SS-31 + MOTs-C vs NAD+

[Chili777]

Yeah I get that there were some very limited rat studies but again, this is hardly definitive science and was done (to my understanding) as a small limited duration study to see if additional study was warranted.

From this people seem to be making large, far reaching assumptions about the need to cycle these substances, doses, etc. which is not born out by any science I'm aware of.

The particular study you referenced is passed along like it's some sort of grail doctrine on these boards that almost everyone is now using as the gold standard reference.

I get we need to start somewhere but when people keep referencing this as the reason for their protocol choices I'm left scratching my head.

Oh yeah. Exactly. You make the choice whether to follow this based on what limited evidence there is or not. I don't know if it's a grail document, but it is the only one I've found focused on mitochondrial rehab and it sure sounds good, even though the same studies are repeated throughout. It also established SS-31 comes before Mots-C, when who knows? But a lot of the peptide protocols are based on limited/anecdotal/rat trial data, so you either climb aboard or you don't. I just look at the data and try to determine what is compelling and what isn't and then test the thesis. On me.

 

[IronPaw.]

I like to use the Gorilla non stim pre-workout if my workout is going to be later than noon.

Yes i find going to the gym on the way home from work the best, so non-stim works for me.

 

[PAPoots]

Yes i find going to the gym on the way home from work the best, so non-stim works for me.

Smart, because when I get off of work, BTW I work from home, I want to hit the couch as soon as I see it. Especially in the winter. I have to go before work.

 

[IronPaw.]

Smart, because when I get off of work, BTW I work from home, I want to hit the couch as soon as I see it. Especially in the winter. I have to go before work.

Oh absolutely , i have yet to go home and back out to the gym, so stopping on the way home is mandatory!

 

[Twowheelr2]

Curious as to why stop the NAD+? I know these protocols typically say to cycle it .. but, why? People taking the NR/NMN pre-cursors do not cycle.

I’m going to research some other peptides.

 

[Twowheelr2]

Yeah I get that there were some very limited rat studies but again, this is hardly definitive science and was done (to my understanding) as a small limited duration study to see if additional study was warranted.

From this people seem to be making large, far reaching assumptions about the need to cycle these substances, doses, etc. which is not born out by any science I'm aware of.

The particular study you referenced is passed along like it's some sort of grail doctrine on these boards that almost everyone is now using as the gold standard reference.

I get we need to start somewhere but when people keep referencing this as the reason for their protocol choices I'm left scratching my head.

Tell us how it’s supposed to be done.

 

[CNCCurrency]

Tell us how it’s supposed to be done.

 

[Twowheelr2]

Then why all the questions about protocols?

 

[CNCCurrency]

Then why all the questions about protocols?

By whom?

 

[timj382]

They're synergistic. Prime with SS-31 to repair mitochondria and then stack MOTS-C and NAD+.

I've had NAD IVs administered by professionals and they take a long time- like an hour to hours depending on the amount of NAD. Even just a 100mg IV takes about an hour. If you take it in faster than that, they say it can cause nausea and other side effects. Even at the slow drip, I still got some nausea. I assume people at home doing this protocol aren't doing their own IV. How is everyone managing these 100 mg NAD doses twice a week? You just use as much bac water as will fit in the vial and pray for fortitude? Or is there something here I don't know? Sincerely asking. Would love to be educated.

 

[timj382]

4 week update on running SS31 with some background:

Late 30s, I’ve been on low dose Reta (0.5mg e5d) for 4 months. No other peps or meds, except a cycle of glow50. Dropped 9% body fat, now around 19%. Took nad+ e3d 50mg and felt significant change in baseline energy. Finished a cycle of ss-31 4mg every day for last 25 days and I’m left with more energy than I can spend. I don’t remember the last time I went to bed without being tired, but still being able to sleep. My head is buzzing in the morning when I wake up. Sleep score is averaging 88 despite getting up at least once to pee at night. I’m going to start mots-c before workouts next week but honestly don’t even feel the need for it. I can stack 2 workouts in a day and not get tired. Recovery is better too. Didn’t even know I could raise my baseline energy levels this high.

Happy to answer any questions and help other level up

Very cool. Thanks for the update. Mind if I ask your age?

 

[Twowheelr2]

Who designed this cycle? Is it based on research? Or a youtube bro? Just curious

These are just your questions.

 

[Twowheelr2]

I've had NAD IVs administered by professionals and they take a long time- like an hour to hours depending on the amount of NAD. Even just a 100mg IV takes about an hour. If you take it in faster than that, they say it can cause nausea and other side effects. Even at the slow drip, I still got some nausea. I assume people at home doing this protocol aren't doing their own IV. How is everyone managing these 100 mg NAD doses twice a week? You just use as much bac water as will fit in the vial and pray for fortitude? Or is there something here I don't know? Sincerely asking. Would love to be educated.

There must be a difference between IV, directly into the blood stream, and subcutaneous inj. SubQ is slowly absorbed by your body.

 

[timj382]

There must be a difference between IV, directly into the blood stream, and subcutaneous inj. SubQ is slowly absorbed by your body.

Guess so. Have you injected the 100mg NAD subq?

 

[Twowheelr2]

Guess so. Have you injected the 100mg NAD subq?

Yes.

 

[Wardor]

People love NAD+ and I’ve purchased and taken over 70 different peptides in the last 4 years and NAD+ is the one I feel did the least (if anything) even at large doses

 

[CNCCurrency]

These are just your questions.

Unless you have a factual answer to them? GIF STANDS

 

[tendency]

I've had NAD IVs administered by professionals and they take a long time- like an hour to hours depending on the amount of NAD. Even just a 100mg IV takes about an hour. If you take it in faster than that, they say it can cause nausea and other side effects. Even at the slow drip, I still got some nausea. I assume people at home doing this protocol aren't doing their own IV. How is everyone managing these 100 mg NAD doses twice a week? You just use as much bac water as will fit in the vial and pray for fortitude? Or is there something here I don't know? Sincerely asking. Would love to be educated.

I take 75mg 3x week via IM injection, SubQ did next to nothing for me. No sides. Using buffered NAD+.

 

[trojanpeptide]

I still don't understand why you guys juice NAD+ when you can just use NMN, NR, or NMNH. NAD+ needs to be converted to NMN or NR before even going into the cell, so it seems strange to do it that way. You might as well inject NMN/NR/NMNH. As well, NMNH is increasing NAD+ levels more than the others:

[Imported image pending local asset: attachments-1772644301684-webp.16911]

so idk why... not worth it imo.

 

[tendency]

I still don't understand why you guys juice NAD+ when you can just use NMN, NR, or NMNH. NAD+ needs to be converted to NMN or NR before even going into the cell, so it seems strange to do it that way. You might as well inject NMN/NR/NMNH. As well, NMNH is increasing NAD+ levels more than the others:

View attachment 16911

so idk why... not worth it imo.

Because we're all different and different strategies work/don't work for certain people. In my case the precursors NMM/NR did nothing.

NAD+ IM injections have been a game changer for me, however.