Why isn’t LLY talking up Reta in the news?

[indolent]

Ruh-tat-tru-tide? I've been saying ret-ta-tru-tide

Reht a TRU' Tied

 

[indolent]

Maybe [archived internal link]

 

[rsmith]

Too busy making money with product already on the market.

I agree. They are making a mint on Tirz and don't want to undercut their own profits until they are ready to roll out Reta. Oh, and that CEO dude needs to learn how to pronounce it correctly ( Reht a TRU' Tied per Indolent).

 

[indolent]

I agree. They are making a mint on Tirz and don't want to undercut their own profits until they are ready to roll out Reta. Oh, and that CEO dude needs to learn how to pronounce it correctly ( Reht a TRU' Tied per Indolent).

When I first saw the word, I thought it was pronounced the way the CEO did in @IshimaruKenta's link. But I'm pretty sure I then saw video showing him pronouncing it the way I typed in comment #22 here. Anyway, they'll find some even worse names for the brands.

 

[TRS123]

If they are worried about liver problems that would make sense why they aren’t saying anything

 

[ZippityDooDah]

Too busy making money with product already on the market.

This exactly.

IMHO, they are going to slow-walk reta to market in order to milk every last penny out of tirz that they can since it's almost guaranteed that the minute reta is FDA approved and available that everybody is going to want the new and shiny thing and demand for name-brand tirz is going to drop like a rock and prices probably along with it.

 

[PackmanJohnny]

This exactly.

IMHO, they are going to slow-walk reta to market in order to milk every last penny out of tirz that they can since it's almost guaranteed that the minute reta is FDA approved and available that everybody is going to want the new and shiny thing and demand for name-brand tirz is going to drop like a rock and prices probably along with it.

I am curious as to how exactly they time it and where they draw the line, because even with Tirz releasing Ozempic sales still grew 26% in 2024 and in 2025 through Q2 its up another 16% YOY. Novo is saying its slowing down but 16% sales growth would be exceptional in most industries(although with the cash cow pharma is that could be viewed differently).

If Tirz' growth mirrors or outpaces Sema's I wonder if they would sit on reta past approval to milk it further or if they even can.

 

[ZippityDooDah]

I am curious as to how exactly they time it and where they draw the line, because even with Tirz releasing Ozempic sales still grew 26% in 2024 and in 2025 through Q2 its up another 16% YOY. Novo is saying its slowing down but 16% sales growth would be exceptional in most industries(although with the cash cow pharma is that could be viewed differently).

If Tirz' growth mirrors or outpaces Sema's I wonder if they would sit on reta past approval to milk it further or if they even can.

I think a lot of it may depend on how the patent system impacts things. Obviously they will want to maximize their exclusivity window on every product, so I have to imagine they have entire teams of statisticians, financial analysts, etc. looking at every possible permutation to decide on the exact day, time, and phase of the moon for every little action they take lol.

Looking at the liraglutide->semaglutide progression at Novo and the dulaglutide->tirzepatide progression at Lilly may give some clues as to how and when future GLP's make it to market. It will be interesting to watch for sure.

 

[rsmith]

I think a lot of it may depend on how the patent system impacts things. Obviously they will want to maximize their exclusivity window on every product, so I have to imagine they have entire teams of statisticians, financial analysts, etc. looking at every possible permutation to decide on the exact day, time, and phase of the moon for every little action they take lol.

Looking at the liraglutide->semaglutide progression at Novo and the dulaglutide->tirzepatide progression at Lilly may give some clues as to how and when future GLP's make it to market. It will be interesting to watch for sure.

I think there is a risk of waiting too long to release retatrutide, given the supersonic development of other potentially more effective agents. For example, Bioglutide is a quadruple-receptor agonist and is in phase 2 trials as an oral formulation and as a combined formulation with other GLPs.

https://firstwordpharma.com/story/5991011#:~:text=NA%2D931%20(Bioglutide%E2%84%A2)%E2%80%94an%20investigational%2C%20oral,many%20of%20which%20are%20injectable

Supposedly, Bioglutide works better, faster, with fewer side effects and causes minimal bone/muscle loss. Best of all, it makes you instantly well-hung, that's right, instantly well-hung (ok, I might have dreamt that last part ).

 

[hexagonal]

If they have serious concerns about liver damage they wouldn't be continuing the trials. Lilly wouldn't want to risk it themselves, but even if they were, TRIUMPH and all the other phase 3 trials I can find have independent data monitoring committees. These committees exist to review the data and pull the plug if there looks to be the sort of health concerns that could cause a drug to fail approval.

 

[ZippityDooDah]

I think there is a risk of waiting too long to release retatrutide, given the supersonic development of other potentially more effective agents. For example, Bioglutide is a quadruple-receptor agonist and is in phase 2 trials as an oral formulation and as a combined formulation with other GLPs.

https://firstwordpharma.com/story/5991011#:~:text=NA%2D931%20(Bioglutide%E2%84%A2)%E2%80%94an%20investigational%2C%20oral,many%20of%20which%20are%20injectable

Supposedly, Bioglutide works better, faster, with fewer side effects and causes minimal bone/muscle loss. Best of all, it makes you instantly well-hung, that's right, instantly well-hung (ok, I might have dreamt that last part ).

Part of me will always be fascinated by what kind of processes take place behind the scenes at big pharma companies making these kinds of decisions. I suspect it's pretty chaotic and and never-ending battle of countless "experts" one-upping each other's expertise and the biggest decisions coming down to a coin toss lol.