瑞他曲肽对酒精渴望的影响？

[hotdog!]

请问有人能分享一下Reta对饮酒量/酒瘾的影响吗？

我听说替拉西肽可以减轻酒瘾和饮酒量。就我个人服用替拉西肽的经验来看，确实如此，但它肯定不是万能药。

我最近彻底戒酒了，但之前我处于功能性酒精依赖的阶段，每天都会喝酒，但只在晚上5点到8点之间喝，而且每次的量都一样。一瓶葡萄酒就能缓解压力和焦虑，而且我早上6点起床也不会宿醉。开始服用替拉西肽后，我减少了饮酒量，但如果我恢复到每天晚上喝一瓶葡萄酒的量，也不会有什么问题。虽然服用替拉西肽期间我感觉生理上的（成瘾性的）饮酒冲动有所减轻，但出于习惯，我仍然会想喝酒。如果我愿意，我可以“克服”替拉西肽的副作用继续喝酒，但我确实感觉饮酒的欲望降低了。当然，我希望自己能少喝点酒。

我只是想知道Reta对饮酒的影响是相同、更强还是更弱。

 

[acatcatcat]

我当时正在谷歌搜索自己是不是酗酒者，结果就碰巧喝完了一瓶酒。以前如果想喝的话，我每晚都能轻松喝完一瓶。自从开始服用Tirz，尤其是Reta之后，我就很难再喝酒了。我就是受不了酒的味道，我也不知道自己到底是怎么回事……我只知道现在我很少喝超过一杯的酒，而且也没有想喝的欲望。

 

[moonpies4misfits]

我相信这肯定会产生影响，因为它们都作用于GLP-1和GIP受体。主要区别在于Reta还作用于胰高血糖素受体。

 

[mopo89]

因为瑞塔，我已经戒酒41天了。我对喝酒的渴望完全消失了。

 

[exploitedworkerbee]

Can anyone report what, if any, effects Reta has had on alcohol consumption/craving to drink?

I have heard about tirzepatide's lessening alcohol cravings and consumption. In my experience with tirz, this has been true, but certainly not a cure-all.

I recently quit drinking altogether, but I was in functional alcoholic territory, where I would drink everyday, but only from 5-8 and always the same amount. 1 bottle of wine would numb the stress and anxiety, but I could still get up at 6am without a hangover. When I started tirz, I cut down, but if I ramped back up to the same bottle of wine every night without issue. The urge to drink is still there, out of habit, even though I felt less of a physiological (addictive) compulsion to drink while taking tirz. I could "drink through" the tirz effect if I decided to, but I did feel less of a desire to drink. Of course, I want to drink less.

I just wondered if Reta had the same, stronger or less effect on drinking.

I’m sorry, I know this isn’t what you asked, but have you considered going to an AA meeting? I’m in recovery, haven’t drank in over a decade, haven’t been to a meeting in a long time, but in the early days of getting sober it was super helpful if just as free group therapy with people who you could relate with. I still use the coping skills and approach in all kinds of life problems.

Good luck getting this sorted out. White knuckling it can be tough. Eventually if you don’t drink for long enough you don’t think about it anymore, or at least that’s how it went for me.

 

[Vacation4us]

Can anyone report what, if any, effects Reta has had on alcohol consumption/craving to drink?

I have heard about tirzepatide's lessening alcohol cravings and consumption. In my experience with tirz, this has been true, but certainly not a cure-all.

I recently quit drinking altogether, but I was in functional alcoholic territory, where I would drink everyday, but only from 5-8 and always the same amount. 1 bottle of wine would numb the stress and anxiety, but I could still get up at 6am without a hangover. When I started tirz, I cut down, but if I ramped back up to the same bottle of wine every night without issue. The urge to drink is still there, out of habit, even though I felt less of a physiological (addictive) compulsion to drink while taking tirz. I could "drink through" the tirz effect if I decided to, but I did feel less of a desire to drink. Of course, I want to drink less.

I just wondered if Reta had the same, stronger or less effect on drinking.

