未定型 Reta 冷冻：是/否

[thatkatmat]

one quick question when I take my Reta out of the freezer to mix up do I have to let it defrost or will the

Let it sit for 20-30 minutes at room temp

 

[thatkatmat]

Can Bac water go in the fridge or just always the cupboard, how long does it last typically?

This is a debatable topic. The directions on the vial say "store" at room temperature. But most people say, after 1st puncture (which seems different than "storage" to me) to keep it in the fridge. I keep mine in the fridge, just seems logical that it would keep better. I mean, you have to keep your peptides in the there after you mix them with bac, as far as "how long does it last? That's less debatable, it lasts 28 days once punctured, but I've read many times that researchers use it for months, I've even read years (lol) without any problems. I follow the 28 day rule and toss it, I just don't want any bacteria growth which could lead to rashes at the injection site or worse. ...But since it's all research, YMMV

 

[Phatmax]

Let it sit for 20-30 minutes at room temp

Thank you. This is what I was thinking but you have cleared that up for me

 

[indolent]

directions on the vial say "store" at room temperature

All good points! There's much speculation about WHY Pfizer's directions are to store at room temperature, but no evidence that it's science-based. Another (completely unfounded) speculative explanation (of mine!) is that it's a marketing tactic to show hospital administrators that they won't need to buy and maintain refrigerators for it.

 

[Phoenix_Vixen]

This is a debatable topic. The directions on the vial say "store" at room temperature. But most people say, after 1st puncture (which seems different than "storage" to me) to keep it in the fridge. I keep mine in the fridge, just seems logical that it would keep better. I mean, you have to keep your peptides in the there after you mix them with bac, as far as "how long does it last? That's less debatable, it lasts 28 days once punctured, but I've read many times that researchers use it for months, I've even read years (lol) without any problems. I follow the 28 day rule and toss it, I just don't want any bacteria growth which could lead to rashes at the injection site or worse. ...But since it's all research, YMMV

This is my only gripe with the 28 days... I only need 10mg vials (3mg, really) as I take tirz 60, but I will have to keep throwing them away and the only Hospira I can get is 30mg.

Pros - I'm still saving cash

Cons - I'm losing cash

 

[Not_Your_Dad]

Somewhere I found and read a proper study that demonstrated some kind of degradation or other negative impact from storing BAC under refrigeration. I'll see if I can find it again and share.

 

[thatkatmat]

Somewhere I found and read a proper study that demonstrated some kind of degradation or other negative impact from storing BAC under refrigeration. I'll see if I can find it again and share.

After the first puncture? Would love to see it, would settle it

 

[Not_Your_Dad]

After the first puncture? Would love to see it, would settle it

This is not the one I was thinking of, but it's a starting point:

Effect of refrigeration on bactericidal activity of four preserved multiple-dose injectable drug products - PubMed

The influence of refrigeration on the bactericidal capability of preservative systems in multiple-dose injectable drug products was studied. Commercially available multiple-dose injectable drug products containing preservatives--atropine/phenol, lidocaine/methylparaben, cyanocobalamin/benzyl...

pubmed.ncbi.nlm.nih.gov

Here's the full abstract:

"Abstract​[archived internal link]
The influence of refrigeration on the bactericidal capability of preservative systems in multiple-dose injectable drug products was studied. Commercially available multiple-dose injectable drug products containing preservatives--atropine/phenol, lidocaine/methylparaben, cyanocobalamin/benzyl alcohol and diphenhydramine/benzethonium chloride--were divided into two groups, one to be maintained under refrigeration (5C) and the other to be maintained at room temperature (25C). In separate tests the multiple-dose vials (MDVs) were individually inoculated with the following organisms: Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Serratia marcescens, and cultured to establish bacterial concentrations at 0, 1, 2, 4, 8 and 24 hours. Bacteria in the preservative systems tested remained viable significantly longer under refrigeration. (Data for diphenhydramine/benzethonium were not obtainable with the methodology used.) It is recommended that sterile medications maintained in preserved MDVs be stored at [sic] romm temperature after initial use (i.e., after exposure to possible contamination) unless drug stability considerations dictate otherwise."

Emphasis in the text is mine

 

[thatkatmat]

"Bacteria in the preservative systems tested remained viable significantly longer under refrigeration."

Thanks so much for this information, it's interesting and counterintuitive to me. I stand corrected and appreciate your input!

 

[Not_Your_Dad]

“经测试，在冷藏条件下，防腐体系中的细菌存活时间明显更长。”

非常感谢您提供的信息，这很有意思，也与我的直觉相悖。我之前的想法有误，感谢您的指正！

这是一项已有五十年历史的研究，但我不知道为什么会有什么变化。我会继续寻找我印象中的那项研究，看看能不能找到。找到什么我都会在这里分享。我觉得关于这个话题我们再怎么讨论也不为过。

 

[thatkatmat]

这是一项已有五十年历史的研究，但我不知道为什么会有什么变化。我会继续寻找我印象中的那项研究，看看能不能找到。找到什么我都会在这里分享。我觉得关于这个话题我们再怎么讨论也不为过。

我看到了，但不确定这会不会有什么改变，毕竟是同一种物质。就像你说的，最好能看到一些佐证数据。

与此同时，我今天下午刚打开并混合了一瓶Cagri，把Bac留在橱柜里了。

 

[Gr33dyOctopus]

因为我有一些特殊需求，所以我一直买Mira牌13.5盎司的保温食品罐，可惜现在他们停产了，虽然我囤的够用，但还是觉得很遗憾。这些保温罐真是太棒了：完美的圆柱形，边缘圆润，带旋盖，能装下30瓶药水，顶部还有足够的空间塞几包干燥剂，盖上盖子，再放进我的冰柜底部。

它们其实不是必需品，但它们真的让我感觉很满足：我那些贴着漂亮标签、颜色各异的小药瓶，旋盖密封性极佳，30瓶药水整齐地分两层摆放，空间刚刚好，而且瓶瓶罐罐都竖着放。我现在还剩下三个空罐和一个装了三分之二Reta的罐子，因为我已经把Tirzep的罐子都装好了，正在慢慢地囤Reta。等我把剩下的罐子都装满，Reta就够用十年了。

总之，我刚在 eBay 上买了个二手的，因为我又出问题了。

哈哈哈哈！！！！我也囤了不少.tirz，但零售的不多，真希望他们能卖120毫克的套装。