Tirz 第一周

[Hotlongs]

It is my second week at .250mcg. I still have appetite suppression, however, I developed some acid reflux and nausea the day after pinning. I guess I am super sensitive to tirz.

I took famotidine at night to resolve the acid reflux and woke up without any issues in the morning.

Today I have eaten a bit more food that I have been able to tolerate in the previous week throughout the day without nausea. I have struggled with food allergies and gastropaeresis in the past. So far, I feel like I am digesting what I am eating and eating what I want without any psychological coercion if that makes sense.

 

[bjw76]

I've been on 2.5mg for 8 weeks now and the appetite suppression has slowly started to creep back in although it is still completely manageable. The first month was surreal, I had to ensure i was eating enough and struggled to get enough calories on some days. Drink far more water than you think you need, add in some calcium and magnesium supplements as well.

I'm away on holiday next week so i'm planning to move up to 3.5mg just before that as i'm sure the temptation to over indulge will be quite high. I'll probably move up to 5mg once a week soon after but hopefully I'll be able to stay on that dose for as long as possible.

 

[lil ghost]

My very first kit of tirz is scheduled to arrive tomorrow! Seeing all your stories here is so inspiring and helpful for my anxious brain

 

[CornPop]

My very first kit of tirz is scheduled to arrive tomorrow! Seeing all your stories here is so inspiring and helpful for my anxious brain

Good luck!

 

[Jdo414]

This is my first week of tirz (2.5mg). I am coming over from wegovy 1mg pens. I wanted to start tirz at 5mg but I was nervous about side effects so i choose to begin on the starter dose.

No crazy side effects just a bit of burping but that went away in a day. I did notice that i felt appetite suppression within a few hours of injecting tirz which never happened to me on wegovy. I was pleasantly surprised.

However, i feel it wearing off by day 4. Im just now learning that the half life of tirz is 5 days not 7 like sema. I think i will go up to 5mg for my next dose and probably do every 5 days.

By the way i lost about 30lbs on wegovy in 3 months. Im looking forward to tirz i just have to find the right dose that works for me.

 

[hoobz]

However, i feel it wearing off by day 4. Im just now learning that the half life of tirz is 5 days not 7 like sema. I think i will go up to 5mg for my next dose and probably do every 5 days.

I'd give it some time. Interestingly, I was feeling 2.5mg of Tirz in week 3 as somewhat weaker than weeks 1-2, but then again in weeks 4, 5, and now 6 (started today), I'm feeling it on full blast, same dose, 2.5mg.

 

[skeptick]

This is my first week of tirz (2.5mg). I am coming over from wegovy 1mg pens. I wanted to start tirz at 5mg but I was nervous about side effects so i choose to begin on the starter dose.

No crazy side effects just a bit of burping but that went away in a day. I did notice that i felt appetite suppression within a few hours of injecting tirz which never happened to me on wegovy. I was pleasantly surprised.

However, i feel it wearing off by day 4. Im just now learning that the half life of tirz is 5 days not 7 like sema. I think i will go up to 5mg for my next dose and probably do every 5 days.

By the way i lost about 30lbs on wegovy in 3 months. Im looking forward to tirz i just have to find the right dose that works for me.

Don't be in to big a hurry to go up in dosage. There are good reasons for not doing so and being in to big a hurry can actually set you back. Ask me how I know.... Your 1st dose partially adds to your 2nd dose and both them add to your 3rd dose and so on. It's all cumulative. Start small and go up slowly is the best medicine which many of the 'old timers' will attest to. For myself, I was doing great at 5mg, got in a hurry to speed up the process and jumped to 7.5mg and got hit with horrible sides and after playing around with split doses for a few weeks and going back down for a few more weeks and ended up starting all over at 5mg and even at that level took a few more weeks for the worst of the sides to pass. Lost all those weeks and put myself thru misery all because I had the "if a little is good lots must be better" addiction mind. The GLP's aren't the 'magic' by them selves ,there's work that has to be put in...

