What to add?

[Delphyne 30738]

Hello,

the more I read about the individual peptides the more I think I need it, so basically I would need at least 20 different ones at the same time which is obviously not possible. I was wondering where to start adding to Tirz.

About myself. Female and in my sixties and have been obese all my life. Had a stroke 3 years ago weighing 340 pounds. I had gastric bypass just over two years ago and lost approx. 70 pounds and then it stopped. Heard about Mounjaro and took it about 11 months and lost another 44 pounds, but have been stalling for 3-4 months. Went up to 7,5 mg and have been using gray Tirz for one month now. Will titrate up to 10 next month and see if I can jump start the weight loss again.

What was your trick/additional peptide that helped you with further weight loss? I need to lose at least another 50 pounds to be in good place. Thinking of adding Reta or Cagri. Also thinking about GHK-cu as my skin is getting quite saggy - then I thing I should repair my mitochondia....a lot in my head.

Any suggestions?

 

[HereKittyKitty]

Congratulations on your successes!

No suggestions. I am researching stacking with Tz so will be following along.

I hope you get good information.

Are you also on Peppy's or other forums/groups?

 

[AcadiaPeptides]

After much reading I am about to start stacking low dose Reta on my weekly 7mg of Tirz. Each once a week on different days.

 

[Calm Logic]

How are your lab results? How is your blood pressure?

Went up to 7,5 mg and have been using gray Tirz for one month now. Will titrate up to 10 next month and see if I can jump start the weight loss again.

Sounds good to me. Upping the dose of tirz is certainly easy breezy compared to adding reta, without having to worry about reta's effect on heart rate. To me, cagri is overrated, which is why reta and tirz are mentioned way more often.

Often, when feeling more rational, my preference for dealing with a non-moving scale is to focus on labs instead or muscle gain (body recomposition). So sometimes I am very patient, taking the long way home with these non-scale victories. I have been at 200 for months now. But I can fit into smaller-sized pants/shorts, despite being the same weight.

 

[Delphyne 30738]

How are your lab results? How is your blood pressure?

Sounds good to me. Upping the dose of tirz is certainly easy breezy compared to adding reta, without having to worry about reta's effect on heart rate. To me, cagri is overrated, which is why reta and tirz are mentioned way more often.

Often, when feeling more rational, my preference for dealing with a non-moving scale is to focus on labs instead or muscle gain (body recomposition). So sometimes I am very patient, taking the long way home with these non-scale victories. I have been at 200 for months now. But I can fit into smaller-sized pants/shorts, despite being the same weight.

I just had my bloodwork done two weeks a ago and it was excellent. My A1c was at 5.3, but I was never diabetic but it reached 6.0 a few years ago. I stopped taking medication for slightly higher T3/T4 but stopped last June and my readings were perfect. Maybe I hold off on Reta and start adding Glow/Klow for my skin. Is it really that stingy? That worries my a bit.

My high blood pressure is the only one that did not go away after weight loss. Still around 140/90 with 10 mg of Lercanidipin.

 

[lessthanhalf]

Given you have previously had a stroke is there a reason why your blood pressure is not being treated to get it closer to 120/80? Off the top of my head I cannot think of a lot of reasons to leave it at 140/90 which is high enough to put you at increased risks of further strokes or other cardiovascular disease. Do you measure it yourself at home?, do you have lots of readings? Have you discussed this with your doctor? Undertreating high blood pressure is very common. In the longer term the tirzepatide might reduce blood pressure a bit, but given the stroke I would suggest treating it sooner rather than later, or at least talking with your doctor about it, and if it drops with further weight loss the extra treatment might be no longer needed but would be safer in the interim.

 

[RubbaDubba1]

I've used the SLU-PP-332 and 5-Amino-1MQ, during my 2 worst stalls. The 5 Amino 1, worked the best between the 2 while changing nothing else. This is simply anecdotal on my part and I took the pill version 5-Amino at the time, but there is a shot available now which I assume would work better being more bioavailable.

Good work btw, I was damn near 600lbs and it took WLS and a GLP1 to get me where I am 179lbs. You got dis!

