I just switched to grey tirz from compounded tirz. My compounding pharmacy compounded tirz with glycine. I was very happy with the combination except for the price. I want to continue using glycine. I have found glycine powder for oral use but I can't find any injectable glycine. Any suggestions?
Tirz with Glycine
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swimmer said:
Glycine is one of the most bioavailable amino acids, you can get it from a capsule. There's no reason to pin it really. Sometimes people add it to GLP-1s if they are susceptible to needle reactions. It's a good buffering agent to lower ph.
However, it is one of the three aminos that makes up glutathione. If you just want to keep pin it but don't care if it is added to the tirz, then buy glutathione
Lyophilized glutathione is readily available. I don't know where you can get just straight lyophilized glycine.Some of the online shops sell it mixed in formulations. Kimera and Soma both have formulations, but not straight glycine.
I think pinning is better, I pin. But here is AI's take on it:swimmer said:
Oral glutathione bioavailability is generally considered poor due to its breakdown in the digestive system. While some studies suggest that oral glutathione can increase blood levels, the increase is often minimal and may not be therapeutically significant. Alternative forms like liposomal glutathione or sublingual glutathione, and methods like intravenous administration, are often favored for better absorption.
Here's a more detailed explanation:
Enzymatic Degradation:
Glutathione is a tripeptide, and enzymes in the gut, particularly gamma-glutamyltransferase, readily break it down before it can be absorbed into the bloodstream.
Limited Absorption:
Even when intact glutathione is absorbed, it is not always effectively transported into the bloodstream, resulting in low bioavailability.
Alternatives:
Liposomal Glutathione: This form is encapsulated in liposomes, which can protect it from degradation in the digestive tract and enhance its absorption.
Sublingual Glutathione: This form is placed under the tongue, allowing for absorption directly into the bloodstream, bypassing the gastrointestinal tract.
Intravenous Glutathione: Intravenous administration delivers glutathione directly into the bloodstream, ensuring high bioavailability.
Boosting Oral Absorption:
While oral glutathione has limited bioavailability, some strategies can potentially improve its absorption, such as:
Combining with Vitamin C: Vitamin C can help regenerate glutathione and potentially enhance its absorption.
Consuming with Healthy Fats: Healthy fats can aid in the absorption of certain nutrients, including glutathione.
Supplementing with Precursors: Consuming precursors like N-acetylcysteine (NAC) can help the body synthesize glutathione.
Research on Oral Glutathione:
Some studies have shown that oral glutathione can increase blood glutathione levels, but the extent of the increase and its therapeutic significance are still under investigation.
In conclusion, while oral glutathione may offer some benefit, it's generally considered less effective than other forms and routes of administration due to its poor bioavailability.
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