 

[spanky2026]

I'm nearly 4 months in now, but my original Day One I remember getting up (pinned the night before and went to bed) convinced Tirz was a dud, didnt feel anything really. Then I sat down to eat...and couldn't finish much of anything. And what little I had was ...dare I say it....enough. my prevailing thought all day long and ever since was, "My God, is this what a normal relationship with food is like?" To NOT be thinking about it all the time. To have a normal sized portion and be completely satisfied with that. Stunning. I still can't get over the surprise of that. All these people who have not had obesity to deal with, living their lives like THIS? Wow.

 

[Jdo414]

我会再观察一段时间。有趣的是，我感觉在服用2.5毫克Tirz的第三周，药效比前两周要弱一些，但到了第四周、第五周，以及现在的第六周（今天开始），同样的剂量（2.5毫克），药效却完全发挥出来了。

不要急于增加剂量。这样做有很多好处，而且操之过急反而会让你事倍功半。问问我是怎么知道的……你第一次服用的剂量会部分累积到第二次，第二次和第三次剂量又会累积到第三次，以此类推。所有剂量都是累积的。从小剂量开始，慢慢增加剂量才是最好的方法，很多“老手”都会认同这一点。就我个人而言，我服用5毫克时效果很好，但为了加快速度，我急于求成，一下子增加到7.5毫克，结果出现了严重的副作用。我尝试了几周的分次服用，又减量几周，最后还是从5毫克重新开始。即使是5毫克，最严重的副作用也持续了好几周才消退。我白白浪费了那些时间，让自己饱受折磨，这一切都源于我“少吃就好，多吃肯定更好”的成瘾心态。 GLP本身并不是“灵丹妙药”，还需要付出努力……

我同意循序渐进地增加剂量。我一开始服用的是 Wegovy，剂量从 0.25 毫克开始，然后是 0.50 毫克，现在刚用完 1 毫克。我之所以想把 Tirz 的剂量增加到 5 毫克，是因为我找到了一些 Sema 和 Tirz 的剂量转换表，上面说 1-2.4 毫克的 Sema 相当于 5 毫克的 Tirz。

为了安全起见，我还是选择从 2.5 毫克的 Tirz 开始服用，但说实话，到了第三天我就感觉食欲抑制作用消失了，所以我在想也许我应该从 5 毫克开始服用。

 

[skeptick]

我同意循序渐进地增加剂量。我一开始服用的是 Wegovy，剂量从 0.25 毫克开始，然后是 0.50 毫克，现在刚用完 1 毫克。我之所以想把 Tirz 的剂量增加到 5 毫克，是因为我找到了一些 Sema 和 Tirz 的剂量转换表，上面说 1-2.4 毫克的 Sema 相当于 5 毫克的 Tirz。

为了安全起见，我还是选择从 2.5 毫克的 Tirz 开始服用，但说实话，到了第三天我就感觉食欲抑制作用消失了，所以我在想也许我应该从 5 毫克开始服用。

查看附件 21594

谢谢，我之前没见过这张图表，也没听说过Sema和Tirz的对比，不过听起来很有道理。你按自己的想法来，然后告诉我们结果如何……

 

[lessthanhalf]

这是我使用Tirz（2.5毫克）的第一周。我之前用的是Wegovy 1毫克注射笔。我本来想从5毫克开始用Tirz，但担心副作用，所以选择了起始剂量。

没有出现什么严重的副作用，只是有点打嗝，但一天后就消失了。我注意到注射Tirz后几个小时内食欲就下降了，这在用Wegovy时从未发生过。我感到很惊喜。

不过，到了第四天，药效似乎就开始减弱了。我现在才知道Tirz的半衰期是5天，而不是像Sema那样是7天。我想下次注射时我会增加到5毫克，可能每5天注射一次。

顺便说一下，我用Wegovy三个月减掉了大约30磅。我很期待Tirz，只是需要找到适合我的剂量。

我花了很长时间试图计算出替拉肽的剂量与我目前使用的司美格鲁肽剂量相当，并计算出每周0.8毫克司美格鲁肽大约相当于3-5毫克替拉肽。由于当时我还没有发现灰色肽，所以只有剂量很小，并且每支60毫克的注射笔至少能用3-4个月（每支690澳元）才行得通。但

