SS-31 and Mots-c Protocol

[reddawg95]

Quick few questions for those with more knowledge and experience on these two.

I am looking for the energy benefits of this protocol, primarily.

In the attached picture and focusing on the Mots-C and Humanin protocol section (I will not be doing the Humanin portion, just the ss-31 and Mots-C). I have a few questions.

1. When it says 2 months of SS-31 - does this mean do two cycles of one of the above listed SS-31 dosing of 4mg per day for 10 -20 days or so 4mg per day for 2 full months?

2. The next instruction says, after one month start Mots-C....does that mean after you complete the 2 full months or cycles of SS-31 wait one month and then start Mots-C? Or does it mean after one month of the 2 month SS-31 dosing start Mots-C dosing (essentially taking ss-31 and Mots-C at the same time for one month)?

3. The Mots-C dosing would be 5mg 3x a week for 4 weeks and then 5mg weekly for 4 weeks, correct? Since not doing Humanin I continue with Mots-C 5mg once a week for an additional month then stop for a month and restart the protocol?

Any clarity/feedback on my questions would be appreciated. Thanks

I've been following this guy on Skool and seems knowledgeable on pep in general. I asked about this particular protocol with added NAD+

Weeks 1-4: SS-31 - 1mg per day, NAD+ - 100mg 3x per week

Weeks 5-8: MOTS-C - 10mg split between three doses per week, NAD+ - 100mg 3x per week, and 5 Amino 1MQ - 10mg split between three doses per week

 

[pughster25]

Ive been doing MOTS-C before SS-31 as per

@drtrevorbachmeyer on youtube

 

[Chili777]

He’s a chiropractor that had his license suspended and got banned for life from CrossFit for cheating. The leading and widely accepted protocol is the 14-week protocol (attached) that starts with SS-31 to prime the mitochondria for the Mots-c, and uses NAD+ throughout. They explain the science thoroughly. I take everything I hear from Trevor with a large grain of salt.

 

[Dos-Dox]

I’m following more of the researchdosing protocol for the SS-31 prep, but modified to build slower as my spouse is doing it also and I’m pretty conservative with what we do together. We did/are doing:

*1 mg/day of SS-31 for 10 days, then upped to 2 mg at day 11.

*Added 2.5 mg of MOTS-C at day 14 - twice weekly SQ for one week (while still at 2 mg SS-31 daily).

*We will up MOTS-C to 5 mg twice weekly and continue running SS-31 at 2 mg for another week.

*Then we’ll drop the SS-31 and continue MOTS-C at 5 mg twice weekly for another 10 weeks.

*Then I’ll probably come back and finish with another week or two of SS-31 only as a compromise to the SS-31 before MOTS-C/SS-31 after MOTS-C debate.

I also follow Bachmeyer but it seems he’s the only one (that I follow) saying MOTS-C FIRST. Most seem to say do the repair first with SS-31 and then do the tune-up/supercharging with MOTS-C. So I’m hedging my bets and doing SS-31 before, a little of overlap, AND after the MOTS-C. My preferred researching strategy is to listen to why other researchers think protocols should be conducted a certain way, decide what I think makes sense, and then take parts and pieces from different sources. It may end up being wasteful or ineffective, but at least I’ll have thought through the reasoning and, in the end, we are our own lab rats.

Good luck!

 

[Chili777]

We are our all own research subjects. I just caution against following what he says verbatim. He mixes pseudoscience with occasional facts, and his primary purpose is to sell his peptides at inflated prices. He is not a doctor, not even close.

 

[looksbadisbad]

This guy says if you are older/have mito damage, don't do mots-c first:

View: https://www.youtube.com/watch?v=MPMJLA38o8M&t=535s

On bachmeyer, any chiropractor calling trainers a sham is a joke. I tried to watch on of his videos once:

View: https://www.youtube.com/watch?v=iCJQ2g3tz_0

Any guy who is a scientist/doctor/professional that talks like he does in the first few minutes of this video is either a fraud or unethical. Then I googled about the crossfit, yep, he got banned...for fraud and unethical...So yep, he hit the twofer.

 

[SakeSan]

I’m following more of the researchdosing protocol for the SS-31 prep, but modified to build slower as my spouse is doing it also and I’m pretty conservative with what we do together. We did/are doing:

*1 mg/day of SS-31 for 10 days, then upped to 2 mg at day 11.

*Added 2.5 mg of MOTS-C at day 14 - twice weekly SQ for one week (while still at 2 mg SS-31 daily).

*We will up MOTS-C to 5 mg twice weekly and continue running SS-31 at 2 mg for another week.

*Then we’ll drop the SS-31 and continue MOTS-C at 5 mg twice weekly for another 10 weeks.

*Then I’ll probably come back and finish with another week or two of SS-31 only as a compromise to the SS-31 before MOTS-C/SS-31 after MOTS-C debate.

I also follow Bachmeyer but it seems he’s the only one (that I follow) saying MOTS-C FIRST. Most seem to say do the repair first with SS-31 and then do the tune-up/supercharging with MOTS-C. So I’m hedging my bets and doing SS-31 before, a little of overlap, AND after the MOTS-C. My preferred researching strategy is to listen to why other researchers think protocols should be conducted a certain way, decide what I think makes sense, and then take parts and pieces from different sources. It may end up being wasteful or ineffective, but at least I’ll have thought through the reasoning and, in the end, we are our own lab rats.

Good luck!

My rat is on a similar modified protocol. Finishing up ss-31 cycle before adding mots-c. Alternating 50mg nad+. This test hasn’t been clean due to other variables (life) so I’m unable to isolate the impact. How’s it going for you?

