Should I stack tirz and reta, or just use reta?

[trinik28]

you should wait, give your brain time to adjust.

There is no point to switching or stacking, give the drug a chance and be patient.

Why did you switch when Tirz worked so well ? Tirz is an amazing drug.

Because I heard reta was better. One of my coworkers is on reta. And she lost petty good on it. The last time I pinned 3 mg of reta I had really bad gas and bloating. I just pinned 3 today so hoping it was the turkey dinner...lol

 

[Rolltide61]

I started on Tirzepatide and lost 20 lbs in a month and heard about reta so I switched, I started at 2 for 2 weeks and I bumped it up to 3 last week ( so I had enough until my order came in) but I have only lost 1 lb. I hardly eat. Im definitely in a calorie deficit. My work keeps me on my feet and walking lots, and I've been doing weights in the morning before work. I havent been eating shitty. I was wondering if I should stack tirz and reta. Or just wait and ride out the reta and go up in the dose. Or switch back to tirz.

I think there is a benefit to stacking the tirz and reta. Tirz is working for you which is good but reta performs nutrient partitioning which is something bodybuilders have dreamed about.

Google it. There are some that claimed that you could do it w/ diet but you can't. That is unless you ate the cleanest and well balanced diet on earth w/ animals that are pure and veggies that are pesticide free and grown in nutrient dense soil. Then there is the pollution in the air... you get my drift.

And never ever eat anything processed ever again.

 

[hexagonal]

Realistically, we have nothing but anecdotal reports on what happens with stacking. We don't know the long term impact and risks, if any.

Other glucagon agonist drugs (NN1177) have failed trials due to safety concerns - it's possible the ratio is important to keeping them safe.

I personally am not a fan of stacking multiple drugs in this category, but a lot of people do seem to be having short to medium term success doing so, and that might carry through to the long term. Might not.

 

[Morbius]

I think @hexagonal nailed it.

If you stack, you really are "researching." Good luck!

 

[Ribboncutter21]

Well this was an impactful thread. I am about to start my second dose 10.0 of tirz. It's been a bit of a surprising last 4 weeks for me. So, I was a sema non-responder. Food noise was much quieter, and I was not completely unhappy, but my insurance was pushing for results or cancel of coverage. I switched to to tirz and bam. Food noise was gone and so was my appetite--like I had to remind myself that food was necessary. BUT, these past few weeks I've noticed that tirz has not been as "powerful" in that area as my initial transition from sema to tirz. As mentioned in a previous introductory thread, I have found myself in the peptide world as I prep for insurance canceled coverage and/or just having more ownership over my access to GLP-1's. I have coverage with tirz until at least Feb 2026, so I was like ya know, let me dip my little toesies in. I JUST placed an order for reta after reading various reddit posts on stacking/split dosing with reta. Reading more on this forum has me me wondering if I made a mistake. Lol. Like I should have bought Cagri instead. I'm just a baby.

 

[fatty33]

Because I heard reta was better. One of my coworkers is on reta. And she lost petty good on it. The last time I pinned 3 mg of reta I had really bad gas and bloating. I just pinned 3 today so hoping it was the turkey dinner...lol

Well when I finally get to reta I hope it doesn't give me gas!!! I just came off a 4 year gas fest from eating cashews daily!! I didn't know that cashews were what was causing the gas!! I thought that it was happening because I was getting old LOL

 

[keangkong]

Well this was an impactful thread. I am about to start my second dose 10.0 of tirz. It's been a bit of a surprising last 4 weeks for me. So, I was a sema non-responder. Food noise was much quieter, and I was not completely unhappy, but my insurance was pushing for results or cancel of coverage. I switched to to tirz and bam. Food noise was gone and so was my appetite--like I had to remind myself that food was necessary. BUT, these past few weeks I've noticed that tirz has not been as "powerful" in that area as my initial transition from sema to tirz. As mentioned in a previous introductory thread, I have found myself in the peptide world as I prep for insurance canceled coverage and/or just having more ownership over my access to GLP-1's. I have coverage with tirz until at least Feb 2026, so I was like ya know, let me dip my little toesies in. I JUST placed an order for reta after reading various reddit posts on stacking/split dosing with reta. Reading more on this forum has me me wondering if I made a mistake. Lol. Like I should have bought Cagri instead. I'm just a baby.

Is there a reason that you're not waiting to see if a higher dose of tirz will work better?

 

[Ribboncutter21]

Is there a reason that you're not waiting to see if a higher dose of tirz will work better?

Fair question. Honestly what I was reading, it sounded like that was the path I needed to go down. With so much info out there (and a lot of stacking being anecdotal) it was like taking a jump and then having second thoughts after I did. I realize at at 10mg on tirz I'm still titrating up. But I was feeling a bit let down at 7.5, so doc agreed it was time to move me up. I was nervous not feeling any difference on the first week at 10mg. With the idea that stacking reta would be no issue (then insert this thread), I thought I was making a choice that would support my current regiment, but a lot of what I am reading is that it could be counterproductive.

 

[trinik28]

So every time I went to my mother-in-law’s place, we’d have sushi—and she always had a bowl of cashews out. Turns out, that combo is basically a biological weapon for me. Instant gas. Like, make-the-dog-leave-the-room level.

Trying to be polite, I’d sneak out onto her balcony for a smoke and to, uh… release some pressure. I thought I was being considerate.

What I didn’t realize is that her air conditioner intake was right there.

So I stroll back inside all relaxed, and everyone’s sniffing around, looking confused, trying to figure out what died. Meanwhile, I’m standing there pretending to be just as concerned—completely unaware I’d just fumigated the entire house through the AC.

Moral of the story: never mix sushi, cashews, and a well-placed air conditioner.

