xgirlmama
GLP-1 Novice 🚫No Source Discussion🚫
I'm tempted to stay on them for life, just maintenance doses. Because my brain is no longer so obsessed with ALL THE THINGS (food, alcohol, shopping) and my head is a much more calm place now
Weight gain after GLP use
- Thread starter drzoid614
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fishjerky
Recently Joined 🚫No Source Discussion🚫
We can definitely go back to our old habits, but I never thought about it from the perspective that Grogu and others mentioned. I guess it depends on how bad of a position you are in!drzoid614 said:
In my experience, GLP-1s have helped me develop the habit of eating two big meals a day. I'm basically doing intermittent fasting with no effort. They say you need to do the same thing for over 20 days to develop a habit. I think that might be true, but I was also in a somewhat "privileged position." I'm only 50 kg over my normal weight, and I'm also tall, which I've noticed allows me to go into a calorie deficit more easily (idk if this last thing makes sense but its what i feel like).
Mr.Tired
GLP-1 Apprentice
Thanks for sharing. When she started the video with: "Do you need to stay on GLPs for life? The answer is...it depends." I was in for the whole thing.Zelmar702 said:
It's refreshing to see it acknowledged that we all are starting from a different place and might have varying requirements for health maintenance. Not many of the YouTube peptide bros seem to do that.
lessthanhalf
GLP-1 Specialist
Not everyone is going to need glp-1 medications long term, those who are not severely overweight, or those who have a bmi of around 30 or so, but they are not really who they were designed for and outside the grey market , in the absence of medical complications of obesity , doctors would be reluctant to prescribe them for those patients.
Now , I did start off very overweight , but 3 years later I am eating more or less exactly the same number of calories per day that I ate to lose the weight, about 1600 to 1800 kcal per day. Initially I lost exactly 6 kilos per month, from 145 to about 90 to 95 kg, then weight loss gradually dropped to zero as i got to 75kg and weight stabilised until I started tirzepatide plus a bit of retatrutide and in the last 7 months have lost another 8 kg, which is slowing down to 100-200 grams a week. During all of this there was no change in calorie input.
When you are very overweight basal metabolic rate is higher from the excess fat mostly but there is usually a bit of extra muscle so you can still walk, but the main reason weight loss slowed to zero or near zero is metabolic adaptation to lowered calorie input. This process while much less extreme in those who lose less weight still occurs, and does not necessarily go away ever. So that maintaining that lowered weight requires less calorie input than would be average for someone of that weight and level of activity, and increased hunger that is directly proportional to the amount of weight lost. ( there is a really good study that shows this ) For nearly everyone, who has been overweight or obese and loses weight this combination causes weight regain, unless something is acting to stop it. The only things that work long term other than medical intervention is permanent diet changes or permanent increases in exercise, and in general people really are pretty bad at achieving those changes and keeping to them forever. In general if you were good at maintaining a healthy amount of exercise and had really good eating habits , you would not have gotten overweight. There is nothing at all wrong with tapering or attempting to stop glp medications at goal weight , so long as you restart them if needed and do not let weight regain get out of hand before restarting them. Unless you are older and have high absolute cardiovascular risks in which case taking them long term is a good idea regardless of effects on weight.
Now , I did start off very overweight , but 3 years later I am eating more or less exactly the same number of calories per day that I ate to lose the weight, about 1600 to 1800 kcal per day. Initially I lost exactly 6 kilos per month, from 145 to about 90 to 95 kg, then weight loss gradually dropped to zero as i got to 75kg and weight stabilised until I started tirzepatide plus a bit of retatrutide and in the last 7 months have lost another 8 kg, which is slowing down to 100-200 grams a week. During all of this there was no change in calorie input.
When you are very overweight basal metabolic rate is higher from the excess fat mostly but there is usually a bit of extra muscle so you can still walk, but the main reason weight loss slowed to zero or near zero is metabolic adaptation to lowered calorie input. This process while much less extreme in those who lose less weight still occurs, and does not necessarily go away ever. So that maintaining that lowered weight requires less calorie input than would be average for someone of that weight and level of activity, and increased hunger that is directly proportional to the amount of weight lost. ( there is a really good study that shows this ) For nearly everyone, who has been overweight or obese and loses weight this combination causes weight regain, unless something is acting to stop it. The only things that work long term other than medical intervention is permanent diet changes or permanent increases in exercise, and in general people really are pretty bad at achieving those changes and keeping to them forever. In general if you were good at maintaining a healthy amount of exercise and had really good eating habits , you would not have gotten overweight. There is nothing at all wrong with tapering or attempting to stop glp medications at goal weight , so long as you restart them if needed and do not let weight regain get out of hand before restarting them. Unless you are older and have high absolute cardiovascular risks in which case taking them long term is a good idea regardless of effects on weight.
