What Percentage of Body Weight Have You Lost?

[desinr-gal]

I am 19% down, and today I fit into that pair of pants I bought years ago that were always too tight! NSV!!

 

[bogardbilla]

13.4% since September 28 2025

 

[Slogger]

16% since June

 

[Grogu]

90lbs down 12 months (27%)

On tirzepatide that entire year and just recently added mid-week stack of sema.

 

[annessa77]

I was looking at the mouse study on Retatrutide and cancer. https://www.nature.com/articles/s44324-025-00054-5 The cancer implications are very interesting on its own, but that is not the purpose of this post. The other thing that caught my eye in the study is that the mice lost 40% to 41% of body weight and stabilized there. We have the Phase II data of 24.2%, but people were still losing weight after 48 weeks. There is no published data on when it plateaus. EL has extended the studies, so it looks like they are trying to find that out.

I have been stacking Tirz and Reta for 8 1/2 months. I have lost 35% of my body weight and I am still losing. I would like to get down to 40% to reach my ideal weight. My question is for people on maintenance or close to maintenance; what percentage of your body weight have you lost? Has anyone hit 40%, or more?

I started Tirz in August and have lost 22% of my weight so far. I have not added exercise in yet because I was large and dis not more around the best. I will be adding cardio starting Monday. I am still on about 5mg may have to move up from getting a little food noise. I am happy so far with the progress and now losing about 2 lbs a week.

 

[MrZardoz]

I started using Tirz in July '25, with BMI of 47.6 -start weight 322 pounds. Now, after a few months when things slowed down, mixing a little Reta into the mix to offset the lengthy plateaus , I am now BMI 38.2 - current weight 258 pounds. Lost 63.2 pounds - have 117 pounds remaining. Rule of thumb: keep going and doing the shots

 

[CNCCurrency]

I started 8/15 and am down 65 pounds

 

[ambot88]

17% down (35lbs) since September 19. only Reta. I love it so much. I'm still overweight but not obese for the first time in years, I didn't think 35lbs would be THAT big a difference, but it really has improved almost every quality of my day to day life.

 

[Such1943]

45M 5'6"

Jan 1, 2024

Weight: 281 lb

BMI: 44.1

Today

Weight: 201.5 lb

BMI: 32.4

Change

Weight loss: 79.5 lb

BMI reduction: 11.7 points

Body weight lost: ~28% of your starting weight

BMI isn’t a great indicator for me, never has been.

 

[Grogu]

BMI isn’t a great indicator for me, never has been.

Yeah, I think that it's widely accepted that BMI is not the best indicator for many, especially for tall or short people. Doesn't work for me either.

 

[JuneBug1956]

44%. From 250 to 140 lbs. Took 2 years.

 

[cygnus]

13% down using semaglutide for a couple months followed by a break and then retatrutide for the last month and a half, but my goal was 27% loss in total on a very slow cut so it all feels within reason. So long as I see a positive trend, feel good, and hold onto my muscle mass, I will be quite happy -- so far, so good on all accounts.

 

[Grogu]

44%. From 250 to 140 lbs. Took 2 years.

Wow! That's fantastic, congratulations. I'm wondering if you were able lose that all on tirzepatide? Or did you transition to a new medication or stack? I'm at one year and at 27% and need to lose another 12% of my starting weight and just hope that I can get there.

 

[JuneBug1956]

Wow! That's fantastic, congratulations. I'm wondering if you were able lose that all on tirzepatide? Or did you transition to a new medication or stack? I'm at one year and at 27% and need to lose another 12% of my starting weight and just hope that I can get there.

I started with Tirz for about 6-8 months. Lost @ 70 lbs my first year. I then added Sema for more appetite suppression. Eventually added Tesofensine. The last addition for the win was Cagri. I am still on all of the above but working my way down in my mg dose. I have stopped the Tesofensine. Presently on Tirz 10 mg every week, Sema 2 mg weekly ( 2 days after the Tirz and then Cagri 2 mg day 5 after the Tirz and done weekly. Love them all. Constipation is my only side but handle with miralax. Cagri and Teso warm me up. Tirz and Sema keep me cold. No fatigue, more energy.

 

[Glenn]

47%. 445lbs to 237 in about 2 years. Still slowly dropping some weight but I've been concentrating on gaining muscle. I'm 60 years old now.

 

[jordekorn]

21% in 11 months, with 2.5 mg tirzepatide, I finally went up to 5mg possibly 2 months or less ago.

 

[Grogu]

I started with Tirz for about 6-8 months. Lost @ 70 lbs my first year. I then added Sema for more appetite suppression. Eventually added Tesofensine. The last addition for the win was Cagri. I am still on all of the above but working my way down in my mg dose. I have stopped the Tesofensine. Presently on Tirz 10 mg every week, Sema 2 mg weekly ( 2 days after the Tirz and then Cagri 2 mg day 5 after the Tirz and done weekly. Love them all. Constipation is my only side but handle with miralax. Cagri and Teso warm me up. Tirz and Sema keep me cold. No fatigue, more energy.

Thanks for the information! Hugely helpful. I just added sema on the third day after my current 15mg weekly dose of tirzepatide and I really like the feel. I'm going to try to ride this stack as long as possible and then add a third medication.

 

[Chucky]

I

I have no particular study, but have read that Cagrilintide works on the homeostatic and hedonic centers of the brain. So I'm assuming it clicks that sensor for me, I was a bit of a hedonist in my younger years! I had already started reducing my pain meds, but once starting Cagri it was easy. I haven't missed it a bit. Its a miracle really. Google “Cagrilintide hedonic”, you can probably find more there.

I just started on Cagri and will stop taking tesa as I don't think it' worth taking till I drop some more weight. I take it in conjunction with Reta and while Reta helps with the food noise, my angry sugar cravings were in overdrive. Since I started on Cagri, no more sugar crazing's and can walk past the confectionary isle at the supermarket without even so much as a look at my favourite lollies.

 

[TexasHoneybadger]

I’ve lost 18.6% of my body weight originally 215 now at 175

 

[Tbagger]

I have gone from 295 to 210 this year. So I’ve lost approximately 30% of my total weight so far. My 2026 goal is 15% body fat. I’ve never been at or below 15%, even when I was in basic training at 18 years old, so I’m pretty excited to have a 6pack for the first time in my life at age 42!