State of the Stack

[Romulusguy]

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So these are some peptides that are being experimented with, not all at the same time.

TB-500 & BPC-157: I have only ever cycled these as a blend, SQ. I think they contributed greatly to the healing process of a torn muscle and damaged tendon. As a side note, my hard on was, well, extra hard when using this combo, although that was certainly not the reason I was using it. I am on an off cycle now but will use again.

Epithalion: I'm on a 10 day cycle of this, almost a week in. The first night, I had vivid dreams. Subsequent nights, not so much. It may be a placebo effect, but I feel like my entire body is tingling, internally (in a good way) when this has been injected SQ. I have noticed I wake up a bit earlier when using this, feeling very refreshed.

Semax & Selank: I use both of these as a nasal spray, and have been on a 3 week cycle, about to cycle off. I was engaged in some heavy professional and academic workload, and I REALLY enjoyed the effects these had on my ability to focus and calming me down from stress.

Oxytocin: I have only tried this once, and I am not sure if I felt anything or not. I was very nervous because I have read mixed information on correct dosage, both for the SQ and nasal spray options. I need to do a bit more research before I feel comfortable using this again SQ, but I am confident in the information I have researched for nasal spray and I will begin experimenting with it this weekend.

PT-141: I have experimented with this twice, and felt nothing both times. I'm pretty dissapointed becuase I heard so many fantastic things about it.

Tirzepatide (not pictured): My first entry into the world of peptides, truly a miracle peptide that has worked swimmingly well for me in the 7 wekks I have been using it.

Lipo-C (The red vials): SQ. This stuff STINGS bad for 30 seconds, then calms down to a dull burn for the next few hours. However, I really like the energy it has given me and my 2 week "slump" broke when I began adding this to my routine (3X a week). Coincidence? Perhaps. But it can't hurt me so I will continue to use it.

Again, I am not using all of these at the same time. But these have been my experiences so far with the stack I have access to.

 

[Lovedog100]

Oxytocin: I have only tried this once, and I am not sure if I felt anything or not. I was very nervous because I have read mixed information on correct dosage, both for the SQ and nasal spray options. I need to do a bit more research before I feel comfortable using this again SQ, but I am confident in the information I have researched for nasal spray and I will begin experimenting with it this weekend.

PT-141: I have experimented with this twice, and felt nothing both times. I'm pretty dissapointed becuase I heard so many fantastic things about it.

I would suggest blending the Oxytocin and PT-141 together. They seem to enhance eachother when used together. I'm supprised that no one has caught on to what a money maker a blend would be on the market.

 

[Calm Logic]

Blending is rarely a good idea, and oxytocin is overrated. Between the four-minute half life and the fragility of the peptide itself, no thanks.

 

[lessthanhalf]

There is reasonably good evidence that oxytocin reduces appetite in human studies as well as animal ones. When I have tried it it does seem to have that effect. Due to the time taken for systemic absorption after s/c injection the real world half life is going to be a lot longer as it is gradually released into the bloodstream. Just about all the peptides have that problem of super short plasma half life unless they have been designed to last longer like GLP's. A lot of the studies of oxytocin are intranasal 25-50iu 4 x a day usually. I have doubts about how well peptides make it directly to the brain from intranasal administration, it is a much much longer way to get there by diffusion than in rats and mice and you cannot really test brain drug levels in humans very easily. It will still get absorbed into the blood from the nose, and then may or may not make it to the brain depending on if it can get through the blood brain barrier.

 

[Mr. Blonde]

Goddamn

 

[flowdragon]

@romolus

Thanks a lot for sharing your perosnal insights! This is a nice add on to the contradicting YT lore we're all flooded with.

 

[Romulusguy]

UPDATE

Epithalion: I moved from 50ML (5mg) to 1ml (10mg) and vivid dreams returned. I again woke up feeling very refreshed. I am trying another 10MG tonight.

