SS-31 protocols?

[Peloma]

I have not read up too much on serotonin syndrome, but it sounds like no fun from what I have read.

I feel like I had some of that when I over dosed myself with Selank (probably why I was gun shy with mixing it with blue). I felt uncomfortable and withdrawn. My head was in a strange place.

Do not pin more than 1mg if you are pep sensitive.

 

[Skidude]

I was introduced to a great website about 10 years ago, I have been a fan ever since!

Think about the "For Dummies" books but covering a wide array of subjects and condensed into short, entertaining, videos.

I have since shared it with many of my friends and would like to share it here.

This is a great subject to introduce Kurzgesagt to you all on as this video covers a few things relatable and important to us.

I am also taking this opportunity to adjust, maybe temporarily, my ava.

 

[Calm Logic]

I love the zombie metaphor for senescent cells. That helps a lot.

 

[Calm Logic]

After looking at many different options my first cycle was 4mg 5days on 2 days off for 6 weeks.

I am now ready for my next and will be stacking with overlaps as well- SS-31, Mots-C, NAD+

This is my current SS-31 protocol- Going with Basic first. 5mg a day also taking CoQ10,TMG,Lipo-c w/b12

Basic SS-31 Cycle (General Health & Mitochondrial Support) Dosage: 5-10 mg subcutaneous (SQ) daily Duration: 6-8 weeks Break Between Cycles: 6-8 weeks off Considerations: Take on an empty stomach for better mitochondrial uptake. Pair with Lipo-C, B12, or CoQ10 for enhanced mitochondrial function. Combine with low-impact exercise (walking, bodyweight training) for best results. Advanced SS-31 Cycle (Athletic Recovery & Performance) Dosage: 10-20 mg SQ daily Duration: 8-12 weeks Break Between Cycles: Equal to cycle length (8-12 weeks) Additional Support: Lipo-C/B12 injections for metabolism & energy. Creatine, TMG, and CoQ10 for added mitochondrial support. Cold therapy or sauna use to enhance mitochondrial function. Optional: Microdosing Approach (for Longevity & Maintenance) Dosage: 5 mg SQ 3-4x per week Duration: Ongoing with periodic breaks Breaks: 2-4 weeks off every 3 months

More info regarding dosing (from Reddit):

 

[Peloma]

More info regarding dosing (from Reddit ):

I find that one hard to believe.

 

[Calm Logic]

I find that one hard to believe.

Yes, but I have no choice but to believe something positive about micro-dosing (which is what 4 mg daily would be compared to 40 mg daily). I have only 100 mg total from SRY

 

[Peloma]

Yes, but I have no choice but to believe something positive about micro-dosing (which is what 4 mg daily would be compared to 40 mg daily). I have only 100 mg total from SRY

Definitely not a knock against you, or the benefit of taking a 4mg dose vs 40mg. I just don't see how every source is quoting the same, flawed study and they're like, "we're good with this..."

 

[Skidude]

More info regarding dosing (from Reddit):

Comment
by
u/lusterdallama from discussion

in
Peptides

Click to expand...

I would love to see more of this that was not 5 years old, I have seen most cycles start at 4mg 5/2 dosing.

My second I am doing 5mg 5/2

 

[Super Trips]

Yes, but I have no choice but to believe something positive about micro-dosing (which is what 4 mg daily would be compared to 40 mg daily). I have only 100 mg total from SRY

40mg would prolly make you superman i think 4-10mg tops would be good enough

 

[Calm Logic]

By @GimmeABreak, an interesting experience with SS-31, with more energy than MOTS-c:

I didn't notice much additional weight loss with SS31 after pinning for 2-3 months. For the first two-months I had great energy/focus from it , but can't really say it helped with weight or body composition.

I did notice some fat loss (maybe not weight, but belly fat) with MOTs-C. I didn't notice any energy increase with it but my waist size went down. This could have been from the Tirz but I think the MOTs played a role in it.

After a couple of months SS31 stopped giving any feels, even pinning a full 34mg vial (in 2 doses) on the same day , so I am taking a break for a month or two. I can't wait to revisit it and hope I get the feelz back.

Hard to say, I don't get a lot of "feelz" from most of the peps I mentioned. NAD+ (not a pep) maybe a little bit of energy but no rush like others report. SS31 was great at first, I guess I am optimized now so I really don't get much from it or MOTs-C.

