wildweasel
GLP-1 Apprentice
Background
I am an endura nce athlete and became interested in DSIP due to its supposed deep-sleep inducing effects.. its name is "Deep Sleep Inducing Peptide" after all.
I performed a 7 day trail on myself and wanted to share results. I'm a very data-driven kind of guy, so when I consider new peptides or compounds, I like to set up a quantitative experiment where I can judge results.
If you want to skip ahead to the ending: "I would not recommend this to anyone, it ended up lowering the quality of my sleep more than improving it"
Existing Medical Literature
DSIP was originally discovered in the 1970s and attracted attention because early animal studies and a handful of small human trials suggested it might influence sleep architecture, especially slow-wave sleep and sleep onset latency.
The human data is extremely sparse, inconsistent and generally low quality by modern standards. Some studies reported improved sleep quality or sedation-like effects, some reported increased heart rates and no changes in sleep, while others failed to find meaningful changes at all.
One unusual aspect of DSIP is that researchers still have not clearly identified a definitive receptor, precursor protein or even fully validated endogenous biological role for it, which has made the peptide somewhat controversial in the literature.
Overall, the current state of medical literature is probably best summarized as: "interesting early findings that never matured into convincing clinical evidence."
Methodology
14 day trial. 7 days captured as a baseline, 7 days captured dosing 1mg DSIP subq about 30-45 before bed.
Results were tracked using a wearable fitness tracker that records sleep stats (Time spent in REM sleep, deep sleep, light sleep, awake each night) as well as sleeping heart rate, Heart rate variation (HRV) and resting heart rate during the day (RHR)
My Results Summary
Total time spent asleep each night significantly trended upwards the longer I was on DSIP, averaging a gain of about +20 minutes more sleeping every night for the 7 day period on DSIP.
Comparing to Baseline, nearly every night on DSIP i spent significantly less time in Deep Sleep and REM Sleep, and significantly more time sleeping overall, The extra time sleeping was mostly spent in Light Sleep
Sleeping HR and RHR trended upwards about 1 bpm every day during the DSIP trial (about +6 bpm to my heart rate over 7 days while taking DSIP). HRV trended downwards during the DSIP trial.
Time spent in light sleep significantly increased during DSIP usage, trending up about 15 minutes each night while on DSIP. REM sleep also increased modestly, trending about +4 minutes each night, but remained less than baseline.
Subjective Experience
I wanted to have deeper more restful sleep. I got the opposite. I did not become especially drowsy after taking it, and during sleep I actually tended to consciously wake up more than without it and had more trouble falling back asleep. My fitness tracker logs micro-awake periods as "Awake" time but during most nights i'm not actually consciously awake... while on DSIP I had frequent Awake periods where I was fully conscious and had trouble falling back asleep.
Even though total sleep time increased while on DSIP, my quality of sleep was much lower (see above). Each morning I woke up feeling less and less refreshed.
If you look at the figure below, the largest gains were nearly all in "Light Sleep" which is non ideal, thats junk sleep... Light Sleep is time spent neither awake nor healing/restoring.
My RHR increases lend credibility to the idea that my sleeps did not just feel lest refreshing, they actually were, as RHR is one of the first things that rises during systemic stress.
I am very sensitive to my body, I know it well being an endurance athlete and such. I noticed that during the DSIP period, my muscles were not recovering as quickly. I train 20 hours a week with intense cardio and weight lifting, and I have been doing this a long time, I know how my body reacts, and what level of training it can handle. My training routing became tougher each day, and my body never felt like it recovered from something 2-3 days prior, which normally I never feel like that
Conclusion
I do not recommend DSIP. My quality of sleep decreased and time spent recovering between training sessions increased.
Figures
[Imported image pending local asset: attachments-dsip-trial-fig01-webp.24485]
I am an endura nce athlete and became interested in DSIP due to its supposed deep-sleep inducing effects.. its name is "Deep Sleep Inducing Peptide" after all.
I performed a 7 day trail on myself and wanted to share results. I'm a very data-driven kind of guy, so when I consider new peptides or compounds, I like to set up a quantitative experiment where I can judge results.
If you want to skip ahead to the ending: "I would not recommend this to anyone, it ended up lowering the quality of my sleep more than improving it"
Existing Medical Literature
DSIP was originally discovered in the 1970s and attracted attention because early animal studies and a handful of small human trials suggested it might influence sleep architecture, especially slow-wave sleep and sleep onset latency.
The human data is extremely sparse, inconsistent and generally low quality by modern standards. Some studies reported improved sleep quality or sedation-like effects, some reported increased heart rates and no changes in sleep, while others failed to find meaningful changes at all.
One unusual aspect of DSIP is that researchers still have not clearly identified a definitive receptor, precursor protein or even fully validated endogenous biological role for it, which has made the peptide somewhat controversial in the literature.
Overall, the current state of medical literature is probably best summarized as: "interesting early findings that never matured into convincing clinical evidence."
Methodology
14 day trial. 7 days captured as a baseline, 7 days captured dosing 1mg DSIP subq about 30-45 before bed.
Results were tracked using a wearable fitness tracker that records sleep stats (Time spent in REM sleep, deep sleep, light sleep, awake each night) as well as sleeping heart rate, Heart rate variation (HRV) and resting heart rate during the day (RHR)
My Results Summary
Total time spent asleep each night significantly trended upwards the longer I was on DSIP, averaging a gain of about +20 minutes more sleeping every night for the 7 day period on DSIP.
Comparing to Baseline, nearly every night on DSIP i spent significantly less time in Deep Sleep and REM Sleep, and significantly more time sleeping overall, The extra time sleeping was mostly spent in Light Sleep
Sleeping HR and RHR trended upwards about 1 bpm every day during the DSIP trial (about +6 bpm to my heart rate over 7 days while taking DSIP). HRV trended downwards during the DSIP trial.
Time spent in light sleep significantly increased during DSIP usage, trending up about 15 minutes each night while on DSIP. REM sleep also increased modestly, trending about +4 minutes each night, but remained less than baseline.
Subjective Experience
I wanted to have deeper more restful sleep. I got the opposite. I did not become especially drowsy after taking it, and during sleep I actually tended to consciously wake up more than without it and had more trouble falling back asleep. My fitness tracker logs micro-awake periods as "Awake" time but during most nights i'm not actually consciously awake... while on DSIP I had frequent Awake periods where I was fully conscious and had trouble falling back asleep.
Even though total sleep time increased while on DSIP, my quality of sleep was much lower (see above). Each morning I woke up feeling less and less refreshed.
If you look at the figure below, the largest gains were nearly all in "Light Sleep" which is non ideal, thats junk sleep... Light Sleep is time spent neither awake nor healing/restoring.
My RHR increases lend credibility to the idea that my sleeps did not just feel lest refreshing, they actually were, as RHR is one of the first things that rises during systemic stress.
I am very sensitive to my body, I know it well being an endurance athlete and such. I noticed that during the DSIP period, my muscles were not recovering as quickly. I train 20 hours a week with intense cardio and weight lifting, and I have been doing this a long time, I know how my body reacts, and what level of training it can handle. My training routing became tougher each day, and my body never felt like it recovered from something 2-3 days prior, which normally I never feel like that
Conclusion
I do not recommend DSIP. My quality of sleep decreased and time spent recovering between training sessions increased.
Figures
[Imported image pending local asset: attachments-dsip-trial-fig01-webp.24485]
