What dose of reta are you at?

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5’10-215lbs 49 yrs old

Week 1-2: 1mg

Week 3-4 1.5 mg

Week 4-7 2mg

Starting weight was 228lbs down 13 lbs

I pin tomorrow and was thinking about going to 3mg. I get very little to any food noise suppression. But I’m losing weight. Just frustrated that I still want to eat chocolate and drink beer all of the time! I do get fuller faster and have better control when eating but want that suppression. Any thought on going up to 3mg? Should I stick with my pattern and go to 2.5? Or should I add Tirz for the appetite control?
 
Started at 2mg, bumped to 3mg after 4 weeks and now at 4mg for the last 3 weeks. Only down 3lbs, but seeing some nice body recomp results so far.
 
Started on 1.5mg, then week 2/3 went to 2mg. My fourth week coming up, I will bump to 3mg.

Definitely losing weight about 4kg so far, but have been having mild headaches sometimes, been eating super clean, no sugar, and drinking loads of water. Not sure whats causing the headaches.
 
Imfrijole said:
5’10-215lbs 49 yrs old

Week 1-2: 1mg

Week 3-4 1.5 mg

Week 4-7 2mg

Starting weight was 228lbs down 13 lbs

I pin tomorrow and was thinking about going to 3mg. I get very little to any food noise suppression. But I’m losing weight. Just frustrated that I still want to eat chocolate and drink beer all of the time! I do get fuller faster and have better control when eating but want that suppression. Any thought on going up to 3mg? Should I stick with my pattern and go to 2.5? Or should I add Tirz for the appetite control?
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If you have no side effects, mainly no nausea, and you are hungry, then increasing the dose is fairly low risk. Usually you will get some indication of adverse effects below the dose where they really kick in, like mild nausea at 3mg would suggest that going to 4mg it is going to be worse. The problem with increasing doses at any stage or to any degree is of worse side effects, and if you are unlucky then they can hit pretty hard, and you end up nauseous or worse puking for a week. The odds of this happening are never going to be zero, no matter how careful you are and how slowly you increase doses, but it is much more likely if you increase doses quickly. In the studies the worst gastrointestinal side effects were typically at the 2 - 4 month stage where doses were increasing, so for tirz around 5-10mg and reta 4-8mg, and then very slowly improved. It does not sound like you need to increase doses based on weight loss, but hunger control is a major part of making weight loss sustainable and wanting to or eating chocolate and drinking beer does not sound like reasonable hunger control

The simplest way to reduce this risk while increasing doses is to dose smaller more often, as side effects are nearly always worst at peak levels, 24 to 48 hours after a dose. But you need to look at GLP plotter and play with it a bit to see what happens with different doses and timings. So at your current dose of 2mg , you could add 1mg half way between doses and see what happens.

It is important to know that the half life of a week means that drug levels will continue to rise for up to 4 weeks after a dose increase, so that peak side effects might be after the 4th dose at a new level - look at glp plotter

If you cannot be bothered with twice a week dosing the risks of increasing to 2.5 with zero side effects at 2mg are very small. And increasing to 3mg is pretty unlikely to cause problems either. But still check out GLP plotter , it makes the doses and timing and side effects make more sense, as the weird pharmacokinetics of GLP's are the opposite of intuitive, and totally different to just about every other drug in existence.
 
Distinct said:
Started on 1.5mg, then week 2/3 went to 2mg. My fourth week coming up, I will bump to 3mg.

Definitely losing weight about 4kg so far, but have been having mild headaches sometimes, been eating super clean, no sugar, and drinking loads of water. Not sure whats causing the headaches.
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Not sure what is causing the headaches, maybe if salt intake is low due to eating less and water intake too high, it could cause issues? Any environmental change including what types or amounts of food eaten can trigger headaches. I had a whole week of waking up at 5am with migraines after starting reta, thankfully they went away pretty quickly with triptans, but kept coming back which I had never had before, but then they went away and did not happen again.

As the drug has a half life of 6 days, peak drug effects and side effects can take up to 4 weeks to occur, which is the reason for increasing doses every 4 weeks. If you are going to do it differently look up GLP plotter, so you can see what blood levels of the drug look like on a graph it makes it easier to understand what is going on. The only real risk of increasing doses more or faster than the standard recommended arrangement is worse side effects. If it is a bit of nausea or constipation it is not a big deal but if you are puking non stop for a week it is a pretty major problem. You need to understand the trade offs of getting a faster response to the medication versus the added risks of worse side effects, and as the drug has a half life of 6 days, side effects can last a long time, usually they are worst 24 to 48 hours after a dose but can last a week or more if you are unlucky.

So increasing to 3mg at 4 weeks is not especially risky, given the standard arrangement is 2mg for 4 weeks then 4mg for 4 weeks, so you are still going slower than that, but still check out glpplotter so you have a better idea of what drug levels are doing over time , it really helps to make sense of the effects and side effects and their timing.
 
Imfrijole said:
5’10-215lbs 49 yrs old

Week 1-2: 1mg

Week 3-4 1.5 mg

Week 4-7 2mg

Starting weight was 228lbs down 13 lbs

I pin tomorrow and was thinking about going to 3mg. I get very little to any food noise suppression. But I’m losing weight. Just frustrated that I still want to eat chocolate and drink beer all of the time! I do get fuller faster and have better control when eating but want that suppression. Any thought on going up to 3mg? Should I stick with my pattern and go to 2.5? Or should I add Tirz for the appetite control?
Click to expand...
Take the dosage up to 4mg.