Pablito
Recently Joined 🚫No Source Discussion🚫
I have bounced back. I've put 75% of the weight back on in about 8 weeks. I dropped down to 7.5mg and then went to 0 though.
Have recently started on 2.5 again and now am looking at Grey. Haven't felt much on 2.5 yet though...
Have recently started on 2.5 again and now am looking at Grey. Haven't felt much on 2.5 yet though...
Can you say more about why you went to 0? I don't understand the urge to drop or stop (unless you're truly buying into the gross shame attempts of some folks) the medications that work so well to solve what (for me) was an otherwise impossible problem. Is it purely financial? I see that you're "looking at Grey" so perhaps it was an affordability problem, which would be something I'd struggle with too if I was name-branding it.Pablito said:
AxlBundy
GLP-1 Apprentice
One thing that most do not account for is that we all look at that lowest recorded body weight and expect to keep that. That weight is usually obtained in a caloric restricted, glycogen depleted, possibly dehydrated state. I would put on at least 5lbs just going into a hydrated, glycogen filled, maintenance diet. I may be 235 today, but I know I’m really 240-245 full. If you have a goal weight of 225, you should probably hover at 220 for awhile before letting off the gas
I went off reta for about five weeks. I gained five pounds. But I was also eating way too much sugar and junk food. I'm restarting reta again. I just consider it a reset. It is like it kicked in right away. And my appetite was reduced the next day.
drzoid614
GLP-1 Apprentice
This is a great resource! Thanks for sharingMr.Tired said:
RefinedRabbit41
Recently Joined 🚫No Source Discussion🚫
This is a really good video but it also makes me sad in a way. I’ve spent the last year learning how to count calories and understand my relationship to food to better it through Noom. I’ve also taken this time to become comfortable with the gym to strengthen my body and increase my cardiovascular health. Through this I lost a considerable amount of weight but still needed Reta to continue to lose. I meet several of her “conditions” for being someone who will need long term GLP-1 use. And I also think it goes further than that. I feel if I truly want to stay healthy I will always have to pursue the gym, always have to count calories and probably always have to use some dose of a GLP-1. To be healthy is to become one with the food scaleZelmar702 said:
RefinedRabbit41 said:This is a really good video but it also makes me sad in a way. I’ve spent the last year learning how to count calories and understand my relationship to food to better it through Noom. I’ve also taken this time to become comfortable with the gym to strengthen my body and increase my cardiovascular health. Through this I lost a considerable amount of weight but still needed Reta to continue to lose. I meet several of her “conditions” for being someone who will need long term GLP-1 use. And I also think it goes further than that. I feel if I truly want to stay healthy I will always have to pursue the gym, always have to count calories and probably always have to use some dose of a GLP-1. To be healthy is to become one with the food scale
Don't be sad! Please, be happy that modern science has found a pharmalogical solution to a metabolic condition that society had made you believe is a character flaw. Glp-1s correct an imbalance in the mind/gut signaling system that you've been suffering. No different then any other medicine people take for a chronic condition.
I had gastric bypass in 2003, so 23 years ago. At the time, even though it was great, I knew it wasn't the solution. I knew at the time that eventually there would be a pharma solution that would actually address the underlying disease.
And there it is in a nutshell. Is obesity a disease? For some, yes. Society is slow to recognize. Just like alcohol use disorder. Don't be sad! Be happy that you live in a beautiful world where scientists would find this for us and relish in the treatment and never look back.
Peptidesearch
GLP-1 Enthusiast
I went on when I wasn't that much over weight to begin but for creeping up A1C but when I stopped I had no idea I would end up heavier than when I started.
I started when mounjaro was first released, I knew nothing like this could happen at the time. I've accepted that there's no going off but I only need a low dose to maintain.
I started when mounjaro was first released, I knew nothing like this could happen at the time. I've accepted that there's no going off but I only need a low dose to maintain.