Might want to consider adding a TMG supplement 30-60 minutes prior to NAD+ pin. It makes sure you have enough methyl donors to supply the NAD+. I take 1000mg 2x a day when taking NAD+, SS31 or MOTs-C.

 

[Skidude]

By @GimmeABreak , an interesting experience with SS-31, with more energy than MOTS-c:

ss-31 energy is anecdotal..

However, the "feeling" is real.

But only you get it.

 

[Peloma]

ss-31 energy is anecdotal..

However, the "feeling" is real.

But only you get it.

True. I just finished my first kit of SS-31, and definitely got feels early on. They dissipated, but the positive energy was still there.

Side note: Mots-c stings as advertised.

 

[Calm Logic]

The International Peptide Society is recommending 200 mg per day???

They certainly seem to be:

SS-31 - The International Peptide Society

SS-31 Szeto-Schiller-31 Elamipretide MTP-131 Bendavia SBT-272 Mitochondrial Antioxidant Support Contents Sequence: D-Arg-Dmt-Lys-Phe-NH2 Molar Weight: 639.8 g/mol Molecular Formula: C32H49N9O5 Most Frequent Uses: Mitochondrial support Neuroinflammation Memory/cognitive support Mitochondrial...

peptidesociety.org

SubQ dosage:
Supplied 100mg/ml

2ml SubQ daily x 4 weeks

 

[Calm Logic]

ss-31 energy is anecdotal..

However, the "feeling" is real.

But only you get it.

And MOTS-c is banned by the World Anti-Doping Agency (WADA), unlike SS-31. So I assume that is more evidence that MOTS-c would potentially provide more of a boost than SS-31.

 

[Peloma]

The International Peptide Society is recommending 200 mg per day???

They certainly seem to be:

SS-31 - The International Peptide Society

SS-31 Szeto-Schiller-31 Elamipretide MTP-131 Bendavia SBT-272 Mitochondrial Antioxidant Support Contents Sequence: D-Arg-Dmt-Lys-Phe-NH2 Molar Weight: 639.8 g/mol Molecular Formula: C32H49N9O5 Most Frequent Uses: Mitochondrial support Neuroinflammation Memory/cognitive support Mitochondrial...

peptidesociety.org

That would get expensive real fast. The most i took in this last cycle was 10mg. I didn't feel any increased benefit, but that's how these things work. Most of the benefit is in the background.

 

[Calm Logic]

I tried to contact them (The International Peptide Society), but their online form isn't working. But I will try to contact them somehow when I get a chance to see if it is a typo.

 

[Heatheranne818]

I read that, and it kept me from my dose of selank. I did just bang 700mg of Semax. Let's see how well they play together.

So how’d it go?

 

[Peloma]

So how’d it go?

Great. I'm two shots into mots-c, and have felt synergies with the nootropics. I'm charged!

Interesting side effect of this protocol... my sex drive got turned up with SS-31. Like ready at the drop of a hat.

 

[narrow11]

My girlfriend has stage 5 chronic kidney disease and took SS-31 at a dosage of 2.5 mg daily for nearly two months, with intermittent breaks, but it had no noticeable impact on her kidney function. It is possible the dosage was too low for her to experience any effects, as most clinical protocols I have seen range between 4–10 mg, so it may be worth considering another attempt. She also has type 1 diabetes, and is currently on MOTS-c and Retatrutide at 0.5 mg weekly, which has effectively stabilized her blood sugar levels around 3–4, something she has never experienced before. I would appreciate any anecdotal input on peptides and protocols that could be beneficial for her condition, as the next stage is dialysis, which she refuses.

 

[Fisherman2356]

I feel ya. I've been on 5mg daily for 11 days. Starting Mots-c on day 14. 5mg daily with two days off (3/2). Ss-31 will probably always be part of the rotation since I have felt some energy and focus gains.

I always doubt when people say I feel some more energy, and also when they say I heal faster. Those two are very subjective. As an example, I have more energy today than I had yesterday even though I never did anything. Long story short after trying almost every peptide there is I've come to the conclusion that at best it is money down the drain, and at worst it is money down the drain plus perhaps some unwanted side effect however small that may be.

So, I'm sorry to be blunt but no, you did not have more energy, or any positive effect from SS-31. GLP1's and HGH are an exception to the rest of peptide rule - being useless. BTW, I wish peptides really worked because I bought into the hype and still have one year or more worth stashed on a medical freezer with about 20-25 most common ones, I doubt I'll ever even use. This is my experience, and I think everyone who's getting great results it is in fact getting a good dose of placebo effect.