I have started with 2mg initially but then food cravings started. Have been on 4mg the last few months. Have lost a lot of weight. Zero food noise.
 
lessthanhalf said:
If you have no side effects, mainly no nausea, and you are hungry, then increasing the dose is fairly low risk. Usually you will get some indication of adverse effects below the dose where they really kick in, like mild nausea at 3mg would suggest that going to 4mg it is going to be worse. The problem with increasing doses at any stage or to any degree is of worse side effects, and if you are unlucky then they can hit pretty hard, and you end up nauseous or worse puking for a week. The odds of this happening are never going to be zero, no matter how careful you are and how slowly you increase doses, but it is much more likely if you increase doses quickly. In the studies the worst gastrointestinal side effects were typically at the 2 - 4 month stage where doses were increasing, so for tirz around 5-10mg and reta 4-8mg, and then very slowly improved. It does not sound like you need to increase doses based on weight loss, but hunger control is a major part of making weight loss sustainable and wanting to or eating chocolate and drinking beer does not sound like reasonable hunger control

The simplest way to reduce this risk while increasing doses is to dose smaller more often, as side effects are nearly always worst at peak levels, 24 to 48 hours after a dose. But you need to look at GLP plotter and play with it a bit to see what happens with different doses and timings. So at your current dose of 2mg , you could add 1mg half way between doses and see what happens.

It is important to know that the half life of a week means that drug levels will continue to rise for up to 4 weeks after a dose increase, so that peak side effects might be after the 4th dose at a new level - look at glp plotter

If you cannot be bothered with twice a week dosing the risks of increasing to 2.5 with zero side effects at 2mg are very small. And increasing to 3mg is pretty unlikely to cause problems either. But still check out GLP plotter , it makes the doses and timing and side effects make more sense, as the weird pharmacokinetics of GLP's are the opposite of intuitive, and totally different to just about every other drug in existence.
Click to expand...
Thanks!
 
I am about 7-8 months in & play between 5-6mg weekly depending on how my body reacts the previous week.

At this point I feel no need to go any higher. When I have previously, I didn't eat for 5 days out of 7 😳

I've lost 20 kilos by doing with minimal effort!
 
Started Jan 2nd at 1.5mg. Stayed there for 4 weeks and then went up to 2mg until I hit my weight-loss goal. I am back down to 1.5mg per week trying to titrate down to a maintenance dose of 0.5mg per week.
 
My wife and I have been at 6mg for 6 weeks, and will likely go to 7mg depending on the scale Friday. She hasn't much appetite suppression and isn't losing. How she knows, as she wont weigh herself. I have no clue.
 
Wife and I started 6 weeks ago; she started with Tirz at 2.5/1wk. I started with Reta at 2.5mg/wk. She has lost about 18lbs and I have dropped 28lbs.

I definitely regret not starting at .5 and titrating up. I allowed my emotions to get the best of me when I made the choice to start on the larger scale of doses. It’s taken my body some time to recover from a 2.5mg start on Reta.
 
6'1"-307lbs 51 yrs old

I've been at 1mg for 7 weeks.

Starting weight was 328lbs down 21 lbs

Waist has dropped 3.5", so visceral fat is going quick.

According to superpower.com AI, I've most likely lost 15lb fat, 5lb lean, with 4.5-6lbs of that being visceral based on waist changes. Total weight loss is about 2.8lbs/week so far.

I have no appetite issues, no adverse symptoms, and I'm still losing so I see no need to titrate up for now. If my appetite causes me problems, I plateau for a couple of weeks, or the visceral fat loss slow, I'll move up.

Reta really is a boutique treatment...should be tailored for each person. Don't just go by the internet dosing (lots of guesswork) or the clinical trials (lean hard on speed to get the trials done).
 
Driftroot said:
Wife and I started 6 weeks ago; she started with Tirz at 2.5/1wk. I started with Reta at 2.5mg/wk. She has lost about 18lbs and I have dropped 28lbs.
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Losing 4.5lbs a week for you is a tad quick in my opinion.
 
catrix said:
View: https://www.youtube.com/watch?v=PEbu7E8QB_Y&t
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Not 100% on this article. I was thinking more like 1/2 dose of each to maybe lessen the unwanted side effects of reta while possibly maintaining the benefits.

I can see how a full dose of each may not be the best thing.
 
Middle of week 3 for me! Taking 0.75mg per week at the moment. Will titrate up to 1mg week 5 and then reassess my dosing plan
 
Jaybird57 said:
Middle of week 3 for me! Taking 0.75mg per week at the moment. Will titrate up to 1mg week 5 and then reassess my dosing plan
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How much do you load in the syringe?
 
Jaylar said:
Hi am also from the UK and have just started on reta I got from a Chinese supplier also got some selank which is great too.
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I’m in Lichfield. Been on Reta for a couple of months and just got into this. I’m awaiting some Semax, I regret not tagging on some sealant also. I’m interested in its benefits
 
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