When I was on Sema/ Wegovy I hardly drank. When my doctor added Contrave ( for binge eating disorder) I had zero desire to drink . Contrave is Wellbutrin and Naltrexone combined. Naltrexone is used in higher doses for addiction. Naltrexone is an extremely inexpensive generic drug. If you could see an doctor for a prescription I would highly recommend it.

 

[YoYoFat]

It’s the GLP-1 that is shown to curb alcohol cravings, so you’d find that particular benefit in Sema, Tirz, and Reta.

 

[Dee X]

Listen to @exploitedworkerbee , he's totally right about the meetings idea. What's the worst that can happen if you go to check it out? You were drinking quite a bit for reasons that'll keep you hooked.

That said, GLP1s (Reta included) will help you, but make sure you don't find another vice AND you know how to deal with those emotions once the assistance from these meds wears off.

Also, you're a very complicated hot dog.

 

[hotdog!]

"Complicated hot dog" made me laugh. I guess it may sound that way. It's mostly anxiety, over-worrying and overthinking as an introvert. I also have a 6-yr-old with an ADHD and ASD diagnosis and that brings its fair share of stress. I drink (and eat) to self-medicate those things. I did online AA groups for a bit and it felt...weird. I just don't wholly buy in to the idea of meetings, and without that buy-in I doubt they'd be an effective tool for me. Maybe that's just me not being ready for it.

I do have an appointment with a psych to discuss anxiety treatment, hopefully medication. I've been on fluoxetine decades ago for depression and feel it was a good fit. I'll ask about the Contrave, thanks @Vacation4us. I appreciate all suggestions and feedback!

 

[mopo89]

"Complicated hot dog" made me laugh. I guess it may sound that way. It's mostly anxiety, over-worrying and overthinking as an introvert. I also have a 6-yr-old with an ADHD and ASD diagnosis and that brings its fair share of stress. I drink (and eat) to self-medicate those things. I did online AA groups for a bit and it felt...weird. I just don't wholly buy in to the idea of meetings, and without that buy-in I doubt they'd be an effective tool for me. Maybe that's just me not being ready for it.

I do have an appointment with a psych to discuss anxiety treatment, hopefully medication. I've been on fluoxetine decades ago for depression and feel it was a good fit. I'll ask about the Contrave, thanks @Vacation4us . I appreciate all suggestions and feedback!

If you don’t like meetings (I don’t), I have found the stopdrinking subreddit very helpful! It’s a good one to lurk in and read stories. I always come out feeling supported even if I haven’t really posted.

And good luck with contrave! I was prescribed it a few years ago for weight loss and it did absolutely nothing for me and I react very poorly to Wellbutrin.

 

[Dee X]

If you don’t like meetings (I don’t), I have found the stopdrinking subreddit very helpful! It’s a good one to lurk in and read stories. I always come out feeling supported even if I haven’t really posted.

And good luck with contrave! I was prescribed it a few years ago for weight loss and it did absolutely nothing for me and I react very poorly to Wellbutrin.

Binge Intervention at the same time.

 

[Rohjay]

"Complicated hot dog" made me laugh. I guess it may sound that way. It's mostly anxiety, over-worrying and overthinking as an introvert. I also have a 6-yr-old with an ADHD and ASD diagnosis and that brings its fair share of stress. I drink (and eat) to self-medicate those things. I did online AA groups for a bit and it felt...weird. I just don't wholly buy in to the idea of meetings, and without that buy-in I doubt they'd be an effective tool for me. Maybe that's just me not being ready for it.

I do have an appointment with a psych to discuss anxiety treatment, hopefully medication. I've been on fluoxetine decades ago for depression and feel it was a good fit. I'll ask about the Contrave, thanks @Vacation4us . I appreciate all suggestions and feedback!

That’s how I handled my stress when my older kids were young. I started blaming the stress for me wanting to escape to a bar. You won’t be surprised to know it solved nothing and made my bad marriage worse. I still find myself wanting to do that with my second family. It’s amazing how effective an aggressively paced walk is to solve your issues.

 

[cldfront]

Can anyone report what, if any, effects Reta has had on alcohol consumption/craving to drink?

I have heard about tirzepatide's lessening alcohol cravings and consumption. In my experience with tirz, this has been true, but certainly not a cure-all.

