What dose of reta are you at?

[Nopenada]

From just a 0.5mg increase?

Yes. I had fatigue as a side effect before the jump. I knew I was risking more fatigue but the vomiting and GI issues are new.

 

[chavez636]

Jumped from 7.5mg of Tirz to 2mg twice weekly of Reta. Running this for 3 weeks now and appetite suppression is good with no sides so will stay at this dose as long as I can. I like the the concept of minimum effective dose and running it as long as possible.

 

[Lyophilized]

Starting my transition since the last week from January

Titrating up Reta slowly but even with this small dose (now 0.35mg every two days) I'm already "feeling"

Tirz was working.. But I started to feel very fatigue and depressed.. Now I'm better

 

[Lyophilized]

 

[ronin365]

I titrated aggressively from 1 to 6 mg in about a month's time. Been at 5 mg since late last year, after experiencing meat aversion at 6 mg. Just increased to 6 mg last week and only have minor altered skin sensations —otherwise no other side effects. I started Reta before the holidays last year and observed a steady decline beginning in December. Gone from 317 lbs to 276 as of last week.

 

[Lyophilized]

I titrated aggressively from 1 to 6 mg in about a month's time. Been at 5 mg since late last year, after experiencing meat aversion at 6 mg. Just increased to 6 mg last week and only have minor altered skin sensations —otherwise no other side effects. I started Reta before the holidays last year and observed a steady decline beginning in December. Gone from 317 lbs to 276 as of last week.

Can I ask if you monitor your heart rate?

 

[woundcarping]

Can I ask if you monitor your heart rate?

I do. I copied my post from earlier this month, I thought I was going to level off at 7mg/week but continued moving up. I'm at 9mg taken in the last week, I figure I'm going to be somewhere between 8-10mg/week leveling off (time will tell).

Click to jump back to that post if you want to see those attached pictures.

I’m leveling off at 7mg/week after starting my bridge from Tirz on 1/10.

 

[Speak_Easy]

I know everyone is different but I read a lot of posts where people start at low doses and don't need to titrate up that high of a dose.

I'm curious as to if people go all the way up to 12mg like in the clinical trials, if if they have reaped most benefits at lower doses.

So my question is:

How long have you been taking Reta for?

Where along are you in your journey?

What is your current dosage?

I'm on Reta 2mg every 3.5 days to minimize sides, then intend to get to dose the whole 4mg every 5-6 days. I previously lost 20 lbs on Tirz, switched to Reta slowly about 8 weeks ago, titrated up .5 a week. I've lost a few lbs in those few weeks. My plan is to stay at 4mg for the next few weeks and see where I am at before I make further adjustments.

 

[headward]

Why do people do 'lowest effective dose'? Why not just try to hit the 12mg max asap if that is what the trials show work? Is it to minimize side effects or to save money? Seems the cost savings are minimal with a lower dose.

 

[RoadRash]

I know everyone is different but I read a lot of posts where people start at low doses and don't need to titrate up that high of a dose.

I'm curious as to if people go all the way up to 12mg like in the clinical trials, if if they have reaped most benefits at lower doses.

So my question is:

How long have you been taking Reta for?

Where along are you in your journey?

What is your current dosage?

I started on 2 mg/ weekly and titrated up after two weeks to 4 mg/ weekly and will be at 4 mg for awhile. I started at 246 and after 5 weeks I'm at 228. Amazing. I am experiencing skin sensitivity which is irritating but other than that Im doing terrific.

 

[Muffyflowers]

Why do people do 'lowest effective dose'? Why not just try to hit the 12mg max asap if that is what the trials show work? Is it to minimize side effects or to save money? Seems the cost savings are minimal with a lower dose.

For me, money, sure. Also, if I rush to the highest dose asap, I’m probably missing some fat loss, possibly burning more muscle, and definitely losing faster than skin can adjust.

 

[ronin365]

Can I ask if you monitor your heart rate?

I do monitor it. For the record I have had an elevated heart rate for a long time. Early last year my resting heart rate was consistently in the low 80s. When I started my new health regimen in July (diet, gym, walking, TRT) my resting heart rate dipped below 80 in August and began to rise again and was back to the low 80s in October. I started Reta at the end of October, and my bpm rose a bit more, peaking in the high 80s in mid-December. But since then to now, its been dropping. I am back in the low 80s and the trend line shows this will likely drop some more. So while I did see a bump up in heart rate from Reta, it appears to have been temporary.

 

[exploitedworkerbee]

Why do people do 'lowest effective dose'? Why not just try to hit the 12mg max asap if that is what the trials show work? Is it to minimize side effects or to save money? Seems the cost savings are minimal with a lower dose.

Because once you’re at the max you’ve been painted into a corner when tolerance kicks in. If you’re at a lower dose you can increase. If you’re at max dose you can either start stacking or exceed max, but that’s about it. So prob best not to rush to an unnecessarily high dose.

 

[Gr33dyOctopus]

Because once you’re at the max you’ve been painted into a corner when tolerance kicks in. If you’re at a lower dose you can increase. If you’re at max dose you can either start stacking or exceed max, but that’s about it. So prob best not to rush to an unnecessarily high dose.

This.

 

[390120]

I started on 2 mg/ weekly and titrated up after two weeks to 4 mg/ weekly and will be at 4 mg for awhile. I started at 246 and after 5 weeks I'm at 228. Amazing. I am experiencing skin sensitivity which is irritating but other than that Im doing terrific.

I did the exact same as you and I’m also experiencing the skin sensitivity. Annoying on legs and stomach

 

[RoadRash]

I did the exact same as you and I’m also experiencing the skin sensitivity. Annoying on legs and stomach

It is really annoying, for me it's everywhere from head down to my ankles. Other than that, I'm loving it.

 

[chavez636]

The main side after 3 weeks at 4mg week in a split dose is a slightly elevated heart rate. I am hoping this will go back to normal in time as I have no plans in coming off Reta, Ever. My diet is so much more healthy and no mental food cravings.

 

[RetCurious]

What exactly is "skin sensitivity"... pain, itch, burning or?

Are the symptoms localized or wide spread?

Do they present as a rash or raised surface?

 

[Speak_Easy]

I'm in week #4 of 2mg. Lost 11lbs in first 2 weeks and 2lbs week #3.

I'm was considering heading up to 4mg this Sat (dose day).

Food noise is less but I also lock down into eating right really well. I have an appetite but also wouldn't have to eat, if that makes sense.

I think phase #3 trial held the dose for 4 weeks before titrating up.

I've read that by week #4 I'm finally getting the max effect or steady state of the 2mg dose.

Should I do all 4 weeks on 2mg? Anyone have thoughts? I'm honestly excited for more aggressive weight loss but can be patient too.

I titrated up to 4mg .5mg a week to get there faster and avoid the GI side effects that I had on Tirz. Jumping from 2mg to 4mg could induce side effects (it would in me, but maybe not you!). So if you have no sides at 2mg maybe a 2 mg jump won't cause them. Managing side effects was the stated the reason they started at 2mg in the trials.

 

[woundcarping]

What exactly is "skin sensitivity"... pain, itch, burning or?

Are the symptoms localized or wide spread?

Do they present as a rash or raised surface?

Is that to someone specifically or in general?

Can be localized or not, commonly described as some variety of a sunburn but no visual signs of the sensitive area.