Tirz vs Reta

[drzoid614]

Hi everyone,

I am new to this journey and have a question, (which i cant seem to see has been discussed before).

I am a late twenties female who gyms regularly however cant shift remaining weight i am trying to loose, hence joining this community and exploring GLPs.

However i am stumped at whether i should be taking reta or tirz. The rapid weightloss with reta scares me a little with the potential of loose skin. Tirz seems more gradual, but does that mean ill have minimal results… i know semaglutide is also an option but id like to retain some muscle.

What would you suggest for somebody trying to loose 10-15kg who will combine GLP use with regular exercise?

Sorry if this is obvious, id just love some outsider opinions.

Thanks in advance

 

[BellyD]

You'll be limited to your food intake either way. I have zero appetite, but push protein down, and follow a diet.

Because these peptides give YOU the power to choose!!!!!

Also!, note you primary only loose fat when your lifting heavy on Triz and Reta.

Just research what you can afford. And follow the clinical data. They did invest millions into these studies after all....

 

[randompersonrandom]

Tirz first, then reta if you stall or get the fatigue and it doesn't go away.

Defense: Tirzepatide is extremely effective for a LOT of people, and we have multi-year safety data on it. Reta's great, I have a stockpile in my freezer, and I think that when it finishes up in clinical trials and we get safety data on it, we'll find out it's equally safe. But I don't actually KNOW. And what I do know is that when demand is as high as it is for glp-1's, eventually something gets out there that hurts or kills people and we'd have known that if we had more data, but we didn't, and people wanted it really bad, and people died while we discovered that it isn't safe.

I expect that WILL happen eventually with GLP-1's. It's not tirz, it probably won't be reta, it might not be the next gen one after that, or the next. But I think it'll happen eventually, so I always want to be starting with the ones that have some degree of long-term proven reasonable safety balanced against great efficacy, and that is tirz right now.

 

[woundcarping]

Reta and Tirz both signal GLP and GIP for appetite suppression and insulin sensitivity. Reta adds GCGR to preserve lean mass and increase base metabolic rate.

Weight loss speed can be controlled to some extent with dosage for either. For me rapid loss hasn’t be an issue, I’ve been relatively aggressive, but nausea hasn’t been a problem at all… if I get too far from my targeted slope I adjust my eating. If I start getting adverse side effects, I’ll adjust my dose.

 

[drzoid614]

You'll be limited to your food intake either way. I have zero appetite, but push protein down, and follow a diet.

Because these peptides give YOU the power to choose!!!!!

Also!, note you primary only loose fat when your lifting heavy on Triz and Reta.

Just research what you can afford. And follow the clinical data. They did invest millions into these studies after all....

This is really great advice thank you!

 

[drzoid614]

Reta and Tirz both signal GLP and GIP for appetite suppression and insulin sensitivity. Reta adds GCGR to preserve lean mass and increase base metabolic rate.

Weight loss speed can be controlled to some extent with dosage for either. For me rapid loss hasn’t be an issue, I’ve been relatively aggressive, but nausea hasn’t been a problem at all… if I get too far from my targeted slope I adjust my eating. If I start getting adverse side effects, I’ll adjust my dose.

Ok thats great to know. Thank you this has been super helpful!

 

[drzoid614]

Tirz first, then reta if you stall or get the fatigue and it doesn't go away.

Defense: Tirzepatide is extremely effective for a LOT of people, and we have multi-year safety data on it. Reta's great, I have a stockpile in my freezer, and I think that when it finishes up in clinical trials and we get safety data on it, we'll find out it's equally safe. But I don't actually KNOW. And what I do know is that when demand is as high as it is for glp-1's, eventually something gets out there that hurts or kills people and we'd have known that if we had more data, but we didn't, and people wanted it really bad, and people died while we discovered that it isn't safe.

I expect that WILL happen eventually with GLP-1's. It's not tirz, it probably won't be reta, it might not be the next gen one after that, or the next. But I think it'll happen eventually, so I always want to be starting with the ones that have some degree of long-term proven reasonable safety balanced against great efficacy, and that is tirz right now.

Thank you for such a detailed response! Its really cleared things up for me. And i totally agree, i feel alot better going with the GLP that has been tested long term. Goodluck with your journey !

 

[ThatNextGril]

Tirz is my bff. It's exactly attuned to my body and what I need in a GLP drug: reduces, but doesn't eliminate, the feeling of hunger and it shuts off the switch of food noise, with no sides.

