Survo - Can I freeze after reconstitution?

[byefatlicia]

Okay, so I'm getting close to starting my Survo research. Problem is, It's a 10mg kit and my starting dose 500mcg will take too long to use safely. My question is: would it be okay to freeze after reconstitution between administration? will that help it last the duration?

 

[peptidesupremacy08]

Okay, so I'm getting close to starting my Survo research. Problem is, It's a 10mg kit and my starting dose 500mcg will take too long to use safely. My question is: would it be okay to freeze after reconstitution between administration? will that help it last the duration?

I'd like to know the same too--I want to buy 60mg kits of Retatrutide because it's 50% more expensive to buy 20mg and more so to buy 10mg. I could just reconstitute the 60mg and break up into 10mg vials myself and defrost as I use them. But I don't know if that'll mess stuff up.

 

[Peotidethrowaway]

I do not know the answer.

I have read you can freeze reconstituted tirz so I would extrapolate that you can also freeze other glp1s but I haven’t seen anything definite

 

[bbrewer]

Okay, so I'm getting close to starting my Survo research. Problem is, It's a 10mg kit and my starting dose 500mcg will take too long to use safely. My question is: would it be okay to freeze after reconstitution between administration? will that help it last the duration?

I don't think you will get much in the way of data driven answers for survo. The data indicates tirz is pretty hardy and can be frozen. But every time it is frozen and thawed it will degrade a little more. If it were me I would freeze in aliquots each being a single dose. Limit it to one freeze thaw cycle. I would not freeze and refreeze the same vial.

 

[byefatlicia]

If it were me I would freeze in aliquots each being a single dose. Limit it to one freeze thaw cycle. I would not freeze and refreeze the same vial.

Thank you. That sounds like solid advise

 

[cldfront]

Two things to say:

1. I have heard from real users that reconned Survo can be frozen without issue.

2. When I first started Tirz from a medi-spa I was instructed to keep my vial frozen, and thaw it before each use. It worked just fine.

 

[indolent]

I'd be more worried about sterility issues when splitting it up into multiple vials.

I'd either move the reconnned vial in and out of freezer (it thaws quickly) or just ignore the 4-week rule and go with 12 weeks refrigerated (as I and many others here do)...assuming always alcohol-swabbing the top before puncture, including at recon.

 

[byefatlicia]

I'd be more worried about sterility issues when splitting it up into multiple vials.

I'd either move the reconnned vial in and out of freezer (it thaws quickly) or just ignore the 4-week rule and go with 12 weeks refrigerated (as I and many others here do)...assuming always alcohol-swabbing the top before puncture, including at recon.

1. I have heard from real users that reconned Survo can be frozen without issue.

2. When I first started Tirz from a medi-spa I was instructed to keep my vial frozen, and thaw it before each use. It worked just fine.

Would it make any sense to use a pen in this case or just re-freeze the vial?

 

[Peotidethrowaway]

Would it make any sense to use a pen in this case or just re-freeze the vial?

I wouldn’t freeze a pen cart if that’s what you’re asking. The rubber plug could pop out

When reconstituting a vial I don’t really see any contamination vector splitting it into multiple sterile vials. I would recon it and syringe filter it into a few vials in one operation

 

[AndyPanda]

Everything I see on the Google machine says freezing is not recommended. If freezing it doesn’t damage the chemical structure, it still might destroy the seal when everything expands and contracts. I caution against it.

 

[byefatlicia]

Everything I see on the Google machine says freezing is not recommended. If freezing it doesn’t damage the chemical structure, it still might destroy the seal when everything expands and contracts. I caution against it.

yikes... Fridge it is!

 

[Peotidethrowaway]

Everything I see on the Google machine says freezing is not recommended. If freezing it doesn’t damage the chemical structure, it still might destroy the seal when everything expands and contracts. I caution against it.

I freeze my lyophylized meds at -40c and have never had a seal fail. They all have a vacuum

 

[indolent]

yikes... Fridge it is!

No yikes. The no-freeze advice comes from the original form of the medication, whose mechanical injector pen would be messed up by freezing. Lab tests have shown that the chemistry itself is unaffected, and quite obviously the crimped-on rubber stopper wouldn't be affected by freezing either.

 

[vewdew34]

According to what I have read so far powder is ok to freeze but once you introduce Bac water you can't freeze it.

 

[peptidesupremacy08]

Two things to say:

1. I have heard from real users that reconned Survo can be frozen without issue.

2. When I first started Tirz from a medi-spa I was instructed to keep my vial frozen, and thaw it before each use. It worked just fine.

Thaw and refreeze after every use, that’s like exactly the opposite of what I’ve heard you should do, lol. Finding this forum and going through it feels a lot like parsing through gym info for the first time again.

 

[cldfront]

Thaw and refreeze after every use, that’s like exactly the opposite of what I’ve heard you should do, lol. Finding this forum and going through it feels a lot like parsing through gym info for the first time again.

No yikes. The no-freeze advice comes from the original form of the medication, whose mechanical injector pen would be messed up by freezing. Lab tests have shown that the chemistry itself is unaffected, and quite obviously the crimped-on rubber stopper wouldn't be affected by freezing either.

It's the opposite of what you've heard to do because people keep parroting the information from the original mechanical issue that freezing would cause and not actual science.

 

[cldfront]

Would it make any sense to use a pen in this case or just re-freeze the vial?

I think others have already responded to this but if you're going to freeze, freeze in vials so that the expansion of the liquid when it's frozen doesn't damage the pen structure.

 

[bbrewer]

Leave plenty of headspace in the vial and freeze it upright. The liquid will expand when freezing, and pressure in the headspace will increase a little. It won't be enough to damage anything.

 

[pavlovs]

It's the opposite of what you've heard to do because people keep parroting the information from the original mechanical issue that freezing would cause and not actual science.

However, the vials the eli lilly and Novo now sell also say to discard if frozen. I don't understand why people take chances that they really don't need to take, because this stuff is so cheap. There are worse things that can happen beyond just letting a little peptide go to waste. But then I always tend to be overly cautious.

 

[lessthanhalf]

Repeated freeze thaw cycles damage peptides, so freeze/thawing it 20 times ( 0.5mg x 20 = 10mg ) does not sound ideal. Keeping it in the fridge for 20 weeks after reconstituting it is not ideal either, it is unlikely but possible to get bacterial or fungal growth over that length of time, especially with 20 needle punctures. It would make sense to mix it with bac water and put 1/4 in each of 4 vials , freeze 3, and use each one for 5 doses (or 5 vials for 4 doses each), and just thaw a new one when you need it. Only one freeze thaw cycle and minimal chance of contamination.