瑞他曲肽对酒精渴望的影响?

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Tirz has about completely removed my desire to drink. I’ve been heavy drinker at times, and completely sober at times. This seems different, just zero desire - there’s been the same bottles on my counter for months!
 
RideTheBike said:
Jealous, I am not experiencing this.
Every study I've seen says sema is best because it bonds best to the right receptor. Maybe try stacking a small amount of sema?
 
I'm currently on Tirz and doing my annual Dry January - and I think it's definitely much easier than in previous years. Before after a long day's working it would have been sitting in my mind - now I'm just finishing work and I don't even want it. The only time it's been hard is when I've went to the pub to meet friends and watch football - or had a meal out last weekend - being surrounded by people drinking makes you have the social urge, rather than a chemical addiction.
 
Well the anti-drinking effects of tirz have greatly diminished for me. The disinterest in drinking just didn't last for me. I'm sad and disappointed about that, but I will keep trying to quit and at least cut down. If only because I'm pretty sure that drinking is effectively canceling out much if not all of the helpful Tirz effects, not just weight loss.
 
hotdog! said:
Well the anti-drinking effects of tirz have greatly diminished for me. The disinterest in drinking just didn't last for me. I'm sad and disappointed about that, but I will keep trying to quit and at least cut down. If only because I'm pretty sure that drinking is effectively canceling out much if not all of the helpful Tirz effects, not just weight loss.
I'm sorry to hear that!

It's definitely died down a bit for me and I get cravings now, which had completely disappeared for me (but could also be attributed to stress right now, idk). But I figure it gives me a chance to practice will power and to continue finding ways to de-stress that don't involve alcohol!
 
Since starting Reta in October I have completely wiped out alcohol. I’ve even tried to have a beer or whiskey and I just can’t stomach it.
 
chmuse said:
Have you done a full panel? My blood work reads well, but you can still have liver issues/ cirrhosis even if your blood looks okay.

First link I found on it
What is included in a full panel?

i looked at the link you provided and it announces the findings from a 2021 study but I can't see where any medical facilities are actually using the Cirrus algorithm.
 
GimmeABreak said:
What is included in a full panel?

i looked at the link you provided and it announces the findings from a 2021 study but I can't see where any medical facilities are actually using the Cirrus algorithm.
Honestly.... I'm not 100% sure all of them. I know it involves more than just AST and ALT. My point was more that liver damage can be sneaky and you won't always see it on basic blood tests until it's pretty far gone.
 
GimmeABreak said:
What is included in a full panel?

i looked at the link you provided and it announces the findings from a 2021 study but I can't see where any medical facilities are actually using the Cirrus algorithm.
Agree. The researcher in that study in the UK talks about a "fingerprint" pointing to cirrhosis in basic blood work when liver enzymes ALT and AST are normal, but makes no mention of what specifically those other markers are in the blood work. It's like they left out this information on purpose.
 
hotdog! said:
最新消息:我的酒瘾大大降低了。虽然还没完全戒酒,但以前每晚都要喝一瓶葡萄酒或六到八瓶啤酒,现在周末出去吃饭时只喝两瓶。我已经好几个星期没喝酒,也不想喝酒了。

有个周五晚上,我只喝了一瓶啤酒。就一瓶!这在我人生中从未发生过。以前我会说:“就一瓶有什么用?根本喝不醉!”现在我就是不想再喝了。这到底是怎么回事?!

这真的太神奇了,我迫切地想要了解这种机制的详细科学解释,最好是生物化学入门级别的。这肯定和成瘾机制密切相关。这对我来说太有趣了。
我的情况和你之前一模一样。所以瑞曲妥肽比单独使用替格列酮更有效?你能详细说说你具体做了哪些调整吗?谢谢!
 
Grannylearner said:
我的情况和你之前一模一样。所以瑞曲妥肽比单独使用替格列酮更有效?你能详细说说你具体做了哪些调整吗?谢谢!
抱歉,我最初问的是瑞塔(Reta)对饮酒的影响,所以大家误以为我是在讨论瑞塔,但实际上我在后续的帖子中讨论的是替拉西肽(Tirzepatide)的影响。如果你读到最后,就会发现这种影响在几个月后已经大大减弱了。我完全可以克服替拉西肽让我对酒精失去兴趣的副作用继续喝酒。我在十二月的大部分时间和一月的部分时间里都是这么做的。有几周时间,我又恢复了每晚喝一瓶葡萄酒或六七瓶啤酒的习惯。不出所料,那段时间我的体重没有减轻。

但服用替拉西肽期间,我更容易下定决心不喝酒。现在我又戒酒了,体重正在慢慢下降。

我尝试服用瑞塔大约六七周,但皮肤敏感是个大问题,而且我以前有过非常痛苦的神经病变,虽然很久以前就痊愈了,但我很害怕复发。我也很不喜欢饥饿感增强,尤其是对甜食的渴望,这在以前对我来说从来都不是问题。所以,我一直没能亲眼见识到瑞塔在抑制酒精渴望方面究竟有多出色。
 
hotdog! said:
Sorry, since I originally asked about Reta's effects on alcohol consumption, it gives the impression I was talking about Reta, but I am talking about the effects of Tirzepatide in these subsequent posts. But if you read through to the end, you'll see that effect is greatly dampened now, just a few months later. I can certainly drink through the Tirz effects that made me uninterested in alcohol. And I did that for most of December, part of January. For a few weeks I went right back to the nightly bottle of wine or 6-7 beers. I lost no weight during that time, unsurprisingly.