Estarossa19
GLP-1 Enthusiast
Yeah no kidding on this one! I feel like the new hobby I picked up was doing everything possible to not gain weight. GLP's have made it so much easier to focus on the other stuff that isn't food.RefinedRabbit41 said:This is a really good video but it also makes me sad in a way. I’ve spent the last year learning how to count calories and understand my relationship to food to better it through Noom. I’ve also taken this time to become comfortable with the gym to strengthen my body and increase my cardiovascular health. Through this I lost a considerable amount of weight but still needed Reta to continue to lose. I meet several of her “conditions” for being someone who will need long term GLP-1 use. And I also think it goes further than that. I feel if I truly want to stay healthy I will always have to pursue the gym, always have to count calories and probably always have to use some dose of a GLP-1. To be healthy is to become one with the food scale
Estarossa19
GLP-1 Enthusiast
It's helpful to reread this type of stuff sometimes. I've lost about 30 pounds in 3 months but still have the thought in the back of my mind that I feel like I'm cheating this time around with how easy it's been. Yay for science!Grogu said:
Estarossa19 said:
And don’t think for a second that feelings of “cheating” aren’t all part of the social phenomena that encompasses fat shaming.
In my mind we would never in a million years think that someone with T1DM can will their minds to make themselves healthy, but society is quick to blame obesity on those that are afflicted.
Some future society will look back on these times and think that we were barbarians on how the obese were treated. It’s a disease for many, not a lack of willpower or personal failing,
Never think you are cheating! You’re finally in a position to make good choices and you are making those choices!
I ran into someone today who had previously lost almost a hundred pounds. They were thin and looked great. I hadn't seen them in months until today. When I saw them they had obviously put much of the weight back on in a very short amount of time. Of course, I didn't say anything. But, this is my worst nightmare. I also have lost over a hundred pounds. The idea of gaining it back is horrific to me. I know that I will be on some form of the medication for life. For now I'm on 8mg reta and 4mg tirz. I could probably do less, but my weight has been stable for the last 8 months. It sounds silly but I recently gained 2 lbs. Even this little bit, which well within a normal range, freaked me out. I weigh myself daily. I have more than 5 years stocked in the freezer. It sounds paranoid (and it probably is), but I can't go back. I just can't. I would rather be paranoid and a hoarder than ever risking putting the weight back on. I don't ever want to see that person in the mirror again.
This is why I'm hesitating to A) titrate up, B) split the dose.
I'm on reta, and so far, I like that you can still eat on it and experience occasional cravings/hunger. Especially if you don't force the constant "high" and go with the peaks and valleys when dosing only once a week.
I keep telling myself it's preparation for when I want to try to get off, or to go back to a maintenance dose. I'm training my fasting muscle and my mind, delaying, trying to resist.
I've been lucky to have guidance from my naturopath, who keeps me as low as possible. Reminding me that that number on the scale isn't the most important thing. And that it took decades to gain, so it will take some time to come off, too.
Now being stalled for a couple of months, and all the effects worn out, I'm titrating up to 3mg.
Lost 16kgs on 2.5mg. Want 10 more.
I'm on reta, and so far, I like that you can still eat on it and experience occasional cravings/hunger. Especially if you don't force the constant "high" and go with the peaks and valleys when dosing only once a week.
I keep telling myself it's preparation for when I want to try to get off, or to go back to a maintenance dose. I'm training my fasting muscle and my mind, delaying, trying to resist.
I've been lucky to have guidance from my naturopath, who keeps me as low as possible. Reminding me that that number on the scale isn't the most important thing. And that it took decades to gain, so it will take some time to come off, too.
Now being stalled for a couple of months, and all the effects worn out, I'm titrating up to 3mg.
Lost 16kgs on 2.5mg. Want 10 more.
lessthanhalf
GLP-1 Specialist
While obviously how you do things is up to you, I disagree with a lot of the underlying logic involved.
I do not know anything about JFinHK but for the sake of interpreting the situation say started at 100kg , lost 16 wants to lose 10 more. I cannot work out BMI without height, but it is going to be low 30's to mid to high 30's.
So on a low dose of reta at 2.5mg you have lost 16% body weight which is better than average, but you want to lose 26%, and are stalled at that low dose, there is no sensible alternative to increasing the dose so it can do its job.
It almost sounds like some sort of self torture for no good reason to try to do it without the drug helping you as well as it can. You have said nothing about side effects limiting the doses, so I assume you are limiting the dose from advice I would regard as bad advice from the naturopath , and trying to do it by self control with just a little help from reta.
There is no doubt that people can lose weight short term by self control, but hardly anyone ever succeeds in keeping weight off long term that way.
