Stuck at same weight for 2 weeks

[derekd419]

type 1 diabetic here. I started taking strictly tirz back in November 2025, 6.5 months ago, so far I've went from 269 lbs. to 216, my current weight. 53 lbs. lost just on tirz. I am on an extremely low calorie & carb diet, I take fiber supplements to get a high amount in, plenty of water, & my blood sugars are like 98% in range always (70-150).

I noticed the past 4 weeks my weight loss has slowed up big time, a few here, a few there. I attend the gym & work out for an hour 5 days a week. I just started a new stack exactly 8 days ago consisting of:

reta - 30 units (3mg) (weekly)

tesamorelin - 10 units (mon-fri)

aod 9604 - 6 units (mon-fri)

5 amino 1q - 6 units (daily)

bpc 157 + tb 500 - 10 units (daily)

mots-c - 10 units (mon-fri)

& then ghk-cu for skin care - 10 units (daily)

with nothing changing other than adding all of these to my weekly 15mg dose of tirz, I didn't lose a single pound last week & remain at 216. I'll be honest - I was shocked & a little disappointed but I know things take time, it's just discouraging with all the work I feel like I'm putting in. My goal weight is 165, & after ½ a year it seems like light years away at this point & I'm trying harder than ever in the gym. I start with weight lifting first for 30 mins, then cardio for 30-45 mins, that's what I've always known helps burn actual fat, lifting then cardio.

Any recommendations from anybody who experienced something similar, please definitely let me know. Maybe add a different peptide? Increase or lower any of my doses? Go harder in the gym? Eat more? I'm feeling lost & need to see some gains here as we all do. Thanks to anyone reading or commenting, I appreciate it so much.

 

[Rickcaps]

You've done great progress but don't panic yet. Often the weight just plateaus and it's a matter of time. Two suggestions, wait it out and keep at it OR shock the body with an unusual routine. The body loves routine and gets accustomed to it.

Have a binge day load up calories. Walk more, walk after meals. In the gym try hitting multiple body parts in a single day. Focus on more weight and volume. You're already on a good cocktail maybe just up your R. Figure out your therapeutic dose. Good luck!

 

[lastresort]

Why are you taking all these at the same time?

 

[CMA Pooky]

Some possibilities: My Reta wasn't effective 1 week because I found I was taking it too close to the time I was taking other peps so I made sure to space them apart by at least 2 hours. Additionally, Reta takes time (couple of weeks) to build up in your system.

 

[deluge]

My Reta wasn't effective 1 week because I found I was taking it too close to the time I was taking other peps so I made sure to space them apart by at least 2 hours.

This is a thing?

 

[igottapee]

Eli lilly phase 3(TRIUMPH) trial dosing is

2mg x 4weeks

4mg x 4weeks

6mg x 4weeks

9mg x 4weeks

12mg x 4weeks

Tesa will cause water retention, so you might let Reta do it's work

 

[lastresort]

Eli lilly phase 3(TRIUMPH) trial dosing is

2mg x 4weeks

4mg x 4weeks

6mg x 4weeks

9mg x 4weeks

12mg x 4weeks

Tesa will cause water retention, so you might let Reta do it's work

You gotta pee out the water retention man

 

[Jfrick11]

type 1 diabetic here. I started taking strictly tirz back in November 2025, 6.5 months ago, so far I've went from 269 lbs. to 216, my current weight. 53 lbs. lost just on tirz. I am on an extremely low calorie & carb diet, I take fiber supplements to get a high amount in, plenty of water, & my blood sugars are like 98% in range always (70-150).