That said, as I've been using it for just over a year and know how my body reacts to it, I feel confident in my recent protocol of adding in some reta. I've still got about 10lb to go until a happy goal weight, and normally I'd just ride that out. But, we've got a big company offsite planned mid March where I'll be seeing all my team in person after 2 years and I admit (vainly) that I want to try and push the needle on the scale a bit more before then. So, by adding in the reta for now, while reducing my tirz just a bit, I'm hoping for the glucagon assist with direct fat burning. I absolutely feel sides with reta (nausea after meals, and feeling colder more often) but as it's only for another 6 weeks, I can deal.

Then it'll be back to my tried and true tirz.

 

[drzoid614]

Tirz is my bff. It's exactly attuned to my body and what I need in a GLP drug: reduces, but doesn't eliminate, the feeling of hunger and it shuts off the switch of food noise, with no sides.

That said, as I've been using it for just over a year and know how my body reacts to it, I feel confident in my recent protocol of adding in some reta. I've still got about 10lb to go until a happy goal weight, and normally I'd just ride that out. But, we've got a big company offsite planned mid March where I'll be seeing all my team in person after 2 years and I admit (vainly) that I want to try and push the needle on the scale a bit more before then. So, by adding in the reta for now, while reducing my tirz just a bit, I'm hoping for the glucagon assist with direct fat burning. I absolutely feel sides with reta (nausea after meals, and feeling colder more often) but as it's only for another 6 weeks, I can deal.

Then it'll be back to my tried and true tirz.

I really look forward to the food noise being switched off! I honestly feel you, i would do the same hahah! May i ask how much you have lost in the last year?

Good to know adding reta now is working for you (minus side effects but thats liveable) ! I imagine down the track its something i will consider. So this has been great to know! Thank you !! I'm sure you'll look amazing for the team meeting

 

[SolidChick]

I like Tirz. I have been having great results with it. So far, I'm down almost 10lbs. I've been on it for about a month. I also didn't experience the nausea that others complained about. I truly appreciate that.

Looking to add more peptides soon.

 

[ThatNextGril]

I really look forward to the food noise being switched off! I honestly feel you, i would do the same hahah! May i ask how much you have lost in the last year?

Good to know adding reta now is working for you (minus side effects but thats liveable) ! I imagine down the track its something i will consider. So this has been great to know! Thank you !! I'm sure you'll look amazing for the team meeting

I started on sema before the tirz and did that for almost 1.5 years. Only lost about 15lb and hated the way sema made me feel super full after (sometimes during) a meal. The food noise was dampened, but not nearly as much as it's been with tirz.

Since starting tirz, I've lost another 20lb. I started stalling around June last year. I seem to be hovering around the same +/- 3 pounds, which is good that my body seems good at this weight in general, but also sucks as it really a stall.

I think you'll really be happy with what tirz does for you. And once you get familiar with how your body reacts to it, you can decide how and when you want to titrate. I'm sure if I reallllyyyyy wanted to I could up my dose of tirz instead of using reta, but since I know how I feel on tirz with the hunger and food noise, I don't think that would really chnage anything at this point.

There's no likelihood that I'd stay on reta for any signifcant amount of time. The current sides are annoying and I'm perfectly good with letting tirz hold the reins long term.

 

[Not_Your_Dad]

For me, the sides that came with high-dose Tirz (> 10 mg) were brutual.

I'd pin in the PM on shot day, and for the next three days I seriously felt like I got hit by a truck. I couldn't drink a glass of water. I couldn't eat anything. Somehow I still lost no weight, but I was absolutely miserable.

Reta, on the other hand, does not have any of those sides for me. I titrated up aggressively, going from 2 mg first week to 6 mg on week 6 and 10 mg on week 7 (with a 6 mg pin on shot day and a 4 mg pin 84 hours later), and the sides are basically nonexistent.

Reta is absolute magic for me.

 

[MFGamesta]

60 yo, 170 lb, 6'0' male here. Went from 201 to 170 in 3 months on 2.5 Zepbound weekly. I reached my goal just as the tirzapatide was losing effectiveness. Switched to 2mg retatrutide to burn a little more fat while loading protein.

If you lose 15 kg, you will have loose skin. Retatrutide will preserve a little more muscle than tirzapatide. I lost a ton of muscle on tirzapatide.

Whatever you do, start with weekly standard dosing protocol and wait 4 weeks before titrating up as that's how long to built up the full amount of gear. Don't overcomplicate it. Let the peptides do their thing.

 

[drzoid614]

I like Tirz. I have been having great results with it. So far, I'm down almost 10lbs. I've been on it for about a month. I also didn't experience the nausea that others complained about. I truly appreciate that.

Looking to add more peptides soon.

