yrrdead said:
Realize in a prior thread that the OP said he is Type 1.
I was trying to work out how you could be in definite diabetes territory with blood sugars above 11 or 200 depending on what units you use.
Using GLP's in type 1 diabetes is a long way from mainstream accepted therapy at this point, although there are several studies suggesting it might be useful and not too dangerous.
I do not know if you are really hitting yourself with that many new peptides at once, or if you were already on most of them, but starting multiple peptides at the same time makes it very hard to work out what is causing what if you get side effects, and in the context of type 1 diabetes , fairly extreme care really is a good idea, one at a time with careful monitoring.
I am also not aware of studies of reta in type 1, I just checked google scholar and found nothing at all. I know sema and tirz have been studied but reta has glucagon, and it could behave differently in low insulin states, as opposed to high insulin and insulin resistant states as would be seen in type 2 diabetes or obesity. So given what you are seeing it is possible the high sugars are from reta, or from reta plus tesamorelin, or from tesamorelin alone, but it seems pretty high for just tesamorelin.
You do realise I hope , that you are at risk of diabetic ketoacidosis at those sugar levels, and GLP drugs do make that more likely, and more dangerous, so assuming you have checked for ketones and do not have it , you will still need to closely monitor sugars and ketones and adjust insulin doses, and due to the long half life , even if you stop it , effects could last a couple of weeks.
Is your diabetes being managed by an endocrinologist? Who you can tell you were taking reta and tesa??? That would likely be the best solution, but it seems you are in the US, where telling your doctor things gets held against you. Obviously if you do start getting into ketosis, you will not get a choice and will need treatment and the doctors will need to know what is going on for your safety. Making them try to treat you in the dark, without that information would be dangerous.
I think from what I can tell, is you need to stop all of them, and closely monitor sugars and ketones. And I think reta is definitely not safe in type 1 diabetes at this point , as there is no research I can find on this combination and the glucagon agonism is important and different to the other GLP's in the context of type 1 diabetes, as I am not sure anyone knows what it will do.
Once the drugs get out of your system in a few weeks, it might be time to think about it. I really cannot recommend anything other than getting expert endocrinologist advice, and my guess is they are likely to be uncomfortable with you on any GLP. If you must take a GLP and without expert advice, and I have no knowledge as to why you are taking them, then semaglutide or tirzepatide are safer choices , in that at least there is some research on using them in type 1 diabetes, but I would not call them safe choices, and you would need to read and understand all the papers on the subject before considering it, and if this is not practical then using them is just too risky. And obviously only one peptide at a time, I would not even consider adding other peptides unless the dose and blood sugars were stable for a month or so first.
Please note , I am not an endocrinologist or a currently practicing doctor, and not particularly knowledgeable about type 1 diabetes. I may be over reacting , but I do consider your situation potentially dangerous based on limited information, and your best option is expert real medical advice.
