Starting Dose Strategy on Reta – Slow Titration vs. Jumping to 2 mg Weekly

[jc1892]

Make sure you get the protein down.

I’ve been taking 4, 50 g shakes. How much do you suggest?

 

[BNLFL]

I’ve been taking 4, 50 g shakes. How much do you suggest?

I don't track that. Just have it in breakfast, protein shake for lunch, meat and a fresh veggie for dinner.

 

[Strawberry man]

I want to start a discussion about starting dose on Reta and hear some real experiences from others.

I started very cautiously:

0.5 mg for 2 weeks

then 1 mg for another 2 weeks

during the second week at 1 mg, I split the week in half and pinned another 1 mg

So now I’m doing:

1 mg every Tuesday morning 6 am

1 mg every Friday evening 6 pm

Honestly, only now do I feel like I’ve reached the right dose for me. Before that, I could barely even say I felt anything, except maybe some mild effect about an hour after injection.

The reason I approached it this way is because I read a lot of reports from rats that jumped straight to 2 mg and regretted it because of sides. But now I’m really wondering if starting lower than 2 mg actually makes sense in practice for adaptation, or if many people simply delay getting meaningful effects.

My weight literally did not move until I reached a total of 2 mg/week. I should also mention that I’m already fit and not massively overweight, so maybe that changes things compared to people with a lot more body fat to lose.

What were your experiences with starting doses?

Do you think the slow titration below 2 mg really helps the body adapt, or is it often unnecessary for people who tolerate it well?

Interested to hear different perspectives. Thank you for considering.

I started at 1 MG. Had what felt like panic attacks but was probably increased heart rate. My chest felt tight and could not get deep breath like normal. I had an episode at the gym and had an ambulance called. The poked and prodded me and found nothing they were concerned with. Fortunately I did not have to take a ride to the hospital. I lowered my dose to 500mcg for a few weeks . Slowly I. Increased dosage by 250mcg every 3 or 4 weeks. Eventually got to 2mg but have since backed back down to 1.5. Been on Reta going in 14 months

 

[Kris P]

I started on this past Monday with 1mg, felt mild sides(crampy slow digestion) perhaps a mild blunting of hunger, I took my second dose Thursday, so I’m starting at 2mgs per week. Feel similar after second dose but food noise has decreased, It’s weird, I can eat but it’s not like I’m starving, I eat because I know I need to. 58 Year old male, 6’2” current weight is 230lbs. I was 238 lbs one week ago.

So my strategy is to stay at 2mgs per week and slowly increase as needed.

 

[BNLFL]

I was 238 lbs one week ago.

8lbs a week is a shitload. If true, it's likely water weight. Did you start dieting too?

 

[RaveBaddie]

I think it depends somewhat how much overweight a person is what the start dosage should be.

And splitting the dose seems for a lot of people a good idea because they experience less side-effects.

So I'm an advocate for starting with 1mg for the first pin when you are obese and pay close attention to your body the next few days.

Then if everything is manageable, pin another 1mg 3,5 days later. Check again for side-effects.

Keep it the same for at least another 2 weeks.

 

[MarcTheAnimal]

I took my first dose at 1mg on Wednesday night. Had some trouble falling asleep even with the magnesium and glycine I take. Nothing but protein shakes and vitamins during the day, even with strength training in the early am, until getting home from work where my wife made dinner Thursday and Friday. Had my first lunch craving today which I acted on. Considering another 1mg tonight, if I do will continue with split dose schedule of another 1mg next Wednesday

I fixed my rats sleep with DSIP

 

[MarcTheAnimal]

I think it depends somewhat how much overweight a person is what the start dosage should be.

And splitting the dose seems for a lit of people a good idea because they experience less side-effects.

So I'm an advocate for starting with 1mg for the first pin when you are obese and pay close attention to your body the next few days.

Then if everything is manageable, pin another 1mg 3,5 days later. Check again for side-effects. Keep it the same for at least another 2 weeks.

That's how my rat is running at the mom, thinking of highering the dose 0.5 by the end of next week... Thank you for the feedback

 

[modoodom]

I want to start a discussion about starting dose on Reta and hear some real experiences from others.

I started very cautiously:

0.5 mg for 2 weeks

then 1 mg for another 2 weeks

during the second week at 1 mg, I split the week in half and pinned another 1 mg

So now I’m doing:

1 mg every Tuesday morning 6 am

1 mg every Friday evening 6 pm

Honestly, only now do I feel like I’ve reached the right dose for me. Before that, I could barely even say I felt anything, except maybe some mild effect about an hour after injection.

