Semaglutide 7.2mg achieved 20.7% weight loss in STEP UP obesity trial

[keangkong]

thepharmaletter, Semaglutide 7.2mg achieved 20.7% weight loss in STEP UP obesity trial (Jan. 17, 2025)

 

[exploitedworkerbee]

Nobody could eat because they were napping all day. I tried sema 7.2 and was fricking exhausted.

 

[m100568]

From the study: "experienced weight loss of 20.7% after 72 weeks, compared to 17.5% in the semaglutide 2.4 mg cohort." So, tripling the dose achieved a 3% increase. I think they have hit the point of diminishing returns. I can't imagine what the side effects would be for that small of an increase. This seems to be a battle for market share. Cagrisema will match tirzepatide, not beat it. Retatrutide and Evil Lilly will be king when it comes out. Semaglutide will be 3rd tier.

 

[chmuse]

From the study: "experienced weight loss of 20.7% after 72 weeks, compared to 17.5% in the semaglutide 2.4 mg cohort." So, tripling the dose achieved a 3% increase. I think they have hit the point of diminishing returns. I can't imagine what the side effects would be for that small of an increase. This seems to be a battle for market share. Cagrisema will match tirzepatide, not beat it. Retatrutide and Evil Lilly will be king when it comes out. Semaglutide will be 3rd tier.

Keeping in mind, they all have other things they work on, too. If you're looking at JUST weight loss, tirz and reta. If you have fatty liver, reta or cagrisema or survo. If you have heart issues, no reta. Sema or cagrisema best for SUD or AUD or BED, and I think I remember sema being best for cognitive decline, as well.

I think they're all going to be useful in different ways.

 

[McFatty]

I was kn 2.4mg and I stalled for months. I had horrible heart burn and felt weird after taking the shot. Switched to tirz, no side effects and weight loss at 7.5 every 5 days. I can't fathom what 7.2 would do to me.

 

[holiday]

If you have heart issues, no reta

I been considering reta.

Regarding heart issues, I'm coming up with stats that suggest around 6% of participants have heart issues, can anyone confirm or know of more recent studies? (for example: https://www.nejm.org/doi/full/10.1056/NEJMoa2301972#fv-t3fn2)

(edit if that link goes to the main article, see table 3 "Adverse Events and Safety." that's what I meant to link to.)

 

[Galora]

I been considering reta.

Regarding heart issues, I'm coming up with stats that suggest around 6% of participants have heart issues, can anyone confirm or know of more recent studies? (for example: https://www.nejm.org/doi/full/10.1056/NEJMoa2301972#fv-t3fn2 )

Table 1 in that article, shows 30-40% of all reta groups with hypertension. Not sure what you call heart issues particularly.

Table 3 I ckudes adverse effects but doesn't call out increased heart rate, so it wasn't severe I guess. Arrhythmia is very low.

 

[keangkong]

I been considering reta.

Regarding heart issues, I'm coming up with stats that suggest around 6% of participants have heart issues, can anyone confirm or know of more recent studies? (for example: https://www.nejm.org/doi/full/10.1056/NEJMoa2301972#fv-t3fn2 )

I used the "find" command in my browser looking for "6." I couldn't find the 6% you referenced.

 

[holiday]

I used the "find" command in my browser looking for "6." I couldn't find the 6% you referenced.

Right most column. Here's a screenshot to clarify. Red circles drawn over relevant data points.

(Edit correct screenshot attached this time)

 

[chmuse]

Right most column. Here's a screenshot to clarify. Red circles drawn over relevant data points.

(Edit correct screenshot attached this time)

Is that that reta caused arrhythmia? Or people with it in general already? That's the one I was worried about- whether people with preexisting heart issues are more at risk.

 

[holiday]

Is that that reta caused arrhythmia? Or people with it in general already? That's the one I was worried about- whether people with preexisting heart issues are more at risk.

Good question. The article doesn't specifically mention it, that I can see.

Interesting that some in the placebo group reported arrhythmia symptoms. This plus the article mentions "discontinuation of at least one antihypertensive medication" so I'll infer from that that some of the participants had hypertension and wouldn't surprise me if they had other pre-existing issues.

 

[chmuse]

Good question. The article doesn't specifically mention it, that I can see.

Interesting that some in the placebo group reported arrhythmia symptoms. This plus the article mentions "discontinuation of at least one antihypertensive medication" so I'll infer from that that some of the participants had hypertension and wouldn't surprise me if they had other pre-existing issues.

I suspect that certain heart issues will make reta contraindicated. But until it's out of trials we won't know for sure.