bogardbilla
GLP-1 Apprentice
Yes, if I understand it correctly taking 2mg of the original Egrifta and 1.28mg of Egrifta WR ends up in the same amount of Tesamorelin getting absorbed by the body.UpDownLeftRightAS* said:
Reta with Tesamorelin
- Thread starter Phatmax
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RadicalCrimson
GLP-1 Apprentice
FWIW, Tesa protocols say no titration, but Isa protocols do, so I’m doing it for both:
0.5 weeks at 100/1000
0.5 weeks at 133/1000
2 weeks at 200/1500
Then 266/2000. Could go to 300/2000.
@Calm Logic had a Gemini answer somewhere mentioning titration as a mitigation for Tesa side effects.
I’m also wearing a glucose monitor, and somehow my glucose seems to be getting lower and lower, so I guess insulin resistance is not a concern, lol.
I’m at the 1500 phase.
0.5 weeks at 100/1000
0.5 weeks at 133/1000
2 weeks at 200/1500
Then 266/2000. Could go to 300/2000.
@Calm Logic had a Gemini answer somewhere mentioning titration as a mitigation for Tesa side effects.
I’m also wearing a glucose monitor, and somehow my glucose seems to be getting lower and lower, so I guess insulin resistance is not a concern, lol.
I’m at the 1500 phase.
RadicalCrimson
GLP-1 Apprentice
The FDA approval paper I linked above says:
If fasting glucose reaches 110, either go back to 1mg, or switch to 2mg every 2 days
If IGF-1 reaches 3 standard deviations (+3.0 Z-score?), discontinue entirely.
If fasting glucose reaches 110, either go back to 1mg, or switch to 2mg every 2 days
If IGF-1 reaches 3 standard deviations (+3.0 Z-score?), discontinue entirely.
RadicalCrimson
GLP-1 Apprentice
Yes, Subcutaneous Adipose Tissue (SAT) even slightly up (+2%), but those people with a 27 BMI (close to mine) saw a 1.4kg (3 pounds) reduction in fat (mostly in the trunk), AND a 1.7kg (almost 4 pounds) increase in lean mass, total delta 3.1kg.Derbyshire said:
IOW, they gained more muscle than they lost fat.
Obese people would probably see even better numbers.
I’ll take it.
RadicalCrimson
GLP-1 Apprentice
Bear in mind that this Phase 2 trial was only for 12 weeks.
The Phase 3 trials were for 52 weeks, but they played the evil switcharoo with placebo at 26 weeks (placebo gets Tesa, half of Tesa gets placebo, the other half is the lucky one that gets the full year).
Those extended results are the green line (T-T):
[Imported image pending local asset: attachments-1775461262618-webp.19057]
If you stop Tesa after 6 months, you’re the blue line (T-P).
Summary of Extension Phases of LIPO-010 and CTR-1011 - Clinical Review Report: Tesamorelin (Egrifta) - NCBI Bookshelf
The Phase 3 trials were for 52 weeks, but they played the evil switcharoo with placebo at 26 weeks (placebo gets Tesa, half of Tesa gets placebo, the other half is the lucky one that gets the full year).
Those extended results are the green line (T-T):
[Imported image pending local asset: attachments-1775461262618-webp.19057]
If you stop Tesa after 6 months, you’re the blue line (T-P).
Summary of Extension Phases of LIPO-010 and CTR-1011 - Clinical Review Report: Tesamorelin (Egrifta) - NCBI Bookshelf
RadicalCrimson
GLP-1 Apprentice
Bear in mind that these are all HIV patients who have been taking their HIV medication for years, AND HAVE CONTINUED TAKING IT AFTER DISCONTINUING TESA.
There has been no official explanation to my knowledge as to what causes extra VAT in patients using HIV medication.
Probably because nobody signed up for the trial that switched those up for placebo
There has been no official explanation to my knowledge as to what causes extra VAT in patients using HIV medication.
