabbit brain. Originally...
pep-pedia.org
I have heard, anecdotally, that some people with chronic insomnia have an inverse reaction to Epitalon taken just before bed and it keeps them up, so you may want to experiment with morning vs. late evening. With DSIP, that may not be an issue. I haven't researched the other two, so I can't comment on the combination.
OK, in that case I've had the same issue. I do sleep better when running epitalon and I can avoid the dreaded 3 am wakeup call. When I'm not cycling it, I've found that Selank (1 mg SQ) has a calming effect and also allows me to sleep well. I usually pin 2 hours before bed. I have noticed I need to go 3 weeks on/1 week off for it to maintain the same effect.DragonOfTheSea said:Yeah, DSIP, my bad. And yes I’ve heard of the inverse effect, however the sleep issues aren’t insomnia based, they’re a GLP use side unfortunately.
The “sleep optimization stack” actually includes all of the peps I mentioned- DSIP+CJC1295+IPA+EPI. However due to the short cycle of the EPI, and the longer cycle-ability of the others, alternating them seems logical.
How many days do you use it and how many days don't you? Does it work for sleep?Shutterdrive said:I do 250-500 mcg of epithalon. Cycling it for a month.