Starting Dose Strategy on Reta – Slow Titration vs. Jumping to 2 mg Weekly

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Llanitox said:
Hahaha I essentially used the wrong amount of bac to reconstitute it (1ml instead of 2ml for a 20mg vial). So what I thought was going to be a 2mg dose was actually a super concentrated 4mg dose
but did you die? lol thanks for sharing with us. I got a label maker today due to this fear
 
bay_area_schizo said:
but did you die? lol thanks for sharing with us. I got a label maker today due to this fear
No but when I was shitting my life away in the toilet I thought I was going to 🤣
 
Llanitox said:
well I fucked up my first dose meant to have 2mg ended up having 4mg (don’t ask) felt like shit didn’t want to eat the works.

The second week I went to 2mg, stomach cramps and either constipation or dhiarea. However as from third week I started dosing 1mg on Mondays and another on Thursdays.

This had been the sweet spot for me no symptoms and losing weight at a steady pace ( too well!)

I have some appetite suppression but nothing major like other people have described food noise is completely gone l. I do stick to my macros and make sure I get all my protein in daily.

I’ve helped two friends start up with feta I recommended the first dose to be 0.5

The first one had all the side effects however by the second week all gone. Next week he will be hoping it to 1mg.

Think everyone should start of at 0.5 until your body can tolerate it and forage up slowly to your desired dose. Most people’s sweet spot seems to be 2mg without drastic rapid weight loss.
Dude i saw your post asking about SSY but was not able to reply on your post, so i want to do it here. Be careful, they scammed me...
 
igottapee said:
Eli lilly phase 3 Trial (Triumph) dosage schedule:

2mg/week x4

4mg/week x4

6mg/week x4

9mg/week x4

12mg/week x4

I got to 12mg for 2 weeks and hit my goal. Now back down to 6mg/week.
Almost the same here . I used one of the early trial schedules. that went 2-4-8-12 all 4/weeks. I modified it a little, I went 2-4-6-8 and on 8mg now. 10 will be next if needed. It's worked well at 1.5-2lbs/week.
 
MarcTheAnimal said:
Dude i saw your post asking about SSY but was not able to reply on your post, so i want to do it here. Be careful, they scammed me...
How so ? Did you not receive your good ?

I’ve got the tracking number for my stuff already and on its way for a small test purchase
 
I did 1mg first week; didn't really feel anything. Increased to 1mg every 3 days second week and definitely felt it then. Skin sensitivity being my only real side effect. Definitely helped with not eating as much in a single sitting. Lost 8lbs in the first few weeks but then stopped. Most likely a lot of water weight. Just entered 5th week and increased to 1.5mg/3 days. No increase in sides and feeling good so far. Will monitor from here and increase as needed. Going slow; no need to rush anything. Weight is currently holding pretty steady but feel like I'm looking better which is more what I'm going for anyway. Weight isn't as important as the way my clothes fit, etc.
 
jc1892 said:
I took my first dose at 1mg on Wednesday night. Had some trouble falling asleep even with the magnesium and glycine I take. Nothing but protein shakes and vitamins during the day, even with strength training in the early am, until getting home from work where my wife made dinner Thursday and Friday. Had my first lunch craving today which I acted on. Considering another 1mg tonight, if I do will continue with split dose schedule of another 1mg next Wednesday
Maybe dose Reta in the morning, to alleviate the issue of trouble falling asleep. I stack with Tesamorelin, in the evening (fasted at least 2 hours before I jab), and it has done wonders for my sleep. Reta once a week in the morning. Tesa 5 days a week, 2 days off.
 
IMO starting at 0.5mg is just not worth it. Starting at 1mg at least and suck it up if you have any side effects. Personally, most people I've known handle 1mg-2mg fairly well when starting.

The thing about Reta is that you want to titrate up get to 4mg minimum as soon as possible. We already saw from the trials that the dose-response curves start going up at 4mg and flattening out at 9mg.

So, taking any less than 4mg means you're not getting much of the amazing fat burning benefits from Reta.

If the effects are too rough, just split dosage.

The Phase-3 Lilly trials have been following a starting dosage of 2mg with titration of 2mg every 4 weeks, and the results have been good.

I personally believe this is the best way to go about it, but then again, I haven't once gotten any side effects from GLPs even at 12mg Tirz and 4mg Reta.
 
I'm taking things VERY slowly. I started on 0.25mg and increased 0.25mg every five days. I'm hanging out at 1.0mg for a total of three weeks (four pins) and will increase to 1.5mg next.
 
ProblemChild said:
I'm taking things VERY slowly. I started on 0.25mg and increased 0.25mg every five days. I'm hanging out at 1.0mg for a total of three weeks (four pins) and will increase to 1.5mg next.
Living on the edge huh?
 
