我今年41岁，男性，体重219磅（约98公斤）。我以前从未觉得自己胖，但根据BMI指数来看，我属于肥胖（我知道这个指数已经过时了）。上周日我开始服用0.5毫克，效果已经让我很惊讶了。第一天没什么感觉，但到了第二天，我的食欲就和平时不一样了。除了服用Reta之外，我的工作也比较耗费体力，而且我平时也会在健身房进行一些适度的举重训练。目前没有任何副作用，而且和一些帖子中提到的不同，我睡得像个婴儿一样香甜。希望我有时间更新这个帖子，分享一些对有类似经历的人有用的信息。欢迎大家提问。
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- Thread starter weightlossking84
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第四天。今天我休息，通常这意味着我会早起送老婆孩子上学，然后美美地享用一顿早餐，再喝杯咖啡。但现在我一点食欲都没有，这对于我这种过去几年一直保持规律作息的人来说，简直难以置信。除了测初始体重之外，我没有称过体重，但如果我记得的话，我会在周日发上来。
说实话，我原本计划服用0.5毫克，持续4周。但如果4周后效果依然良好，我觉得没必要增加剂量。我的目标体重是200磅左右，所以不想为了每周减掉5磅就把剂量增加到2毫克或4毫克。Diytrader said:
Totally messed my days up, today is 6 and obviously yesterday was 5. Sleep has been amazing. Not sure if I attribute that to no alcohol and healthy eating but either way I am enjoying it. Woke up today with a slight headache, felt like I had my protein and carbs yesterday so today I'm going to add electrolytes into some of my drinks. Weighing in Sunday and looking forward to it. This weekend I am going away with a few couples where food and drinks will be flowing. Im not worried about the eating but I am worried about the awful hangovers people have experienced. Will keep you guys updated.
That's great, welcome !
Last night for dinner, my wife and daughter wanted pizza.... So we had pizza lol. Never in my life have I ever had 1 slice and stopped. Well last night I did. Just couldn't do it. Not sure if it was a mental thing knowing that I'm on this journey or the reta working. I did eat half of a grilled chicken wrap so I could keep the calories up. Weighed in this morning at 216. Surprised I lost 3 pounds but happy at the same time. Tonight will be the big test, large group eating and drinking. Wish me luck!
Just wanted to add this as food for thought. I'm almost exactly 7 days from the first dose last Sunday ... Appetite is still very suppressed, really debating not pinning tomorrow and seeing how long I can go with this .5 still working. Does anyone have any experience with not pinning every 7 days?
Sure. Space it out however you want. Less is best. Just listen to you body. Sounds like you are responding great, like in the top 10% of responders ! You will be at target in no time. Keep up the protein intake and hit the gym too. Follow the scale sure but also follow your waist size, clothes fit and if possible body fat loss. Those scales are nice that do weight and body fat. As you go to the gym and work out and eat more protein you will put on muscle. It weighs more than fat but that’s good weight. If body fat is going down and weight is staying the same or going up slightly it is likely muscle that’s building. (it could be water weight as well as being full of shit however). Good luck!weightlossking84 said:
Ok so 1 full week. Down 3 pounds while having very very minimal side effects. Went out last night and had a few drinks, few beers and felt ok today. .5 pinned a few minutes ago. Looking forward to this week.
Not sure who is still following, but happy to say still no side effects. Sleeping like a baby, normal bowel movements, no nausea and plenty of energy. Only week 2 at .5mg but I feel great. I was off yesterday and a normal day around the house consists of me snacking all day. Zero desire to snack. Protein shake for breakfast, chicken salad for lunch and meatloaf and veggies for dinner. Keeping up with my lifting and would love to add cardio but it's still frigid here in NY, no treadmill at work which is where I do my lifting so it will have to wait .
For anyone still following, didn't eat enough yesterday and today was sluggish in the AM. Had breakfast for the first time in almost two weeks to get some calories in. I wake up at 4am and out the door by 415 so skipping isn't out of the ordinary. Weighing in Sunday but in 10+ days I honestly notice weight loss in my face and waist. When they say miracle drug, they aren't kidding.