 

[KevinS]

This guy says if you are older/have mito damage, don't do mots-c first:

View: https://www.youtube.com/watch?v=MPMJLA38o8M&t=535s

On bachmeyer, any chiropractor calling trainers a sham is a joke. I tried to watch on of his videos once:

View: https://www.youtube.com/watch?v=iCJQ2g3tz_0

Any guy who is a scientist/doctor/professional that talks like he does in the first few minutes of this video is either a fraud or unethical. Then I googled about the crossfit, yep, he got banned...for fraud and unethical...So yep, he hit the twofer.

Josh Holyfield is just so easy to listen to. Seems like when he talks, it is understandable and relatable. I truly enjoy his videos.

Dr. T is entertaining. I am sure he has a lot of experience and knowledge. His constant self promotion and rants do get a little old. However, I still listen to him.

I’m following more of the researchdosing protocol for the SS-31 prep, but modified to build slower as my spouse is doing it also and I’m pretty conservative with what we do together. We did/are doing:

*1 mg/day of SS-31 for 10 days, then upped to 2 mg at day 11.

*Added 2.5 mg of MOTS-C at day 14 - twice weekly SQ for one week (while still at 2 mg SS-31 daily).

*We will up MOTS-C to 5 mg twice weekly and continue running SS-31 at 2 mg for another week.

*Then we’ll drop the SS-31 and continue MOTS-C at 5 mg twice weekly for another 10 weeks.

*Then I’ll probably come back and finish with another week or two of SS-31 only as a compromise to the SS-31 before MOTS-C/SS-31 after MOTS-C debate.

I also follow Bachmeyer but it seems he’s the only one (that I follow) saying MOTS-C FIRST. Most seem to say do the repair first with SS-31 and then do the tune-up/supercharging with MOTS-C. So I’m hedging my bets and doing SS-31 before, a little of overlap, AND after the MOTS-C. My preferred researching strategy is to listen to why other researchers think protocols should be conducted a certain way, decide what I think makes sense, and then take parts and pieces from different sources. It may end up being wasteful or ineffective, but at least I’ll have thought through the reasoning and, in the end, we are our own lab rats.

Good luck!

Click to expand...

I do like your version. I may incorporate this in my system.

 

[SakeSan]

posted an update in the other thread

Post in thread 'SS-31 + MOTs-C vs NAD+'

[archived internal link]

 

[Dos-Dox]

How’s it going for you?

We’re still in the MOTS-C stage of the research. Not noticing much yet, TBH. We’re definitely going to finish our modified protocol and see how the metrics look at the end, especially when it comes to blood markers for the T2D RS.

 

[Twowheelr2]

Here's a ss31 mots nad protocol some are personalizing.

My ss31 dose began at 1mg and I chose to titrate up to 3mg max.

Jay Cambell and Hunter Williams protocol doses are always more aggressive then say Dr Seeds. They may be going for an increased athletic performance effect and the later may be an anti aging and/or general repair effect; speculating. I suspect dosing for men and dosing for women based on kgs may be different as well.

Part of testing is finding personal sweet spot dosing.

This is the protocol I started researching. Began week 3 today with the addition of 4mg SS-31 and upping the NAD+ to 50mg. Not much to report, maybe some extra energy. Will add some exercise to see if the subject has more endurance.

 

[narrow11]

I will be joining shortly to run the same protocol and update my findings here weekly.

 

[looksbadisbad]

I just got a big order in, I need to do blood work, but I will be running a bit different but very similar protocol I can update/share as well.

 

[narrow11]

I just got a big order in, I need to do blood work, but I will be running a bit different but very similar protocol I can update/share as well.

What kind of blood work do you recommend doing before starting this protocol?

 

[looksbadisbad]

well i am adding some other things in there, but i will do lipids, hormones, cmp/cbc, havent fully reserached yet. might not start until jan., had something come up that will make me travel a lot last week of december and might just wait to start massive peptide switch.

 

[Twowheelr2]

Starting my 4th week now. This is the first experiment that requires daily ingggexshuns. No noticeable side effects reported. Energy boost is modest. Once the mitochondria have been enhanced there may be more noticeable energy and endurance gains.

 

[Waclive]

Anyone running SS-31 ever experience any mid day crash from it? I was reading some people saying they are just dead tired after the first part of the day when taking it in the morning.

I've also read that some people say 4mg is too much and they have better results with 3mg or less. Can anyone weigh in on this with personal experiences?

 

[Casme]

Anyone running SS-31 ever experience any mid day crash from it? I was reading some people saying they are just dead tired after the first part of the day when taking it in the morning.

I've also read that some people say 4mg is too much and they have better results with 3mg or less. Can anyone weigh in on this with personal experiences?

Yes. Sometimes it happens despite best efforts but part of it is you’re depleting methyl donor groups and crashing when too low. You need to take some NAD+ and TMG Betaine. NAD+ is like 100 mg twice per week and Betaine is 4,000 mg split into day and night doses

 

[Twowheelr2]

Anyone running SS-31 ever experience any mid day crash from it? I was reading some people saying they are just dead tired after the first part of the day when taking it in the morning.

I've also read that some people say 4mg is too much and they have better results with 3mg or less. Can anyone weigh in on this with personal experiences?

Finished 1 week of daily dosing of 4mg SS-31. Energy boost is modest and no reports of crashing. All doses administered in the morning so far.

 

[Waclive]

Finished 1 week of daily dosing of 4mg SS-31. Energy boost is modest and no reports of crashing. All doses administered in the morning so far.

Thank you. Did you start at 4mg?