On the other hand drugs like retatrutide can solve the problem long term by simply taking them and staying on them once the weight is lost. Given your response so far you are likely to do well on a higher dose and have a very good chance of getting to your target. Now is basically the first and only time ever there has been a treatment option for obesity that actually works and works well, and while it is at it improves blood sugar , blood pressure, lipids and most likely reduces the risks of many serious long term health issues caused by overweight and obesity.
While you do not suffer from severe obesity ( I am guessing without the right numbers ) the degree of overweight is definitely enough to increase long term health risks of both serious illness and in some ways more importantly reduced quality of life either from health consequences or the social disadvantages of being overweight or obese.
I think a lot of societies' uninformed opinions, biases and bigotry about obesity gets internalised, so a lot of people with obesity feel it is their fault and they should be able to control it as that is what they have been told most of their life.
My way of thinking is choose the options that work, even better if there is solid scientific evidence to support what treatment options work.
Trying to achieve long term weight loss and maintenance from diet exercise and willpower is unlikely to succeed, maybe 5%.
Doing it with retatrutide is going to have vastly higher success rates, not 100% as some people will not tolerate the side effects and some will respond less well than average . But going on the studies with an average weight loss of 29% in a year or so, the odds of losing 26% of your weight and keeping it off long term are better than 50/50, and given your response to low doses probably a lot better than that.
It is not bad for you , addictive or immoral, and it is hard to see many downsides , it cannot be cost as the legit version is not even out yet. It makes a lot more sense to increase the dose to the dose that causes the weight loss you want to achieve .
I do not know anything about JFinHK but for the sake of interpreting the situation say started at 100kg , lost 16 wants to lose 10 more. I cannot work out BMI without height, but it is going to be low 30's to mid to high 30's.
So on a low dose of reta at 2.5mg you have lost 16% body weight which is better than average, but you want to lose 26%, and are stalled at that low dose, there is no sensible alternative to increasing the dose so it can do its job.
It almost sounds like some sort of self torture for no good reason to try to do it without the drug helping you as well as it can. You have said nothing about side effects limiting the doses, so I assume you are limiting the dose from advice I would regard as bad advice from the naturopath , and trying to do it by self control with just a little help from reta.
There is no doubt that people can lose weight short term by self control, but hardly anyone ever succeeds in keeping weight off long term that way.
On the other hand drugs like retatrutide can solve the problem long term by simply taking them and staying on them once the weight is lost. Given your response so far you are likely to do well on a higher dose and have a very good chance of getting to your target. Now is basically the first and only time ever there has been a treatment option for obesity that actually works and works well, and while it is at it improves blood sugar , blood pressure, lipids and most likely reduces the risks of many serious long term health issues caused by overweight and obesity.
While you do not suffer from severe obesity ( I am guessing without the right numbers ) the degree of overweight is definitely enough to increase long term health risks of both serious illness and in some ways more importantly reduced quality of life either from health consequences or the social disadvantages of being overweight or obese.
I think a lot of societies' uninformed opinions, biases and bigotry about obesity gets internalised, so a lot of people with obesity feel it is their fault and they should be able to control it as that is what they have been told most of their life.
My way of thinking is choose the options that work, even better if there is solid scientific evidence to support what treatment options work.
Trying to achieve long term weight loss and maintenance from diet exercise and willpower is unlikely to succeed, maybe 5%.
Doing it with retatrutide is going to have vastly higher success rates, not 100% as some people will not tolerate the side effects and some will respond less well than average . But going on the studies with an average weight loss of 29% in a year or so, the odds of losing 26% of your weight and keeping it off long term are better than 50/50, and given your response to low doses probably a lot better than that.
It is not bad for you , addictive or immoral, and it is hard to see many downsides , it cannot be cost as the legit version is not even out yet. It makes a lot more sense to increase the dose to the dose that causes the weight loss you want to achieve .
I am not opposed to higher doses, but I'm in no rush. The only side effect for now is increased HR. This is the 1st week on 3mg.lessthanhalf said:
Mainly, still trying to get into some exercise routine and am afraid of more excess skin on my belly if I lose too fast. 54 yo, female, 178cm, started at 108kgs. in peri. High BP, cholesterol (recently "resolved" by RYR). I got on glp because of fatty liver - resolved, thank you, Reta. So that was the priority.
(I am also a teacher, so I really don't need the extra attention if I lose too fast.
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