You might find this dosage plotter helpful, it graphs concentration estimates according to GLP peptide, dosage and schedule.weightlossking84 said:
GLP-1 Plotter - Semaglutide (Ozempic/Wegovy) & Tirzepatide (Mounjaro) Dose Calculator
Plot graphs and calculate levels for GLP-1 Receptor Agonists Semaglutide (Ozempic/Wegovy/Rybelsus) or Tirzepatide (Mounjaro) based on dose & half-life.
glp1plotter.com
I just checked out the site and just had 1 question.. when it says "offset" does that mean days between doses or something else?RetCurious said:
Good question, made me look it up on Reddit where it was first announced by the author.
Here's one answer:
View: https://www.reddit.com/r/Semaglutide/comments/1gkfgyf/glp1_plotter_offset_days/
I'm finding the original release post helpful also:
View: https://www.reddit.com/r/Semaglutide/comments/142t642/plot_your_semaglutide_dose_glp1_plotter/
FWIW We started on the 9th with a .5 dosage of Reta and the peak concentration points so far are consistently where I've notice side effect symptoms.
Here's one answer:
View: https://www.reddit.com/r/Semaglutide/comments/1gkfgyf/glp1_plotter_offset_days/
I'm finding the original release post helpful also:
View: https://www.reddit.com/r/Semaglutide/comments/142t642/plot_your_semaglutide_dose_glp1_plotter/
FWIW We started on the 9th with a .5 dosage of Reta and the peak concentration points so far are consistently where I've notice side effect symptoms.
Re microdosing: I'm pretty sure I'm spinning my wheels and wasting product to cater to my cautious nature and we'll be going up in our dosage next (3rd) week... probably up it to 1mg for a couple of weeks, reevaluate and move to 2mg (the starting trial dose) for the next month.
This video kind of explains my thought process.
How To Properly Dose Retatrutide (And Why Microdosing Doesn't Work)
This video kind of explains my thought process.
How To Properly Dose Retatrutide (And Why Microdosing Doesn't Work)
Watching that, he compares 2mg/week to .1mg/day. I'm still working my way through it, but he seems to be conflating micro dosing and split dosing.RetCurious said:
He compares 2mg/week to .7mg/week, and says it "kinda sounds like you might be getting close to the same amount, right? Wrong." Who thinks that .7mg/week sounds the same as 2mg/week?
I don't know where he gets 2mg/week creates a "consistent amount in your system, about 3.6mg on average". It peaks at 3.6mg, troughs at 1.6mg, and averages 2.5mg.
Using what I think is his math (bolus, all instantly available vs a 24 hour absorption window, for example):
-If you take the 1mg twice a week, you end up with a peak of 3mg, trough of 2mg, and average of 2.5mg.
-If you take .285mg daily, the peak is 2.62mg, trough is 2.33mg, and the average is still 2.5mg.
-If you take 4mg every other week, the peak is 5mg, the trough is 1mg, and the average is still 2.5mg.
I agree that you need a minimum effective dose and half lives stack. Taking the same amount per week, split into multiple injections raises troughs and suppresses peaks, creating a tighter band of exposure/signaling (less variability).
Average amount is relatively irrelevant, otherwise we could take a dose once every 4 weeks (for example) and radically reduce the pin cushion effect. The problem with this is the symptoms would likely be massive, receptors could be blunted, and the adjustment window is very coarse. The way I think about it is peaks trigger symptoms and troughs need to be high enough to be therapeutically effective. Split dosing can reduce symptoms and keep the floor high enough to work.
Just for my own reference... Week 1 I took .5mg and by Saturday felt it wearing down. Week 2 also .5 and by Friday it was wearing off. This third week I stayed with .5 and by Friday again the appetite returned. I weighed in this morning 2 days past my normal weight in date and I was 2 lbs heavier. I'm not going to jump the gun and up my dose I'm going to stay patient. Based on a glp plotter it seems once I hit 4/5 weeks I should have a steady amount of reta in my system.
weightlossking84 said:
The voice of reason, I'll join you and hold till the full 4 weeks, thanks.
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