The reason I approached it this way is because I read a lot of reports from rats that jumped straight to 2 mg and regretted it because of sides. But now I’m really wondering if starting lower than 2 mg actually makes sense in practice for adaptation, or if many people simply delay getting meaningful effects.

My weight literally did not move until I reached a total of 2 mg/week. I should also mention that I’m already fit and not massively overweight, so maybe that changes things compared to people with a lot more body fat to lose.

What were your experiences with starting doses?

Do you think the slow titration below 2 mg really helps the body adapt, or is it often unnecessary for people who tolerate it well?

Interested to hear different perspectives. Thank you for considering.

I’m only on week 4 myself, but I took a pretty similar approach:

0.5mg for 2 weeks, then 0.75mg for the next 2 weeks. Even at those lower doses I’ve already had pretty strong appetite suppression and reduced food noise, so I haven’t felt a huge rush to climb yet.

My mindset has been “minimal effective dose.” I’d rather slowly work upward if needed than overshoot early, deal with sides, or build tolerance faster than necessary. I also want to clearly understand what each dose change is actually doing.

I think a lot of people define “working” differently too. Some mean scale movement, others mean appetite suppression, impulse control, body composition, inflammation, etc.

I’m around 13% body fat already eating roughly 2000 calories with ~200g protein daily, so I’m not seeing massive scale movement yet, but visually I can definitely see body composition changes already.

Personally, I think slower titration helps with adaptation and self-awareness, even if it delays peak effects a bit.

 

[BNLFL]

Personally, I think slower titration helps with adaptation and self-awareness,

What the heck does this mean?

 

[modoodom]

What the heck does this mean?

Mostly just that slower titration gives me more time to actually observe how my body responds before changing variables again.

Things like hunger, energy, sleep, recovery, mood, cravings, GI effects, training performance, etc. can all shift a bit, and if I’m constantly jumping doses it becomes harder to tell what’s actually causing what.

By “self-awareness” I basically mean paying attention to those patterns instead of just chasing faster results immediately.

 

[Vriende]

Mostly just that slower titration gives me more time to actually observe how my body responds before changing variables again. ...

.

By “self-awareness” I basically mean paying attention to those patterns instead of just chasing faster results immediately.

I love the nuances in your posts and being gentle, working with your body rather than attempting to pound it into submission.

 

[Kris P]

8lbs a week is a shitload. If true, it's likely water weight. Did you start dieting too?

I was eating pretty clean, Keto “ish” but not high fat. The Reta seemed to help with the willpower and I just didn’t seem to eat as often. I swear I was stuck at 238 lbs for weeks, 230 was a nice surprise.

 

[A-Train]

I’m only on week 4 myself, but I took a pretty similar approach:

0.5mg for 2 weeks, then 0.75mg for the next 2 weeks. Even at those lower doses I’ve already had pretty strong appetite suppression and reduced food noise, so I haven’t felt a huge rush to climb yet.

My mindset has been “minimal effective dose.” I’d rather slowly work upward if needed than overshoot early, deal with sides, or build tolerance faster than necessary. I also want to clearly understand what each dose change is actually doing.

I think a lot of people define “working” differently too. Some mean scale movement, others mean appetite suppression, impulse control, body composition, inflammation, etc.

I’m around 13% body fat already eating roughly 2000 calories with ~200g protein daily, so I’m not seeing massive scale movement yet, but visually I can definitely see body composition changes already.

Personally, I think slower titration helps with adaptation and self-awareness, even if it delays peak effects a bit.

My mindset is very similar.

I started at 0.25 every 7 days for 4 weeks. Then moved to 0.5 every 6 days for 4 weeks. Currently at 1mg every 5 days and will remain here for at least 4 weeks before titrating up.

I also already have strong appetite suppression and reduced food noise. Also experienced a handful of side effects even at this low dose. I've dealt with nausea and fatigue at 0.25, increased RHR at 0.5, and irregular menstrual cycle since the beginning.

Very little scale movement, but I know that will come eventually. I also really don't want to lose more than 1-1.5lb/week so my plan is to titrate up every 4 weeks until I reach that 1lb/wk mark and stay at that dose until it is no longer helping me lose that amount per week.

 

[Waterslither]

I want to start a discussion about starting dose on Reta and hear some real experiences from others.