How good!!! Happy for you! Yeah im now definitely leaning towards it

 

[drzoid614]

I started on sema before the tirz and did that for almost 1.5 years. Only lost about 15lb and hated the way sema made me feel super full after (sometimes during) a meal. The food noise was dampened, but not nearly as much as it's been with tirz.

Since starting tirz, I've lost another 20lb. I started stalling around June last year. I seem to be hovering around the same +/- 3 pounds, which is good that my body seems good at this weight in general, but also sucks as it really a stall.

I think you'll really be happy with what tirz does for you. And once you get familiar with how your body reacts to it, you can decide how and when you want to titrate. I'm sure if I reallllyyyyy wanted to I could up my dose of tirz instead of using reta, but since I know how I feel on tirz with the hunger and food noise, I don't think that would really chnage anything at this point.

There's no likelihood that I'd stay on reta for any signifcant amount of time. The current sides are annoying and I'm perfectly good with letting tirz hold the reins long term.

Sounds like youve really perfected it for your body! Really hope my journey looks like yours! Thanks again for the advice

 

[SolidChick]

How good!!! Happy for you! Yeah im now definitely leaning towards it

Great!

I hope you enjoy your experience.

Also, I wanted to add that I microdosed initially, which may have helped me as well.

I started at 1.25 mg for 2 weeks, then 1.5 mg for 2 weeks, and 2.5mg for 2 weeks, and I plan to stay here on 2.5 until I no longer see progress.

 

[miss-sanne]

Hi everyone,

I am new to this journey and have a question, (which i cant seem to see has been discussed before).

I am a late twenties female who gyms regularly however cant shift remaining weight i am trying to loose, hence joining this community and exploring GLPs.

However i am stumped at whether i should be taking reta or tirz. The rapid weightloss with reta scares me a little with the potential of loose skin. Tirz seems more gradual, but does that mean ill have minimal results… i know semaglutide is also an option but id like to retain some muscle.

What would you suggest for somebody trying to loose 10-15kg who will combine GLP use with regular exercise?

Sorry if this is obvious, id just love some outsider opinions.

Thanks in advance

I would go for Tirz, it has amazing appetite suppression.

 

[DjJoshua]

Hi everyone,

I am new to this journey and have a question, (which i cant seem to see has been discussed before).

I am a late twenties female who gyms regularly however cant shift remaining weight i am trying to loose, hence joining this community and exploring GLPs.

However i am stumped at whether i should be taking reta or tirz. The rapid weightloss with reta scares me a little with the potential of loose skin. Tirz seems more gradual, but does that mean ill have minimal results… i know semaglutide is also an option but id like to retain some muscle.

What would you suggest for somebody trying to loose 10-15kg who will combine GLP use with regular exercise?

Sorry if this is obvious, id just love some outsider opinions.

Thanks in advance

I started with Tirzepatide because I did not know about Retatrutide at the time and I stocked up on a END of the WORLD amount in my freezer .lol…

My personal two cents If I would start this I would start with Tirzepatide. Just because inside in my mine Tirzepatide is FDA-approved and I think, long-term safety so less anxiety in my mind if I even get heart burn etc…

 

[Not_Your_Dad]

I started with Tirzepatide because I did not know about Retatrutide at the time and I stocked up on a END of the WORLD amount in my freezer .lol…

My personal two cents If I would start this I would start with Tirzepatide. Just because inside in my mine Tirzepatide is FDA-approved and I think, long-term safety so less anxiety in my mind if I even get heart burn etc…

I think starting on Tirz is probably not a bad plan. It's still significantly cheaper than Reta. I know many of us tend to LOL at FDA approval but if it does matter to anyone, Tirz and Sema and good places to go.

 

[woundcarping]

Significantly cheaper seems like a stretch. 1200mg of Tirz is around $.20/mg, Reta is ~$.48/mg.

At highest published trial doses, that's a $2.76/week difference in cost, assuming you're buying in bulk to get the lowest pricing. $2.76/week is worth it to me for preserving an estimated 6-10lb of lean mass along the 80lb drop through GCGR protecting lean mass and providing more stabile energy for resistance training.

If I hit the same target weight either way, with Tirz I'd still have 6-10lb more fat than the same weight with Reta, not to mention the time it'd take to build the lean fiber back.

Energy levels for training compliance anecdotal evidence:

My first day taking Reta (No meaningful reta exposure) my walking heart rate exercising averaged 114bpm, with the average the day before and after being 115bmp.

18 days later, the same exercise now with more incline and less perceived effort has my average heart rate the past 3 days at ~130bmp with reta levels at 6-9.2mg (Tirz tapering 2.5mg to ~1.7mg).

I had no problems with Tirz, so far I have no regrets switching to reta.