SS-31 + MOTs-C vs NAD+

[PAPoots]

For those of us running some form of the

SS-31/MOTs-C/NAD+ protocol, what is going to be your next protocol? At 55, I'm looking to improve cognitive and energy and I'm debating Cerebrolysin. I forgot where I read it but due to suggested cycles it seems to be a good one to follow up ss31 and epitalon protocols with.

 

[Calm Logic]

5 amino 1MQ is trendy for energy and is included in an NAD combo along with MOTS (in an expensive combo by the vendor WWB):

[Imported image pending local asset: attachments-screenshot_20251207_125927_adobe-acrobat-webp.11084]

The problem with 5 amino is playing with the dosing. It is like SS-31 or MOTS where there is no exact amount and pricing is an issue. I tried 5+ mg for my first subq dose. But that was a whole vial So I will get a 50+ mg vial/kit next time.

 

[PAPoots]

5 amino 1MQ is trendy for energy and is included in an NAD combo along with MOTS (in an expensive combo vial by the vendor WWB):

View attachment 11084

The problem with 5 amino is playing with the dosing. It is like SS-31 or MOTS where there is no exact amount and pricing is an issue. I tried 5+ mg for my first subq dose. But that was a whole vial So I will get a 50 mg vial next time.

I have the MOTS-c and NAD+. I'll have to keep my eye out for the 5 Amino when I get some green to shop with. Lack of energy is my biggest problem. I think the reta is causing that.

 

[Calm Logic]

Yeah, the fatigue from GLPs can really suck but eventually went away for me (unless I up the dose again). I never used controlled substances until I had tirz fatigue (taking modafinil from India and hopping on TRT).

Caffeine pills from Walmart may be just as helpful though (or just raising carb/calorie intake or adding electrolyte drinks if not drinking enough).

Some mild dehyration seems surprisingly common with GLPs due to lessening the desire for everything sometimes.

 

[PAPoots]

I have LIT pre-workout and a few other supps with caffeine, but i gotta get out of bed to get them.

I'm also in TRT, other than muscle gains, I never got much else.

I started down the mitochondria path hoping sleep would get better, but I think Reta messes my sleep up also. A higher heart rate shows up in my sleep score with a lot of restlessness.

 

[PopTart]

View: https://youtu.be/MPMJLA38o8M?si=HqZrRzuXPIUedmsN

I was pleasantly surprised by this video and that he addressed preventative (younger) vs repair (older) approaches.

I haven’t put much thought into adding 5 AM to the protocol but it sounds like it works like a turbo charger so something to explore.

I subscribed to his YouTube channel so hoping his other videos are as informative as this one.

 

[PAPoots]

I saw that video. I'm really hoping the MOTS-c will do something beneficial and noticeable when I get to that phase of the protocol.

 

[ocuzuc]

Yeah, the fatigue from GLPs can really suck but eventually went away for me (unless I up the dose again). I never used controlled substances until I had tirz fatigue (taking modafinil from India and hopping on TRT).

Caffeine pills from Walmart may be just as helpful though (or just raising carb/calorie intake or adding electrolyte drinks if not drinking enough).

Some mild dehyration seems surprisingly common with GLPs due to lessening the desire for everything sometimes.

same. early 60s. got tirz fatigue so bad i couldn’t keep my eyes open at my desk at work in the afternoons and i would go under. I tried caffeine, lots of it, gave me the jitters, bug time. Tried SAD

bright light therapy, at wake up, which worked up until the afternoon. My doctor gave me an Rx for modafinil. It was amazing. I was just awake, no jitters, no insomnia. I was on it for 3 months and weaned off and the fatigue had faded away, so no need to it anymore.

 

[Calm Logic]

I was pleasantly surprised by this video and that he addressed preventative (younger) vs repair (older) approaches.

I haven’t put much thought into adding 5 AM to the protocol but it sounds like it works like a turbo charger so something to explore.

I subscribed to his YouTube channel so hoping his other videos are as informative as this one.

YouTube AI summary:

Many people use MOTS-C for fat loss and energy but often see minimal results due to not addressing underlying mitochondrial health (0:00). The video explains that NAD+ is crucial for energy production in mitochondria, and its levels decrease with age (1:14).

Here's how the discussed peptides and compounds work:

SS-31 (Elamipretide): Repairs damaged mitochondrial membranes, reducing electron leakage during energy production by 40-60% (1:43). Think of it as a mechanic fixing structural damage (2:08).

MOTS-C: Activates AMPK, your metabolic master switch, improving insulin sensitivity and reducing reactive oxygen species (ROS) production, which damages mitochondria (2:17). It acts as a performance upgrade and a protective system (2:36).

NAD+: Critical for ATP production in the mitochondria (1:21).