I started very cautiously:

0.5 mg for 2 weeks

then 1 mg for another 2 weeks

during the second week at 1 mg, I split the week in half and pinned another 1 mg

So now I’m doing:

1 mg every Tuesday morning 6 am

1 mg every Friday evening 6 pm

Honestly, only now do I feel like I’ve reached the right dose for me. Before that, I could barely even say I felt anything, except maybe some mild effect about an hour after injection.

The reason I approached it this way is because I read a lot of reports from rats that jumped straight to 2 mg and regretted it because of sides. But now I’m really wondering if starting lower than 2 mg actually makes sense in practice for adaptation, or if many people simply delay getting meaningful effects.

My weight literally did not move until I reached a total of 2 mg/week. I should also mention that I’m already fit and not massively overweight, so maybe that changes things compared to people with a lot more body fat to lose.

What were your experiences with starting doses?

Do you think the slow titration below 2 mg really helps the body adapt, or is it often unnecessary for people who tolerate it well?

Interested to hear different perspectives. Thank you for considering.

So I actually started with 1mg Reta last Wed and then besides more frequent bathroom visits I didn't notice any other side effects or effects I was expecting from Reta. Then I took another 1mg Sat cuz why not, for all I knew it's not even Reta in the vial. Basically felt no food noise reduction except that maybe I could eat a little bit less after every meal. Also wasn't fully sure if it was just because I'm also eating the same meals everyday for a little over 2 weeks. Might try a slightly higher dose this upcoming week as long as I still don't notice the effects.

 

[Johnny D]

I started at 1 MG. Had what felt like panic attacks but was probably increased heart rate. My chest felt tight and could not get deep breath like normal. I had an episode at the gym and had an ambulance called. The poked and prodded me and found nothing they were concerned with. Fortunately I did not have to take a ride to the hospital. I lowered my dose to 500mcg for a few weeks . Slowly I. Increased dosage by 250mcg every 3 or 4 weeks. Eventually got to 2mg but have since backed back down to 1.5. Been on Reta going in 14 months

How much weight have you lost in those 14 months?

 

[Strawberry man]

How much weight have you lost in those 14 months?

The reason I started was because I heard this can help with alcohol consumption. My drinking has been cut in half. I lost 30lbs before Reta doing Keto diet. Started Reta at 178, got down to 154 which was to much weight loss. Lots of consistent bike riding and swimming helped me lose also. I have been floating around 170lbs for probably the last 5 months. Smooth sailing at the moment at 1.5 mg. I am not dieting or doing any consistent bike riding.

 

[PAPoots]

There's a lot of scary posts in this thread. Rapid titration schedules, massive starting doses, using a triple agonist at 13% bodyfat and trying to go lower. There are reasons why there are multiple peptides out there. Most of them are designed to help sugar control and the weight loss was a secondary effect. Reta will raise your RHR, why would anyone without any comorbidities take it knowing their sleep quality will go down when all they might need is the appetite suppression from Cagri. Not to mention the other side effects like allodynia, dehydration.

Don't use a sledgehammer to put a nail in the wall for a 4x6 picture frame.

 

[bay_area_schizo]

well I fucked up my first dose meant to have 2mg ended up having 4mg (don’t ask) felt like shit didn’t want to eat the works.

The second week I went to 2mg, stomach cramps and either constipation or dhiarea. However as from third week I started dosing 1mg on Mondays and another on Thursdays.

This had been the sweet spot for me no symptoms and losing weight at a steady pace ( too well!)

I have some appetite suppression but nothing major like other people have described food noise is completely gone l. I do stick to my macros and make sure I get all my protein in daily.

I’ve helped two friends start up with feta I recommended the first dose to be 0.5

The first one had all the side effects however by the second week all gone. Next week he will be hoping it to 1mg.

Think everyone should start of at 0.5 until your body can tolerate it and forage up slowly to your desired dose. Most people’s sweet spot seems to be 2mg without drastic rapid weight loss.

I know you said don't ask but I gotta do it what happened that you mistakenly doubled your expected dose? your experience can help some other rat

 

[Llanitox]

I know you said don't ask but I gotta do it what happened that you mistakenly doubled your expected dose? your experience can help some other rat

Hahaha I essentially used the wrong amount of bac to reconstitute it (1ml instead of 2ml for a 20mg vial). So what I thought was going to be a 2mg dose was actually a super concentrated 4mg dose