Oxytocin: I reconstituted 10mg with 25ML saline into a nasal spray bottle. Prior to this, I weighed a full spray bottle, activated the sprayer 10 times, then weighed again in order to calculate the correct dosage of 1–2 pumps per nostril (so 2–4 total pumps per dose), giving me roughly 112–224mcg (56–112 IU) per dosing event. I did feel a calmness about me, but as to feeling any closer to my fellow human being? That's a negative. I am going to continue using this for the next 2 weeks to see if I begin to feel something, or if there are any noticeable effects.

 

[Romulusguy]

UPDATE

Epithalion: I again took 1ml/10mg SQ before bed, and again I had vivid dreams and I slept for 10 hours, feeling very refreshed upon waking up. 10mg seems to be the ideal dose for my body so far. I have a few days left and I will continue using 10mg.

 

[yota96 38658]

What’s your Epi dosage been? There was a recent post that showed the dosage protocol may be much lower than previously thought.

 

[Romulusguy]

What’s your Epi dosage been? There was a recent post that showed the dosage protocol may be much lower than previously thought.

11MG reconstituted with 1ml (the 3 lab tests I have seen for this batch showed 11mg for a 10mg vial, so I just factor them all as 11mg even though it was sold as 10mg), dosage is 5mg/45 units about 30 minutes before bed.

 

[yota96 38658]

11MG reconstituted with 1ml (the 3 lab tests I have seen for this batch showed 11mg for a 10mg vial, so I just factor them all as 11mg even though it was sold as 10mg), dosage is 5mg/45 units about 30 minutes before bed.

You might want to read this thread.As well as https://pep-pedia.org/peptides/epitalon. I’ve never heard of dosing that high.

 

[Romulusguy]

You might want to read this thread. As well as https://pep-pedia.org/peptides/epitalon . I’ve never heard of dosing that high.

Thanks for the resources, I am looking closely at them. I began at much lower dose, but I felt little to nothing. Then, I came across a LOT of information, much of it anecdotal from others experimenting with the peptide, and decided to adjust.

https://www.peptides.org/epithalon-dosage/ recommends 10MG (wow). As I am now feeling fantastic results including intense and vivid dreams from the 5mg dose, I think I will finish up with 5mg for my last night.

https://peptidedosages.com/single-peptide-dosages/epitalon-epithalon-10-mg-vial-dosage-protocol/ Also recommends 5MG and is a decent resource for dosing information for peptides.

 

[Researcher6076]

I did a trial run with partial doses of the Khavinson protocol. My trial was just 1.6mg Thymalin + 1.6mg Epitalon, daily for 6 days . I tolerated it well and it eliminated my seasonal allergies , completely for 3 months. That's consistent with the immune mechanisms in place. Sincer there were no negative side effects I'm going to procced with the full Khavinson protocol of 10mg each for 10 days once my new order arrives.

There is good clinical safety data from human trials for this dose for an annual 10 day reset pulse like this. (When do we ever get good clinical data?) There are good reports from individuals that it can be run twice a year. Khavinson made clear in his papers that the biological mechanisms underlying Epitalon pointed to periodic pulse use and not continuous use .

 

[lessthanhalf]

While it is true that there is some human clinical trial data on these peptides , to say there is good clinical safety data is overstating it. It is still better than for many of the peptides people use with zero human testing.

The fact that this research is Russian , like all the bioregulator studies and semax and selank, does not mean the research is bad, but the fact that there is essentially no outside studies confirming results is more than enough for skepticism.

Unfortunately many people have financial motives to support and promote peptide usage and very often overstate the science , confuse in vitro/animal and human research data, often implying data is from human research when it is not, and not mentioning that evidence in preclinical studies is not evidence of safety or efficacy in humans, with most promising drugs over 90% fail when tested in humans.

A highly prompted for scientific accuracy version of chatgpt summary of the research is:

Some small human studies exist, mostly from Russia.

Evidence quality is weak by modern clinical trial standards.

The 10-day pulse protocol is not validated by rigorous trials.

Safety data are limited rather than robust.