Retatrutide 1 mg/week – When Did It Start Working for you?

[dandam]

I’m currently on retatrutide 1 mg per week, split into 0.5 mg twice weekly.

For those using the same or similar dosing:

After how long did you start noticing appetite suppression?

When did weight loss become evident?

What side effects did you experience, if any?

Sharing timelines and concrete experiences would be very helpful.

 

[CNCCurrency]

Not until around 4mg

 

[HumanusExMachina]

Appetite suppression started working for me about 3 days in at 1mg once weekly. I had weight loss in the second week. As far as side-effects, I had brief bouts of fatigue over the first 2-3 weeks, along with some stomach discomfort that wasn't quite up to nausea.

 

[yrrdead]

I started about the same dosing as you(hard to know exactly with smaller vials and overfill) but lets assume similar dosing. Though I am dosing every 3 days.

1. Probably after my second pin. Though hard to know what is drug vs placebo.

2. Well I was tracking calories from my first pin and trying to weigh myself at the same time every day. So the weight loss was almost immediate due to water/inflammation + calorie deficit. I will say that is pretty normal with any calorie restriction in my experience.

3. Burping (no sulphur), constipation (calorie restriction doesn't help), little indigestion w/ fatty meals. Some dehydration headaches.

 

[Indiana]

It took 3 days before the food noise stopped. One thing I don't like about it is the skin sensitivity. But I love how my body looks now.

 

[randombetrayal 22579]

I’m currently on retatrutide 1 mg per week, split into 0.5 mg twice weekly.

For those using the same or similar dosing:

After how long did you start noticing appetite suppression?

When did weight loss become evident?

What side effects did you experience, if any?

Sharing timelines and concrete experiences would be very helpful.

I am on this same dosing for maintenance and general body recomp efforts, 0.5 mg every 3 days. I found that about 4-6 weeks was when I felt the appetite control. I initially lost about 12 pounds earlier this spring and have maintained it since that point, as it was my goal weight. As mentioned, I am now in maintenance and attempting to recomp approximately 5 pounds of fat into muscle and tap into the insulin-resistant benefits Reta provides. If I increase the dose, I find it too hard to keep hitting my macros to actually add muscle. Plus, with the amount of protein needed coupled with a larger dose, I am not sure the bowel movement issue would be too good of a situation, at least for me.

 

[Fait88]

First time user of peptides here. I pinned myself 1mg reta last Jan 3rd and I noticed the following day I was ignoring the foods in the kitchen which I normally “taste and take a bite” and eventually eat the whole plate later on.

No nausea or any side efffects. I started calorie deficit on Dec 29, so i can’t tell the weightloss was from reta alone because prior pinning myself, i was in a deficit already. Lots of water weightloss tho.

 

[Gohengrin]

I noticed it with 4mg. 6mg Was better. I did 2mg 4 weeks, then 4mg 4 weeks and so on. The last 4mg shot was noticable.

I also had no side effects until then. Now I get red itchy spots at injection site, because of the reta itself.

 

[woundcarping]

…Plus, with the amount of protein needed coupled with a larger dose, I am not sure the bowel movement issue would be too good of a situation, at least for me.

Are you monitoring/achieving fiber and water intake?

 

[cowboy54]

started on 0.5mg weekly and found that within a day the food noise disappeared, however I could generally eat 3 meals a day but wasnt overeating.

Weight I had lost 6 pounds in the first 2 weeks, I know a good percentage was probably water loss

Side effects I only noticed more fatigue when running, I am training for a marathon so over 10 miles was finding harder. Ive since tried 0.5mg every 2 weeks, and am now cutting out reta until I complete the race as just cant do both.

Start of March I will go back to 0.5 or 1mg for a few months as long distances will scale down

 

[AxlBundy]

I had already been eating on a plan when I introduced Reta so it was pretty quick that I noticed that it was becoming easier to stick to my plans. Even dropped a meal out of the day. I had even considered what about placebo effect and my conclusion was “who cares if it’s placebo if it’s working”

 

[Coulter1966]

Wow everyone is so very different. I guess that it really is a test and see pep.

 

[weightlossking84]

I started with .5 and within 2 days I noticed a difference in my food cravings.

 

[Thedooman445]

I'm on about 4MG right now and have been on it for about 6 weeks or so now.. I have had no side effects or really any issues - I can still eat just fine. But I have lost about 24 pounds so it must be doing something lol.

 

[WholesomeApril]

I usually pin 1mg a week for 3 or 4 weeks as maintenance when needed.

I notice suppression as soon as I wake the next day and I have a very mild morning sickness/sea sickness feeling for the next 2-3 days.

I did my big weight loss about 18 months ago so just do a little maintenance burst if I feel like I’m getting a little to crazy with the food

 

[Floki575]

When I started 6 weeks ago I needed atleast 3-4 mg to feel any appetite suppresion. But there was a thin line between a good dose and to much suppresion and not being able to eat even 1000kcal a day.

I did to much at some occasion.

Its a little tricky to find the sweet spot.

 

[WYSiWYG]

I started at 1mg/ week - food noise and head clarity was almost immediate for me.

Appetite suppression was mild, as others have stated, wasn't necessarily hungry but was still able to eat to desired macros without issue.

About to pin my 3rd week at 1.5 - and for me - that .5 bump made a huge difference in satiating at meal time - meaning my eyes are way bigger than what I can eat in a sitting. That is taking some adjustment for me - as I forget to eat during the work day - and then try to catch up a bit later in the day - and I am not able to do so.

I will also note - that it has been more than 18 months since I tried any other GLP - and that was sema, never went above 1 mg on that - hated how I felt.

 

[PAPoots]

It took 3 days before the food noise stopped. One thing I don't like about it is the skin sensitivity. But I love how my body looks now.

Getting allodynia at the starting dose seems odd. I'd suggest not titrating up until those affects pass.

That was a weird feeling. I could rub a spot and be fine, but a T-shirt sliding across my skin and it felt like needles coming through from under the skin. I titrated up to 12mg eventually and never got the effects again.

Now my problem is food noise. Or I'm just burnt out on chicken and rice.

 

[Not_Your_Dad]

I titrated from 0 to 8 mg (4 mg pins 84 hours apart) over 8 weeks.

Starting feeling GLP-ish effects around 6 mg. Rolling hard at 8.

 

[Valyra]

Started out at 1mg and it would work on the second day for me. Hunger went away, but I could still eat if I wanted to. The day after, I got full fast. At my second week with 2mg now and I’m not hungry often and I get full after a few bites, even from drinking.

My husband is also at week 2 and it’s starting to work for him now. He’s not hungry anymore and gets full a little faster. Today he hasn’t eaten at all, despite us being at the gym and taking a walk, so he will end up force feeding himself some protein lol