BNLFL said:
Living on the edge huh?
No, I have afib and know that Reta can trigger episodes so I'm taking my time titrating up. I'm in no hurry.
 
ProblemChild said:
No, I have afib and know that Reta can trigger episodes so I'm taking my time titrating up. I'm in no hurry.
What meds do they have you on? I had that 3.7 years ago. Very bad pneumonia put me into it. They had me on everything in the hospital. Cardiologist still has me on 2 meds.
 
BNLFL said:
What meds do they have you on? I had that 3.7 years ago. Very bad pneumonia put me into it. They had me on everything in the hospital. Cardiologist still has me on 2 meds.
No meds anymore. Had an ablation back in 2021 and have had no episodes to date (knock on wood).

I ran across this clip that talks about supplementing Taurine to help with the heart-related side effects of Reta.
 
Llanitox said:
How so ? Did you not receive your good ?

I’ve got the tracking number for my stuff already and on its way for a small test purchase
I got scammed, and they tried even to scam twice, as they contacted me over whatsapp that theys have a tracking number but had to pay an adiitional insurane fee of minimum 200$ The number was allocated to New York
 
pharaoh said:
IMO starting at 0.5mg is just not worth it. Starting at 1mg at least and suck it up if you have any side effects. Personally, most people I've known handle 1mg-2mg fairly well when starting.

The thing about Reta is that you want to titrate up get to 4mg minimum as soon as possible. We already saw from the trials that the dose-response curves start going up at 4mg and flattening out at 9mg.

So, taking any less than 4mg means you're not getting much of the amazing fat burning benefits from Reta.

If the effects are too rough, just split dosage.

The Phase-3 Lilly trials have been following a starting dosage of 2mg with titration of 2mg every 4 weeks, and the results have been good.

I personally believe this is the best way to go about it, but then again, I haven't once gotten any side effects from GLPs even at 12mg Tirz and 4mg Reta.
We also have to remember they are in business to make money and sell drugs. Why keep going up if you are still losing your goal per week?
 
Peoples individual responses to GLP drugs seems to be very variable, both side effects and useful effects. The advantage of starting at lower doses than standard is to reduce the risks of unpleasant side effects that happen suddenly. One person might get mild nausea at 8mg and another vomiting at 2mg , but the standard start doses were chosen for a reason, for reasonably low chances of severe side effects on starting. Starting at 1mg for a couple of weeks is reasonably sensible but not essential, starting even lower is probably in most people a waste of time.

People who are not overweight or only mildly so do seem to sometimes get stronger responses to lower doses. And in that case low doses and slow increases make sense, mainly as any health risks from taking the drugs are not counterbalanced by the health benefits of treating obesity. And usually those people are not going to need very high doses anyway.

I am not sure that how slowly you build up the doses makes any difference to the dose that will cause side effects in that person, which you can only find out by starting them and seeing what the effects are. Getting mild side effects at a lower dose is an indication that they will get worse with dose increases, which can be used to slow down dose increases, and is likely the main advantage of slow small dose increases. Tolerance to GI side effects like nausea is usually a fairly slow process, probably slower than even very cautious dose increase plans.

Interesting, that is the third person on this forum describing a panic attack like episode from starting reta, assuming it is a different person, it is not reported in the studies and probably should be.
 
lessthanhalf said:
Peoples individual responses to GLP drugs seems to be very variable, both side effects and useful effects. The advantage of starting at lower doses than standard is to reduce the risks of unpleasant side effects that happen suddenly. One person might get mild nausea at 8mg and another vomiting at 2mg , but the standard start doses were chosen for a reason, for reasonably low chances of severe side effects on starting. Starting at 1mg for a couple of weeks is reasonably sensible but not essential, starting even lower is probably in most people a waste of time.

People who are not overweight or only mildly so do seem to sometimes get stronger responses to lower doses. And in that case low doses and slow increases make sense, mainly as any health risks from taking the drugs are not counterbalanced by the health benefits of treating obesity. And usually those people are not going to need very high doses anyway.

I am not sure that how slowly you build up the doses makes any difference to the dose that will cause side effects in that person, which you can only find out by starting them and seeing what the effects are. Getting mild side effects at a lower dose is an indication that they will get worse with dose increases, which can be used to slow down dose increases, and is likely the main advantage of slow small dose increases. Tolerance to GI side effects like nausea is usually a fairly slow process, probably slower than even very cautious dose increase plans.

Interesting, that is the third person on this forum describing a panic attack like episode from starting reta, assuming it is a different person, it is not reported in the studies and probably should be.
Thank you for your reply, and I agree with you.

It was only after I recently increased my dose to 2 mg twice a week that I started experiencing skin sensitivity and allodynia. I don't think my initial dose had any effect on that.

I also think I would have experienced these side effects once I reached 4 mg per week, regardless of what dose I started with.
 
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