 

[HereKittyKitty]

I've used the SLU-PP-332 and 5-Amino-1MQ, during my 2 worst stalls. The 5 Amino 1, worked the best between the 2 while changing nothing else. This is simply anecdotal on my part and I took the pill version 5-Amino at the time, but there is a shot available now which I assume would work better being more bioavailable.

Good work btw, I was damn near 600lbs and it took WLS and a GLP1 to get me where I am 179lbs. You got dis!

Fantastic success!

 

[Delphyne 30738]

I've used the SLU-PP-332 and 5-Amino-1MQ, during my 2 worst stalls. The 5 Amino 1, worked the best between the 2 while changing nothing else. This is simply anecdotal on my part and I took the pill version 5-Amino at the time, but there is a shot available now which I assume would work better being more bioavailable.

Good work btw, I was damn near 600lbs and it took WLS and a GLP1 to get me where I am 179lbs. You got dis!

Congratulation. Sometimes it takes WLS and GLP-1 to reach goal

 

[Calm Logic]

I just had my bloodwork done two weeks a ago and it was excellent. My A1c was at 5.3, but I was never diabetic but it reached 6.0 a few years ago.

So lipids were good too?

Do they check vitamin D over there? They barely check it here, unless you ask for it. "Vitamin D deficiency is frequently linked to arterial stiffness and hypertension, and standard panels often overlook it" (Google Gemini).

My high blood pressure is the only one that did not go away after weight loss. Still around 140/90 with 10 mg of Lercanidipin.

Yeah, I would have a "come to Jesus" over this. In other words, I would be religious about it. Have you tried the DASH diet? Lots of medical diets for blood pressure, including starch-based with the late John McDougall. He became a doctor and medical researcher after having a massive stroke at age 18, and the doctors were mostly worthless for him back then. He attributed the stroke to a Western diet, smoking, and bad genes, and he was influenced by the rice diet at Duke University by Dr. Walter Kempner.

I realize the docs now can get whatever number you want with enough meds, but the anabolic steroid users are a good example of why lab results and vitals are not enough.

I have also found intermittent fasting appealing since it is less restrictive in a way. I do eat out a few times a week at least, like at my favorite Mexican restaurant. I use Gemini to help me order, like what kind of customizations to make. It already knows what is on the menu, usually.

 

[Delphyne 30738]

So lipids were good too?

Do they check vitamin D over there? They barely check it here, unless you ask for it. "Vitamin D deficiency is frequently linked to arterial stiffness and hypertension, and standard panels often overlook it" (Google Gemini).

Yeah, I would have a "come to Jesus" over this. In other words, I would be religious about it. Have you tried the DASH diet ? Lots of medical diets for blood pressure, including starch-based with the late John McDougall. He became a doctor and medical researcher after having a massive stroke at age 18, and the doctors were mostly worthless for him back then. He attributed the stroke to a Western diet, smoking, and bad genes, and he was influenced by the rice diet at Duke University by Dr. Walter Kempner.

I realize the docs now can get whatever number you want with enough meds, but the anabolic steroid users are a good example of why lab results and vitals are not enough .

I have also found intermittent fasting appealing since it is less restrictive in a way. I do eat out a few times a week at least, like at my favorite Mexican restaurant. I use Gemini to help me order, like what kind of customizations to make. It already knows what is on the menu, usually.

Yes, my lipids were good. Good HDL, LDL was a little bit elevated since I eat keto every now and then so I am not worried about that. I had a CAC scan when I had my stroke and my arteries are clear therefore I am refusing statins.

My vitamin D was a bit low so I am taking a supplement right now.

I will watch my blood pressure more regularly. An hour ago it was 135`:80 which is good enough for me.

 

[Calm Logic]

An hour ago it was 135`:80 which is good enough for me.

Okay.... Your thinking there still seems very old school, unless your doctor is the one with the old school thinking.

Some supplements can help with blood pressure too, sometimes surprisingly so.

 

[Delphyne 30738]

Okay.... Your thinking there still seems very old school, unless your doctor is the one with the old school thinking.

Can you explain more, please?

