chunkyTN said:
This is just my .02. Sema is the cheapest. Not a bad place to start and it gives you somewhere to advance to.
You can get a kit of 10 vials of 10mg sema for about $50. Starting dose is .25. That kit will last you a year if you do well on it. I still use it basically as a base and then a dose of tirz as a topper halfway thru the week. I'm saving reta for future burn out if I need it.
Opinion may vary tho.
I might be a bit biased as I had a year of nausea and malaise from low dose semaglutide before I discovered cheaper Chinese peptides and then had very few side effects from Tirzepatide, but in general I really do not think semaglutide is a good starting point at this stage.
Semaglutide is the cheapest and that is it in it's favour. Given the price of better drugs I do not see it as a useful option, except as a low dose add on to full doses of tirz or reta if large weight losses are required and not achieved by full doses of reta or tirz. If you have significant heart disease or chronic kidney disease semaglutide has better evidence of being helpful in those cases as it has had more studies done as it has been around longer. 15% wt loss
Tirzepatide has less side effects and is more effective than semaglutide, so there really is no valid argument in favour of it over tirzepatide, this is based on solid science. Cost is less than $5 a week /15mg unless buying very small vials. 20-24% wt loss
Retatrutide is less well studied and not yet officially approved, maybe has a bit more side effects than Tirz but is more effective for weight loss. Cost per mg is a bit less than twice tirz at $6-8/week /12mg. 25-29% wt loss
The idea that you should start on one drug and move to others when it stops working is internet logic not science. Tolerance to GLP drugs either does not exist or is extremely rare. There is no way in advance to know if it will help you to lose more or less than the average amount of weight, it just depends on what side effects you get that might limit doses or you might be more or less sensitive to the drug than average , but switching between drugs is not going to change that, you have at least doubled your chances of getting an allergic reaction by using two drugs instead of one with no effect in the end on how much weight you lose or what side effects you get.
There is also no real evidence that any of the GLP drugs are better than the others for preventing muscle loss while losing weight. Bodybuilders prefer reta, but there are no scientific studies to say it is better. High protein intake ( 1.2-1.6g/kg/day ) and resistance training make a difference, which GLP you use probably does not.