I noticed the past 4 weeks my weight loss has slowed up big time, a few here, a few there. I attend the gym & work out for an hour 5 days a week. I just started a new stack exactly 8 days ago consisting of:

reta - 30 units (3mg) (weekly)

tesamorelin - 10 units (mon-fri)

aod 9604 - 6 units (mon-fri)

5 amino 1q - 6 units (daily)

bpc 157 + tb 500 - 10 units (daily)

mots-c - 10 units (mon-fri)

& then ghk-cu for skin care - 10 units (daily)

with nothing changing other than adding all of these to my weekly 15mg dose of tirz, I didn't lose a single pound last week & remain at 216. I'll be honest - I was shocked & a little disappointed but I know things take time, it's just discouraging with all the work I feel like I'm putting in. My goal weight is 165, & after ½ a year it seems like light years away at this point & I'm trying harder than ever in the gym. I start with weight lifting first for 30 mins, then cardio for 30-45 mins, that's what I've always known helps burn actual fat, lifting then cardio.

Any recommendations from anybody who experienced something similar, please definitely let me know. Maybe add a different peptide? Increase or lower any of my doses? Go harder in the gym? Eat more? I'm feeling lost & need to see some gains here as we all do. Thanks to anyone reading or commenting, I appreciate it so much.

Honestly for me..... this reads less like “nothing is working” and more like someone whose body is waving a giant “I need a minute” flag.

You've lost 53 lbs in 6.5 months. That’s a huge amount of weight loss. The closer you get to a lower weight, the harder your body fights to maintain homeostasis. A slowdown after that kind of drop is extremely common..... especially when you are:

eating very low calorie,

training hard 5x/week,

on a GLP,

and stacking a pharmacy’s worth of peptides on top.

A few things jump out at me....

Two weeks is not a true stall. Especially when you're lifting weights that hard and that much. Water retention from inflammation/muscle repair alone can completely mask fat loss on the scale.

You added a ton of compounds all at once. If anything causes stress, inflammation, water retention, cortisol elevation, sleep disruption, or appetite changes, there’s no way to tell which one.

“Go harder” is probably the last thing you need... Chronically under-eating + overtraining often leads to holding water and feeling wrecked.

You may actually need more food, especially protein/carbs around workouts.

Type 1 diabetes adds another layer because insulin changes can also affect weight/water storage significantly.

I would also be conscious of tge mindset trap that can happen in this space where we assume:

“If weight loss slows, I need another peptide.”

Sometimes the answer is the opposite:

simplify

stabilize

recover

sleep better

eat adequately

let the body catch up

enjoy and be proud for a bit of what you've accomplished so far

 

[gimmeshelter]

That stack is crazy man. U have no idea what is working or holding u back. And, you had a few bad weeks or was it one week? Regardless, u have lost alot - look at this over a larger window of time.

 

[lessthanhalf]

The tesamorelin is new and an expected side effect of it is fluid retention, so most likely you have lost a pound or 2 of fat and gained it in water from the tesamorelin. If you are continuing to lose weight even if not showing on the scales eventually you will stop retaining extra water and weight will start going down again, or if you stop the tesa the extra fluid will be gone in a week or 2. But otherwise the extra fluid will hang around until you stop the tesa. But this only explains weight not changing since you started tesa 8 days ago and you said weight has not really changed for 4 weeks.

If you only started tirz in november, and you are still on 15mg, and if I am reading it correctly you added in 3mg of reta on top of the tirz, and the number of calories you are eating has not changed, then it is very unlikely the fat loss has stopped. I would need to see the progression of weight over the past couple of months. If it was gradually slowing down then stopped , it could be a real stall, but it is still more likely to be fluid balance changes even before you added in the tesa. Usually if you are on a decent dose, and weight has been dropping, and then suddenly stops, it is more likely to be a glitch and just extra fluid which is temporary, in the studies it usually took about a year or a year and a bit to hit steady state weight, and you have been on it about 6 months, so it again sounds a bit early for a true stall.

The reason that weight loss stops on GLP drugs is that energy expenditure drops with weight loss, partly due to less lean and fat mass cells using energy , which just depends on weight loss, and then due to metabolic adaptation to low calorie input, but that is usually more based on time so at least 6 to 12 months. Added to that is increased hunger from weight loss, and there is a point where the GLP drugs are enough to keep calorie intake from rising and putting weight back on, but not enough to lose more weight. Which is the end stable state at a lower weight on GLP drugs, and you hope you get to your target weight before this happens.