 

[Calm Logic]

Systolic Blood Pressure Intervention Trial - American College of Cardiology

Dharam J. Kumbhani, MD, SM, FACC

www.acc.org

"Intensive BP control to SBP <120 mm Hg results in significant cardiovascular benefit in high-risk patients with hypertension compared with routine BP control to <140 mm Hg."

 

[PAPoots]

I have a similar question. I have stalled on Reta. I worked my way to 12mg, but the sleep deprivation was tearing me up. And I stalled. So, I have dropped to 8mg weekly on Sundays to improve my sleep. It has helped a little. My scores went from the 40-50s to 60-75. Still not great, but I don't have crazy night sweats every night and I don't wake up like clockwork every hour or two. Now I wake up twice at the most, but I can get back to sleep relatively quickly.

I'm thinking of getting cagri, since towards the end of the week my appetite becomes ferocious.

I tried Tesamorelin to help with the visceral fat, but after about a month I got carpal tunnel in both hands so bad the pain would keep me up at night. I'd wake up and have to shake out my arms and move my fingers to get feeling back.

Is a low dose of Cagri the best option when combined with my Reta. I don't want to starve, since I am taking test and trying to get about 200 grams of protein a day to keep the muscle gains.

 

[Calm Logic]

I'm thinking of getting cagri, since towards the end of the week my appetite becomes ferocious.

Have you tried splitting the dose of reta to twice a week? That can also help with side effects, to some degree.

The biggest problem with cagri, to me, is waiting around for the miracle to happen (getting the dose right). And then sooner or later, it is known to not work as well (based on reports here by veteran members). So a stall buster, at best. OTOH, still some FOMO out there with cagri. So why deny yourself, haha.

It seems a lot easier to me to just up the GLP (which is safer with split dosing) than to add cagri, or even to make dietary optimizations for the long-term. Personally, I have been cutting back on coffee creamer, doing more intermittent fasting (which is easier with my H/GH fasting ritual), having more pickled veggies, rarely using butter, etc. I am motivated largely because of side effects with higher doses of GLPs.

 

[PAPoots]

Have you tried splitting the dose of reta to twice a week? That can also help with side effects, to some degree.

The biggest problem with cagri, to me, is waiting around for the miracle to happen (getting the dose right). And then sooner or later, it is known to not work as well (based on reports here by veteran members). So a stall buster, at best. OTOH, still some FOMO out there with cagri. So why deny yourself, haha.

It seems a lot easier to me to just up the GLP (which is safer with split dosing) than to add cagri, or even to make dietary optimizations for the long-term. Personally, I have been cutting back on coffee creamer, doing more intermittent fasting (which is easier with my H/GH fasting ritual), having more pickled veggies, rarely using butter, etc. I am motivated largely because of side effects with higher doses of GLPs.

I tried split dosing and for some reason it did not work much better than taking once a week. Plus my sleep was worse. I took my 8mg dose yesterday and it is a struggle to not go down and eat. Yet I have to occasionally to get my protein in. If I IF during the day, I miss my protein goal. I probably need some hypnosis. ;-)

I guess I'll order more salads and fight through the struggle of wanting more.

 

[designing677]

After much reading I am about to start stacking low dose Reta on my weekly 7mg of Tirz. Each once a week on different days.

What led you to that decision? Rather than upping your tirz dose?

 

[Calm Logic]

To get an idea of cagri's effectiveness (or lack thereof):

News Details

www.novonordisk.com

People treated with CagriSema achieved a superior weight loss of 22.7% after 68 weeks compared to a reduction of 11.8% with cagrilintide 2.4 mg , 16.1% with semaglutide 2.4 mg and 2.3% with placebo alone.

In addition, 40.4% of patients who received CagriSema reached a weight loss of 25% or more after 68 weeks, compared to 6.0% with cagrilintide 2.4 mg , 16.2% with semaglutide 2.4 mg, and 0.9% with placebo.

 

[AcadiaPeptides]

What led you to that decision? Rather than upping your tirz dose?

Shiny object envy probably. I have years of tirz stocked at my current dose but already know I need to titrate up soon. Reta being the new up and coming hotness seems like an interesting add to perhaps glean some of its unique qualities?