最终结果却完全不同。尽管每两天注射0.2毫克司美格鲁肽会引起严重的恶心，但替拉肽几乎没有恶心感，而且食欲抑制作用也不像司美格鲁肽那么强。为了比司美格鲁肽更好地控制饥饿感，我最终使用了15毫克的替拉肽，但副作用却少得多。幸运的是，我找到了这个论坛和价格低廉的中国产肽类药物，解决了成本问题。

不同 GLP 的效果和副作用似乎因人而异，任何转换表充其量只能作为粗略的指导，你需要根据饥饿感和副作用来计算剂量。

 

[hoobz]

为了安全起见，我还是选择从 2.5 毫克的 tirz 开始服用，但说实话，到了第三天，我感觉食欲抑制作用消失了，所以我在想也许我应该从 5 毫克开始服用。

图表不错，谢谢！

有些人喜欢在“官方”剂量之间调整，比如从 2​​.5 毫克增加到 3.75 毫克，而不是 5 毫克。

我想等 2.5 毫克效果不好的时候，我也打算这么做。我打算尽量保持低剂量。不过，这种方法可能并不适合所有人，有些人反应比较慢，可能需要更高的剂量。请告诉我们你的进展，祝你一切顺利！

 

[lessthanhalf]

I think the official dose increments for tirz are pretty good, just going up 2.5 no matter what the dose with lower odds of bad side effects.

I think if you already have mild tolerable side effects , it is a good indication to either not increase the dose or increase by a small amount, to minimise the risks of being hit with suddenly very unpleasant effects.

Reta with 2 4 8 12 is a bit less conservative, and I would add 6 and 10mg in there

Semaglutide is not as well thought out 0.25 0.5 1 1.7 2.4, but the later drugs had more time and experience to fine tune the schedule. The jump from 0.5 to 1mg is not a good idea, and should be to 0.75, especially given it tends to cause more GI side effects anyway.

 

[Elocin]

I previously used prescription Ozempic, and found it very ineffective. The only thing it did was give me really bad constipation lol. It was a waste of $ for me.

When I started Tirz, I did a lot of reading, and decided I wanted to go the every 5 day route.

First pin I did 1mg. Second I did 1.5mg. I’ll be honest, I didn’t feel anything after the first pin, but after the 2nd, the appetite suppression kicked in hard. Which is exactly what I need to reel in my binge eating. I can eat no problem, it’s just a lot less, which is amazing. Not sure if I will pin #3 at 1.5mg again, or do 2mg.

My husband on the other hand.. he seems to be very sensitive to GLP1’s. Poor guy had awful gastro side effects on the Ozempic, and it looks to be the same with Tirz. Funny how different everyone reacts.

 

[CornPop]

I previously used prescription Ozempic, and found it very ineffective. The only thing it did was give me really bad constipation lol. It was a waste of $ for me.

When I started Tirz, I did a lot of reading, and decided I wanted to go the every 5 day route.

First pin I did 1mg. Second I did 1.5mg. I’ll be honest, I didn’t feel anything after the first pin, but after the 2nd, the appetite suppression kicked in hard. Which is exactly what I need to reel in my binge eating. I can eat no problem, it’s just a lot less, which is amazing. Not sure if I will pin #3 at 1.5mg again, or do 2mg.

My husband on the other hand.. he seems to be very sensitive to GLP1’s. Poor guy had awful gastro side effects on the Ozempic, and it looks to be the same with Tirz. Funny how different everyone reacts.

I think it’s smart to take it slow and only go up if necessary. I will say the first couple weeks I was doing great with no issues and then the third week I was so irritated. Especially at night. Just irrational irritation and moodiness.

I got some magnesium and did a full day fast and I’ve been much better. I think my body was not used to being at such a deficit and wasn’t burning my fat stores. By fasting I was forcing my body to use the stored fat. It was shocking how much it helped.

 

[Elocin]

my only side effects on the first day was the anxiety i gave myself for wondering if this is even a good idea, but i'm over it

I relate so much to this!! lol. I have really bad anxiety and panic disorder. Was able to talk myself down, thankfully

 

[Not_Your_Dad]

I previously used prescription Ozempic, and found it very ineffective. The only thing it did was give me really bad constipation lol. It was a waste of $ for me.