The reality is there is not a lot of research on using tirz in type 1 and none at all with reta. Weight loss does work differently in type 2 diabetics with GLP drugs, where they usually lose less weight than non diabetic obese persons, but for type 1 - no idea. But it still sounds more like you have an extra couple of kilos of fluid rather than having the weight/fat loss stop, just going on the doses and the timing and no changes in diet. I suspect you will see it drop after a month or so but it depends on how much extra fluid the tesa causes to hang around, and I have no way of guessing that. You can measure waist circumference , and if it is going down you are definitely losing fat, but getting super accurate measurements is pretty difficult as it depend on exact position of the tape and how tight it is.

 

[CMA Pooky]

This is a thing?

It can be.

 

[bogardbilla]

I should point out that you used units instead of milligrams to describe your dosage. That indicates there may still be some gaps in your understanding of peptides and medication dosing.

On top of that you seem very impatient, needlessly worried about a two-week weight loss stall.

I suggest you calm down and go through the basics once again, otherwise it's highly likely you'll end up hurting yourself one way or another.

 

[Crowreap]

What's the number of calories you consume daily and your macronutrient breakdown, roughly? If you didn't lose a single pound for 2 weeks, then what's going on is it's simple. You were not in a calorie deficit for the past 14 days. Because a calorie deficit is the only way to lose weight. That's why I ask you how many calories do you consume in a day? It's absolutely essential to have a number, a daily number like this, so that way you can track and make little minor adjustments.

It's not as simple as taking peptides to move the number on the scale. Even if you are on peptides or not, you have to be in a calorie deficit daily to get leaner slowly over time. GLP-1s are just a tool; they just make being in a calorie deficit easier, nothing else because they reduce appetite and cravings. They don't cause the weight loss. They simply aid in your goal of losing weight. Weight loss happens by burning more calories than consuming.

 

[Jfrick11]

What's the number of calories you consume daily and your macronutrient breakdown, roughly? If you didn't lose a single pound for 2 weeks, then what's going on is it's simple. You were not in a calorie deficit for the past 14 days.

I’d be a little careful with making it that black and white. A calorie deficit is absolutely required for fat loss over time, but the scale itself is not a real time fatloss monitor..... especially in someone who has already lost 53 lbs, is lifting hard 5x/week, is type 1 diabetic, and just added multiple compounds including tesamorelin, which is known for fluid retention.

Add to that the possibility of water retention from training stress, glycogen shifts, inflammation, insulin changes, sodium intake, sleep, cortisol, etc. Which all can easily mask fat loss temporarily.

Also, he mentioned he’s barely eating while training aggressively. Sometimes the issue isn’t push harder, it’s that recovery, nutrition, and overall stress load are becoming limiting factors. His body very well may be screaming.... Let me rest, give me fuel, let me feel safe again after all of this change.

I do absolutely agree with you though that having at least a good idea of calories/macros intake is a must, especially after that much loss and especially with all the pedals he's pushing.

 

[Crowreap]

Add to that the possibility of water retention from training stress, glycogen shifts, inflammation, insulin changes, sodium intake, sleep, cortisol, etc. Which all can easily mask fat loss temporarily.

Yes, definitely, it could be a lot of water retention and all of the things that you mentioned. But if the number on the scale hasn't moved in the past two weeks, then most likely it has to do with the number of calories he is consuming. If the number on the scale hasn't moved in a few days, then it isnt really an issue cause it could be a whole host of factors. I only mention the scale because 2 weeks without change is a long time compared to a few days if theres no change on the scale especially if on glp1s. Also, you are right about the scale itself is not a real time fat loss monitor because a body recomposition is completely possible where the scale barely moves or stays the same, but then you get leaner.

 

[QueenMuntha]

Being a T1D, you should be very careful not to get too low in balancing insulin and this cocktail of drugs. Hypoglycemia can kill you my man.