 

[keangkong]

So every time I went to my mother-in-law’s place, we’d have sushi—and she always had a bowl of cashews out. Turns out, that combo is basically a biological weapon for me. Instant gas. Like, make-the-dog-leave-the-room level.

Trying to be polite, I’d sneak out onto her balcony for a smoke and to, uh… release some pressure. I thought I was being considerate.

What I didn’t realize is that her air conditioner intake was right there.

So I stroll back inside all relaxed, and everyone’s sniffing around, looking confused, trying to figure out what died. Meanwhile, I’m standing there pretending to be just as concerned—completely unaware I’d just fumigated the entire house through the AC.

Moral of the story: never mix sushi, cashews, and a well-placed air conditioner.

I don't worry about situations like that since I know that my farts smell great.

 

[cgall88]

Hi. Been taking mounjaro (tirz) 15mg for last 6 months and stalled completely so ordered Reta as I am now obsessed with doing weights and it seems a better fit. Probably have around 10kg of fat still to lose but want to hammer the weights as well which can get conflicting as need calories to grow muscle. Really thought about an immediate switch to Reta 2mg and stopping tirz at same time ie swap. Then I thought why not take 5mg tirz for say 5weeks with the 2mg Reta after reading a few forums on here rather than going cold turkey in the tirz. Interested in any feedback on the 2 options as decision to be made 1 week today and I’m so undecided although won’t lie temped in the take both for 5 weeks to minimise food noise.

Decision time and I appreciate it’s mine to make but feedback most welcome

Cheers all for the great informative discussions that go down daily on here, love it

 

[keangkong]

I’d stick with tirz and slowly add Reta while leaving the tirz dose the same. I’m trying to avoid having you regain wait during a transition from tirz to Reta.

 

[cgall88]

I’d stick with tirz and slowly add Reta while leaving the tirz dose the same. I’m trying to avoid having you regain wait during a transition from tirz to Reta.

Thanks for feedback

 

[desinr-gal]

I am stacking both, and it is working well. The tirz kills my appetite, the reta is driving weightloss and gives more energy than tirz alone.

 

[cgall88]

I am stacking both, and it is working well. The tirz kills my appetite, the reta is driving weightloss and gives more energy than tirz alone.

Thanks. I know keangkong suggested sticking with full dose of tirz and gradually introduce Reta but although appreciate this advice I’m not really wanting to go 15 + 2. All be maybe reducing my tirz to 5 while adding 2mg Reta may not be sufficient. Maybe somewhere in middle.

Could I ask what your stack mix is if you don’t mind and do you separate the 2 once a week but split etc?

 

[desinr-gal]

Thanks. I know keangkong suggested sticking with full dose of tirz and gradually introduce Reta but although appreciate this advice I’m not really wanting to go 15 + 2. All be maybe reducing my tirz to 5 while adding 2mg Reta may not be sufficient. Maybe somewhere in middle.

Could I ask what your stack mix is if you don’t mind and do you separate the 2 once a week but split etc?

Its best to tweak and see.. I am at 3mg Tirz and 2.75 Reta, averaged week, I split these into doses every 3 days on staggered days. 1.2 R and 1.1R. I suggest starting low on Reta and then adding more bit by bit, because it does raise your heart rate. mine varies between 63 and 80 at rest..

 

[Juliana]

i've been on terzepatide since July and currently on 12.5mg. Recently purchased reta and took 1mg 4 days after the terzepatide dose. I'm thinking of upping the reta dose whilst reducing the terzepatide.

 

[cgall88]

I am stacking both, and it is working well. The tirz kills my appetite, the reta is driving weightloss and gives more energy than tirz alone.

Thanks. I know keangkong suggested sticking with full dose of tirz and gradually introduce Reta but although appreciate this advice I’m not really wanting to go 15 + 2. All maybe reducing my tirz to 5 while adding 2mg Reta may not be sufficient. Maybe somewhere in middle.

Could I ask what your stack mix is if you don’t mind and do you separate the 2 once a week but split etc?

i've been on terzepatide since July and currently on 12.5mg. Recently purchased reta and took 1mg 4 days after the terzepatide dose. I'm thinking of upping the reta dose whilst reducing the terzepatide.

Thanks Juliana I think I’m going to drop to 7.5mg with 1mg Reta for a few weeks and get the lay of the land then take it from there. Ideally don’t want to be long term doubling GLP peps. The end goal for me is to switch completely from Tirz to Reta and hopefully maintain around the 8mg Reta long term. I guess everybody reacts differently as these forums and threats clearly indicate. Would love to know how your journey progresses and happy to share mine. Thanks again

 

[desinr-gal]

i've been on terzepatide since July and currently on 12.5mg. Recently purchased reta and took 1mg 4 days after the terzepatide dose. I'm thinking of upping the reta dose whilst reducing the terzepatide.

A lot of people find that Reta doesnt kill the appetite/food noise like Tirz does, until you get to higher doses.

 

[lostlakebear]

You're on an introductory dose of the most proven effective FDA approved drug for weightloss. If you paid Lily's price for Tirz you'd be taking this more seriously and not having FOMO.

Another vote for sticking with the Tirz.

I am an inbetweener, so I am not sure this logic applies. My Tirz is a brand name but has been free most of the year because a spouse's triple bypass maxed out our deductible/out of pocket. With 2026 looming, I am looking at options. I have slowly lost 30-40 pounds, but it appears I have plateaued. At 260lbs,I want to go further. Would you vote to continue Tirz (but from a more reasonable source) or jump to Reta. 7.5mg is my current dosage. Also a Type 2 diabetic and Tirz this has been a miracle for my A1C. Thank you!