5-Amino-1MQ: Prevents energy waste and helps recycle NAD+ for greater efficiency (7:37).

There are two main protocols for using these peptides, both scientifically valid:

Repair First Protocol (4:58): Recommended for individuals aged 35-55 with existing metabolic dysfunction, declining energy, and poor recovery.

Weeks 1-4: Use SS-31 (1-2mg daily) and NAD+ (100mg three times/week) to repair mitochondrial damage and boost cellular fuel (5:05).

Weeks 5-12: Replace SS-31 with MOTS-C (10mg split into three injections/week) and continue NAD+ (100mg three times/week) to optimize the repaired mitochondria (5:26).

Take a 4-8 week break after the 12-week cycle and repeat 2-3 times per year (5:47).

Prevention First Protocol (5:55): Suitable for younger, healthier individuals seeking preventative optimization.

Start with MOTS-C (10mg split into three injections/week) and NAD+ (100mg three times/week) indefinitely with occasional breaks (6:00).

Assess at weeks 4-8: If significant fatigue or metabolic issues persist, add SS-31 (1-2mg daily for 4-8 weeks) while continuing MOTS-C and NAD+ (6:30).

Return to MOTS-C and NAD+ maintenance after the SS-31 cycle (7:00).

Important Considerations:

Cycling: NAD+ supplementation requires cycling (8-12 weeks on, 4-8 weeks off) to prevent resistance and natural NAD+ production suppression (9:11). MOTS-C can be taken long-term with periodic breaks (9:38).

Foundation: These protocols enhance a solid foundation of proper sleep, nutrition, and exercise; they do not replace them (9:06).

 

[Twowheelr2]

For those of us running some form of the

SS-31/MOTs-C/NAD+ protocol, what is going to be your next protocol? At 55, I'm looking to improve cognitive and energy and I'm debating Cerebrolysin. I forgot where I read it but due to suggested cycles it seems to be a good one to follow up ss31 and epitalon protocols with.

74 year old male. My research is to follow the 14 week mitochondria protocol for molecular repair and enhancement. After that, my research will be 6 weeks on followed by 3 weeks off for a few cycles of GLOW. This will benefit cellular repair and enhancement. Molecular first followed by cellular.

 

[ConnieL]

Do any of you notice having more dreams when taking RETA? I hope this doesn't last long because they are not always pleasant dreams, and I remember them too long.

 

[ContainHer]

Is anyone filtering their NAD+? I'd like to filter mine but wasn't sure if it can be done.

 

[PAPoots]

Somewhere in there someone should work in 5A1MQ. Mix in that freaky orange stuff for added energy and increased NAD+ through the NNMT inhibition.

You had me a freaky orange stuff.

 

[PAPoots]

Do any of you notice having more dreams when taking RETA? I hope this doesn't last long because they are not always pleasant dreams, and I remember them too long.

You might ask that in the Reta forum. For me, no. The higher heart rate, more frequent trips to the bathroom... according to my sleep tracker I get a lot less REM sleep. So rarely do i dream. I'm hoping long term my body adjusts, or when I get to my goal weight, I can back off enough to get better sleep.

 

[AndyPanda]

Do any of you notice having more dreams when taking RETA? I hope this doesn't last long because they are not always pleasant dreams, and I remember them too long.

Get yourself some Prazosin. It will stop your dreams.

 

[Chili777]

74 year old male. My research is to follow the 14 week mitochondria protocol for molecular repair and enhancement. After that, my research will be 6 weeks on followed by 3 weeks off for a few cycles of GLOW. This will benefit cellular repair and enhancement. Molecular first followed by cellular.

I'm doing the same. I looked at cerebrolysin but I think I'm going to start with Epitalon for brain health first followed by Semax, both via IN. I read that Epitalon potentially helps with TBIs by restoring brain signal intensity. I've had a couple due to car accidents, none my fault. I read that Epitalon followed by Cerebrolysin acts synergistically. So, continuing Reta, followed by the mitochondrial protocol, followed by KLOW and then the brain health protocol, sequentially.

 

[Labcat]

This is a 14 Week protocol. Weeks 13 and 14 are the same as Week 12..MOTS-c and NADS+. The PDF has links to files and research documentation to explain the reasoning behind this schedule. I started it Firday.

Could you please please please link me to the pdf with the research documentation? I’m not finding it somehow.

 

[Labcat]

Did you make it or did it originate here? I just had the PDF shared with me.

Does your pdf have the references to the research supporting the protocol? Would you mind sharing that with me please?

 

[Chili777]

Does your pdf have the references to the research supporting the protocol? Would you mind sharing that with me please?

It has all that info. I attached it.

 

[Labcat]

It has all that info. I attached it.

Ah, thank you so much! I see the attachment. ETA oooh very meaty and presented so thoroughly!