 

[Jfrick11]

Yes, definitely, it could be a lot of water retention and all of the things that you mentioned. But if the number on the scale hasn't moved in the past two weeks, then most likely it has to do with the number of calories he is consuming. If the number on the scale hasn't moved in a few days, then it isnt really an issue cause it could be a whole host of factors. I only mention the scale because 2 weeks without change is a long time compared to a few days if theres no change on the scale especially if on glp1s. Also, you are right about the scale itself is not a real time fat loss monitor because a body recomposition is completely possible where the scale barely moves or stays the same, but then you get leaner.

I think we probably agree more than disagree .

Over a long enough timeline, energy balance absolutely matters. I just think in cases like this..... major recent weight loss, aggressive training, very low calories, type 1 diabetes, and a bunch of new compounds including one known for fluid retention..... the scale can become a pretty noisy short term metric.

Especially because 53 lbs down in 6.5 months already suggests he has been in a substantial deficit overall.

I also think in these communities people interpret “scale not moving for 2 weeks” as “something is broken, add another peptide, train harder, eat less,”...... when sometimes the body may actually need recovery, stabilization, and adequate nutrition to continue progressing.

And you know... I don’t just think that theoretically..... I see it all the time here and in my own practice. People can become so focused on forcing the scale to move that they stop recognizing the signs that their body is overstressed, underfueled, inflamed, exhausted, or simply trying to adapt after massive weight loss. Goes equal for body comp changes, just starting on the meds and the basic principle that every single body is different.

And a hell yes that tracking intake/macros becomes increasingly important as weight loss progresses and the margins get smaller.

 

[staffn1]

Recomp unlikely. Weight loss rate before was pretty normal, 2lb per week. No way gaining 2lb per week of muscle to overcome such a weight loss.

 

[Jfrick11]

Recomp unlikely. Weight loss rate before was pretty normal, 2lb per week. No way gaining 2lb per week of muscle to overcome such a weight loss.

I was just saying recomp in general (not his/hers... Just talking about people in general) can cause a stall on the scale and people can react and immediately jump to "more meds, more peptides, eat less, etc*

 

[Habibibi]

type 1 diabetic here. I started taking strictly tirz back in November 2025, 6.5 months ago, so far I've went from 269 lbs. to 216, my current weight. 53 lbs. lost just on tirz. I am on an extremely low calorie & carb diet, I take fiber supplements to get a high amount in, plenty of water, & my blood sugars are like 98% in range always (70-150).

I noticed the past 4 weeks my weight loss has slowed up big time, a few here, a few there. I attend the gym & work out for an hour 5 days a week. I just started a new stack exactly 8 days ago consisting of:

reta - 30 units (3mg) (weekly)

tesamorelin - 10 units (mon-fri)

aod 9604 - 6 units (mon-fri)

5 amino 1q - 6 units (daily)

bpc 157 + tb 500 - 10 units (daily)

mots-c - 10 units (mon-fri)

& then ghk-cu for skin care - 10 units (daily)

with nothing changing other than adding all of these to my weekly 15mg dose of tirz, I didn't lose a single pound last week & remain at 216. I'll be honest - I was shocked & a little disappointed but I know things take time, it's just discouraging with all the work I feel like I'm putting in. My goal weight is 165, & after ½ a year it seems like light years away at this point & I'm trying harder than ever in the gym. I start with weight lifting first for 30 mins, then cardio for 30-45 mins, that's what I've always known helps burn actual fat, lifting then cardio.

Any recommendations from anybody who experienced something similar, please definitely let me know. Maybe add a different peptide? Increase or lower any of my doses? Go harder in the gym? Eat more? I'm feeling lost & need to see some gains here as we all do. Thanks to anyone reading or commenting, I appreciate it so much.

Units tell us nothing. You could be taking 10mg tesamorelin or 1mg. Please use mg.

Weight loss plateau is not 2 weeks without the weight moving, it's closer to 5-6 weeks. So you're not in a plateau.

You're taking too many things, especailly if you don't have a scale that tells you if your weight stall is coming from increased fat, or increased water retention. You should probably stop tesamorelin if you don't like to put on water weight.