But it is still easier to make the decision to not drink when I am on tirz. Now that I cut out drinking again, the weight is slowly moving back down again.

I tried Reta for about 6-7 weeks but the skin sensitivity was a big issue, plus I had a history of a very painful neuropathy issue that resolved long ago and I am very afraid of getting again. I also disliked the increased feeling of hunger, specifically cravings for sweets which were previously never an issue for me. So I was never able to see first hand how much better Reta was at suppressing alcohol cravings.
Thank you for responding! I have heard that the alcohol cravings aren’t as reduced for people who are not obese. I am just a little overweight, so I wondered if that might be why I haven’t experienced the lack of interest or distaste for alcohol. I noticed one comment suggested stacking a bit of semi with the tirz. Maybe I will try that. Of course, I agree that other recovery programs may be helpful, but I’m looking at both paths. ❤️
 
Grannylearner said:
Thank you for responding! I have heard that the alcohol cravings aren’t as reduced for people who are not obese. I am just a little overweight, so I wondered if that might be why I haven’t experienced the lack of interest or distaste for alcohol. I noticed one comment suggested stacking a bit of semi with the tirz. Maybe I will try that. Of course, I agree that other recovery programs may be helpful, but I’m looking at both paths. ❤️
I've only been on sema, but I can confirm it works well. Anecdotes I've seen seem to show sema is best for addictive behaviors.
 
Grannylearner said:
Thank you for responding! I have heard that the alcohol cravings aren’t as reduced for people who are not obese. I am just a little overweight, so I wondered if that might be why I haven’t experienced the lack of interest or distaste for alcohol. I noticed one comment suggested stacking a bit of semi with the tirz. Maybe I will try that. Of course, I agree that other recovery programs may be helpful, but I’m looking at both paths. ❤️
Oh no, I am obese, started at class III and now at class I. So I can't say whether that's true for others, but it's not the case for me. For me it is more a Pavlovian conditioning, functional type of alcohol addiction. But still an addiction, I'm not deluding myself about that.
 
hotdog! said:
Oh no, I am obese, started at class III and now at class I. So I can't say whether that's true for others, but it's not the case for me. For me it is more a Pavlovian conditioning, functional type of alcohol addiction. But still an addiction, I'm not deluding myself about that.
Moving from class 3 to 1 is fantastic -that is a lot to celebrate right there. I’m also very functional which makes it easier to ignore the negative consequences. When I have had periods of sobriety, my anxiety is lower. Wishing you the best.
 
chmuse said:
I've only been on sema, but I can confirm it works well. Anecdotes I've seen seem to show sema is best for addictive behaviors.
Thank you. Has the effect been consistent over time? Or did you notice less or more after several weeks on it?
 
Grannylearner said:
Thank you. Has the effect been consistent over time? Or did you notice less or more after several weeks on it?
Volume wise it was immediately down like 95%. I just didn't feel like drinking as much. By 2 months in I managed to be sober a solid two weeks, before I ended up drinking emotionally. I'd say I'm still down 90% from the amount I was drinking before sema- if I go out, I have a shot or two or just don't feel like drinking at all. I'm still capable of getting shitty drunk if something gets me all up in my feels, but I pay the price the next day and it puts me off trying again for a while.

Context: my first shot was Oct 1
 
I go for vodka and diet sports drinks. Seems to keep my electrolytes more balanced especially doing keto and glp1.
 
Yes, I, like most obese people, know all about the calories.

I have preferences for certain reasons that have to do with attempts at self-moderation. I tend to guzzle when I drink, so if I'm guzzling liquor I will end up way, way more drunk far quicker than I intend. In fact, if I drink liquor drinks I will end up passed-out drunk and probably close to alcohol poisoning with the world's most debilitating hangover the next day. The volume and feeling of fullness from beer and wine is a safety that slows me down.
 
hotdog! said:
Yes, I, like most obese people, know all about the calories.

I have preferences for certain reasons that have to do with attempts at self-moderation. I tend to guzzle when I drink, so if I'm guzzling liquor I will end up way, way more drunk far quicker than I intend. In fact, if I drink liquor drinks I will end up passed-out drunk and probably close to alcohol poisoning with the world's most debilitating hangover the next day. The volume and feeling of fullness from beer and wine is a safety that slows me down.
I have the exact same issue, years of beer drinking gives me a certain rhythm. It is not suitable for wine or stronger mixed drinks. I mix vodka and diet sports drinks down to about 4.5%. Unsweet tea with diet lemonade is also good. I get full and slow down.
 
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