When I started Tirz, I did a lot of reading, and decided I wanted to go the every 5 day route.

First pin I did 1mg. Second I did 1.5mg. I’ll be honest, I didn’t feel anything after the first pin, but after the 2nd, the appetite suppression kicked in hard. Which is exactly what I need to reel in my binge eating. I can eat no problem, it’s just a lot less, which is amazing. Not sure if I will pin #3 at 1.5mg again, or do 2mg.

My husband on the other hand.. he seems to be very sensitive to GLP1’s. Poor guy had awful gastro side effects on the Ozempic, and it looks to be the same with Tirz. Funny how different everyone reacts.

Have hubs consider Reta - I switched from high-dose Tirz and the gastro sides are almost non-existent for me. I went full send on it too, started at 2 mg and titrated up to 6 mg every 84 hours over 8 weeks.

On the whole, I think it's reasonable to keep the dose you're on as long as it's effective for your goals. I've heard of some folks never going over 5 mg and losing 40% of their body weight. Mrs. NYD has lost over 50% of her body weight but had to work up to 10 mg every 84 hours and now she's transitioning over to Reta as the GI sides have been absolutely brutal for her at that dose.

 

[Elocin]

Have hubs consider Reta - I switched from high-dose Tirz and the gastro sides are almost non-existent for me. I went full send on it too, started at 2 mg and titrated up to 6 mg every 84 hours over 8 weeks.

On the whole, I think it's reasonable to keep the dose you're on as long as it's effective for your goals. I've heard of some folks never going over 5 mg and losing 40% of their body weight. Mrs. NYD has lost over 50% of her body weight but had to work up to 10 mg every 84 hours and now she's transitioning over to Reta as the GI sides have been absolutely brutal for her at that dose.

50% is amazing!!

Other than the GI issues, any other side effects titrating every 84 hours?

I will definitely talk to him about Reta. I think he would be willing to try, if the GI stuff stops.

 

[Not_Your_Dad]

50% is amazing!!

Other than the GI issues, any other side effects titrating every 84 hours?

I will definitely talk to him about Reta. I think he would be willing to try, if the GI stuff stops.

She had slightly less difficult GI sides with 10 mg / 84 hours, but it was still rough for her.

For me on Reta, no. I was at either 12.5 or 15 on Tirz and for 48 hours after that shot I felt like I got hit by a train. And the GI sides were awful. Plus I had stalled on loss for 8-12 weeks (I don't remember any more). I would have dealt with the sides if I continued to lose, but with no loss, I couldn't do it any more. The worst I have with Reta, even with this high dose I'm on, is a little nausea now and then. I find that I just absolutely don't want to eat, and I'll go 18 hours on maybe 300 calories and then I'll get so nauseous that I have to eat something. Mentally I'd be fine not eating for 2 or 3 days, I suspect, but I get such a strong physical reaction to it (and lets be real, as humans we should not just voluntarily want to eat only every 72 hours) that I have to eat.

 

[Elocin]

她服用10毫克/84小时的剂量时，胃肠道副作用稍微轻一些，但对她来说仍然很痛苦。而

我服用Reta时则完全不同。我当时服用Tirz的剂量是12.5毫克或15毫克，注射后48小时内感觉就像被火车撞了一样。而且胃肠道副作用非常严重。此外，我的体重已经停滞了8到12周（具体时间我记不清了）。如果体重继续下降，我或许还能忍受这些副作用，但现在体重没有下降，我实在无法继续忍受了。即使我现在服用Reta的剂量很高，我最严重的副作用也只是偶尔会感到轻微的恶心。我发现自己完全不想吃东西，可能18个小时只摄入300卡路里，然后就会恶心到不得不吃点东西。我怀疑，从心理上来说，我可以两三天不吃饭，但是我的生理反应非常强烈（而且说实话，作为人类，我们不应该自愿每 72 小时才想吃一次东西），所以我必须吃东西。

感谢您提供的所有见解！这确实让我老公好好思考了一番。