“Therapeutic range: The dose or blood-concentration range at which a treatment produces the intended clinical benefit with an acceptable level of side effects, balancing efficacy against toxicity.”
Phase 2 data suggests 4mg/week is the starting therapeutic range with 8mg showing ~33% higher loss compared to 4, and 12mg only showing a 6% higher loss compared to 8mg. That suggests a therapeutic range of 4mg+/week being therapeutic, and demolishing returns over ~8mg/week. In my head I split the middle and for myself consider 6mg+ to be therapeutic, higher doses typically have better losses but are limited by side effects.
Some of my goals include sustainable fat loss, lean mass preservation, and a general timeline I’d like to achieve it. I have cagri, tirz, and reta on hand for weight loss assistance (I have options). My plan centers around reta because it appears to be the most efficient way to get where I want to be, based on current knowledge and observations. If side effects cause problems (zero so far), I’ll reweigh my options and adjust accordingly.
For now my plan is to get my average exposure to ~7.5-10mg/week, which is the average steady state for ~6-8mg/week. That means tolerating peaks to 9-14.5mg depending on dosage frequency.
My current stage of my current plan involves getting off Tirz as Reta takes over intake control. It is not in the plan to take cagri, unless the situation changes. Lean mass preservation requires calories and effort. Appetite suppression and food noise control is my goal, not obliterating my desire and ability to eat. Through that I can make better decisions about when, what, and why I eat, which promotes sustainability.