Probably because nobody signed up for the trial that switched those up for placebo
Derbyshire
GLP-1 Apprentice
Thank you for this. The Blue line is the one that bothers me. But if the people on this kept taking their meds for HIV which is believed to be the reason for the extra VAT, I suppose the reveral is highly likely. It would be interesting to see on people who wasn't taking the HIV meds and see where that blue line would then go. Reading what people say about Tesa and the results they get, seems that Tesa is the way to go instead of CJC-1295 without DAC + IPA?
UpDownLeftRightAS*
GLP-1 Apprentice
As an aside, it seems a bit surprising that this drug is still in production with a 2025 new formula (outside of off-label use), given that the HIV therapies most associated with fat redistribution, particularly early protease inhibitors dating back to the late ’80s and early ’90s.
When you look at what patients went through during that era, often relying on experimental treatments with significant side effects, it really underscores how far the science has come.
From what I’ve seen, including some summaries from Perplexity, modern therapies tend to be associated more with modest overall weight gain rather than the pronounced fat redistribution patterns seen with earlier regimens.
[Imported image pending local asset: attachments-1775490161380-webp.19073]
https://www.perplexity.ai/search/do-modern-hiv-drugs-still-caus-EYVrnphfRjqY.7n8AJjKXQ
When you look at what patients went through during that era, often relying on experimental treatments with significant side effects, it really underscores how far the science has come.
From what I’ve seen, including some summaries from Perplexity, modern therapies tend to be associated more with modest overall weight gain rather than the pronounced fat redistribution patterns seen with earlier regimens.
[Imported image pending local asset: attachments-1775490161380-webp.19073]
https://www.perplexity.ai/search/do-modern-hiv-drugs-still-caus-EYVrnphfRjqY.7n8AJjKXQ
Quatroskin
GLP-1 Apprentice
What was your starting dose and schedule? 5 on 2 off or everyday?RadicalCrimson said:
RadicalCrimson
GLP-1 Apprentice
See above, I’ve only started 2 weeks ago. Every day.Quatroskin said:
bogardbilla
GLP-1 Apprentice
It's not.reyqaz said:
Can you share if you stack it with reta?Zydeceltico said:
What's the intent behind this , is it just the muscle gain or fat loss too?
I stumbled upon a protocol and it said
Fasted at night
2mg tesa
200mcg cjc no dac and 200mcg ipa
Followed by fasted 200mcg ipa in morning
Thinking if it will make sense for weight loss with reta.
What are your thoughts? @Calm Logic would be great if you too can comment.
UpDownLeftRightAS*
GLP-1 Apprentice
Also, as far as I know from the indications nothing states to really be fasted or specific time of day. For GH/Sg's it makes since to maximize the results however as these are very well studied. I take my dose in the am when I wake up fasted anyway (generally I only have a coffee with some vital protein). Same w/ Reta, it wired me too much so I had to take it in the mornings.Phatmax said:
chewonmysac
GLP-1 Enthusiast
I do the exact same. This is my second cycle. The first one only lasted a month. Did not calculate correctly. Saw some decent improvement in waist circumference. This time will be 8 weeks. At week 3 now. No days off. It will be (12) ten mg vials. I do not refrigerate after reconstituting. Really hoping I can wear my netted half-shirt in the summer.UpDownLeftRightAS* said:
The Tesa and the CJC are going to flood the same receptors if you take them at the same time. When you take either one with Ipa you get a 1+1=3 effect, when you take them with each other you get a 1+1=1.5 effect lol. The general idea might still work if you moved your dose of Tesa to the AM with your first dose of Ipa, that’s something I intend to try myself in a month or so.Rickcaps said:
WYSiWYG
GLP-1 Apprentice
So this thread, and the education here in, has me wondering if I should use the 2 kits I just received. I was planning to run Tesa along with Reta in the goal of reducing overall BF. I have a pretty solid handle on diet/nutrition and exercise in the moment - but reading through this, seems like it may not be the right direction in the moment.
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