I recently quit drinking altogether, but I was in functional alcoholic territory, where I would drink everyday, but only from 5-8 and always the same amount. 1 bottle of wine would numb the stress and anxiety, but I could still get up at 6am without a hangover. When I started tirz, I cut down, but if I ramped back up to the same bottle of wine every night without issue. The urge to drink is still there, out of habit, even though I felt less of a physiological (addictive) compulsion to drink while taking tirz. I could "drink through" the tirz effect if I decided to, but I did feel less of a desire to drink. Of course, I want to drink less.

I just wondered if Reta had the same, stronger or less effect on drinking.

This describes me precisely. And I just had a very bad experience drinking on Halloween with Tirz - pretty sure I was drunk driving into work the next day and I quit at 11p the night before. No bueno, especially when you can't eat. Anyway, thanks for putting this question out there. Day 3, here we go...

 

[hotdog!]

As an update, I'm happy to report that the desire to drink is GREATLY dampened. I have not gone completely dry, but instead of 1 bottle of wine or 6-8 beers nightly, I have 2 beers when we go out to dinner on the weekend. I have gone weeks without drinking or wanting to drink.

One Friday night I stopped at one beer. ONE. That has never happened in my life. Before I would have said, "What is the point of ONE? Doesn't even get me drunk!" Now I simply don't want another. Like, what *is* that???

It's really quite amazing, such that I'm dying to know a detailed, scientific, Biochem 101 explanation of exactly how this mechanism works. It must be very tied to addiction pathways. It's fascinating to me.

 

[problems]

Following

 

[DaddyBigRig]

"Complicated hot dog" made me laugh. I guess it may sound that way. It's mostly anxiety, over-worrying and overthinking as an introvert. I also have a 6-yr-old with an ADHD and ASD diagnosis and that brings its fair share of stress. I drink (and eat) to self-medicate those things. I did online AA groups for a bit and it felt...weird. I just don't wholly buy in to the idea of meetings, and without that buy-in I doubt they'd be an effective tool for me. Maybe that's just me not being ready for it.

I do have an appointment with a psych to discuss anxiety treatment, hopefully medication. I've been on fluoxetine decades ago for depression and feel it was a good fit. I'll ask about the Contrave, thanks @Vacation4us . I appreciate all suggestions and feedback!

Has been better than any adhd medication I have taken, which over the years of trial and error has been most. No desire to drink, I go to bed on time, have energy, mood regulation. Of course sleep, exercise and diet creates an inflow effect.

 

[Christine S]

As an update, I'm happy to report that the desire to drink is GREATLY dampened. I have not gone completely dry, but instead of 1 bottle of wine or 6-8 beers nightly, I have 2 beers when we go out to dinner on the weekend. I have gone weeks without drinking or wanting to drink.

One Friday night I stopped at one beer. ONE. That has never happened in my life. Before I would have said, "What is the point of ONE? Doesn't even get me drunk!" Now I simply don't want another. Like, what *is* that???

It's really quite amazing, such that I'm dying to know a detailed, scientific, Biochem 101 explanation of exactly how this mechanism works. It must be very tied to addiction pathways. It's fascinating to me.

What I've found in my research is that glp1s effect the pleasure sensors of the brain. Just as it helps to quiet the food noise, it also helps to control addiction. Not only do they help with my alcohol cravings, but with my stess related shopping trips as well. I just dont find pleasure in them anymore.

 

[G Vice]

My experience as well. When I started Tirz at the lowest dose of 2.5 mg way back in March, it blew my mind how I could not finish one glass of wine or finish one margarita. But I"m back up to 2 glasses of wine or 2 cocktails again, even at higher doses. Currently at maintenance dose of 5.0 mg.

Libido remains way down however.

 

[Dee X]

My experience as well. When I started Tirz at the lowest dose of 2.5 mg way back in March, it blew my mind how I could not finish one glass of wine or finish one margarita. But I"m back up to 2 glasses of wine or 2 cocktails again, even at higher doses. Currently at maintenance dose of 5.0 mg.

Libido remains way down however.

It's interesting how for some people, libido skyrockets. For others, it completely tanks.

 

[RideTheBike]

I am 41 days sober because of Reta. The desire to drink is completely gone

Jealous, I am not experiencing this.